Nature Reviews Molecular Cell Biology contents June 2017 Volume 18 Number 6 pp 339-401

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TABLE OF CONTENTS
June 2017 Volume 18 Number 6
2015 2-year Impact Factor 38.602 Journal Metrics 2-year Median 30	In this issue Comment Research Highlights Reviews Perspectives Also this month Article series: RNA processing and modifications  Featured article: The HSP90 chaperone machinery Florian H. Schopf, Maximilian M. Biebl & Johannes Buchner
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Article series: RNA processing and modifications Comment: Charting the unknown epitranscriptome Eva Maria Novoa, Christopher E. Mason & John S. Mattick p339 | doi:10.1038/nrm.2017.49 Novoa, Mason and Mattick propose to use phage display technology and direct sequencing through nanopores to facilitate systematic interrogation of RNA modifications. Abstract | Full Text | PDF
RESEARCH HIGHLIGHTS Top Ageing: Is fat a key to longevity? p341 | doi:10.1038/nrm.2017.45 Worms with impaired H3K4 trimethylation have an extended lifespan, which is associated with the accumulation of monounsaturated fatty acids in their intestines. PDF Metabolism: Methyl groups sink into phospholipids and histones p342 | doi:10.1038/nrm.2017.44 Phospholipids and histones act as sinks for methyl groups, thereby regulating methylation reactions and contributing to metabolic homeostasis. PDF Cell death: ESCRTing dying cells back to life p342 | doi:10.1038/nrm.2017.46 The ESCRT-III complex is shown to counteract the loss of plasma membrane integrity in cells undergoing necroptosis, thereby preventing or delaying cell death. PDF RNA decay: The anti-apoptotic function of ADAR1 p343 | doi:10.1038/nrm.2017.51 An isoform of the RNA-editing protein ADAR1 is shown to be activated through nuclear export in response to cellular stress and to protect anti-apoptotic mRNAs from Staufen 1-mediated decay. PDF JOURNAL CLUB The moment when translational control had a theory of everything p344 | doi:10.1038/nrm.2017.33 Allan Jacobson reminds us of how a study by Dever et al. published in 1992 connected several data on translational regulation, bringing attention to its crucial role in the regulation of gene expression. PDF Mechanisms of diseases: Excessive polyQ tracts curb autophagy p344 | doi:10.1038/nrm.2017.50 Expansion of polyglutamine tracts in proteins interferes with the process of autophagy and may contribute to the pathology of neurodegenerative diseases. PDF Molecular Cell Biology JOBS of the week Post-doctoral Positions in Skeletal muscle Stem Cells and molecular medicine Biology of the neuromuscular system Team IMRB U955-E10 Postdoc Position University Hospital RWTH Aachen, Institute for Pathology Postdoctoral Fellows in Statistical Genetics / Computational Biology Columbia University POSTDOC in Cardiopulmonary Molecular Biology Hannover Medical School (MHH) Postdoctoral Positions University of Minnesota More Science jobs from Molecular Cell Biology EVENT OMICs 2017 28.10.17 Varadero, Cuba More science events from
REVIEWS		Top
The HSP90 chaperone machinery Florian H. Schopf, Maximilian M. Biebl & Johannes Buchner p345 | doi:10.1038/nrm.2017.20 The heat shock protein 90 (HSP90) chaperone machinery is a key regulator of proteostasis. Recent progress has shed light on the interactions of HSP90 with its clients and co-chaperones, and on their functional implications. This opens up new avenues for the development of drugs that target HSP90, which could be valuable for the treatment of cancers and protein-misfolding diseases. Abstract | Full Text | PDF
The mystery of membrane organization: composition, regulation and roles of lipid rafts Erdinc Sezgin, Ilya Levental, Satyajit Mayor & Christian Eggeling p361 | doi:10.1038/nrm.2017.16 Lipid rafts are relatively ordered membrane domains that are enriched in cholesterol and saturated lipids, and selectively recruit other lipids and proteins. They are dynamic and heterogeneous in composition and are thus challenging to visualize in vivo. New technologies are providing novel insights into the formation, organization and functions of these membrane domains. Abstract | Full Text | PDF | Supplementary information
Planar cell polarity in development and disease Mitchell T. Butler & John B. Wallingford p375 | doi:10.1038/nrm.2017.11 Planar cell polarity — the asymmetric distribution of proteins in the plane of a cell sheet — dictates the orientation of various subcellular structures and drives collective cell rearrangements. Better understanding of this conserved axis of polarity can shed light on the mechanisms of morphogenetic processes and explain the underlying causes of human birth defects. Abstract | Full Text | PDF | Supplementary information
PERSPECTIVES		Top
OPINION Global treadmilling coordinates actin turnover and controls the size of actin networks Marie-France Carlier & Shashank Shekhar p389 | doi:10.1038/nrm.2016.172 In animal cells, actin is dynamically distributed between multiple coexisting arrays. Carlier and Shekhar propose that a global treadmilling process — whereby the various actin networks grow and shrink depending on the local activity of actin regulators — establishes a steady-state concentration of actin monomers that supports this homeostatic actin turnover. Abstract | Full Text | PDF | Supplementary information
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