Thursday, May 18, 2017

Nature Reviews Neuroscience contents June 2017 Volume 18 Number 6 pp 321 - 384

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Nature Reviews Neuroscience

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June 2017 Volume 18 Number 6
Nature Reviews Neuroscience cover
2015 2-year Impact Factor 29.298 Journal Metrics 2-year Median 22
In this issue
Research Highlights

Also this month
 Featured article:
Adult hippocampal neurogenesis and cognitive flexibility — linking memory and mood
Christoph Anacker & René Hen

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Learning and memory: Consolidation circuitry
p321 | doi:10.1038/nrn.2017.58
A new study in mice shows that memory engram cells associated with long-term memories form in the prefrontal cortex early during learning in a contextual fear conditioning paradigm and reveals details of the circuitry involved in long-term memory consolidation.


Navigation: Sounds like non-spatial navigation
p322 | doi:10.1038/nrn.2017.53
Neurons in the hippocampus and entorhinal cortex of rats manipulating the frequency of a tone exhibit 'frequency fields', akin to place fields seen during spatial navigation.


Brain ageing: A youthful reminder
p322 | doi:10.1038/nrn.2017.59
A study shows that systemic adminstration of plasma from human umbilical cord counteracts ageing-induced impairment of hippocampal function in mice and identifies a key protein in plasma that confers such effects.


Neural development: Keeping a lid on alternative fates
p323 | doi:10.1038/nrn.2017.54
The transcription factor MYT1L contributes to the induction and maintenance of neuronal identity through the repression of multiple alternative lineages.


Working memory: Keeping short-term memories alive
p324 | doi:10.1038/nrn.2017.60
Different interneuron populations modulate delay activity representing action plans in the dorsomedial prefrontal cortex.



Learning and memory: A state to remember | Neuronal development: The source of the signal | Brain evolution: Genetic layering | Sleep: Dream a little dream

Nature reviews Neuroscience
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Progranulin, lysosomal regulation and neurodegenerative disease
Aimee W. Kao et al.
p325 | doi:10.1038/nrn.2017.36
Recent studies suggest that progranulin has an important role in lysosome biogenesis and innate immunity in the brain. In this Progress article, Kao and colleagues suggest that progranulin also plays a part in suppressing excessive neuroinflammation during ageing.

Abstract | Full Text | PDF
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Adult hippocampal neurogenesis and cognitive flexibility — linking memory and mood
Christoph Anacker & René Hen
p335 | doi:10.1038/nrn.2017.45
In this Review, Anacker and Hen explore how regulation of dentate gyrus function by adult hippocampal neurogenesis may link the memory and mood functions of the hippocampus. They also examine the potential of targeting such regulation for mood disorders.
Abstract | Full Text | PDF

The emerging field of epigenetics in neurodegeneration and neuroprotection
Jee-Yeon Hwang, Kelly A. Aromolaran & R. Suzanne Zukin
p347 | doi:10.1038/nrn.2017.46
The contribution of epigenetics to many aspects of neuronal development and function is becoming apparent. In this Review, Zukin and colleagues describe how the dysregulation of epigenetic mechanisms may contribute to neurodegenerative diseases.
Abstract | Full Text | PDF

The brain, sirtuins, and ageing
Akiko Satoh, Shin-ichiro Imai & Leonard Guarente
p362 | doi:10.1038/nrn.2017.42
Sirtuins and the neuron–microglia network have a key role in the ageing process. In this Review article, Satoh and colleagues discuss the role of sirtuins in age-related changes in communication between peripheral tissues and the brain, which has a key influence on ageing and longevity in mammals.
Abstract | Full Text | PDF

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How and why do T cells and their derived cytokines affect the injured and healthy brain?
Anthony J. Filiano, Sachin P. Gadani & Jonathan Kipnis
p375 | doi:10.1038/nrn.2017.39
Recent evidence suggests that T cells and their derived cytokines affect the brain in disease and health. In this Opinion article, Kipnis and colleagues describe their effects and possible underlying mechanisms, and propose an evolutionary model to explain why the T cell-derived cytokine interferon-γ has both pro-social and immune effects.
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