Scientific Reports Biology Table of Contents e-alert: 20 June 2017

If you are unable to see the message below, click here to view.

20 June 2017      •Visit Scientific Reports •Submit your manuscript to Scientific Reports     Welcome to your Table of Contents e-alert for Scientific Reports               Biological Sciences               Chemosensory sensitivity reflects reproductive status in the ant Harpegnathos saltatorChemosensory sensitivity reflects reproductive status in the ant Harpegnathos saltator ▶     Majid Ghaninia, Kevin Haight, Shelley L. Berger et al.             Nucleotide based covalent inhibitors of KRas can only be efficient in vivo if they bind reversibly with GTP-like affinityNucleotide based covalent inhibitors of KRas can only be efficient in vivo if they bind reversibly with GTP-like affinity ▶     Matthias P. Müller, Sadasivam Jeganathan, Angelika Heidrich et al.             Revealing protein networks and gene-drug connectivity in cancer from direct informationRevealing protein networks and gene-drug connectivity in cancer from direct information ▶     Xian-Li JiangEmmanuel Martinez-LedesmaFaruck Morcos             EV-3, an endogenous human erythropoietin isoform with distinct functional relevanceEV-3, an endogenous human erythropoietin isoform with distinct functional relevance ▶     Christel Bonnas, Liane Wüstefeld, Daniela Winkler et al.             C-C Chemokine Ligand-5 is critical for facilitating macrophage infiltration in the early phase of liver ischemia/reperfusion injuryC-C Chemokine Ligand-5 is critical for facilitating macrophage infiltration in the early phase of liver ischemia/reperfusion injury ▶     Chiou-Mei Lee, Hsin-Hsin Peng, Polung Yang et al.             Highly functional T-cell receptor repertoires are abundant in stem memory T cells and highly shared among individualsHighly functional T-cell receptor repertoires are abundant in stem memory T cells and highly shared among individuals ▶     Takahiko Miyama, Takakazu Kawase, Kazutaka Kitaura et al.             Gag-protease coevolution analyses define novel structural surfaces in the HIV-1 matrix and capsid involved in resistance to Protease InhibitorsGag-protease coevolution analyses define novel structural surfaces in the HIV-1 matrix and capsid involved in resistance to Protease Inhibitors ▶     Francisco M Codoñer, Ruth Peña, Oscar Blanch-Lombarte et al.             Dysbiosis in chronic periodontitis: Key microbial players and interactions with the human hostDysbiosis in chronic periodontitis: Key microbial players and interactions with the human host ▶     Zhi-Luo Deng, Szymon P. Szafrański, Michael Jarek et al.             Allosteric modulatory effects of SRI-20041 and SRI-30827 on cocaine and HIV-1 Tat protein binding to human dopamine transporterAllosteric modulatory effects of SRI-20041 and SRI-30827 on cocaine and HIV-1 Tat protein binding to human dopamine transporter ▶     Wei-Lun Sun, Pamela M. Quizon, Yaxia Yuan et al.             Interaction of the Antimicrobial Peptide Aurein 1.2 and Charged Lipid BilayerInteraction of the Antimicrobial Peptide Aurein 1.2 and Charged Lipid Bilayer ▶     Durgesh K. RaiShuo Qian             Prediction of lncRNA-protein interactions using HeteSim scores based on heterogeneous networksPrediction of lncRNA-protein interactions using HeteSim scores based on heterogeneous networks ▶     Yun XiaoJingpu ZhangLei Deng             Novel complex of HAT protein TIP60 and nuclear receptor PXR promotes cell migration and adhesionNovel complex of HAT protein TIP60 and nuclear receptor PXR promotes cell migration and adhesion ▶     Karishma Bakshi, B. Ranjitha, Shraddha Dubey et al.             High-throughput mass spectrometry analysis revealed a role for glucosamine in potentiating recovery following desiccation stress in ChironomusHigh-throughput mass spectrometry analysis revealed a role for glucosamine in potentiating recovery following desiccation stress in Chironomus ▶     Leena Thorat, Dasharath Oulkar, Kaushik Banerjee et al.             