Nature Immunology Contents: June 2017 Volume 18 pp595 - 705

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Advertisement A*STAR Research - Highlighting the latest breakthroughs at the Agency for Science, Technology and Research (A*STAR), Singapore's premier research organization  Recent Immunology Highlights Charting T cell territory | A human gene atlas for virus replication | Immune barriers remain intact after defense molecule loss http://www.research.a-star.edu.sg/research Download the A*STAR Research app now! TABLE OF CONTENTS June 2017 Volume 18, Issue 6 News and Views Research Highlights Reviews Articles Corrigendum Errata Advertisement   What can you measure with Flow Cytometry? Download our new white paper highlighting the power of Flow Cytometry in Immunology Models and learn how to use these techniques to yield promising therapeutic candidates. Download this White Paper now Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement Nature Reviews Microbiology: Collection on Antimicrobial Resistance  This collection of articles from several Nature journals describes how antimicrobial resistance emerges and details discovery strategies for urgently needed new antimicrobials.  Access this collection free online for six months Produced with support from  Merck & Co., Inc., Kenilworth, NJ, USA   Advertisement NATURE CONFERENCE ON INFLAMMATORY DISEASES Presented by: Chinese Academy of Medical Sciences & Peking Union Medical College | Chinese Society for Immunology (CSI) | Nature Reviews Immunology | Nature Immunology | Nature | Nature Communications This conference will feature sessions on microbiota, cell death, metabolism, technologies, and innate sensing and signaling as they relate to inflammatory diseases and cancer. September 17-20, 2017 | Beijing, China REGISTER NOW!   News and Views Top RNA-binding proteins, the guardians of the marginal zone   pp595 - 597 Palaniraja Thandapani, Beatriz Aranda-Orgilles and Iannis Aifantis doi:10.1038/ni.3752 RNA-binding proteins (RBPs) take control of binary cell-fate 'decisions' and cellular identity in lymphoid organs, as the RBP ZFP36L1 is shown to negatively regulate the stability of the transcription factors KLF2 and IRF8 to control the maintenance, survival and localization of marginal zone B cells. See also: Article by Newman et al. STAT5 alters the state of transcriptional networks, driving aggressive leukemia   pp597 - 598 Sinisa Dovat and Kimberly J Payne doi:10.1038/ni.3747 The transcription factor STAT5 acts as an oncoprotein in B cell acute lymphoblastic leukemia, competing with the transcription factors NF-κB and Ikaros for binding to DNA. See also: Article by Katerndahl et al. Alternative monocytes settle in for the long term   pp599 - 600 Allan McI Mowat and Calum C Bain doi:10.1038/ni.3749 Monocytes recruited to the peritoneum under conditions of a type 2 inflammatory reaction can convert into resident-type macrophages under the control of vitamin A. See also: Article by Gundra et al. Unusual suspects: dancing with stromal cells   pp601 - 602 Gabrielle T Belz and Francisca F Almeida doi:10.1038/ni.3741 M cells sample gut lumenal antigens and microbes to induce gut immune responses. A novel population of stromal cell—the M cell inducers—are essential for sustaining M cell differentiation and bacteria-specific production of immunoglobulin A to maintain the gut-immune system symbiosis. See also: Article by Nagashima et al. Immunology JOBS of the week Assistant / Associate Editor for Cancer Immunology Research American Association for Cancer Research (AACR) Postdoctoral position available in Cancer Immunology and Immunotherapy at Weill Cornell Medicine in New York City Weill Cornell Medicine Immunology & Immuno-Oncology lead scientist Evotec Post Doctoral Scholar in Immunology: Mechanisms of Tolerance Induction Boston Children's Hospital; Harvard Medical School Postdoctoral Research Fellow, Mark Wilson Lab - Immunology Genentech Research More Science jobs from Immunology EVENT International Conference on Immunology and Immunotechnology 01.11.17 Barcelona, Spain More science events from Research Highlights Top Monocyte and DC atlas | Superinduction! | Enchained growth | Fertilization and nucleic acid sensing | Exploitation by Mtb | Zika-neutralizing antibodies Reviews Top IL-17+ γδ T cells as kick-starters of inflammation   pp604 - 611 Pedro H Papotto, Julie C Ribot and Bruno Silva-Santos doi:10.1038/ni.3726 Silva-Santos and colleagues review the activation and pathophysiological functions of γδ17 T cells during inflammatory responses. Interleukin 17 is a chief orchestrator of immunity   pp612 - 621 Marc Veldhoen doi:10.1038/ni.3742 Although interleukin 17 (IL-17) has modest activity on its own, it has a substantial impact in immunity through its synergistic action with other factors and its self-sustaining feedback loop. Veldhoen discusses the role of IL-17 during infections. Advertisement Accelerate Genome Edit Detection  Detect genome edits present at frequencies of ≤0.5% using Droplet Digital™ PCR technology and our genome edit detection assays. Learn more   Articles Top S100-alarmin-induced innate immune programming protects newborn infants from sepsis   