Nature Reviews Neuroscience contents June 2017 Volume 18 Number 6 pp 321 - 384

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TABLE OF CONTENTS
June 2017 Volume 18 Number 6
2015 2-year Impact Factor 29.298 Journal Metrics 2-year Median 22	In this issue Research Highlights Progress Reviews Perspectives Also this month  Featured article: Adult hippocampal neurogenesis and cognitive flexibility — linking memory and mood Christoph Anacker & René Hen
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RESEARCH HIGHLIGHTS Top Learning and memory: Consolidation circuitry p321 | doi:10.1038/nrn.2017.58 A new study in mice shows that memory engram cells associated with long-term memories form in the prefrontal cortex early during learning in a contextual fear conditioning paradigm and reveals details of the circuitry involved in long-term memory consolidation. PDF Navigation: Sounds like non-spatial navigation p322 | doi:10.1038/nrn.2017.53 Neurons in the hippocampus and entorhinal cortex of rats manipulating the frequency of a tone exhibit 'frequency fields', akin to place fields seen during spatial navigation. PDF Brain ageing: A youthful reminder p322 | doi:10.1038/nrn.2017.59 A study shows that systemic adminstration of plasma from human umbilical cord counteracts ageing-induced impairment of hippocampal function in mice and identifies a key protein in plasma that confers such effects. PDF Neural development: Keeping a lid on alternative fates p323 | doi:10.1038/nrn.2017.54 The transcription factor MYT1L contributes to the induction and maintenance of neuronal identity through the repression of multiple alternative lineages. PDF Working memory: Keeping short-term memories alive p324 | doi:10.1038/nrn.2017.60 Different interneuron populations modulate delay activity representing action plans in the dorsomedial prefrontal cortex. PDF IN BRIEF Learning and memory: A state to remember | Neuronal development: The source of the signal | Brain evolution: Genetic layering | Sleep: Dream a little dream PDF Nature reviews Neuroscience JOBS of the week Chair in Translational Neuroscience University College London (UCL) Tenure-Track Faculty Positions in Neuroscience & Behavioral Disorders at the Duke-NUS Medical School, Singapore (Assistant or Associate Levels) DUKE-NUS Medical school Tenure-track Positions in Neuroscience Research at Nankai University The State Key Laboratory of Medicinal Chemical Biology (SKLMCB) of Nankai University Tenure Track Faculty Positions: Neuroscience Initiative, CUNY Advanced Science Research Center City University of New York, Advanced Science Research Center Neuroscience Scholars Program Society for Neuroscience More Science jobs from Nature reviews Neuroscience EVENT Neurotech Investing and Partnering Conference Europe 2017 03.10.17 Geneva, Switzerland More science events from
PROGRESS		Top
Progranulin, lysosomal regulation and neurodegenerative disease Aimee W. Kao et al. p325 | doi:10.1038/nrn.2017.36 Recent studies suggest that progranulin has an important role in lysosome biogenesis and innate immunity in the brain. In this Progress article, Kao and colleagues suggest that progranulin also plays a part in suppressing excessive neuroinflammation during ageing. Abstract | Full Text | PDF
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REVIEWS		Top
Adult hippocampal neurogenesis and cognitive flexibility — linking memory and mood Christoph Anacker & René Hen p335 | doi:10.1038/nrn.2017.45 In this Review, Anacker and Hen explore how regulation of dentate gyrus function by adult hippocampal neurogenesis may link the memory and mood functions of the hippocampus. They also examine the potential of targeting such regulation for mood disorders. Abstract | Full Text | PDF
The emerging field of epigenetics in neurodegeneration and neuroprotection Jee-Yeon Hwang, Kelly A. Aromolaran & R. Suzanne Zukin p347 | doi:10.1038/nrn.2017.46 The contribution of epigenetics to many aspects of neuronal development and function is becoming apparent. In this Review, Zukin and colleagues describe how the dysregulation of epigenetic mechanisms may contribute to neurodegenerative diseases. Abstract | Full Text | PDF
The brain, sirtuins, and ageing Akiko Satoh, Shin-ichiro Imai & Leonard Guarente p362 | doi:10.1038/nrn.2017.42 Sirtuins and the neuron–microglia network have a key role in the ageing process. In this Review article, Satoh and colleagues discuss the role of sirtuins in age-related changes in communication between peripheral tissues and the brain, which has a key influence on ageing and longevity in mammals. Abstract | Full Text | PDF
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PERSPECTIVES		Top
OPINION How and why do T cells and their derived cytokines affect the injured and healthy brain? Anthony J. Filiano, Sachin P. Gadani & Jonathan Kipnis p375 | doi:10.1038/nrn.2017.39 Recent evidence suggests that T cells and their derived cytokines affect the brain in disease and health. In this Opinion article, Kipnis and colleagues describe their effects and possible underlying mechanisms, and propose an evolutionary model to explain why the T cell-derived cytokine interferon-γ has both pro-social and immune effects. Abstract | Full Text | PDF
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