Friday, May 26, 2017

Nature Reviews Immunology Contents June 2017 Volume 17 Number 6 pp 341-402

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Nature Reviews Immunology

Rapid, real-time T cell activation assay

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Research Highlights

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 Featured article:
Multi-receptor detection of individual bacterial products by the innate immune system
Karen J. Kieser & Jonathan C. Kagan
Nature Reviews Cancer: Poster on Multifaceted effects of the microenvironment on tumour progression

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Nature Milestones: Interactive antibody timeline

Nature Milestones: Antibodies presents an interactive timeline on the history of antibodies covering everything from their initial description in antisera through to their application in immunotherapy. The timeline includes written content, video interviews and animations. 

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Presented by: Chinese Academy of Medical Sciences & Peking Union Medical College | Chinese Society for Immunology (CSI) | Nature Reviews Immunology | Nature Immunology | Nature | Nature Communications

This conference will feature sessions on microbiota, cell death, metabolism, technologies, and innate sensing and signaling as they relate to inflammatory diseases and cancer.

September 17-20, 2017 | Beijing, China

Comment: Emil von Behring: translational medicine at the dawn of immunology
Stefan H. E. Kaufmann
p341 | doi:10.1038/nri.2017.37
Remembering Emil von Behring, one of the founders of immunology, 100 years after his death.
Abstract | Full Text | PDF

Immune regulation: IL-10 targets macrophage metabolism
p345 | doi:10.1038/nri.2017.57
The anti-inflammatory effects of IL-10 involve mTORC1-regulated metabolic and autophagic pathways in macrophages.

Neuroimmunology: Macrophages help you burn energy
p346 | doi:10.1038/nri.2017.56
Macrophages in brown adipose tissue support sympathetic innervation to ensure proper homeostatic energy expenditure.

Asthma and allergy: The NET effect of respiratory viruses
p346 | doi:10.1038/nri.2017.60
Rhinovirus infections exacerbate asthma by inducing the release of neutrophil extracellular traps.

Tumour immunology: Immune atlas sheds light on anticancer responses
p347 | doi:10.1038/nri.2017.59
Multiscale immune profiling strategies facilitate unprecedented insights into the subtypes and composition of immune cells in the tumour microenvironment.

Medullary Thymic epithelial cell progenitors: hidden in plain sight

p348 | doi:10.1038/nri.2017.27
Graham Anderson describes a 2001 study by Rodewald and colleagues that provided the first experimental evidence for thymic epithelial cell progenitors.

Tumour immunology: Platelets — a new target in cancer immunotherapy?
p348 | doi:10.1038/nri.2017.61
Activation of TGFβ by platelets limits the efficacy of anti-tumour T cell responses.

Nature Reviews Immunology
JOBS of the week
Assistant / Associate Editor for Cancer Immunology Research
American Association for Cancer Research (AACR)
Postdoctoral position available in Cancer Immunology and Immunotherapy at Weill Cornell Medicine in New York City
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Post Doctoral Scholar in Immunology: Mechanisms of Tolerance Induction
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Genentech Research
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Nature Reviews Immunology
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Nature Outlook: Animal Health

Animal and human health are closely linked. This Outlook examines how climate change is pushing diseases into formerly 'safe' regions of the world, the challenges in treating parasites, the efforts to vaccinate gorillas against Ebola and how a holistic approach to disease could further the well-being of animals. 

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Monocyte differentiation and antigen-presenting functions
Claudia V. Jakubzick, Gwendalyn J. Randolph & Peter M. Henson
p349 | doi:10.1038/nri.2017.28
Monocytes not only serve as precursors for macrophages, but also contribute to tissue immunity by presenting antigen to T cells and producing immunomodulatory mediators. In this Review, the authors discuss some of these less well-appreciated immune functions of monocytes.
Abstract | Full Text | PDF | Supplementary information
Mitochondrial DNA in innate immune responses and inflammatory pathology
A. Phillip West & Gerald S. Shadel
p363 | doi:10.1038/nri.2017.21
Mitochondrial DNA (mtDNA) can engage multiple pattern-recognition receptors to trigger pro-inflammatory and type I interferon responses. This Review provides an overview of how these responses are activated by summarizing the unique features of mtDNA and how it is exposed during cellular stress.
Abstract | Full Text | PDF
Multi-receptor detection of individual bacterial products by the innate immune system
Karen J. Kieser & Jonathan C. Kagan
p376 | doi:10.1038/nri.2017.25
The detection of cell wall components has a critical role in the recognition of bacteria and the initiation of host defence. In this Review, Kieser and Kagan discuss common themes associated with the detection of individual bacterial products by diverse receptors of the innate immune system.
Abstract | Full Text | PDF
Antigen-inexperienced memory CD8+ T cells: where they come from and why we need them
Jason T. White, Eric W. Cross & Ross M. Kedl
p391 | doi:10.1038/nri.2017.34
In this Opinion article, the authors discuss our growing appreciation of antigen-inexperienced memory T cell subsets. They focus on the development and functions of the recently described 'virtual memory' and 'innate memory' CD8+ T cell populations, and propose a unified nomenclature for these subsets.
Abstract | Full Text | PDF
Immunosuppressive cell death in cancer
Jiajie Hou, Tim F. Greten & Qiang Xia
p401 | doi:10.1038/nri.2017.46
Full Text | PDF
Reply: Immunosuppressive cell death in cancer
Lorenzo Galluzzi et al.
p402 | doi:10.1038/nri.2017.48
Full Text | PDF
Online-only and open access, npj Primary Care Respiratory Medicine is the only fully-indexed scientific journal devoted to the management of respiratory diseases in primary care.

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