Wednesday, April 12, 2017

Nature Reviews Genetics Contents May 2017 Volume 18 Number 5 pp269-326

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Nature Reviews Genetics

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In this issue
Research Highlights

Also this month
Article series:
Study designs
Regulatory elements
Translational genetics
 Featured article:
Detecting RNA modifications in the epitranscriptome: predict and validate
Mark Helm & Yuri Motorin

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Leena Peltonen School of Human Genomics (20-24 August 2017) 
This workshop provides a unique opportunity to learn and be inspired by those that have shaped our understanding of human genomics over the past decade. The programme will cover a range of topics including our current understanding of the genomics of rare and complex human diseases. Applications by 23 May
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November 16-18, 2017 | Milan, Italy

Genome organization: Zooming in on nuclear organization
p269 | doi:10.1038/nrg.2017.23

Regulatory elements: A boost to RNA processing
270 | doi:10.1038/nrg.2017.20

Genetic variation: Linear INSIGHTs into non-coding DNA
p270 | doi:10.1038/nrg.2017.24

Disease genomics: Transitioning from association to causation with eQTLs
p271 | doi:10.1038/nrg.2017.22

Genetic screens: CRISPR-based mapping of genetic interactions
p272 | doi:10.1038/nrg.2017.25

RNA: Translated circular RNAs
p272 | doi:10.1038/nrg.2017.27

Gene regulation: The nuclear pore — a scaffold for inducible genes
p273 | doi:10.1038/nrg.2017.29

Synthetic Biology: Building a custom eukaryotic genome de novo
p274 | doi:10.1038/nrg.2017.30

JOBS of the week
Postdoctoral Research Fellow, Cancer Genetics and Epigenetics
Fred Hutchinson Cancer Research Center
Faculty Position in the Department of Molecular Biology and Genetics at Bogaziçi University
Bogaziçi University
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Columbia University Medical Center
Postdoctoral Fellow / Pediatrics
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Article series: Study designs
Detecting RNA modifications in the epitranscriptome: predict and validate
Mark Helm & Yuri Motorin
p275 | doi:10.1038/nrg.2016.169
Although it has been known for decades that RNA is subjected to numerous covalent modifications, there has been a recent surge in interest driven by sequencing-based transcriptome-wide detection methods and the realization that RNA modifications have important roles in diverse biological processes. This Review describes the range of detection strategies for RNA modifications, their particular strengths and limitations, and how responsible and complementary application of these techniques will be required to ensure the quality and interpretability of the rapidly accumulating data sets.
Abstract | Full Text | PDF

Article series: Regulatory elements
Integration site selection by retroviruses and transposable elements in eukaryotes
Tania Sultana, Alessia Zamborlini, Gael Cristofari & Pascale Lesage
p292 | doi:10.1038/nrg.2017.7
Next-generation sequencing has facilitated the study of how transposable elements and retroviruses select their diverse genomic sites of integration, and revealed integration site preferences that range from specific nucleotide sequences to particular chromatin states. The authors review the various mechanisms of integration site selection in eukaryotes, as well as the molecular and cellular determinants that guide this process.
Abstract | Full Text | PDF | Supplementary information

Article series: Translational genetics
Transplant genetics and genomics
Joshua Y. C. Yang & Minnie M. Sarwal
p309 | doi:10.1038/nrg.2017.12
Advances in genetics and genomics have transformed the field of organ transplantation. Here, the authors review the role of genetic dissimilarities between donor and recipient in transplant tolerance and rejection, and how the identification of genetic variants that predict adverse transplant outcomes can be used for personalized medicine.
Abstract | Full Text | PDF

April 2017 marks the 25th Anniversary of Nature Genetics! To celebrate, the editors have selected some past papers which are free to read for a limited time. 

Click here to read!
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