Thursday, June 15, 2017

Nature Reviews Genetics Contents July 2017 Volume 18 Number 7 pp 391-451

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Nature Reviews Genetics

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2015 2-year Impact Factor 35.898 Journal Metrics 2-year Median 32
In this issue
Research Highlights

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Article series:
Disease mechanisms
Applications of next-generation sequencing
 Featured article:
The evolutionary significance of polyploid
Yves Van de Peer, Eshchar Mizrachi & Kathleen Marchal

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Cancer genomics: Tracking cancer evolution
p391 | doi:10.1038/nrg.2017.43

Genetic testing: The diagnostic power of RNA-seq
p392 | doi:10.1038/nrg.2017.39

Technology: Nucleic acid detection — it's elementary with SHERLOCK!
p392 | doi:10.1038/nrg.2017.40

Plant genetics: Branching out for crop improvement
p393 | doi:10.1038/nrg.2017.48

Plant genetics: Spatial transcriptomics in plants
p394 | doi:10.1038/nrg.2017.41

Stem cells: The different flavours of iPS cells
p394 | doi:10.1038/nrg.2017.42

Call for nominations: 2017 John Maddox Prize for Standing up for Science.

Recognising the work of individuals who promote science in the face of hostility. Winners will be announced at a reception in London, as well as in Nature, and will receive £2,000.

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Article series: Disease mechanisms
Functional variomics and network perturbation: connecting genotype to phenotype in cancer
Song Yi, Shengda Lin, Yongsheng Li, Wei Zhao, Gordon B. Mills & Nidhi Sahni
p395 | doi:10.1038/nrg.2017.8
The abundance and heterogeneity of mutations in cancer create challenges for understanding their effects, but such functional characterization will be crucial for optimizing clinical care. In this Review, the authors discuss diverse computational tools and systems biology experimental strategies for elucidating the functional effects of cancer mutations, including consequences on gene regulation, protein structure and local and global perturbations of molecular interaction networks.
Abstract | Full Text | PDF | Supplementary information

The evolutionary significance of polyploidy
Yves Van de Peer, Eshchar Mizrachi & Kathleen Marchal
p411 | doi:10.1038/nrg.2017.26
Polyploidy occurs frequently but is usually detrimental to survival; thus, few polyploids survive in the long term. Here, evidence linking the short-term evolutionary success of polyploids to environmental upheaval is reviewed and possible longer-term evolutionary benefits of polyploidy are discussed.
Abstract | Full Text | PDF

Article series: Applications of next-generation sequencing
Comparative transcriptomics in human and mouse
Alessandra Breschi, Thomas R. Gingeras & Roderic Guigó
p425 | doi:10.1038/nrg.2017.19
Next-generation sequencing technologies have enabled the comprehensive characterization of human and mouse genomes, including at the transcriptional level. This article reviews the degree of conservation of human and mouse transcriptomes, along with the challenges of identifying when the mouse is a suitable model of human physiology.
Abstract | Full Text | PDF

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Article series: Epigenetics
Associating cellular epigenetic models with human phenotypes
Tuuli Lappalainen & John M. Greally
p441 | doi:10.1038/nrg.2017.32
Epigenome-wide association studies (EWAS) are potentially powerful approaches for identifying transcriptional regulatory perturbations (particularly DNA methylation) that associate with phenotypes of interest. In this Opinion article, Lappalainen and Greally provide their views on how to maximize the interpretability and biological insights from these associations, such as by hypothesis-driven consideration of cellular phenotypes, characterizing the roles of transcription factors, dissecting directions of causality and moving towards multi-omics profiling.
Abstract | Full Text | PDF

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