Nature Structural & Molecular Biology Contents: 2017 Volume #24 pp 431 - 490

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Advertisement Nature Milestones: Antibodies  Nature Milestones: Antibodies chronicles the history of antibodies from their earliest description in antisera, their structure, generation and function, right through to their recent application in cancer immunotherapy. It also includes a timeline and a collection of seminal papers reproduced from Springer Nature.  Access the Milestone free online Produced with support from:  BioLegend UCB TABLE OF CONTENTS May 2017 Volume 24, Issue 5 Obituary News and Views Perspective Articles Subscribe   Facebook   RSS   Recommend to library   Twitter   Obituary Top Anna Tramontano 1957-2017   pp431 - 432 Janet M Thornton, Alfonso Valencia and Torsten Schwede doi:10.1038/nsmb.3410 News and Views Top Carb cutting works better with a partner   pp433 - 435 Jennifer J Kohler doi:10.1038/nsmb.3405 O-GlcNAc is a reversible post-translational modification that is added by O-GlcNAc transferase (OGT) and removed by O-GlcNAcase (OGA). OGA is emerging as a therapeutic target for multiple diseases, but its structure has been elusive until now. Splicing of Ezh1 gets muscle out of stressful situations   pp435 - 437 Marjorie Brand and F Jeffrey Dilworth doi:10.1038/nsmb.3406 As cells undergo terminal differentiation, the composition of Polycomb-repressive complex 2 (PRC2) changes and the histone H3K27 methyltransferase Ezh2 is progressively replaced by its homolog Ezh1. By identifying an enzymatically inactive splice variant of Ezh1 that is sensitive to cellular stress, Bodega et al. now demonstrate that PRC2-Ezh1 has an essential role in establishing an altered gene expression program required for postmitotic muscle cells to adapt to environmental changes. See also: Article by Bodega et al. Capturing heterogeneity: single-cell structures of the 3D genome   pp437 - 438 Elzo de Wit doi:10.1038/nsmb.3404 One of the striking features of cells seen through a microscope is the heterogeneous organization of the nuclei. A combination of molecular methods and computational modeling has now been used to reconstruct accurate 3D structures of the genome inside single nuclei. Perspective DNA-RNA hybrids: the risks of DNA breakage during transcription   pp439 - 443 Andrés Aguilera and Belen Gómez-González doi:10.1038/nsmb.3395 In this Perspective, the authors consider how DNA breaks stimulate R-loop formation, particularly within actively transcribed genomic regions, and discuss the cellular mechanisms that prevent or remove RNA-DNA hybrids to preserve genome integrity. Structural & Molecular Biology JOBS of the week Senior Scientist – Computational Medicinal Chemist Philip Morris International (PMI) Junior Group Leader Symposium Philipps-Universität Marburg PhD Position in Biochemistry: Prague, Czech Republic Institute of Organic Chemistry and Biochemistry AS CR, v.v.i. (IOCB) Postdoc positions in Molecular and Cellular Biology / Biochemistry / Structural Biology Max Planck Institute for Developmental Biology International PhD Programme IGBMC (Institute of Genetics & Molecular & Cellular Biology)/ CERBM GIE More Science jobs from Structural & Molecular Biology EVENT ISFMS2017 - 2nd International Symposium on Frontiers in Molecular Science Non-Coding RNAs and Epigenetics in Cancer 21.06.17 Basel, Switzerland More science events from Advertisement nature.com webcasts Springer Nature presents a custom webcast on: Perturb-seq: High Throughput CRISPR Screening via Single-Cell RNA Sequencing Date: Wednesday May 10, 2017 Time: 11AM PDT | 2PM EDT  Register FREE   Sponsored by:  10x Genomics   Articles Top A cytosolic Ezh1 isoform modulates a PRC2-Ezh1 epigenetic adaptive response in postmitotic cells   pp444 - 452 Beatrice Bodega, Federica Marasca, Valeria Ranzani, Alessandro Cherubini, Francesco Della Valle et al. doi:10.1038/nsmb.3392 A cytosolic isoform of Ezh1 that lacks the catalytic domain controls nuclear PRC2 activity in response to atrophic oxidative stress in skeletal muscle cells by trapping Eed in the cytoplasm. See also: News and Views by Brand & Dilworth Structure of the 40S-ABCE1 post-splitting complex in ribosome recycling and translation initiation   pp453 - 460 Andre Heuer, Milan Gerovac, Christian Schmidt, Simon Trowitzsch, Anne Preis et al. doi:10.1038/nsmb.3396 Cryo-EM structures of the yeast 40S in complex with ribosome-splitting protein ABCE1, along with functional analyses, reveal that the FeS cluster domain undergoes a 150° rotation to dissociate ribosomal subunits. Intraflagellar transport dynein is autoinhibited by trapping of its mechanical and track-binding elements   pp461 - 468 Katerina Toropova, Miroslav Mladenov and Anthony J Roberts doi:10.1038/nsmb.3391 Molecular motor dynein-2, involved in retrograde intraflagellar transport, adopts an autoinhibited conformation, in which the mechanical linker and track-binding stalk are trapped via a newly described motor-motor interface. Structural basis for lipopolysaccharide extraction by ABC transporter LptB2FG   pp469 - 474 Qingshan Luo, Xu Yang, Shan Yu, Huigang Shi, Kun Wang et al. doi:10.1038/nsmb.3399 The crystal structure of LptB2FG, an ABC transporter that extracts LPS from the bacterial inner membrane and transports it to the outer membrane, indicates a transport mechanism distinct from classical ABC transporters. Parkin-phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity   pp475 - 483 Atul Kumar, Viduth K Chaugule, Tara E C Condos, Kathryn R Barber, Clare Johnson et al. doi:10.1038/nsmb.3400 The human RBR E3 ligase Parkin is captured in complex with phosphoubiquitin, revealing a cryptic ubiquitin-binding site and indicating a mechanism of cooperation between RBR modules for activation. An orthogonal single-molecule experiment reveals multiple-attempt dynamics of type IA topoisomerases   pp484 - 490 Kathryn H Gunn, John F Marko and Alfonso Mondragon doi:10.1038/nsmb.3401 A novel combination of magnetic tweezers and single-molecule TIRF microscopy reveals that topoisomerase IA makes multiple attempts to engage DNA before successfully catalyzing strand passage and DNA relaxation. Top Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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