Wednesday, June 21, 2017

Nature contents: 22 June 2017

If you are unable to see the message below, click here to view.

  journal cover  
Nature Volume 546 Issue 7659
This Week  
Don’t let Europe’s open-science dream drift
Now that the major players have agreed to the giant European Open Science Cloud, it’s time to get the project moving.
Protect funding for US earthquake early-warning system
Donald Trump’s proposed cuts to ShakeAlert puts the west coast at risk.
Heatwaves to soar above the hot air of climate politics
Future generations will fear, rather than fend for, the global environment.
A*STAR Research - Highlighting the latest breakthroughs at the Agency for Science, Technology and Research (A*STAR), Singapore's premier research organization
Drug safety: Turning stem cells into ?canaries? | Tuberculosis: Enzyme makes TB bacteria eat themselves | Materials: Graphene chills out
Download the A*STAR Research app now! 
World View  
A year on, Brexit brings lessons in uncertainty
It is more important to understand the electorate than to make predictions about the outcome of elections, says Jane Green.
Seven Days  
New journal blacklist, palm-oil ban and the world’s top supercomputers
The week in science: 16–22 June 2017.
Research Highlights  
This issue's Research Highlights
Selections from the scientific literature.

September 27-29, 2017 | Seoul, Korea

Presented by: Institute for Basic Science | Institute of Genetics and Developmental Biology, CAS | Nature | Nature Biotechnology

