Surveillance states pp339 - 341 Pradyot Dash and Paul G Thomas doi:10.1038/nsmb.3398 The binding of foreign peptides to host major histocompatibility complex (MHC) forms the basis of adaptive immune recognition. The MHC and T cell receptors (TCRs) use diverse structural solutions to enhance peptide presentation and recognition, and two new reports provide insights into noncanonical modes of detection and binding.
Remodelers tap into nucleosome plasticity pp341 - 343 Hari R Singh, Magdalena Murawska and Andreas G Ladurner doi:10.1038/nsmb.3394 Chromatin-remodeling enzymes perform the formidable task of reorganizing the structure of a stable macromolecular assembly, the nucleosome. Recently published work demonstrates that the SNF2H chromatin remodeler distorts the histone octamer structure upon binding to the nucleosome, then taps into this induced plasticity to productively achieve nucleosome sliding.
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