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July 2017 Volume 17 Number 7 | Advertisement | |||||||||||||||||||||||||||||||||||||||||||||
In this issue Comment Research Highlights Reviews Perspectives
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Article series: Clinical insights Comment: Melanoma: a global perspective Raul Ossio, Rodrigo Roldán-Marín, Héctor Martínez-Said, David J. Adams & Carla Daniela Robles-Espinoza p393 | doi:10.1038/nrc.2017.43 Most of our current knowledge of melanoma is derived from the study of patients from populations of European descent, for whom public health, sun protection initiatives and screening measures have appreciably decreased disease mortality. Notably, some melanoma subtypes that most commonly develop in other populations are not associated with exposure to ultraviolet (UV) light, suggesting a different disease aetiology. Further study of these subtypes is necessary to understand their risk factors and genomic architecture, and to tailor therapies and public health campaigns to benefit patients of all ethnic groups. Abstract | Full Text | PDF | Supplementary information | ||||||||||||||||||||||||||||||||||||||||||||||
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REVIEWS | Top | |||||||||||||||||||||||||||||||||||||||||||||
Imaging of anticancer drug action in single cells Miles A. Miller & Ralph Weissleder p399 | doi:10.1038/nrc.2017.41 This Review summarizes developments in the imaging of in vivo anticancer drug action, with a focus on microscopy approaches at the single-cell level and translational lessons for the clinic. Abstract | Full Text | PDF | Supplementary information | ||||||||||||||||||||||||||||||||||||||||||||||
Transposable elements in cancer Kathleen H. Burns p415 | doi:10.1038/nrc.2017.35 Long interspersed element-1 (LINE-1) transposable elements are active in the human genome. In this Review, Burns describes how the retrotransposition activity of LINE-1 in cancer genomes can result in somatically acquired insertions that mark evolving tumour clones. Abstract | Full Text | PDF | ||||||||||||||||||||||||||||||||||||||||||||||
Turning the tide in myelodysplastic/myeloproliferative neoplasms Michael W. N. Deininger, Jeffrey W. Tyner & Eric Solary p425 | doi:10.1038/nrc.2017.40 This Review describes our current understanding of the relationship between genotype and phenotype in myelodysplastic syndromes/myeloproliferative neoplasms (MDS/MPN) and discusses how this knowledge could be used to inform strategies to develop more effective treatments and improve clinical success. Abstract | Full Text | PDF | Supplementary information | ||||||||||||||||||||||||||||||||||||||||||||||
PERSPECTIVES | Top | |||||||||||||||||||||||||||||||||||||||||||||
OPINION Common pitfalls in preclinical cancer target validation William G. Kaelin, Jr p425 | doi:10.1038/nrc.2017.32 This Perspective discusses some of the causes of the robustness and reproducibility problem in preclinical cancer research and suggests solutions. Abstract | Full Text | PDF | ||||||||||||||||||||||||||||||||||||||||||||||
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