News in Focus
Macron consolidates electoral victory
The party of France’s recently elected president won an absolute majority in its first general elections, with an agenda that included strong support for research.
Declan Butler
  Ancient oak's youthful genome surprises biologists
DNA of 234-year-old tree has few mutations, giving weight to idea that plants protect their stem cells.
Heidi Ledford
China’s genomics giant to make stock-market debut
Once the world's biggest DNA sequencer for research, BGI is now looking to medical applications to boost profits.
David Cyranoski
  Teeth tell tale of hippo’s quick spread across Africa
Fossils from ancient hippo ancestor suggest that grass helped the animals to conquer a continent.
Traci Watson
New concerns raised over value of genome-wide disease studies
Large analyses dredge up 'peripheral' genetic associations that offer little biological insight, researchers say.
Ewen Callaway
  China cracks down on fake peer reviews
Funding agencies announce harsh penalties and stronger policing efforts.
David Cyranoski
The fight to save thousands of lives with sea-floor sensors
Geophysicists are ramping up their efforts to monitor major undersea faults for movement, and search for signs of the next catastrophic quake.
Alexandra Witze
Track batteries degrading in real time
Monitor deforming electrodes to speed development of renewable-energy storage, write Liqiang Mai, Mengyu Yan and Yunlong Zhao.
Liqiang Mai, Mengyu Yan, Yunlong Zhao
Books and Arts  
Botany: He made plants a profession
Jim Endersby revisits the legacy of trailblazing botanist Joseph Dalton Hooker.
Jim Endersby
Consent: Data-sharing for indigenous peoples
Emma Kowal, Bastien Llamas, Sarah Tishkoff
  Philosophy: Religion's openness towards science
Frank W. Nicholas
Counterfeit drugs: Fight fake reagents with digital tools
Don Gunasekera
  Ecology: Document India's floral biodiversity
Kamaljit S. Bawa, R. Ganesan
Eardrum regeneration: membrane repair
David Holmes
  Marching to a new beat
David Holmes
Sponsor Sponsor
Infectious diseases: Predictions of virus spillover across species
Most human infectious diseases are initially transmitted from animals. An analysis of all known mammalian viruses improves our understanding of such cross-species spillover, with potential benefits for public health.
Molecular biology: A liquid reservoir for silent chromatin
The protein HP1 mediates compaction of DNA into a repressive structure called heterochromatin. Analysis reveals that HP1 has liquid-like properties, offering a fresh perspective on genome organization.
Immunology: Gut sensor halts viral attack
Intestinal infection with rotavirus is a major cause of diarrhoea in infants, and can be fatal. The identification of immune sensor proteins that detect and restrict this viral infection now illuminates the body's defence system.
Immunology: The patterns of T-cell target recognition
The binding of T-cell receptors to peptide molecules not normally present in the body can trigger an immune response. Predicting which peptide a T-cell receptor will bind to — a difficult feat — has now been achieved.
Astrophysics: Stellar siblings grow closer with age
High-mass stars often pair up to form binary systems. Observations reveal that the stars in such systems are born farther apart than was formerly thought, casting fresh light on an enduring debate about star formation.
Quantifiable predictive features define epitope-specific T cell receptor repertoires
The authors characterize epitope-specific T cell repertoires, identify shared and recognizable features of TCRs, and develop tools to classify antigen specificity on the basis of sequence analysis.
Observation of three-component fermions in the topological semimetal molybdenum phosphide
A new type of fermion, corresponding to a three-fold degeneracy in the electronic band structure of crystalline molybdenum phosphide, is observed, which lies conceptually between Dirac and Weyl fermions.
Catalytic allylic oxidation of internal alkenes to a multifunctional chiral building block
Non-symmetric internal alkenes are selectively converted into allylic functionalized products with high stereoselectivity and regioselectivity.
Surface tension prevails over solute effect in organic-influenced cloud droplet activation
A phase-separation mechanism is proposed for the dominance of the surface tension effect over the solute effect in the observed activation of ultrafine cloud condensation nuclei.
Selective sp3 C–H alkylation via polarity-match-based cross-coupling
Using a triple catalytic approach, a selective sp 3 C–H alkylation is demonstrated that is applicable in late-stage functionalization of pharmaceutical compounds.
Trans-kingdom mimicry underlies ribosome customization by a poxvirus kinase
The poxvirus vaccinia virus phosphorylates serine/threonine residues in the human small ribosomal subunit RACK1, converting it to a plant-like state to favour translation of poxvirus mRNAs.
T cells from patients with Parkinson’s disease recognize α-synuclein peptides
Epitopes derived from two regions of α-synuclein elicit immune responses in patients with Parkinson’s disease, involving IL-5-secreting CD4+ T cells, as well as IFNγ-secreting CD8+ cytotoxic T cells.
Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin
Phosphorylation or DNA binding promotes the physical partitioning of HP1α out of a soluble aqueous phase into droplets, suggesting that the repressive action of heterochromatin may in part be mediated by the phase separation of HP1.
Hidden morphological diversity among early tetrapods
Detailed micro-computed tomography analysis of the skull of Lethiscus stocki places it much earlier in the tetrapod lineage that was previously thought, showing that early tetrapods were more morphologically diverse than has been believed.
Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells
The inflammasome receptor Nlrp9b defends against enteric viruses by interacting with double-stranded viral RNA-bound helicase Dhx9, triggering gasdermin-D-dependent pyroptotic cell death of infected cells and secretion of Il-18.
Crystal structure of the potassium-importing KdpFABC membrane complex
The crystal structure of the bacterial potassium import complex KdpFABC shows how ATP hydrolysis is coupled to potassium transport to maintain cellular homeostasis under low potassium conditions.
Host and viral traits predict zoonotic spillover from mammals
Analysis of a comprehensive database of mammalian host–virus relationships reveals that both the total number of viruses that infect a given species and the proportion likely to be zoonotic are predictable and that this enables identification of mammalian species and geographic locations where novel zoonoses are likely to be found.
