Monday, April 3, 2017

The EMBO Journal Table of Contents for 03 April 2017; Vol. 36, No. 7

Beatson Conference www.beatson.gla.ac.co.uk/conf
03 April 2017 | Volume 36, Number 7 Submit


Table of Contents

News & Views
Articles
COVER

Volume 36, Number 7



News & Views
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Haematopoietic stem cell ageing is prevented by osteopontin secretion from young bone marrow stroma.

Karin Gustafsson and David T Scadden
Published online 13.03.2017

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New high‐resolution cryo‐EM structures capture the final stages of 60S subunit maturation, illustrating the ordered remodeling and assembly factor release steps required for the formation of a functional ribosome.

Aida Razi and Joaquin Ortega
Published online 13.03.2017

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The transcription factor Id2 controls emergence of intestinal stem cells during embryonic development.

Kai Kretzschmar and Hans Clevers
Published online 15.03.2017

Articles
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Reduced levels of the secreted matrix protein osteopontin (OPN) in aged bone marrow stroma confer aging‐associated features to hematopoietic stem cells, which can be reverted by treatment with a thrombin‐activated OPN fragment.

Novella Guidi, Mehmet Sacma, Ludger Ständker, Karin Soller, Gina Marka, Karina Eiwen, Johannes M Weiss, Frank Kirchhoff, Tanja Weil, Jose A Cancelas, Maria Carolina Florian, and Hartmut Geiger
Published online 02.03.2017 Open Access

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Cryo‐EM structures of the yeast 60S subunit bound to assembly factors Nmd3, Lsg1, and Tif6 reveal the conformational rearrangements that take place during final ribosome maturation in the cytoplasm.

Andrey G Malyutin, Sharmishtha Musalgaonkar, Stephanie Patchett, Joachim Frank, and Arlen W Johnson
Published online 08.02.2017

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Transcriptional regulator Id2 prevents early specification of Lgr5+ intestinal stem cells by blocking Wnt signalling in the murine embryonic epithelium.

Lira Nigmatullina, Maxim Norkin, Margarita M Dzama, Berith Messner, Sergi Sayols, and Natalia Soshnikova
Published online 11.01.2017

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Auxin signaling activates the small GTPase ROP2, causing TOR activation and increased translation of uORF‐containing mRNAs, thus making ROP2 the intervening link between auxin signaling and TOR‐dependent translation control.

Mikhail Schepetilnikov, Joelle Makarian, Ola Srour, Angèle Geldreich, Zhenbiao Yang, Johana Chicher, Philippe Hammann, and Lyubov A Ryabova
Published online 28.02.2017

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Transcription factor CONSTANS (CO) is a photoperiodic flowering timer in Arabidopsis. PRR circadian‐clock proteins bind and stabilize CO at specific times during the day to affect its accumulation and to thereby regulate seasonal flowering.

Ryosuke Hayama, Liron Sarid‐Krebs, René Richter, Virginia Fernández, Seonghoe Jang, and George Coupland
Published online 07.03.2017 Open Access

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Crystal structures of the Zika virus (ZIKV) NS5 methyltransferase and RdRP domains reveal conservation in drug targeting sites between dengue virus (DENV) and ZIKV, supporting the potential use of anti‐DENV inhibitors to therapeutically target ZIKV.

Wenqian Duan, Hao Song, Haiyuan Wang, Yan Chai, Chao Su, Jianxun Qi, Yi Shi, and George F Gao
Published online 02.03.2017

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In addition to its role as a negative regulator of transcription elongation by RNA polymerase II, the 7SK snRNP also functions as a canonical transcription factor to positively regulate snRNA transcription.

Sylvain Egloff, Patrice Vitali, Michael Tellier, Raoul Raffel, Shona Murphy, and Tamás Kiss
Published online 02.03.2017

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Formic acid transport by E. coli FocA proceeds via substrate charge neutralization, revealing a general transport mechanism in formate–nitrite and ammonium transporters.

Marie Wiechert and Eric Beitz
Published online 01.03.2017

 

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