|TABLE OF CONTENTS|
|May 2017 Volume 18 Number 5||Advertisement|
|In this issue |
|Article series: Study designs|
Detecting RNA modifications in the epitranscriptome: predict and validate
Mark Helm & Yuri Motorin
p275 | doi:10.1038/nrg.2016.169
Although it has been known for decades that RNA is subjected to numerous covalent modifications, there has been a recent surge in interest driven by sequencing-based transcriptome-wide detection methods and the realization that RNA modifications have important roles in diverse biological processes. This Review describes the range of detection strategies for RNA modifications, their particular strengths and limitations, and how responsible and complementary application of these techniques will be required to ensure the quality and interpretability of the rapidly accumulating data sets.
Abstract | Full Text | PDF
|Article series: Regulatory elements|
Integration site selection by retroviruses and transposable elements in eukaryotes
Tania Sultana, Alessia Zamborlini, Gael Cristofari & Pascale Lesage
p292 | doi:10.1038/nrg.2017.7
Next-generation sequencing has facilitated the study of how transposable elements and retroviruses select their diverse genomic sites of integration, and revealed integration site preferences that range from specific nucleotide sequences to particular chromatin states. The authors review the various mechanisms of integration site selection in eukaryotes, as well as the molecular and cellular determinants that guide this process.
Abstract | Full Text | PDF | Supplementary information
|Article series: Translational genetics|
Transplant genetics and genomics
Joshua Y. C. Yang & Minnie M. Sarwal
p309 | doi:10.1038/nrg.2017.12
Advances in genetics and genomics have transformed the field of organ transplantation. Here, the authors review the role of genetic dissimilarities between donor and recipient in transplant tolerance and rejection, and how the identification of genetic variants that predict adverse transplant outcomes can be used for personalized medicine.
Abstract | Full Text | PDF
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