Aging research has yielded valuable knowledge into the molecular mechanisms of aging and longevity. Expanding the existing model organisms with extremely long‐ or short‐lived species, such as the African turquoise killifish, the planarian flatworm or the naked mole rat, could yield new insights into their unique adaptations and provide platforms on which to test interventions against aging processes.
Dario Riccardo Valenzano, Aziz Aboobaker, Andrei Seluanov, and Vera Gorbunova
AKT‐phosphorylated FOXO1 possesses a tumor suppressor function in the cytoplasm by binding to the scaffold protein IQGAP1, thereby inhibiting MAPK signaling. This role of FOXO1 can be exploited to overcome resistance to chemotherapies.
Chun‐Wu Pan, Xin Jin, Yu Zhao, Yunqian Pan, Jing Yang, R Jeffrey Karnes, Jun Zhang, Liguo Wang, and Haojie Huang
FAD‐dependent lysine‐specific demethylase 1 (LSD1) promotes survival of cancer cells by demethylating the ubiquitin ligase component RACK1 and inhibiting HIF‐1α degradation.
Suk‐Jin Yang, Young Soo Park, Jung Hee Cho, Byul Moon, Hyun‐Jung An, Ju Yeon Lee, Zhi Xie, Yuli Wang, David Pocalyko, Dong Chul Lee, Hyun Ahm Sohn, Minho Kang, Jin Young Kim, Eunhee Kim, Kyung Chan Park, Jung‐Ae Kim, and Young Il Yeom
A Caenorhabditis elegans screen for mitochondrial regulators of cellular immunity reveals that the HSP‐60 chaperone feeds into a conserved anti‐bacterial signaling pathway by stabilizing MKK3/SEK‐1.
Dae‐Eun Jeong, Dongyeop Lee, Sun‐Young Hwang, Yujin Lee, Jee‐Eun Lee, Mihwa Seo, Wooseon Hwang, Keunhee Seo, Ara B Hwang, Murat Artan, Heehwa G Son, Jay‐Hyun Jo, Haeshim Baek, Young Min Oh, Youngjae Ryu, Hyung‐Jun Kim, Chang Man Ha, Joo‐Yeon Yoo, and Seung‐Jae V Lee
Characterization of a new patient mutation in the complement system regulator properdin shows that its oligomerization is essential for activation of the alternative pathway and bacteriolysis.
Dennis V Pedersen, Lubka Roumenina, Rasmus K Jensen, Trine AF Gadeberg, Chiara Marinozzi, Capucine Picard, Tania Rybkine, Steffen Thiel, Uffe BS Sørensen, Cordula Stover, Veronique Fremeaux‐Bacchi, and Gregers R Andersen
Overexpression of fluorescently tagged Atg8/LC3 proteins to visualize autophagosomes can lead to artifacts; new peptide sensors have been developed that allow live‐imaging of endogenous LC3/GABARAP proteins at autophagosomes and at depolarized mitochondria.
You‐Kyung Lee, Yong‐Woo Jun, Ha‐Eun Choi, Yang Hoon Huh, Bong‐Kiun Kaang, Deok‐Jin Jang, and Jin‐A Lee