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Laboratory Investigation - Table of Contents alert Volume 97 Issue 6

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Laboratory Investigation


Volume 97, Issue 6 (June 2017)

In this issue
Inside the USCAP Journals
Pathobiology in Focus
Mini Reviews
Research Articles

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Inside the USCAP Journals


Malignant melanoma: from cause to cure

2017 97: 628-629; 10.1038/labinvest.2017.57

Full Text

Pathobiology in Focus


Malignant melanoma of sun-protected sites: a review of clinical, histological, and molecular features

In most cases of cutaneous melanoma, ultraviolet radiation is recognized as a prominent risk factor. Less is known regarding the pathogenesis of melanoma arising in sun-protected sites. In this review, the authors summarize clinical, histological and molecular features of acral and mucosal melanoma. They also discuss potential mechanisms of mutagenesis and offer direction for future investigations.

Emily A Merkel and Pedram Gerami

2017 97: 630-635; advance online publication, January 16, 2017; 10.1038/labinvest.2016.147

Abstract | Full Text

Identification of microRNAs associated with invasive and aggressive phenotype in cutaneous melanoma by next-generation sequencing

The comprehensive repertoire of microRNAs involved in early melanoma invasion remains unknown. By sequencing microRNAs isolated from annotated invasive melanomas, the authors defined a set of top-40 miRNAs, segregating the lesions into thin and thick groups. After validation, they show that increased levels of miR-21-5p and decreased let-7b levels were significantly associated with an invasive and aggressive melanoma phenotype.

Sankhiros Babapoor, Rong Wu, James Kozubek, Donna Auidi, Jane M Grant-Kels and Soheil S Dadras

2017 97: 636-648; advance online publication, February 20, 2017; 10.1038/labinvest.2017.5

Abstract | Full Text

The master role of microphthalmia-associated transcription factor in melanocyte and melanoma biology

MITF, a master transcription factor in melanocytes and melanoma, regulates melanocyte development and differentiation, and functions as a melanoma oncogene. This review summarizes the current understanding of MITF on melanocyte and melanoma biology, and discusses key questions yet to be answered about MITF.

Akinori Kawakami and David E Fisher

2017 97: 649-656; advance online publication, March 6, 2017; 10.1038/labinvest.2017.9

Abstract | Full Text

Regression in primary cutaneous melanoma: etiopathogenesis and clinical significance

This review examines the biologic mechanisms underlying regression in primary cutaneous melanomas, with emphasis on the role of immunotherapy. It also summarizes the conflicting data on the potential significance of histologic assessment of regression in predicting clinical outcome of melanoma patients, such as recurrence and metastasis.

Phyu P Aung, Priyadharsini Nagarajan and Victor G Prieto

2017 97: 657-668; advance online publication, February 27, 2017; 10.1038/labinvest.2017.8

Abstract | Full Text

T-lymphocyte homing: an underappreciated yet critical hurdle for successful cancer immunotherapy

Immunotherapeutic eradication of cancer hinges upon the underappreciated ability of immune cells, especially T effector (Teff) cells, to home into lesional tissues. However, Teff infiltration is commonly thwarted by the tumor microenvironment (TME), thereby reducing immunotherapeutic efficacy. Herein, the authors discuss homing mediators of Teff cell lesional entry, their dysregulation within the tumor microenvironment, and emerging options for therapeutically improving Teff homing and immunotherapy in cancer patients.

Robert Sackstein, Tobias Schatton and Steven R Barthel

2017 97: 669-697; advance online publication, March 27, 2017; 10.1038/labinvest.2017.25

Abstract | Full Text

Mini Reviews


Mouse models of UV-induced melanoma: genetics, pathology, and clinical relevance

This review focuses on genetically engineered mouse models of UV-induced melanoma. Work in the field has examined the interaction between UV radiation and melanoma oncogenes, the role of sunscreen in preventing melanoma, and the effect of UV exposure on the skin microenvironment. The authors describe relevant models and discuss how they can best be translated to the study of human skin and cutaneous melanoma.

Chi-Ping Day, Rachel Marchalik, Glenn Merlino and Helen Michael

2017 97: 698-705; advance online publication, January 16, 2017; 10.1038/labinvest.2016.155

Abstract | Full Text

Vitamin D signaling and melanoma: role of vitamin D and its receptors in melanoma progression and management

Defects in the canonical and non-canonical vitamin D signaling that include systemic or local defects in vitamin D activation and inactivation, and in expression and signaling through the corresponding receptors, can affect melanomagenesis, tumor progression and outcome of the disease. Optimal vitamin D management can be beneficial for melanoma patients.

Andrzej T Slominski, Anna A Brożyna, Michal A Zmijewski, Wojciech Jóźwicki, Anton M Jetten, Rebecca S Mason, Robert C Tuckey and Craig A Elmets

2017 97: 706-724; advance online publication, February 20, 2017; 10.1038/labinvest.2017.3

Abstract | Full Text

Research Articles


Notch3 signaling-mediated melanoma–endothelial crosstalk regulates melanoma stem-like cell homeostasis and niche morphogenesis

Tumor heterogeneity driven by melanoma stem-like cells (MSLCs) constitutes the ultimate clinical challenge. Although the functional integrity of MSLCs depends on their niche, the underlying mechanisms remain unexplored. This study identifies Notch3 as a niche signal governing MSLC phenotypic switch and vascular niche morphogenesis in a novel niche co-culture system in vitro and a melanoma xenograft model in vivo.

Mei-Yu Hsu, Moon Hee Yang, Caroline I Schnegg, Soonyean Hwang, Byungwoo Ryu and Rhoda M Alani

2017 97: 725-736; advance online publication, February 6, 2017; 10.1038/labinvest.2017.1

Abstract | Full Text

Adipogenic niches for melanoma cell colonization and growth in bone marrow

Bone metastasis is a devastating complication of malignant melanoma. The authors show that a significant increase in bone marrow adipocytes may play a role in osteolytic metastases and that bone marrow adipocytes are in direct contact with the metastasizing melanoma cells in the bone metastatic niche and support their proliferation and cell cycle transitions. As a key cellular component of the metastatic tumor niche for reactivation of dormant tumor cells, bone marrow adipocytes are potential therapeutic targets.

Juan Wang, Guang-liang Chen, Shan Cao, Ming-chun Zhao, Yong-qing Liu, Xiao-Xiang Chen and Cheng Qian

2017 97: 737-745; advance online publication, February 20, 2017; 10.1038/labinvest.2017.14

Abstract | Full Text

The biological and prognostic significance of angiotropism in uveal melanoma

This study illustrates that the microscopic detection of angiotropic melanoma cells along vascular channels of the sclera in human uveal melanoma is a prognostic factor for metastasis and death and potentially an important alternative mechanism for local and possibly more distant spread of cancerous cells.

Raymond L Barnhill, Mengliang Ye, Aude Batistella, Marc-Henri Stern, Sergio Roman-Roman, Rémi Dendale, Olivier Lantz, Sophie Piperno-Neumann, Laurence Desjardins, Nathalie Cassoux and Claire Lugassy

2017 97: 746-759; advance online publication, February 27, 2017; 10.1038/labinvest.2017.16

Abstract | Full Text

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