The EMBO Journal Table of Contents for 14 June 2017; Vol. 36, No. 12

14 June 2017 | Volume 36, Number 12 Submit Table of Contents Commentary News & Views Articles Volume 36, Number 12 Commentary Is magnetogenetics the new optogenetics? The technology has great potential as a tool for precise and efficient activation of neurons in any species without the need for invasive surgery but many technical and biological hurdles still stand in the way of application. Simon Nimpf and David A Keays Published online 23.05.2017 News & Views Getting stress out of stressed‐out stress granules Accumulation of misfolded proteins, including ALS disease‐associated variants, in cytoplasmic stress granules induces their conversion from a functional, dynamic state towards solid, pathological aggregates targeted by autophagy. Pratibha Siwach and Daniel Kaganovich Published online 23.05.2017 NIX‐ing mitochondria: from development to pathology Hypoxia‐induced NIP‐3‐like protein X (NIX) triggers a mitophagy‐dependent metabolic shift towards glycolysis to allow retinal ganglion cell differentiation and M1 macrophage polarization; these findings might also shed light on hypoxia‐induced pathological conditions in the brain. Aleksandra Deczkowska and Michal Schwartz Published online 22.05.2017 Articles Zika virus induces massive cytoplasmic vacuolization and paraptosis‐like death in infected cells Characterizing the effects of the antiviral restriction factor IFITM3 shows that viral production can be impeded by counteracting induction of ER stress and cell death. Blandine Monel, Alex A Compton, Timothée Bruel, Sonia Amraoui, Julien Burlaud‐Gaillard, Nicolas Roy, Florence Guivel‐Benhassine, Françoise Porrot, Pierre Génin, Laurent Meertens, Laura Sinigaglia, Nolwenn Jouvenet, Robert Weil, Nicoletta Casartelli, Caroline Demangel, Etienne Simon‐Lorière, Arnaud Moris, Philippe Roingeard, Ali Amara, and Olivier Schwartz Published online 04.05.2017 An aberrant phase transition of stress granules triggered by misfolded protein and prevented by chaperone function The presence of misfolded protein, such as ALS‐linked variants of SOD1, in stress granules (SGs) leads to a gradual loss of dynamics, suggesting that SG loss‐of‐function could be a factor in aggregation‐linked disease. Daniel Mateju, Titus M Franzmann, Avinash Patel, Andrii Kopach, Edgar E Boczek, Shovamayee Maharana, Hyun O Lee, Serena Carra, Anthony A Hyman, and Simon Alberti Published online 04.04.2017 Programmed mitophagy is essential for the glycolytic switch during cell differentiation Retinal ganglion cell differentiation and M1 macrophage polarization depend on metabolic reprogramming towards glycolysis, which is triggered by hypoxia‐induced autophagic degradation of mitochondria (mitophagy). Lorena Esteban‐Martínez, Elena Sierra‐Filardi, Rebecca S McGreal, María Salazar‐Roa, Guillermo Mariño, Esther Seco, Sylvère Durand, David Enot, Osvaldo Graña, Marcos Malumbres, Ales Cvekl, Ana María Cuervo, Guido Kroemer, and Patricia Boya Published online 02.05.2017 Deletion of PIKfyve alters alveolar macrophage populations and exacerbates allergic inflammation in mice Proper development of tissue‐resident macrophages and suppression of allergic responses in the lung is compromised by ablation of a phosphoinositide kinase in myeloid cells. Takumi Kawasaki, Kosuke Ito, Haruhiko Miyata, Shizuo Akira, and Taro Kawai Published online 22.05.2017 Autophagosome formation is initiated at phosphatidylinositol synthase‐enriched ER subdomains The autophagy initiating ULK complex is recruited to an endoplasmic reticulum subdomain enriched in phosphatidylinositol synthase and subsequently translocates to ATG9A‐positive autophagosome precursors in a phosphatidylinositol‐dependent manner. Taki Nishimura, Norito Tamura, Nozomu Kono, Yuta Shimanaka, Hiroyuki Arai, Hayashi Yamamoto, and Noboru Mizushima Published online 11.05.2017 Sphingolipid metabolic flow controls phosphoinositide turnover at the trans‐Golgi network Sphingolipid production at the trans‐Golgi network triggers a PtdIns(4)P level‐dependent negative feedback loop that ensures maintenance of distinct post‐Golgi endomembrane sphingolipid content and thus counterbalances alterations in lipid metabolic fluxes. Serena Capasso, Lucia Sticco, Riccardo Rizzo, Marinella Pirozzi, Domenico Russo, Nina A Dathan, Felix Campelo, Josse van Galen, Maarit Hölttä‐Vuori, Gabriele Turacchio, Angelika Hausser, Vivek Malhotra, Isabelle Riezman, Howard Riezman, Elina Ikonen, Chiara Luberto, Seetharaman Parashuraman, Alberto Luini, and Giovanni D'Angelo Published online 10.05.2017 A postprandial FGF19‐SHP‐LSD1 regulatory axis mediates epigenetic repression of hepatic autophagy The release of FGF19 upon feeding triggers SHP‐dependent recruitment of LSD1 to autophagy genes, resulting in their repression and illustrating how autophagy rates are adjusted to nutrient state. Sangwon Byun, Young‐Chae Kim, Yang Zhang, Bo Kong, Grace Guo, Junichi Sadoshima, Jian Ma, Byron Kemper, and Jongsook Kim Kemper Published online 26.04.2017 A microRNA‐129‐5p/Rbfox crosstalk coordinates homeostatic downscaling of excitatory synapses Combining miRNA and mRNA profiling with proteomics reveals roles for miR‐129‐5p and the RNA‐binding protein Rbfox in excitatory synapse function and epileptic seizure. Marek Rajman, Franziska Metge, Roberto Fiore, Sharof Khudayberdiev, Ayla Aksoy‐Aksel, Silvia Bicker, Cristina Ruedell Reschke, Rana Raoof, Gary P Brennan, Norman Delanty, Michael A Farrell, Donncha F O'Brien, Sebastian Bauer, Braxton Norwood, Morten T Veno, Marcus Krüger, Thomas Braun, Jørgen Kjems, Felix Rosenow, David C Henshall, Christoph Dieterich, and Gerhard Schratt Published online 09.05.2017 An activated Q‐SNARE/SM protein complex as a possible intermediate in SNARE assembly The ternary complex syntaxin1, SNAP25a and Munc18‐1 acts as an intermediate in the SNARE assembly pathway by functioning as an acceptor for synaptobrevin/VAMP‐2. Shrutee Jakhanwal, Chung‐Tien Lee, Henning Urlaub, and Reinhard Jahn Published online 08.05.2017   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 973 University Avenue * Los Gatos, CA 95032 * U.S.A. Copyright © 2017 by the European Molecular Biology Organisation.