Thursday, April 13, 2017

The EMBO Journal Table of Contents for 13 April 2017; Vol. 36, No. 8

13 April 2017 | Volume 36, Number 8 Submit


Table of Contents

Commentary
News & Views
Articles
Resource
COVER

Volume 36, Number 8



Commentary
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Aging research has yielded valuable knowledge into the molecular mechanisms of aging and longevity. Expanding the existing model organisms with extremely long‐ or short‐lived species, such as the African turquoise killifish, the planarian flatworm or the naked mole rat, could yield new insights into their unique adaptations and provide platforms on which to test interventions against aging processes.

Dario Riccardo Valenzano, Aziz Aboobaker, Andrei Seluanov, and Vera Gorbunova
Published online 20.03.2017

News & Views
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A new study showing Polycomb recruitment to be the consequence—not the cause—of target gene repression by lncRNA HOTAIR questions the role of lncRNA–PRC2 complexes in transcriptional silencing.

Mario R Blanco and Mitchell Guttman
Published online 15.03.2017

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ERK and Akt signaling are inversely correlated in some cancers. New work shows that Akt‐phosphorylated FOXO1 turns off ERK activity by reshaping the Ras‐ERK scaffold protein IQGAP1.

Suyong Choi and Richard A Anderson
Published online 20.03.2017

Articles
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A genetic interaction between histone demethylases IBM1 and LDL2 reveals that H3K9 methylation in gene bodies induces transcriptional silencing by triggering the loss of H3K4 monomethylation.

Soichi Inagaki, Mayumi Takahashi, Aoi Hosaka, Tasuku Ito, Atsushi Toyoda, Asao Fujiyama, Yoshiaki Tarutani, and Tetsuji Kakutani
Published online 18.01.2017

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Recruitment of chromatin‐modifying factors may not be the sought‐after mechanism for gene silencing by HOTAIR lncRNA, but rather its downstream consequence.

Manuela Portoso, Roberta Ragazzini, Živa Brenčič, Arianna Moiani, Audrey Michaud, Ivaylo Vassilev, Michel Wassef, Nicolas Servant, Bruno Sargueil, and Raphaël Margueron
Published online 06.02.2017 Open Access

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AKT‐phosphorylated FOXO1 possesses a tumor suppressor function in the cytoplasm by binding to the scaffold protein IQGAP1, thereby inhibiting MAPK signaling. This role of FOXO1 can be exploited to overcome resistance to chemotherapies.

Chun‐Wu Pan, Xin Jin, Yu Zhao, Yunqian Pan, Jing Yang, R Jeffrey Karnes, Jun Zhang, Liguo Wang, and Haojie Huang
Published online 09.03.2017

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FAD‐dependent lysine‐specific demethylase 1 (LSD1) promotes survival of cancer cells by demethylating the ubiquitin ligase component RACK1 and inhibiting HIF‐1α degradation.

Suk‐Jin Yang, Young Soo Park, Jung Hee Cho, Byul Moon, Hyun‐Jung An, Ju Yeon Lee, Zhi Xie, Yuli Wang, David Pocalyko, Dong Chul Lee, Hyun Ahm Sohn, Minho Kang, Jin Young Kim, Eunhee Kim, Kyung Chan Park, Jung‐Ae Kim, and Young Il Yeom
Published online 09.03.2017

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The global RNA‐binding protein ProQ stabilizes bacterial small RNA RaiZ and facilitates translational repression of its target mRNA, thus exemplifying an Hfq‐independent RNA regulon.

Alexandre Smirnov, Chuan Wang, Lisa L Drewry, and Jörg Vogel
Published online 23.03.2017 Open Access

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A Caenorhabditis elegans screen for mitochondrial regulators of cellular immunity reveals that the HSP‐60 chaperone feeds into a conserved anti‐bacterial signaling pathway by stabilizing MKK3/SEK‐1.

Dae‐Eun Jeong, Dongyeop Lee, Sun‐Young Hwang, Yujin Lee, Jee‐Eun Lee, Mihwa Seo, Wooseon Hwang, Keunhee Seo, Ara B Hwang, Murat Artan, Heehwa G Son, Jay‐Hyun Jo, Haeshim Baek, Young Min Oh, Youngjae Ryu, Hyung‐Jun Kim, Chang Man Ha, Joo‐Yeon Yoo, and Seung‐Jae V Lee
Published online 10.03.2017

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SUMOylation at DNA damage sites recruits and stimulates the deubiquitylation enzyme ataxin‐3, in order to delay ubiquitin‐dependent removal of the upstream checkpoint mediator.

Annika Pfeiffer, Martijn S Luijsterburg, Klara Acs, Wouter W Wiegant, Angela Helfricht, Laura K Herzog, Melania Minoia, Claudia Böttcher, Florian A Salomons, Haico van Attikum, and Nico P Dantuma
Published online 08.03.2017 Open Access

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Characterization of a new patient mutation in the complement system regulator properdin shows that its oligomerization is essential for activation of the alternative pathway and bacteriolysis.

Dennis V Pedersen, Lubka Roumenina, Rasmus K Jensen, Trine AF Gadeberg, Chiara Marinozzi, Capucine Picard, Tania Rybkine, Steffen Thiel, Uffe BS Sørensen, Cordula Stover, Veronique Fremeaux‐Bacchi, and Gregers R Andersen
Published online 06.03.2017

Resource
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Overexpression of fluorescently tagged Atg8/LC3 proteins to visualize autophagosomes can lead to artifacts; new peptide sensors have been developed that allow live‐imaging of endogenous LC3/GABARAP proteins at autophagosomes and at depolarized mitochondria.

You‐Kyung Lee, Yong‐Woo Jun, Ha‐Eun Choi, Yang Hoon Huh, Bong‐Kiun Kaang, Deok‐Jin Jang, and Jin‐A Lee
Published online 20.03.2017

 

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