Nature Reviews Genetics Contents May 2017 Volume 18 Number 5 pp269-326

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TABLE OF CONTENTS
May 2017 Volume 18 Number 5		Advertisement
2015 2–year Impact Factor 35.898 Journal Metrics 2–year Median 32	In this issue Research Highlights Reviews Also this month Article series: Study designs Regulatory elements Translational genetics  Featured article: Detecting RNA modifications in the epitranscriptome: predict and validate Mark Helm & Yuri Motorin	Cancer Evolution Collection This collection highlights the most recent research and review articles published on this topic. Access this collection free online for six months Produced with support from  EMD Serono
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RESEARCH HIGHLIGHTS Top Genome organization: Zooming in on nuclear organization p269 | doi:10.1038/nrg.2017.23 PDF Regulatory elements: A boost to RNA processing 270 | doi:10.1038/nrg.2017.20 PDF Genetic variation: Linear INSIGHTs into non-coding DNA p270 | doi:10.1038/nrg.2017.24 PDF Disease genomics: Transitioning from association to causation with eQTLs p271 | doi:10.1038/nrg.2017.22 PDF Genetic screens: CRISPR-based mapping of genetic interactions p272 | doi:10.1038/nrg.2017.25 PDF RNA: Translated circular RNAs p272 | doi:10.1038/nrg.2017.27 PDF Gene regulation: The nuclear pore — a scaffold for inducible genes p273 | doi:10.1038/nrg.2017.29 PDF Synthetic Biology: Building a custom eukaryotic genome de novo p274 | doi:10.1038/nrg.2017.30 PDF Genetics JOBS of the week Postdoctoral Research Fellow, Cancer Genetics and Epigenetics Fred Hutchinson Cancer Research Center Faculty Position in the Department of Molecular Biology and Genetics at Bogaziçi University Bogaziçi University Faculty Positions Institute for Cancer Genetics Columbia University Medical Center Postdoctoral Fellow / Pediatrics The University of Tennessee Health Science Center Director, Four Diamonds Epigentics and Gene Regulation Research Program in Pediatric Oncology Penn State Hershey Children's Hospital More Science jobs from Genetics EVENT Variant Detection 2017 05.06.17 Santiago de Compostela, Spain More science events from
REVIEWS		Top
Article series: Study designs Detecting RNA modifications in the epitranscriptome: predict and validate Mark Helm & Yuri Motorin p275 | doi:10.1038/nrg.2016.169 Although it has been known for decades that RNA is subjected to numerous covalent modifications, there has been a recent surge in interest driven by sequencing-based transcriptome-wide detection methods and the realization that RNA modifications have important roles in diverse biological processes. This Review describes the range of detection strategies for RNA modifications, their particular strengths and limitations, and how responsible and complementary application of these techniques will be required to ensure the quality and interpretability of the rapidly accumulating data sets. Abstract | Full Text | PDF
Article series: Regulatory elements Integration site selection by retroviruses and transposable elements in eukaryotes Tania Sultana, Alessia Zamborlini, Gael Cristofari & Pascale Lesage p292 | doi:10.1038/nrg.2017.7 Next-generation sequencing has facilitated the study of how transposable elements and retroviruses select their diverse genomic sites of integration, and revealed integration site preferences that range from specific nucleotide sequences to particular chromatin states. The authors review the various mechanisms of integration site selection in eukaryotes, as well as the molecular and cellular determinants that guide this process. Abstract | Full Text | PDF | Supplementary information
Article series: Translational genetics Transplant genetics and genomics Joshua Y. C. Yang & Minnie M. Sarwal p309 | doi:10.1038/nrg.2017.12 Advances in genetics and genomics have transformed the field of organ transplantation. Here, the authors review the role of genetic dissimilarities between donor and recipient in transplant tolerance and rejection, and how the identification of genetic variants that predict adverse transplant outcomes can be used for personalized medicine. Abstract | Full Text | PDF
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April 2017 marks the 25th Anniversary of Nature Genetics! To celebrate, the editors have selected some past papers which are free to read for a limited time.  Click here to read!
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