Nature Reviews Immunology Contents June 2017 Volume 17 Number 6 pp 341-402

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TABLE OF CONTENTS
June 2017 Volume 17 Number 6		Advertisement
2015 2-year Impact Factor 39.416 Journal Metrics 2-year Median 31	In this issue Comment Research Highlights Reviews Perspectives Correspondence Also this month  Featured article: Multi-receptor detection of individual bacterial products by the innate immune system Karen J. Kieser & Jonathan C. Kagan	Nature Reviews Cancer: Poster on Multifaceted effects of the microenvironment on tumour progression Available to download free online Produced with support from  Fluidigm Corporation
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Nature Milestones: Interactive antibody timeline Nature Milestones: Antibodies presents an interactive timeline on the history of antibodies covering everything from their initial description in antisera through to their application in immunotherapy. The timeline includes written content, video interviews and animations.  Access the timeline free online Produced with support from BioLegend UCB
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NATURE CONFERENCE ON INFLAMMATORY DISEASES Presented by: Chinese Academy of Medical Sciences & Peking Union Medical College | Chinese Society for Immunology (CSI) | Nature Reviews Immunology | Nature Immunology | Nature | Nature Communications This conference will feature sessions on microbiota, cell death, metabolism, technologies, and innate sensing and signaling as they relate to inflammatory diseases and cancer. September 17-20, 2017 | Beijing, China REGISTER NOW!
Comment: Emil von Behring: translational medicine at the dawn of immunology Stefan H. E. Kaufmann p341 | doi:10.1038/nri.2017.37 Remembering Emil von Behring, one of the founders of immunology, 100 years after his death. Abstract | Full Text | PDF
RESEARCH HIGHLIGHTS Top Immune regulation: IL-10 targets macrophage metabolism p345 | doi:10.1038/nri.2017.57 The anti-inflammatory effects of IL-10 involve mTORC1-regulated metabolic and autophagic pathways in macrophages. PDF Neuroimmunology: Macrophages help you burn energy p346 | doi:10.1038/nri.2017.56 Macrophages in brown adipose tissue support sympathetic innervation to ensure proper homeostatic energy expenditure. PDF Asthma and allergy: The NET effect of respiratory viruses p346 | doi:10.1038/nri.2017.60 Rhinovirus infections exacerbate asthma by inducing the release of neutrophil extracellular traps. PDF Tumour immunology: Immune atlas sheds light on anticancer responses p347 | doi:10.1038/nri.2017.59 Multiscale immune profiling strategies facilitate unprecedented insights into the subtypes and composition of immune cells in the tumour microenvironment. PDF JOURNAL CLUB Medullary Thymic epithelial cell progenitors: hidden in plain sight p348 | doi:10.1038/nri.2017.27 Graham Anderson describes a 2001 study by Rodewald and colleagues that provided the first experimental evidence for thymic epithelial cell progenitors. PDF Tumour immunology: Platelets — a new target in cancer immunotherapy? p348 | doi:10.1038/nri.2017.61 Activation of TGFβ by platelets limits the efficacy of anti-tumour T cell responses. PDF Nature Reviews Immunology JOBS of the week Assistant / Associate Editor for Cancer Immunology Research American Association for Cancer Research (AACR) Postdoctoral position available in Cancer Immunology and Immunotherapy at Weill Cornell Medicine in New York City Weill Cornell Medicine Immunology & Immuno-Oncology lead scientist Evotec Post Doctoral Scholar in Immunology: Mechanisms of Tolerance Induction Boston Children's Hospital; Harvard Medical School Postdoctoral Research Fellow, Mark Wilson Lab - Immunology Genentech Research More Science jobs from Nature Reviews Immunology EVENT International Conference on Immunology and Immunotechnology 01.11.17 Barcelona, Spain More science events from
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Nature Outlook: Animal Health Animal and human health are closely linked. This Outlook examines how climate change is pushing diseases into formerly 'safe' regions of the world, the challenges in treating parasites, the efforts to vaccinate gorillas against Ebola and how a holistic approach to disease could further the well-being of animals.  Access the Outlook free online   Produced with support from  Bayer Animal Health GmbH
REVIEWS		Top
Monocyte differentiation and antigen-presenting functions Claudia V. Jakubzick, Gwendalyn J. Randolph & Peter M. Henson p349 | doi:10.1038/nri.2017.28 Monocytes not only serve as precursors for macrophages, but also contribute to tissue immunity by presenting antigen to T cells and producing immunomodulatory mediators. In this Review, the authors discuss some of these less well-appreciated immune functions of monocytes. Abstract | Full Text | PDF | Supplementary information
Mitochondrial DNA in innate immune responses and inflammatory pathology A. Phillip West & Gerald S. Shadel p363 | doi:10.1038/nri.2017.21 Mitochondrial DNA (mtDNA) can engage multiple pattern-recognition receptors to trigger pro-inflammatory and type I interferon responses. This Review provides an overview of how these responses are activated by summarizing the unique features of mtDNA and how it is exposed during cellular stress. Abstract | Full Text | PDF
Multi-receptor detection of individual bacterial products by the innate immune system Karen J. Kieser & Jonathan C. Kagan p376 | doi:10.1038/nri.2017.25 The detection of cell wall components has a critical role in the recognition of bacteria and the initiation of host defence. In this Review, Kieser and Kagan discuss common themes associated with the detection of individual bacterial products by diverse receptors of the innate immune system. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Antigen-inexperienced memory CD8+ T cells: where they come from and why we need them Jason T. White, Eric W. Cross & Ross M. Kedl p391 | doi:10.1038/nri.2017.34 In this Opinion article, the authors discuss our growing appreciation of antigen-inexperienced memory T cell subsets. They focus on the development and functions of the recently described 'virtual memory' and 'innate memory' CD8+ T cell populations, and propose a unified nomenclature for these subsets. Abstract | Full Text | PDF
CORRESPONDENCE		Top
Immunosuppressive cell death in cancer Jiajie Hou, Tim F. Greten & Qiang Xia p401 | doi:10.1038/nri.2017.46 Full Text | PDF
Reply: Immunosuppressive cell death in cancer Lorenzo Galluzzi et al. p402 | doi:10.1038/nri.2017.48 Full Text | PDF
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