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July 2017 Volume 15 Number 7 | Advertisement | ||||||||||||||||||||||||||||||||||||
In this issue Research Highlights News and Analysis Reviews
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NEWS AND ANALYSIS | Top | ||||||||||||||||||||||||||||||||||||
Genome watch: Klebsiella pneumoniae: when a colonizer turns bad Matthew J. Dorman & Francesca L. Short p384 | doi:10.1038/nrmicro.2017.64 This month's Genome Watch highlights how whole-genome sequencing (WGS) and epidemiological studies can be combined to explore the link between colonization and infection by Klebsiella pneumoniae in patients who are hospitalised. | |||||||||||||||||||||||||||||||||||||
REVIEWS | Top | ||||||||||||||||||||||||||||||||||||
Oxidative stress, protein damage and repair in bacteria Benjamin Ezraty, Alexandra Gennaris, Frédéric Barras & Jean-François Collet p385 | doi:10.1038/nrmicro.2017.26 Oxidative damage can have a devastating effect on the structure and activity of proteins, leading to cell death. This Review discusses how bacteria repair oxidized proteins and highlights the importance of these repair systems in physiology and virulence. Abstract | Full Text | PDF | |||||||||||||||||||||||||||||||||||||
Article series: Microbiome Menage a trois in the human gut: interactions between host, bacteria and phages Mohammadali Khan Mirzaei & Corinne F. Maurice p397 | doi:10.1038/nrmicro.2017.30 The human gut is host to a dense microbial community that includes a large bacteriophage population. This Review summarizes bacteria and phage dynamics in health and disease, and considers how phages may be harnessed as novel therapeutics to improve disease outcomes. Abstract | Full Text | PDF | |||||||||||||||||||||||||||||||||||||
Ustilago maydis effectors and their impact on virulence Daniel Lanver, Marie Tollot, Gabriel Schweizer, Libera Lo Presti, Stefanie Reissmann, Lay-Sun Ma, Mariana Schuster, Shigeyuki Tanaka, Liang Liang, Nicole Ludwig & Regine Kahmann p409 | doi:10.1038/nrmicro.2017.33 Biotrophic fungal plant pathogens secrete protein effectors that support colonization of the host. Here, Kahmann and colleagues discuss new insights into the effector repertoire of smut fungi, the molecular mechanisms whereby effectors of Ustilago maydis change plant cell processes, how the respective genes are regulated and how effectors evolve. Abstract | Full Text | PDF | |||||||||||||||||||||||||||||||||||||
Next-generation approaches to understand and combat the antibiotic resistome Terence S. Crofts, Andrew J. Gasparrini & Gautam Dantas p422 | doi:10.1038/nrmicro.2017.28 Antibiotic resistance is a global problem that threatens individual and societal well-being. In this Review, Crofts, Gasparrini and Dantas summarize how research has changed from the discovery of resistant bacteria to community-level resistome studies, and they propose future therapeutic and surveillance approaches. Abstract | Full Text | PDF | Supplementary information | |||||||||||||||||||||||||||||||||||||
Leukocidins: staphylococcal bi-component pore-forming toxins find their receptors András N. Spaan, Jos A. G. van Strijp & Victor J. Torres p435 | doi:10.1038/nrmicro.2017.27 In this Review, Spaan, van Strijp and Torres discuss the implications of the identification of the cellular receptors for the Staphylococcus aureus bi-component leukocidins, the mechanisms of action of the leukocidins, their diverse roles during pathogenesis and their potential as targets for therapeutic interventions. Abstract | Full Text | PDF | |||||||||||||||||||||||||||||||||||||
Corrigendum: Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need Mark C. Field, David Horn, Alan H. Fairlamb, Michael A. J. Ferguson, David W. Gray, Kevin D. Read, Manu De Rycker, Leah S. Torrie, Paul G. Wyatt, Susan Wyllie & Ian H. Gilbert p447 | doi:10.1038/nrmicro.2017.69 Full Text | PDF | |||||||||||||||||||||||||||||||||||||
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