High-Risk Human Papillomavirus E7 Alters Host DNA Methylome and Represses HLA-E Expression in Human KeratinocytesHigh-Risk Human Papillomavirus E7 Alters Host DNA Methylome and Represses HLA-E Expression in Human Keratinocytes ▶     Louis Cicchini, Rachel Z. Blumhagen, Joseph A. Westrich et al.             Seabirds supply nitrogen to reef-building corals on remote Pacific isletsSeabirds supply nitrogen to reef-building corals on remote Pacific islets ▶     Anne Lorrain, Fanny Houlbrèque, Francesca Benzoni et al.             Rho-kinase inhibitor Y-27632 and hypoxia synergistically enhance chondrocytic phenotype and modify S100 protein profiles in human chondrosarcoma cellsRho-kinase inhibitor Y-27632 and hypoxia synergistically enhance chondrocytic phenotype and modify S100 protein profiles in human chondrosarcoma cells ▶     Juha Piltti, Joakim Bygdell, Cecilia Fernández-Echevarría et al.             Complex neuroanatomy in the rostrum of the Isle of Wight theropod Neovenator saleriiComplex neuroanatomy in the rostrum of the Isle of Wight theropod Neovenator salerii ▶     Chris Tijani Barker, Darren Naish, Elis Newham et al.             Identification of rare genetic variation of NLRP1 gene in familial multiple sclerosisIdentification of rare genetic variation of NLRP1 gene in familial multiple sclerosis ▶     Ales Maver, Polona Lavtar, Smiljana Ristić et al.             Exosomes derived from palmitic acid-treated hepatocytes induce fibrotic activation of hepatic stellate cellsExosomes derived from palmitic acid-treated hepatocytes induce fibrotic activation of hepatic stellate cells ▶     Young-Sun Lee, So Yeon Kim, Eunjung Ko et al.             Endothelial Cell-derived Extracellular Vesicles Size-dependently Exert Procoagulant Activity Detected by ThromboelastometryEndothelial Cell-derived Extracellular Vesicles Size-dependently Exert Procoagulant Activity Detected by Thromboelastometry ▶     Wolfgang Holnthoner, Cornelia Bonstingl, Carina Hromada et al.             Optofluidic device for the quantification of circulating tumor cells in breast cancerOptofluidic device for the quantification of circulating tumor cells in breast cancer ▶     Eric Pedrol, Manuel Garcia-Algar, Jaume Massons et al.             Structural and Biochemical Characterization of Poly-ADP-ribose Polymerase from Trypanosoma bruceiStructural and Biochemical Characterization of Poly-ADP-ribose Polymerase from Trypanosoma brucei ▶     Teemu Haikarainen, Mariana Schlesinger, Ezeogo Obaji et al.             Updating the Phylogenetic Dating of New Caledonian Biodiversity with a Meta-analysis of the Available EvidenceUpdating the Phylogenetic Dating of New Caledonian Biodiversity with a Meta-analysis of the Available Evidence ▶     Romain Nattier, Roseli Pellens, Tony Robillard et al.             Inhibition of Calpains Protects Mn-Induced Neurotransmitter release disorders in Synaptosomes from Mice: Involvement of SNARE Complex and Synaptic Vesicle FusionInhibition of Calpains Protects Mn-Induced Neurotransmitter release disorders in Synaptosomes from Mice: Involvement of SNARE Complex and Synaptic Vesicle Fusion ▶     Can Wang, Bin Xu, Zhuo Ma et al.             Fibronectin promotes directional persistence in fibroblast migration through interactions with both its cell-binding and heparin-binding domainsFibronectin promotes directional persistence in fibroblast migration through interactions with both its cell-binding and heparin-binding domains ▶     Dimitris Missirlis, Tamás Haraszti, Horst Kessler et al.             Improved Growth Patterns in Cystic Fibrosis Mice after Loss of Histone Deacetylase 6Improved Growth Patterns in Cystic Fibrosis Mice after Loss of Histone Deacetylase 6 ▶     Sharon M. Rymut, Deborah A. Corey, Dana M. Valerio et al.             Metabolic and evolutionary patterns in the extremely acidophilic archaeon Ferroplasma acidiphilum YTMetabolic and evolutionary patterns in the extremely acidophilic archaeon Ferroplasma acidiphilum YT ▶     Olga V. Golyshina, Hai Tran, Oleg N. Reva et al.             Dosage compensation in the process of inactivation/reactivation during both germ cell development and early embryogenesis in mouseDosage compensation in the process of inactivation/reactivation during both germ cell development and early embryogenesis in mouse ▶     Xiaoyong Li, Zhiqiang Hu, Xuelin Yu et al.             