The EMBO Journal Table of Contents for 15 May 2017; Vol. 36, No. 10

15 May 2017 | Volume 36, Number 10 Submit Table of Contents News & Views Review Articles Resource Corrigenda Volume 36, Number 10 News & Views Revealing the inner workings of organoids The finding that human cerebral organoids autonomously develop forebrain‐like structures with similar spatiotemporal patterning suggests that organoid generation mirrors physiological brain development. Cristina Dias and François Guillemot Published online 24.04.2017 Review Focus: Metabolism: Cancer cell metabolism: the essential role of the nonessential amino acid, glutamine As part of our Metabolism focus series, Thompson and colleagues review the diverse biosynthetic and regulatory functions of glutamine in instructing cell proliferation, stress resistance and cellular identity. Ji Zhang, Natalya N Pavlova, and Craig B Thompson Published online 18.04.2017 Articles Self‐organized developmental patterning and differentiation in cerebral organoids Cerebral organoids have the intrinsic propensity to develop into differentiated brain tissue with regions of discrete identities in the absence of exogenously added patterning signals. Magdalena Renner, Madeline A Lancaster, Shan Bian, Heejin Choi, Taeyun Ku, Angela Peer, Kwanghun Chung, and Juergen A Knoblich Published online 10.03.2017 Fatty acid synthesis is critical for stem cell pluripotency via promoting mitochondrial fission Lipid products and stabilization of fission factor FIS1 upon lipogenic consumption of acetyl‐CoA jointly impinge on mitochondrial dynamics to promote ESC maintenance and iPSC formation. Lihua Wang, Tong Zhang, Lin Wang, Yongping Cai, Xiuying Zhong, Xiaoping He, Lan Hu, Shengya Tian, Mian Wu, Lijian Hui, Huafeng Zhang, and Ping Gao Published online 04.04.2017 Hypoxia enhances antibody‐dependent dengue virus infection Dengue virus uptake via the Fc gamma receptor IIA is facilitated by HIF1α‐dependent and HIF1α‐independent changes to myeloid cells under low oxygen levels. Esther Shuyi Gan, Wei Fun Cheong, Kuan Rong Chan, Eugenia Ziying Ong, Xiaoran Chai, Hwee Cheng Tan, Sujoy Ghosh, Markus R Wenk, and Eng Eong Ooi Published online 20.03.2017 A second Wpl1 anti‐cohesion pathway requires dephosphorylation of fission yeast kleisin Rad21 by PP4 In addition to protecting cohesin from Wpl1‐dependent removal, the acetyltransferase Eso1 also counteracts a novel phosphatase‐mediated mechanism for rendering cohesin on DNA non‐cohesive. Adrien Birot, Karen Eguienta, Stéphanie Vazquez, Stéphane Claverol, Marc Bonneu, Karl Ekwall, Jean‐Paul Javerzat, and Sabine Vaur Published online 24.04.2017 let‐7 regulates radial migration of new‐born neurons through positive regulation of autophagy Adult neurogenesis requires interneurons to migrate and integrate in the olfactory bulb in a process that depends on let‐7‐dependent control of autophagy. Rebecca Petri, Karolina Pircs, Marie E Jönsson, Malin Åkerblom, Per Ludvik Brattås, Thies Klussendorf, and Johan Jakobsson Published online 23.03.2017 The SAC1 domain in synaptojanin is required for autophagosome maturation at presynaptic terminals The Parkinson's disease‐associated lipid phosphatase synaptojanin promotes synaptic autophagosome formation, a function that is impaired by pathogenic mutations. Roeland Vanhauwaert, Sabine Kuenen, Roy Masius, Adekunle Bademosi, Julia Manetsberger, Nils Schoovaerts, Laura Bounti, Serguei Gontcharenko, Jef Swerts, Sven Vilain, Marina Picillo, Paolo Barone, Shashini T Munshi, Femke MS de Vrij, Steven A Kushner, Natalia V Gounko, Wim Mandemakers, Vincenzo Bonifati, Frederic A Meunier, Sandra‐Fausia Soukup, and Patrik Verstreken Published online 22.03.2017 STARD3 mediates endoplasmic reticulum‐to‐endosome cholesterol transport at membrane contact sites The cholesterol transfer protein STARD3, which scaffolds ER–endosome contact sites, controls cellular cholesterol distribution by efficiently delivering ER cholesterol to endosomes. Léa P Wilhelm, Corinne Wendling, Benoît Védie, Toshihide Kobayashi, Marie‐Pierre Chenard, Catherine Tomasetto, Guillaume Drin, and Fabien Alpy Published online 04.04.2017 USP49 negatively regulates tumorigenesis and chemoresistance through FKBP51‐AKT signaling Deubiquitination stabilizes an immunophilin scaffold protein to facilitate AKT dephosphorylation and suppress cancer cell proliferation. Kuntian Luo, Yunhui Li, Yujiao Yin, Lei Li, Chenming Wu, Yuping Chen, Somaira Nowsheen, Qi Hu, Lizhi Zhang, Zhenkun Lou, and Jian Yuan Published online 31.03.2017 Resource Unusual semi‐extractability as a hallmark of nuclear body‐associated architectural noncoding RNAs A modified RNA extraction protocol allows the identification of several new architectural long noncoding RNAs and sheds light on the properties of cellular RNA‐protein granules. Takeshi Chujo, Tomohiro Yamazaki, Tetsuya Kawaguchi, Satoshi Kurosaka, Toru Takumi, Shinichi Nakagawa, and Tetsuro Hirose Published online 12.04.2017 Corrigenda Osteopontin attenuates aging‐associated phenotypes of hematopoietic stem cells Novella Guidi, Mehmet Sacma, Ludger Ständker, Karin Soller, Gina Marka, Karina Eiwen, Johannes M Weiss, Frank Kirchhoff, Tanja Weil, Jose A Cancelas, Maria Carolina Florian, and Hartmut Geiger Published online 15.05.2017 Endothelial basement membrane laminin 511 is essential for shear stress response Jacopo Di Russo, Anna‐Liisa Luik, Lema Yousif, Sigmund Budny, Hans Oberleithner, Verena Hofschröer, Juergen Klingauf, Ed van Bavel, Erik NTP Bakker, Per Hellstrand, Anirban Bhattachariya, Sebastian Albinsson, Frederic Pincet, Rupert Hallmann, and Lydia M Sorokin Published online 15.05.2017   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 973 University Avenue * Los Gatos, CA 95032 * U.S.A. Copyright © 2017 by the European Molecular Biology Organisation.