Nature Reviews Molecular Cell Biology contents May 2017 Volume 18 Number 5 pp 275-337

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TABLE OF CONTENTS
May 2017 Volume 18 Number 5		Advertisement
2015 2-year Impact Factor 38.602 Journal Metrics 2-year Median 30	In this issue Research Highlights Progress Reviews Perspectives Also this month Poster: Bone marrow niches and HSC fates Article series: DNA damage  Featured article: Biomolecular condensates: organizers of cellular biochemistry Salman F. Banani, Hyun O. Lee, Anthony A. Hyman & Michael K. Rosen	Nature Index Japan 2017  Japan's status as a science superstar is vulnerable. Nature Index 2017 Japan reveals that although the country is still among the upper echelons of global research, its output has continued to slide. Read the full supplement free for six months
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RESEARCH HIGHLIGHTS Top Genome Organization: Zooming in on nuclear organization p275 | doi:10.1038/nrm.2017.28 Two studies report new methods for studying the 3D genome — one captures three-way contacts and the other calculates 3D structures of genomes in single cells. PDF Epigenetics: Cytosolic EZH1 muscles PRC2 out of the nucleus p276 | doi:10.1038/nrm.2017.37 In mouse muscle cells, an isoform of EZH1 — a subunit of Polycomb repressive complex 2 (PRC2) — sequesters another subunit in the cytosol, thereby inhibiting PRC2 function. PDF Stress Responses: Membrane-to-nucleus signals modulate plant cold tolerance p276 | doi:10.1038/nrm.2017.38 Cold stress activates Arabidopsis thaliana plasma membrane-localized CRPK1, which leads to 14-3-3 proteins entering the nucleus and promoting the degradation of CBF transcription factors, thus attenuating the cold-induced response. PDF JOURNAL CLUB Coming to grips with cell surface polarity p278 | doi:10.1038/nrm.2017.32 Kai Simons discusses how MDCK cells grown on semi-permeable filters have become a model for studying apico-basal cell polarity with the use of viruses. PDF Plant cell development: Forcing cell polarity p278 | doi:10.1038/nrm.2017.34 Mechanical tension is shown to contribute to the establishment of the cell polarity axis in plant epidermal stem cells, which is important for regulating asymmetric cell division. PDF IN BRIEF Cell Senescence: A new role for ATM | DNA Damage Response: RNA m6A regulates DNA repair | Lipid Metabolism: Cholesterol feeds into cell growth control PDF Nature Reviews Molecular Cell Biology JOBS of the week Principle investigator / Researcher (tenure track) VU University Medical Center (VUmc) Postdoctoral Fellow Positions Focusing on Gene Regulation in Cancer Progression University of Texas Health Science Center at San Antonio Faculty and Postdoctoral Positions in Molecular Pathogenesis, The TEDA Institute of Biological Sciences and Biotechnology The TEDA Institute of Biological Sciences and Biotechnology, Nankai University Senior Scientist, Oncology Ionis Pharmaceuticals, Inc. Group Leader in Allergic Inflammation University of South Australia (UniSA) More Science jobs from
PROGRESS		Top
DNA G-quadruplexes in the human genome: detection, functions and therapeutic potential Robert Hansel-Hertsch, Marco Di Antonio & Shankar Balasubramanian p279 | doi:10.1038/nrm.2017.3 DNA G-quadruplexes (G4s) are guanine-rich sequences that fold into four-stranded structures. Recent progress in the detection and mapping of genomic G4 structures has provided new insights into their functions in regulating transcription and genome stability, and has revealed their potential relevance for cancer therapy. Abstract | Full Text | PDF
REVIEWS		Top
Biomolecular condensates: organizers of cellular biochemistry Salman F. Banani, Hyun O. Lee, Anthony A. Hyman & Michael K. Rosen p285 | doi:10.1038/nrm.2017.7 In addition to membrane-bound organelles, eukaryotic cells feature various membraneless compartments, including the centrosome, the nucleolus and various granules. Many of these compartments form through liquid-liquid phase separation, and the principles, mechanisms and regulation of their assembly as well as their cellular functions are now beginning to emerge. Abstract | Full Text | PDF | Supplementary information
Variants of core histones and their roles in cell fate decisions, development and cancer Marcus Buschbeck & Sandra B. Hake p299 | doi:10.1038/nrm.2016.166 Core histone proteins are deposited on chromatin during DNA replication, whereas their replication-independent variants are deposited throughout the cell cycle by specific chaperones and chromatin remodellers. This dynamic deposition of histone variants has important roles in cell fate specification and has been implicated in development and tumorigenesis. Abstract | Full Text | PDF
Article series: DNA damage Control of structure-specific endonucleases to maintain genome stability Pierre-Marie Dehe & Pierre-Henri L. Gaillard p315 | doi:10.1038/nrm.2016.177 Structure-specific endonucleases (SSEs) function in concert with other DNA-remodelling enzymes and cell cycle control machineries in processes such as DNA adduct repair, Holliday junction processing and the response to replication stress. As SSEs have specificity for DNA structures rather than sequence, tight regulation of their activity is important to ensure genome stability. Abstract | Full Text | PDF | Supplementary information
PERSPECTIVES		Top
OPINION Regulatory feedback from nascent RNA to chromatin and transcription Lenka Skalska, Manuel Beltran-Nebot, Jernej Ule & Richard G. Jenner p331 | doi:10.1038/nrm.2017.12 Although non-coding RNAs have roles in transcription and chromatin function, nascent pre-mRNA is usually considered to be passive during these processes. Recently identified interactions between nascent pre-mRNAs and regulatory proteins suggest that both types of RNA regulate transcription and chromatin function. Abstract | Full Text | PDF | Supplementary information
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