Crystal structure of the DNA-binding domain of Myelin-gene Regulatory FactorCrystal structure of the DNA-binding domain of Myelin-gene Regulatory Factor ▶     Xiangkai Zhen, Bowen Li, Fen Hu et al.             Recovery of the first full-length genome sequence of a parapoxvirus directly from a clinical sampleRecovery of the first full-length genome sequence of a parapoxvirus directly from a clinical sample ▶     Thomas Günther, Ludwig Haas, Malik Alawi et al.             Epigenetic and antitumor effects of platinum(IV)-octanoato conjugatesEpigenetic and antitumor effects of platinum(IV)-octanoato conjugates ▶     Vojtech Novohradsky, Ilaria Zanellato, Cristina Marzano et al.             Hif-1α Knockdown Reduces Glycolytic Metabolism and Induces Cell Death of Human Synovial Fibroblasts Under Normoxic ConditionsHif-1α Knockdown Reduces Glycolytic Metabolism and Induces Cell Death of Human Synovial Fibroblasts Under Normoxic Conditions ▶     Manuel J. Del Rey, Álvaro Valín, Alicia Usategui et al.             H2S and homocysteine control a novel feedback regulation of cystathionine beta synthase and cystathionine gamma lyase in cardiomyocytesH2S and homocysteine control a novel feedback regulation of cystathionine beta synthase and cystathionine gamma lyase in cardiomyocytes ▶     Shyam Sundar NandiParas Kumar Mishra             A novel imaging method for correlating 2D light microscopic data and 3D volume data based on block-face imagingA novel imaging method for correlating 2D light microscopic data and 3D volume data based on block-face imaging ▶     Yuki Tajika, Tohru Murakami, Keiya Iijima et al.             Early-onset primary antibody deficiency resembling common variable immunodeficiency challenges the diagnosis of Wiedeman-Steiner and Roifman syndromesEarly-onset primary antibody deficiency resembling common variable immunodeficiency challenges the diagnosis of Wiedeman-Steiner and Roifman syndromes ▶     Delfien J. Bogaert, Melissa Dullaers, Hye Sun Kuehn et al.             Ascorbate induces apoptosis in melanoma cells by suppressing Clusterin expressionAscorbate induces apoptosis in melanoma cells by suppressing Clusterin expression ▶     Sushmita Mustafi, David W. Sant, Zhao-Jun Liu et al.             Divergent Regulation of Actin Dynamics and Megakaryoblastic Leukemia-1 and -2 (Mkl1/2) by cAMP in Endothelial and Smooth Muscle CellsDivergent Regulation of Actin Dynamics and Megakaryoblastic Leukemia-1 and -2 (Mkl1/2) by cAMP in Endothelial and Smooth Muscle Cells ▶     Madeleine C. Smith, Claire A. Hudson, Tomomi E. Kimura et al.             Heritability and responses to high fat diet of plasma lipidomics in a twin studyHeritability and responses to high fat diet of plasma lipidomics in a twin study ▶     Turid Frahnow, Martin A. Osterhoff, Silke Hornemann et al.             Qualifying a eukaryotic cell-free system for fluorescence based GPCR analysesQualifying a eukaryotic cell-free system for fluorescence based GPCR analyses ▶     Anne Zemella, Solveig Grossmann, Rita Sachse et al.             Comparative transcriptomic and proteomic analyses provide insights into the key genes involved in high-altitude adaptation in the Tibetan pigComparative transcriptomic and proteomic analyses provide insights into the key genes involved in high-altitude adaptation in the Tibetan pig ▶     Bo Zhang, Yangzom Chamba, Peng Shang et al.             Constraint-based modeling identifies new putative targets to fight colistin-resistant A. baumannii infectionsConstraint-based modeling identifies new putative targets to fight colistin-resistant A. baumannii infections ▶     Luana Presta, Emanuele Bosi, Leila Mansouri et al.             Metabolic fingerprinting of bacteria by fluorescence lifetime imaging microscopyMetabolic fingerprinting of bacteria by fluorescence lifetime imaging microscopy ▶     Arunima Bhattacharjee, Rupsa Datta, Enrico Gratton et al.             Trait choice profoundly affected the ecological conclusions drawn from functional diversity measuresTrait choice profoundly affected the ecological conclusions drawn from functional diversity measures ▶     Linhai Zhu, Bojie Fu, Huoxing Zhu et al.             