pp622 - 632 Thomas Ulas, Sabine Pirr, Beate Fehlhaber, Marie S Bickes, Torsten G Loof et al. doi:10.1038/ni.3745 Neonates are thought to have impaired immune responses, yet, paradoxically, they can also demonstrate hyperinflammation. Ulas et al. show that a neonatal burst of the alarmins S100A8 and S100A9 activates a distinct innate immune response without dangerous hyperinflammation. Mice deficient in NRROS show abnormal microglial development and neurological disorders   pp633 - 641 Kit Wong, Rajkumar Noubade, Paolo Manzanillo, Naruhisa Ota, Oded Foreman et al. doi:10.1038/ni.3743 Microglia are the tissue-resident macrophages of the brain. Ouyang and colleagues show the ER-resident transmembrane protein NRROS is necessary for proper development and function of microglia. Mice lacking NRROS exhibit neurologic defects and die prematurely. Vitamin A mediates conversion of monocyte-derived macrophages into tissue-resident macrophages during alternative activation   pp642 - 653 Uma Mahesh Gundra, Natasha M Girgis, Michael A Gonzalez, Mei San Tang, Hendrik J P Van Der Zande et al. doi:10.1038/ni.3734 Loke and colleagues show that vitamin A is required for the conversion of interleukin 4 (IL-4)-activated monocyte-derived macrophages into macrophages with a tissue-resident phenotype in the peritoneal cavity and in S. mansoni-induced liver granulomas in mice. See also: News and Views by Mowat & Bain A self-sustained loop of inflammation-driven inhibition of beige adipogenesis in obesity   pp654 - 664 Kyoung-Jin Chung, Antonios Chatzigeorgiou, Matina Economopoulou, Ruben Garcia-Martin, Vasileia I Alexaki et al. doi:10.1038/ni.3728 Obesity is commonly accompanied by inflammatory responses in white adipose tissues. Chavakis and colleagues identify a vicious cycle involving α4 integrins and the adhesion molecule VCAM-1 that promotes inflammatory macrophage-adipocyte interactions and suppresses beige adipogenesis. Brown-adipose-tissue macrophages control tissue innervation and homeostatic energy expenditure   pp665 - 674 Yochai Wolf, Sigalit Boura-Halfon, Nina Cortese, Zhana Haimon, Hadas Sar Shalom et al. doi:10.1038/ni.3746 Macrophages serve important functions in defense and tissue homeostasis. Jung and colleagues demonstrate that a resident population of macrophages controls the innervation of brown adipose tissue and thereby regulates energy use. Identification of subepithelial mesenchymal cells that induce IgA and diversify gut microbiota   pp675 - 682 Kazuki Nagashima, Shinichiro Sawa, Takeshi Nitta, Masanori Tsutsumi, Tadashi Okamura et al. doi:10.1038/ni.3732 IgA is necessary for maintaining gut homeostasis, and its production depends on microbial sampling by the gut-associated lymphoid tissue (GALT). Takayanagi and colleagues identify a novel population of mesenchymal cells in the GALT that control M cell differentiation and function of gut epithelium. See also: News and Views by Belz & Almeida Maintenance of the marginal-zone B cell compartment specifically requires the RNA-binding protein ZFP36L1   pp683 - 693 Rebecca Newman, Helena Ahlfors, Alexander Saveliev, Alison Galloway, Daniel J Hodson et al. doi:10.1038/ni.3724 Turner and colleagues show that the RNA-binding protein ZFP36L1 regulates a post-transcriptional hub that determines the identity of marginal-zone B cells by promoting their localization and survival. See also: News and Views by Thandapani et al. Antagonism of B cell enhancer networks by STAT5 drives leukemia and poor patient survival   pp694 - 704 Casey D S Katerndahl, Lynn M Heltemes-Harris, Mark J L Willette, Christine M Henzler, Seth Frietze et al. doi:10.1038/ni.3716 Transcription factors compete for superenhancer sites and have antagonist functions. Farrar and colleagues identify regulatory competition between STAT5 and IKAROS or NF-κB in B cells and show that the ratio of STAT5 to IKAROS or to NF-κB can serve as a prognostic marker of disease severity of the leukemia B-ALL. See also: News and Views by Dovat & Payne Advertisement A cell sorter for rare and precious cells  Find out how Lossless Cell Sorting on the S3e™ Cell Sorter lets you maximize recovery of rare and precious samples. Learn more   Corrigendum Top Corrigendum: Quantifying the shifting landscape of B cell immunodominance   p705 Gordon A Dale, Jessica R Shartouny and Joshy Jacob doi:10.1038/ni0617-705a Errata Top Erratum: Epigenetic landscapes reveal transcription factors that regulate CD8+ T cell differentiation   p705 Bingfei Yu, Kai Zhang, J Justin Milner, Clara Toma, Runqiang Chen et al. doi:10.1038/ni0617-705b Erratum: THEMIS enhances TCR signaling and enables positive selection by selective inhibition of the phosphatase SHP-1   p705 Seeyoung Choi, Claude Warzecha, Ekaterina Zvezdova, Jan Lee, Jérémy Argenty et al. doi:10.1038/ni0617-705c Erratum: CCL19-CCR7-dependent reverse transendothelial migration of myeloid cells clears Chlamydia muridarum from the arterial intima   p705 Mark Roufaiel, Eric Gracey, Allan Siu, Su-Ning Zhu, Andrew Lau et al. doi:10.1038/ni0617-705d Top Advertisement Intestinal microflora in health and disease  The human gut teems with trillions of microorganisms. 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