Nature Reviews Microbiology contents July 2017 Volume 15 Number 7 pp 381-447

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TABLE OF CONTENTS
July 2017 Volume 15 Number 7		Advertisement
2015 2-year Impact Factor 24.727 Journal Metrics 2-year Median 19.5	In this issue Research Highlights News and Analysis Reviews Also this month Article series: Microbiome  Featured article: Next-generation approaches to understand and combat the antibiotic resistome Terence S. Crofts, Andrew J. Gasparrini & Gautam Dantas	Take part in our PhD survey for your chance to win Tell us what you love about life as PhD student, about your plans, and some of the challenges you face at this all-important career stage. Take part in Nature Research Group's biennial global PhD survey, and you'll also have the chance to enter a prize draw to win a £100/$150 Amazon gift card.
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Intestinal microflora in health and disease  The human gut teems with trillions of microorganisms. The search for links between these microbes and our health is yielding promising insights.  Access this free collection of leading resources and keep up to date Produced by Yakult in partnership with Springer Nature  Yakult
RESEARCH HIGHLIGHTS Top Viral evolution: Zika is on point to increase spread p381 | doi:10.1038/nrmicro.2017.62 This study suggests that the valine residue at position 188 of NS1 has a crucial role in antigenaemia, which is essential for the transmission of Zika virus from mammalian hosts to mosquitoes. PDF Bacterial pathogenesis: Campylobacter follows the clues p382 | doi:10.1038/nrmicro.2017.63 Luethy et al. show that metabolites produced by the gut microbiota can modulate the expression of Campylobacter jejuni determinants that are required for growth, commensalism and virulence. PDF Bacterial evolution: The origins of pathogenic enterococci p382 | doi:10.1038/nrmicro.2017.65 This study investigates the origins of multidrug-resistant pathogenic enterococci. PDF Bacterial physiology: An inside job on metabolism p383 | doi:10.1038/nrmicro.2017.68 Two new studies reveal how Mycobacterium tuberculosis adapts to environmental stresses that are associated with an intracellular lifestyle. PDF IN BRIEF Parasite biology: New insights into Plasmodium hepatocyte entry | Viral evolution: Phage infection strategies | Fungal physiology: Acidic pH interferes with Candida persistence PDF
NEWS AND ANALYSIS		Top
Genome watch: Klebsiella pneumoniae: when a colonizer turns bad Matthew J. Dorman & Francesca L. Short p384 | doi:10.1038/nrmicro.2017.64 This month's Genome Watch highlights how whole-genome sequencing (WGS) and epidemiological studies can be combined to explore the link between colonization and infection by Klebsiella pneumoniae in patients who are hospitalised. PDF
REVIEWS		Top
Oxidative stress, protein damage and repair in bacteria Benjamin Ezraty, Alexandra Gennaris, Frédéric Barras & Jean-François Collet p385 | doi:10.1038/nrmicro.2017.26 Oxidative damage can have a devastating effect on the structure and activity of proteins, leading to cell death. This Review discusses how bacteria repair oxidized proteins and highlights the importance of these repair systems in physiology and virulence. Abstract | Full Text | PDF
Article series: Microbiome Menage a trois in the human gut: interactions between host, bacteria and phages Mohammadali Khan Mirzaei & Corinne F. Maurice p397 | doi:10.1038/nrmicro.2017.30 The human gut is host to a dense microbial community that includes a large bacteriophage population. This Review summarizes bacteria and phage dynamics in health and disease, and considers how phages may be harnessed as novel therapeutics to improve disease outcomes. Abstract | Full Text | PDF
Ustilago maydis effectors and their impact on virulence Daniel Lanver, Marie Tollot, Gabriel Schweizer, Libera Lo Presti, Stefanie Reissmann, Lay-Sun Ma, Mariana Schuster, Shigeyuki Tanaka, Liang Liang, Nicole Ludwig & Regine Kahmann p409 | doi:10.1038/nrmicro.2017.33 Biotrophic fungal plant pathogens secrete protein effectors that support colonization of the host. Here, Kahmann and colleagues discuss new insights into the effector repertoire of smut fungi, the molecular mechanisms whereby effectors of Ustilago maydis change plant cell processes, how the respective genes are regulated and how effectors evolve. Abstract | Full Text | PDF
Next-generation approaches to understand and combat the antibiotic resistome Terence S. Crofts, Andrew J. Gasparrini & Gautam Dantas p422 | doi:10.1038/nrmicro.2017.28 Antibiotic resistance is a global problem that threatens individual and societal well-being. In this Review, Crofts, Gasparrini and Dantas summarize how research has changed from the discovery of resistant bacteria to community-level resistome studies, and they propose future therapeutic and surveillance approaches. Abstract | Full Text | PDF | Supplementary information
Leukocidins: staphylococcal bi-component pore-forming toxins find their receptors András N. Spaan, Jos A. G. van Strijp & Victor J. Torres p435 | doi:10.1038/nrmicro.2017.27 In this Review, Spaan, van Strijp and Torres discuss the implications of the identification of the cellular receptors for the Staphylococcus aureus bi-component leukocidins, the mechanisms of action of the leukocidins, their diverse roles during pathogenesis and their potential as targets for therapeutic interventions. Abstract | Full Text | PDF
Corrigendum: Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need Mark C. Field, David Horn, Alan H. Fairlamb, Michael A. J. Ferguson, David W. Gray, Kevin D. Read, Manu De Rycker, Leah S. Torrie, Paul G. Wyatt, Susan Wyllie & Ian H. Gilbert p447 | doi:10.1038/nrmicro.2017.69 Full Text | PDF
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