Chromatin organization regulates viral egress dynamicsChromatin organization regulates viral egress dynamics ▶     Vesa Aho, Markko Myllys, Visa Ruokolainen et al.             Reduction in chromosome mobility accompanies nuclear organization during early embryogenesis in Caenorhabditis elegansReduction in chromosome mobility accompanies nuclear organization during early embryogenesis in Caenorhabditis elegans ▶     Ritsuko Arai, Takeshi Sugawara, Yuko Sato et al.             RUFY3 interaction with FOXK1 promotes invasion and metastasis in colorectal cancerRUFY3 interaction with FOXK1 promotes invasion and metastasis in colorectal cancer ▶     Ruyi Xie, Jing Wang, Xuehua Liu et al.             Impact of Module-X2 and Carbohydrate Binding Module-3 on the catalytic activity of associated glycoside hydrolases towards plant biomassImpact of Module-X2 and Carbohydrate Binding Module-3 on the catalytic activity of associated glycoside hydrolases towards plant biomass ▶     Nandita Pasari, Nidhi Adlakha, Mayank Gupta et al.             Arabidopsis Transporter ABCG37/PDR9 contributes primarily highly oxygenated Coumarins to Root ExudationArabidopsis Transporter ABCG37/PDR9 contributes primarily highly oxygenated Coumarins to Root Exudation ▶     Jörg Ziegler, Stephan Schmidt, Nadine Strehmel et al.             Regulation of sub-compartmental targeting and folding properties of the Prion-like protein ShadooRegulation of sub-compartmental targeting and folding properties of the Prion-like protein Shadoo ▶     Anna Pepe, Rosario Avolio, Danilo Swann Matassa et al.             Structure of the human TRiC/CCT Subunit 5 associated with hereditary sensory neuropathyStructure of the human TRiC/CCT Subunit 5 associated with hereditary sensory neuropathy ▶     Jose H. Pereira, Ryan P. McAndrew, Oksana A. Sergeeva et al.             In Vivo Quantification of Placental Insufficiency by BOLD MRI: A Human StudyIn Vivo Quantification of Placental Insufficiency by BOLD MRI: A Human Study ▶     Jie Luo, Esra Abaci Turk, Carolina Bibbo et al.             Molecular Identification of Multiple Antibiotic Resistant Fish Pathogenic Enterococcus faecalis and their Control by Medicinal HerbsMolecular Identification of Multiple Antibiotic Resistant Fish Pathogenic Enterococcus faecalis and their Control by Medicinal Herbs ▶     Muntasir Rahman, Md. Mahbubur Rahman, Suzan Chandra Deb et al.             MicroRNA-34a Encapsulated in Hyaluronic Acid Nanoparticles Induces Epigenetic Changes with Altered Mitochondrial Bioenergetics and Apoptosis in Non-Small-Cell Lung Cancer CellsMicroRNA-34a Encapsulated in Hyaluronic Acid Nanoparticles Induces Epigenetic Changes with Altered Mitochondrial Bioenergetics and Apoptosis in Non-Small-Cell Lung Cancer Cells ▶     Malav Trivedi, Amit Singh, Meghna Talekar et al.             Machine learning workflow to enhance predictions of Adverse Drug Reactions (ADRs) through drug-gene interactions: application to drugs for cutaneous diseasesMachine learning workflow to enhance predictions of Adverse Drug Reactions (ADRs) through drug-gene interactions: application to drugs for cutaneous diseases ▶     Kalpana Raja, Matthew Patrick, James T. Elder et al.             Distribution and kinetics of the Kv1.3-blocking peptide HsTX1[R14A] in experimental ratsDistribution and kinetics of the Kv1.3-blocking peptide HsTX1[R14A] in experimental rats ▶     Ralf Bergmann, Manja Kubeil, Kristof Zarschler et al.             Regulation of Angiopoietin Signalling by Soluble Tie2 Ectodomain and Engineered Ligand TrapRegulation of Angiopoietin Signalling by Soluble Tie2 Ectodomain and Engineered Ligand Trap ▶     Deborah O. A. Alawo, Tariq A. Tahir, Marlies Fischer et al.             Rapid discrimination of human oesophageal squamous cell carcinoma by mass spectrometry based on differences in amino acid metabolismRapid discrimination of human oesophageal squamous cell carcinoma by mass spectrometry based on differences in amino acid metabolism ▶     Zhang Jianyong, Xu Jianjun, Ouyang Yongzhong et al.             ADAMTS-7 is associated with a high-risk plaque phenotype in human atherosclerosisADAMTS-7 is associated with a high-risk plaque phenotype in human atherosclerosis ▶     Eva Bengtsson, Karin Hultman, Pontus Dunér et al.             