Identifying specificity groups in the T cell receptor repertoire
The authors devise an algorithm that can cluster T cell receptor (TCR) sequences sharing the same specificity, predict the HLA restriction of these TCR clusters on the basis of subjects’ genotypes and help to identify specific peptide major histocompatibility complex ligands.
Phase separation drives heterochromatin domain formation
HP1a can nucleate into foci that display liquid properties during the early stages of heterochromatin domain formation in Drosophila embryos, suggesting that the repressive action of heterochromatin may be mediated in part by emergent properties of phase separation.
Brief Communications Arising  
Effects of a ketamine metabolite on synaptic NMDAR function
Kanzo Suzuki, Elena Nosyreva, Kevin W. Hunt et al.
Zanos et al. reply
Panos Zanos, Ruin Moaddel, Patrick J. Morris et al.
News and Views  
Bacterial pathogens: A spoonful of sugar could be the medicine
Hea-Jin Jung, Eric G. Pamer
Genomics: The feline line
Luíseach Nic Eoin
Quantum physics: Interactions propel a magnetic dance
Lindsay J. LeBlanc
Neuroinflammation: Synapses pruned in lupus
Sarah McGlasson, David Hunt
Vision: These retinas are made for walkin'
Jonathan B. Demb, Damon A. Clark
Particle physics: No sign of asymmetry in the strong force
Alexandru Florin Dobrin
50 & 100 Years Ago
Climate science: Clouds unfazed by haze
Bjorn Stevens
Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer
Exosomes improve the delivery of siRNA to mutant KRAS in the pancreatic tumours and bypass immune clearance better than artificial liposomes, probably owing to enhanced macropinocytocis and presence of CD47 on exosomes, respectively.
Sushrut Kamerkar, Valerie S. LeBleu, Hikaru Sugimoto et al.
Strong constraints on aerosol–cloud interactions from volcanic eruptions
Investigations of an Icelandic volcanic eruption confirm that sulfate aerosols caused a discernible yet transient brightening effect, as predicted, but their effect on the liquid water path was unexpectedly negligible.
Florent F. Malavelle, Jim M. Haywood, Andy Jones et al.
A retinal code for motion along the gravitational and body axes
Global mapping shows that mouse retinal neurons prefer visual motion produced when the animal moves along two behaviourally relevant axes, allowing the encoding of the animal’s every translation and rotation.
Shai Sabbah, John A. Gemmer, Ananya Bhatia-Lin et al.
Structure of the human multidrug transporter ABCG2
The structure of human ABCG2 bound to an inhibitory antibody using cryo-electron microscopy, representing the first high-resolution structural data of a human multidrug transporter.
Nicholas M. I. Taylor, Ioannis Manolaridis, Scott M. Jackson et al.
A giant planet undergoing extreme-ultraviolet irradiation by its hot massive-star host
The giant planet KELT-9b has a dayside temperature of about 4,600 K, which is sufficiently high to dissociate molecules and to evaporate its atmosphere, owing to its hot stellar host.
B. Scott Gaudi, Keivan G. Stassun, Karen A. Collins et al.
A massive, dead disk galaxy in the early Universe
When the Universe was just 3 billion years old, half of the most massive galaxies had already ceased star formation, and such a galaxy has now been observed using gravitational lensing, unexpectedly turning out to be a compact, fast-spinning disk galaxy rather than a proto-bulge galaxy.
Sune Toft, Johannes Zabl, Johan Richard et al.
Microglia-dependent synapse loss in type I interferon-mediated lupus
Abnormal behavioural phenotypes and synapse loss in the brain of lupus-prone mice are prevented by blocking type I interferon signalling, which is further shown to stimulate microglial phagocytosis of neuronal material in the brains of these mice.
Allison R. Bialas, Jessy Presumey, Abhishek Das et al.
PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth
PTEN, a known tumour suppressor, inhibits the FXBL2-dependent degradation of IP3R3, an IP3 receptor, thus augmenting IP3R3-mediated calcium release from the endoplasmic reticulum to mitochondria and inducing apoptosis; inhibiting FXBL2 sensitizes PTEN-deficient tumours to photodynamic therapy.
Shafi Kuchay, Carlotta Giorgi, Daniele Simoneschi et al.
Structure of the Cpf1 endonuclease R-loop complex after target DNA cleavage
The structure of Cpf1, a CRISPR–Cas/RNA-guided nuclease, is presented with a three-stranded RNA–DNA loop after cleavage, providing insight into its working mechanism.
Stefano Stella, Pablo Alcón, Guillermo Montoya
Multilineage communication regulates human liver bud development from pluripotency
Single-cell RNA sequencing analysis of two- and three-dimensional hepatic differentiation reveals that both systems recapitulate certain transcriptomic features of human hepatogenesis.
J. Gray Camp, Keisuke Sekine, Tobias Gerber et al.
Histone deacetylase 3 prepares brown adipose tissue for acute thermogenic challenge
Histone deacetylase 3 (HDAC3) is required to activate brown adipose tissue enhancers to ensure thermogenic aptitude.
Matthew J. Emmett, Hee-Woong Lim, Jennifer Jager et al.
Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist
Both F17-like and type 1 pili promote intestinal colonization in mouse colonic crypts, and the high-affinity mannoside M4284 reduces intestinal colonization of uropathogenic Escherichia coli while simultaneously treating urinary tract infections without disrupting the composition of the gut microbiota.
Caitlin N. Spaulding, Roger D. Klein, Ségolène Ruer et al.
Improved maize reference genome with single-molecule technologies OPEN
An improved reference genome for maize, using single-molecule sequencing and high-resolution optical mapping, enables characterization of structural variation and repetitive regions, and identifies lineage expansions of transposable elements that are unique to maize.
Yinping Jiao, Paul Peluso, Jinghua Shi et al.
BAP1 regulates IP3R3-mediated Ca2+ flux to mitochondria suppressing cell transformation
BRCA1-associated protein 1 (BAP1) regulates calcium flux in the endoplasmic reticulum to facilitate the execution of apoptosis, unveiling a new facet of the role of BAP1 as an environmental tumour suppressor.
Angela Bononi, Carlotta Giorgi, Simone Patergnani et al.
Microscopy of the interacting Harper–Hofstadter model in the two-body limit
The combination of interparticle interactions and a synthetic gauge field leads to chirality in the propagation dynamics of particles in a ladder-like lattice.
M. Eric Tai, Alexander Lukin, Matthew Rispoli et al.
Addendum: The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease
Jeff Sevigny, Ping Chiao, Thierry Bussière et al.
Careers & Jobs
Sustainability: A greener culture
Julia Rosen
Career Briefs  
Women in science: Finding consensus
Memories to come
Is this the real life?
Paul Alex Gray
  Science jobs of the week


