Nature Reviews Genetics Contents July 2017 Volume 18 Number 7 pp 391-451

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TABLE OF CONTENTS
July 2017 Volume 18 Number 7		Advertisement
2015 2-year Impact Factor 35.898 Journal Metrics 2-year Median 32	In this issue Research Highlights Reviews Perspectives Also this month Article series: Disease mechanisms Applications of next-generation sequencing Epigenetics  Featured article: The evolutionary significance of polyploid Yves Van de Peer, Eshchar Mizrachi & Kathleen Marchal	Open for Submissions npj Precision Oncology is a new open access, online-only, peer-reviewed journal committed to publishing cutting-edge scientific research in all aspects of precision oncology from basic science to translational applications, to clinical medicine. The journal is part of the Nature Partner Journals series and published in partnership with The Hormel Institute, University of Minnesota. Explore the benefits of submitting your manuscript.
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RESEARCH HIGHLIGHTS Top Cancer genomics: Tracking cancer evolution p391 | doi:10.1038/nrg.2017.43 PDF Genetic testing: The diagnostic power of RNA-seq p392 | doi:10.1038/nrg.2017.39 PDF Technology: Nucleic acid detection — it's elementary with SHERLOCK! p392 | doi:10.1038/nrg.2017.40 PDF Plant genetics: Branching out for crop improvement p393 | doi:10.1038/nrg.2017.48 PDF Plant genetics: Spatial transcriptomics in plants p394 | doi:10.1038/nrg.2017.41 PDF Stem cells: The different flavours of iPS cells p394 | doi:10.1038/nrg.2017.42 PDF
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REVIEWS		Top
Article series: Disease mechanisms Functional variomics and network perturbation: connecting genotype to phenotype in cancer Song Yi, Shengda Lin, Yongsheng Li, Wei Zhao, Gordon B. Mills & Nidhi Sahni p395 | doi:10.1038/nrg.2017.8 The abundance and heterogeneity of mutations in cancer create challenges for understanding their effects, but such functional characterization will be crucial for optimizing clinical care. In this Review, the authors discuss diverse computational tools and systems biology experimental strategies for elucidating the functional effects of cancer mutations, including consequences on gene regulation, protein structure and local and global perturbations of molecular interaction networks. Abstract | Full Text | PDF | Supplementary information
The evolutionary significance of polyploidy Yves Van de Peer, Eshchar Mizrachi & Kathleen Marchal p411 | doi:10.1038/nrg.2017.26 Polyploidy occurs frequently but is usually detrimental to survival; thus, few polyploids survive in the long term. Here, evidence linking the short-term evolutionary success of polyploids to environmental upheaval is reviewed and possible longer-term evolutionary benefits of polyploidy are discussed. Abstract | Full Text | PDF
Article series: Applications of next-generation sequencing Comparative transcriptomics in human and mouse Alessandra Breschi, Thomas R. Gingeras & Roderic Guigó p425 | doi:10.1038/nrg.2017.19 Next-generation sequencing technologies have enabled the comprehensive characterization of human and mouse genomes, including at the transcriptional level. This article reviews the degree of conservation of human and mouse transcriptomes, along with the challenges of identifying when the mouse is a suitable model of human physiology. Abstract | Full Text | PDF
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PERSPECTIVES		Top
OPINION Article series: Epigenetics Associating cellular epigenetic models with human phenotypes Tuuli Lappalainen & John M. Greally p441 | doi:10.1038/nrg.2017.32 Epigenome-wide association studies (EWAS) are potentially powerful approaches for identifying transcriptional regulatory perturbations (particularly DNA methylation) that associate with phenotypes of interest. In this Opinion article, Lappalainen and Greally provide their views on how to maximize the interpretability and biological insights from these associations, such as by hypothesis-driven consideration of cellular phenotypes, characterizing the roles of transcription factors, dissecting directions of causality and moving towards multi-omics profiling. Abstract | Full Text | PDF
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