Adiponectin regulates BMSC osteogenic differentiation and osteogenesis through the Wnt/β-catenin pathwayAdiponectin regulates BMSC osteogenic differentiation and osteogenesis through the Wnt/β-catenin pathway ▶     Yiyao Wang, Xiaohui Zhang, Jun Shao et al.             Diversity of endophytic mycobiota of tropical tree Tectona grandis Linn.f.: Spatiotemporal and tissue type effectsDiversity of endophytic mycobiota of tropical tree Tectona grandis Linn.f.: Spatiotemporal and tissue type effects ▶     Dheeraj K Singh, Vijay K Sharma, Jitendra Kumar et al.             Bovine antibodies targeting primary and recurrent Clostridium difficile disease are a potent antibiotic alternativeBovine antibodies targeting primary and recurrent Clostridium difficile disease are a potent antibiotic alternative ▶     Melanie L. Hutton, Bliss A. Cunningham, Kate E. Mackin et al.             Insecticide susceptibility of Anopheles mosquitoes changes in response to variations in the larval environmentInsecticide susceptibility of Anopheles mosquitoes changes in response to variations in the larval environment ▶     Henry F. OwusuNakul ChitnisPie Müller             Multiplexed Spliced-Leader Sequencing: A high-throughput, selective method for RNA-seq in TrypanosomatidsMultiplexed Spliced-Leader Sequencing: A high-throughput, selective method for RNA-seq in Trypanosomatids ▶     Bart Cuypers, Malgorzata A. Domagalska, Pieter Meysman et al.             An essential role of PI3K in the control of West Nile virus infectionAn essential role of PI3K in the control of West Nile virus infection ▶     Leilei Wang, Long Yang, Erol Fikrig et al.             Probing spermiogenesis: a digital strategy for mouse acrosome classificationProbing spermiogenesis: a digital strategy for mouse acrosome classification ▶     Alessandro Taloni, Francesc Font-Clos, Luca Guidetti et al.             The role of PTEN - HCV core interaction in hepatitis C virus replicationThe role of PTEN - HCV core interaction in hepatitis C virus replication ▶     Qi Wu, Zhubing Li, Paul Mellor et al.             Natural variation in Arabidopsis thaliana Cd responses and the detection of quantitative trait loci affecting Cd toleranceNatural variation in Arabidopsis thaliana Cd responses and the detection of quantitative trait loci affecting Cd tolerance ▶     Sina FischerThomas SpielauStephan Clemens             Adenovirus-mediated suppression of hypothalamic glucokinase affects feeding behaviorAdenovirus-mediated suppression of hypothalamic glucokinase affects feeding behavior ▶     Romina María Uranga, Carola Millán, María José Barahona et al.             Sialic acid linkage differentiation of glycopeptides using capillary electrophoresis – electrospray ionization – mass spectrometrySialic acid linkage differentiation of glycopeptides using capillary electrophoresis – electrospray ionization – mass spectrometry ▶     Guinevere S. M. Kammeijer, Bas C. Jansen, Isabelle Kohler et al.             A new paradigm for antiangiogenic therapy through controlled release of bevacizumab from PLGA nanoparticlesA new paradigm for antiangiogenic therapy through controlled release of bevacizumab from PLGA nanoparticles ▶     Flávia Sousa, Andrea Cruz, Pedro Fonte et al.             Machine Learning and Network Analysis of Molecular Dynamics Trajectories Reveal Two Chains of Red/Ox-specific Residue Interactions in Human Protein Disulfide IsomeraseMachine Learning and Network Analysis of Molecular Dynamics Trajectories Reveal Two Chains of Red/Ox-specific Residue Interactions in Human Protein Disulfide Isomerase ▶     Razieh Karamzadeh, Mohammad Hossein Karimi-Jafari, Ali Sharifi-Zarchi et al.             High-resolution imaging of a cell-attached nanointerface using a gold-nanoparticle two-dimensional sheetHigh-resolution imaging of a cell-attached nanointerface using a gold-nanoparticle two-dimensional sheet ▶     Shihomi Masuda, Yuhki Yanase, Eiji Usukura et al.             