Thursday, April 20, 2017

Nature Reviews Molecular Cell Biology contents May 2017 Volume 18 Number 5 pp 275-337

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Nature Reviews Molecular Cell Biology

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Research Highlights

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Bone marrow niches and HSC fates
Article series:
DNA damage
 Featured article:
Biomolecular condensates: organizers of cellular biochemistry
Salman F. Banani, Hyun O. Lee, Anthony A. Hyman & Michael K. Rosen
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Genome Organization: Zooming in on nuclear organization
p275 | doi:10.1038/nrm.2017.28
Two studies report new methods for studying the 3D genome — one captures three-way contacts and the other calculates 3D structures of genomes in single cells.


Epigenetics: Cytosolic EZH1 muscles PRC2 out of the nucleus
p276 | doi:10.1038/nrm.2017.37
In mouse muscle cells, an isoform of EZH1 — a subunit of Polycomb repressive complex 2 (PRC2) — sequesters another subunit in the cytosol, thereby inhibiting PRC2 function.


Stress Responses: Membrane-to-nucleus signals modulate plant cold tolerance
p276 | doi:10.1038/nrm.2017.38
Cold stress activates Arabidopsis thaliana plasma membrane-localized CRPK1, which leads to 14-3-3 proteins entering the nucleus and promoting the degradation of CBF transcription factors, thus attenuating the cold-induced response.


Coming to grips with cell surface polarity

p278 | doi:10.1038/nrm.2017.32
Kai Simons discusses how MDCK cells grown on semi-permeable filters have become a model for studying apico-basal cell polarity with the use of viruses.


Plant cell development: Forcing cell polarity
p278 | doi:10.1038/nrm.2017.34
Mechanical tension is shown to contribute to the establishment of the cell polarity axis in plant epidermal stem cells, which is important for regulating asymmetric cell division.



Cell Senescence: A new role for ATM | DNA Damage Response: RNA m6A regulates DNA repair | Lipid Metabolism: Cholesterol feeds into cell growth control

Nature Reviews Molecular Cell Biology
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DNA G-quadruplexes in the human genome: detection, functions and therapeutic potential
Robert Hansel-Hertsch, Marco Di Antonio & Shankar Balasubramanian
p279 | doi:10.1038/nrm.2017.3
DNA G-quadruplexes (G4s) are guanine-rich sequences that fold into four-stranded structures. Recent progress in the detection and mapping of genomic G4 structures has provided new insights into their functions in regulating transcription and genome stability, and has revealed their potential relevance for cancer therapy.

Abstract | Full Text | PDF
Biomolecular condensates: organizers of cellular biochemistry
Salman F. Banani, Hyun O. Lee, Anthony A. Hyman & Michael K. Rosen
p285 | doi:10.1038/nrm.2017.7
In addition to membrane-bound organelles, eukaryotic cells feature various membraneless compartments, including the centrosome, the nucleolus and various granules. Many of these compartments form through liquid-liquid phase separation, and the principles, mechanisms and regulation of their assembly as well as their cellular functions are now beginning to emerge.
Abstract | Full Text | PDF | Supplementary information
Variants of core histones and their roles in cell fate decisions, development and cancer
Marcus Buschbeck & Sandra B. Hake
p299 | doi:10.1038/nrm.2016.166
Core histone proteins are deposited on chromatin during DNA replication, whereas their replication-independent variants are deposited throughout the cell cycle by specific chaperones and chromatin remodellers. This dynamic deposition of histone variants has important roles in cell fate specification and has been implicated in development and tumorigenesis.
Abstract | Full Text | PDF
Article series: DNA damage
Control of structure-specific endonucleases to maintain genome stability
Pierre-Marie Dehe & Pierre-Henri L. Gaillard
p315 | doi:10.1038/nrm.2016.177
Structure-specific endonucleases (SSEs) function in concert with other DNA-remodelling enzymes and cell cycle control machineries in processes such as DNA adduct repair, Holliday junction processing and the response to replication stress. As SSEs have specificity for DNA structures rather than sequence, tight regulation of their activity is important to ensure genome stability.
Abstract | Full Text | PDF | Supplementary information
Regulatory feedback from nascent RNA to chromatin and transcription
Lenka Skalska, Manuel Beltran-Nebot, Jernej Ule & Richard G. Jenner
p331 | doi:10.1038/nrm.2017.12
Although non-coding RNAs have roles in transcription and chromatin function, nascent pre-mRNA is usually considered to be passive during these processes. Recently identified interactions between nascent pre-mRNAs and regulatory proteins suggest that both types of RNA regulate transcription and chromatin function.
Abstract | Full Text | PDF | Supplementary information
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