New high‐resolution cryo‐EM structures capture the final stages of 60S subunit maturation, illustrating the ordered remodeling and assembly factor release steps required for the formation of a functional ribosome.
Reduced levels of the secreted matrix protein osteopontin (OPN) in aged bone marrow stroma confer aging‐associated features to hematopoietic stem cells, which can be reverted by treatment with a thrombin‐activated OPN fragment.
Novella Guidi, Mehmet Sacma, Ludger Ständker, Karin Soller, Gina Marka, Karina Eiwen, Johannes M Weiss, Frank Kirchhoff, Tanja Weil, Jose A Cancelas, Maria Carolina Florian, and Hartmut Geiger
Auxin signaling activates the small GTPase ROP2, causing TOR activation and increased translation of uORF‐containing mRNAs, thus making ROP2 the intervening link between auxin signaling and TOR‐dependent translation control.
Mikhail Schepetilnikov, Joelle Makarian, Ola Srour, Angèle Geldreich, Zhenbiao Yang, Johana Chicher, Philippe Hammann, and Lyubov A Ryabova
Transcription factor CONSTANS (CO) is a photoperiodic flowering timer in Arabidopsis. PRR circadian‐clock proteins bind and stabilize CO at specific times during the day to affect its accumulation and to thereby regulate seasonal flowering.
Ryosuke Hayama, Liron Sarid‐Krebs, René Richter, Virginia Fernández, Seonghoe Jang, and George Coupland
Crystal structures of the Zika virus (ZIKV) NS5 methyltransferase and RdRP domains reveal conservation in drug targeting sites between dengue virus (DENV) and ZIKV, supporting the potential use of anti‐DENV inhibitors to therapeutically target ZIKV.
Wenqian Duan, Hao Song, Haiyuan Wang, Yan Chai, Chao Su, Jianxun Qi, Yi Shi, and George F Gao
In addition to its role as a negative regulator of transcription elongation by RNA polymerase II, the 7SK snRNP also functions as a canonical transcription factor to positively regulate snRNA transcription.
Sylvain Egloff, Patrice Vitali, Michael Tellier, Raoul Raffel, Shona Murphy, and Tamás Kiss