Head of Computational Chemistry


Heptares Therapeutics  


Associate Research Scientist


Herbert Irving Comprehensive Cancer Center 


Research Fellow in Cell Biology


The University of Warwick 


Cancer Genetic Scientist


Wellcome Trust Sanger Institute 


No matter what your career stage, student, postdoc or senior scientist, you will find articles on to help guide you in your science career. Keep up-to-date with the latest sector trends, vote in our reader poll and sign-up to receive the monthly Naturejobs newsletter.

  Natureevents Directory featured events   - The premier science events website

natureevents directory featured events


Chemistry, Stem Cells Regenerative Medicine


11.09.17 London, UK


Natureevents Directory is the premier resource for scientists looking for the latest scientific conferences, courses, meetings and symposia. Featured across Nature Publishing Group journals and centrally at it is an essential reference guide to scientific events worldwide.

Your email address is in the Nature mailing list.

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your account at: (You will need to log in to be recognised as a registrant).
For further technical assistance, please contact our registration department at

For print subscription enquiries, please contact our subscription department at

For other enquiries, please contact

Nature Research | One New York Plaza, Suite 4500 | New York | NY 10004-1562 | USA

Nature Research's offices:

Principal offices: London - New York - Tokyo

Worldwide offices: Basingstoke - Beijing - Boston - Buenos Aires - Delhi - Heidelberg - Hong Kong - Madrid - Melbourne - Munich - Paris - San Francisco - Seoul - Shanghai - Washington DC - Sydney

Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at The Campus, 4 Crinan Street, London, N1 9XW.

© 2017 Macmillan Publishers Limited. All Rights Reserved.

No comments: