Monday, April 10, 2017

Nature Reviews Microbiology contents May 2017 Volume 15 Number 5 pp 255-318

Nature Reviews Microbiology

May 2017 Volume 15 Number 5

Nature Reviews Microbiology cover
2015 2-year Impact Factor 24.727 Journal Metrics 2-year Median 19.5
In this issue
Research Highlights
News and Analysis

Also this month
Featured article:
 Featured article:
The microbiota of the respiratory tract: gatekeeper to respiratory health
Wing Ho Man, Wouter A.A. de Steenhuijsen Piters & Debby Bogaert

Recommend to library
Seeking PhD in microbiology or biochemistry to working with transformable host organisms to produce biofuel components at both lab and pilot scale. Experience in metabolic pathway improvement via transformation, microbial/pathway evolution, transformation of non-standard hosts or solid/liquid fermentation a plus.

For full job description, click here.

Presented by: Chinese Academy of Medical Sciences & Peking Union Medical College | Chinese Society for Immunology (CSI) | Nature Reviews Immunology | Nature Immunology | Nature | Nature Communications

This conference will feature sessions on microbiota, cell death, metabolism, technologies, and innate sensing and signaling as they relate to inflammatory diseases and cancer.

September 17-20, 2017 | Beijing, China




Bacterial physiology: Phage injection establishes CRISPR immunity
p255 | doi:10.1038/nrmicro.2017.39
A new study by Maraffini and colleagues shows that CRISPR-Cas systems capture phage DNA during genome injection, which protects cells from subsequent infection before the lytic cycle begins.


Bacterial physiology: When things turn sour for Helicobacter
p256 | doi:10.1038/nrmicro.2017.32
This study reports that BabA-mediated adherence to gastric epithelial cells is acid-sensitive and enables efficient adaptation to changes in gastric mucosal pH.


Structural biology: The tick-tock of circadian clocks
p256 | doi:10.1038/nrmicro.2017.37
Two new studies provide a structural basis to help us understand the periodic assembly of cyanobacterial clock proteins.


Bacterial pathogenesis: What makes some E. coli efficient bladder colonizers?
p257 | doi:10.1038/nrmicro.2017.38
A detailed study of E. coli strains that were isolated from the urine of women shows that bladder colonization does not require previously defined virulence factors but is linked to the differential regulation of core functions.



Environmental microbiology: Is evidence for ancient microbial life set in stone? | Viral evolution: On the origin of capsids | Structural biology: In situ architecture of the type III secretion system

Nature Reviews Microbiology
JOBS of the week
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VII International Conference on Environmental, Industrial and Applied Microbiology - BioMicroWorld2017
Madrid, Spain
More science events from

Evolve and survive
Alena Pance
p258 | doi:10.1038/nrmicro.2017.31
This month's Genome Watch explores how in vitro directed evolution can be used to identify the target of a drug for the treatment of Chagas disease, which is caused by Trypanosoma cruzi.



September 17-19, 2017 | Seattle, WA, USA

Presented by: Adaptive Biotechnologies | Nature Immunology | Nature Medicine | Nature Biotechnology



Article series: Microbiome
The microbiota of the respiratory tract: gatekeeper to respiratory health
Wing Ho Man, Wouter A.A. de Steenhuijsen Piters & Debby Bogaert
p259 | doi:10.1038/nrmicro.2017.14
The respiratory tract spans from the nostrils to the lung alveoli and these distinct niches host a diverse microbiota. In this Review, Man, de Steenhuijsen Piters and Bogaert discuss the role of the respiratory microbiota in the maintenance of human health.
Abstract | Full Text | PDF

Cyclic di-GMP: second messenger extraordinaire
Urs Jenal, Alberto Reinders & Christian Lori
p271 | doi:10.1038/nrmicro.2016.190
Cyclic dinucleotides are highly versatile signalling molecules that control important biological processes in bacteria, including motility, virulence, biofilm formation and cell cycle progression. In this Review, Jenal and colleagues discuss the molecular principles of cyclic di-GMP (c-di-GMP) synthesis and degradation, and the cellular functions that are exerted by c-di-GMP-binding effectors and their diverse targets.
Abstract | Full Text | PDF

Xerotolerant bacteria: surviving through a dry spell
Pedro H. Lebre, Pieter De Maayer & Don A. Cowan
p285 | doi:10.1038/nrmicro.2017.16
Understanding the ecology and function of dry-adapted communities is important for understanding and preventing desertification. In this Review, Lebre, De Maayer and Cowan discuss the adaptations that enable xerotolerant bacteria to survive extreme dry conditions and highlight insights from recent metagenomic and transcriptomic studies.
Abstract | Full Text | PDF

Virulence of the zoonotic agent of leptospirosis: still terra incognita?
Mathieu Picardeau
p297 | doi:10.1038/nrmicro.2017.5
Pathogenic leptospires are the bacterial agents of leptospirosis, which is an emerging zoonotic disease that affects both animals and humans worldwide. In this Review, the recent advances in our understanding of the epidemiology, taxonomy, genomics and the molecular basis of virulence in leptospires, and of how these properties contribute to the pathogenesis of leptospirosis, are discussed.
Abstract | Full Text | PDF


Microorganisms maintain crowding homeostasis
Jonas van den Berg, Arnold J. Boersma & Bert Poolman
p309 | doi:10.1038/nrmicro.2017.17
Macromolecular crowding affects the physicochemistry of the cytoplasm and, in turn, microbial physiology. We propose that cells maintain the overall concentration of macromolecules within a narrow range (a process that we refer to as 'homeocrowding') and discuss possible mechanisms for achieving this.
Abstract | Full Text | PDF | Supplementary information

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