Behavioural and physiological responses to prey-related cues reflect higher competitiveness of invasive vs. native ladybirdsBehavioural and physiological responses to prey-related cues reflect higher competitiveness of invasive vs. native ladybirds ▶     Gabriele Rondoni, Fulvio Ielo, Carlo Ricci et al.             Structural Characterization of the SMRT Corepressor Interacting with Histone Deacetylase 7Structural Characterization of the SMRT Corepressor Interacting with Histone Deacetylase 7 ▶     Danielle C. Desravines, Itziar Serna Martin, Robert Schneider et al.             Integrated optical waveguide-based fluorescent immunosensor for fast and sensitive detection of microcystin-LR in lakes: Optimization and AnalysisIntegrated optical waveguide-based fluorescent immunosensor for fast and sensitive detection of microcystin-LR in lakes: Optimization and Analysis ▶     Lanhua Liu, Xiaohong Zhou, James S. Wilkinson et al.             Identification of transcripts with short stuORFs as targets for DENR•MCTS1-dependent translation in human cellsIdentification of transcripts with short stuORFs as targets for DENR•MCTS1-dependent translation in human cells ▶     Sibylle Schleich, Julieta M. Acevedo, Katharina Clemm von Hohenberg et al.             ZipA and FtsA* stabilize FtsZ-GDP miniring structuresZipA and FtsA* stabilize FtsZ-GDP miniring structures ▶     Yaodong Chen, Haiyan Huang, Masaki Osawa et al.             Exendin-4 attenuates blast traumatic brain injury induced cognitive impairments, losses of synaptophysin and in vitro TBI-induced hippocampal cellular degenerationExendin-4 attenuates blast traumatic brain injury induced cognitive impairments, losses of synaptophysin and in vitro TBI-induced hippocampal cellular degeneration ▶     Lital Rachmany, David Tweedie, Vardit Rubovitch et al.                 • Careers & Jobs           naturejobs.com Science jobs of the week       Clinical Research Fellow     King's College London            Post-doctoral position at the Center for Advanced Biomaterials for Health Care     Fondazione Istituto Italiano di Tecnologia            Lecturer, Senior Lecturer or Professor positions in Global Agriculture and Food Security     University of Edinburgh            Postdoctoral Position     University of Utah            Postdoctoral Fellow     Case Western Reserve University, School of Medicine            Chair, Department of Microbiology and Immunology     Rosalind Franklin University of Medicine and Science            Postdoctoral position     Universitätsklinikum Bonn AöR            Associate Professor / Professor     Melbourne University            Postdoctoral Fellow     Memorial Sloan Kettering Cancer Center (MSKCC)             Assistant / Associate Professor (tenure-track)     McGill University          No matter what your career stage, student, postdoc or senior scientist, you will find articles on naturejobs.com to help guide you in your science career. Keep up-to-date with the latest sector trends, vote in our reader poll and sign-up to receive the monthly Naturejobs newsletter.           • Scientific Reports events Directory featured events           natureevents directory featured events         Advances in Stem Cell Biology Summer Course     26.06.17 France         Natureevents Directory is the premier resource for scientists looking for the latest scientific conferences, courses, meetings and symposia. Featured across Nature Publishing Group journals and centrally at natureevents.com it is an essential reference guide to scientific events worldwide.               Your email address is in the Scientific Reports: Biological Sciences mailing list. You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/nams/svc/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department For other enquiries, please contact our customer feedback department Springer Nature | One New York Plaza, Suite 4500 | New York | NY 10004-1562 | USA Springer Nature's offices: Principal offices: London - New York - Tokyo Worldwide offices: Basingstoke - Boston - Buenos Aires - Delhi - Hong Kong - Madrid - Melbourne - Munich - Paris - San Francisco - Seoul - Washington DC Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at The Campus, 4 Crinan Street, London, N1 9XW. © 2017 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.