Monday, April 24, 2017

Nature Reviews Cancer contents May 2017 Volume 17 Number 5 pp269-332

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Nature Reviews Cancer

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2015 2-year Impact Factor 34.244 Journal Metrics 2-year Median 27
In this issue
Research Highlights

Also this month
 Featured article:
Microbiota: a key orchestrator of cancer therapy
Soumen Roy & Giorgio Trinchieri

Discover What's Driving Tumor Cell Biology

Cancer cells reprogram their metabolism to generate the energy and building blocks they need to proliferate. Agilent Seahorse XF technology measures changes in both glycolytic and mitochondrial activity in real time, providing a window into the Warburg effect, substrate dependency, and other metabolic aspects of tumor cell biology.

Recommend to library
BEATSON INTERNATIONAL CANCER CONFERENCE 'Feeding the Beast' – the Metabolic Landscape of the Tumour and its Host
2nd–5th July 2017, Glasgow
This meeting will provide a topical view of the metabolic vulnerabilities of cancer cells and how the interplay between tumour, stroma and systemic metabolism contributes to cancer progression and highlights opportunities for cancer treatment and prevention. Register here
Tenth AACR Conference on The Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved 
Join us September 25-28, 2017 in Atlanta, GA to advance the understanding of and, ultimately, help to eliminate the disparities in cancer that represent a major public health problem in our country. For more information, visit
Cancer Evolution Collection

This collection highlights the most recent research and review articles published on this topic.
Produced with support from

Tumour Suppressors: Following the clues of cancer-resistant tissues
p269 | doi:10.1038/nrc.2017.29
Using gene expression analyses of cancer-resistant differentiated muscle cells, Keckesova et al. identify a mitochondrial protein, lactamase β (LACTB), that affects lipid metabolism and can induce differentiation and suppress proliferation of breast cancer cells in vitro and in vivo.


Metastasis: Breaching barriers
p270 | doi:10.1038/nrc.2017.27
Boire et al. describe a mechanism by which cancer cells can survive and grow in the leptomeninges of the brain by upregulating complement component 3 (C3) to disrupt blood–cerebrospinal fluid barrier function, allowing entry of growth-promoting factors.


JOBS of the week
Postdoctoral Fellow Positions Focusing on Gene Regulation in Cancer Progression
San Antonio, TX, United States
Postdoc/scientist Cancer genomics and immunology
west lafayette, IN, United States
PhD Positions in Cancer Research at the German Cancer Research Center
Helmholtz Association
Postdoctoral Position in Cell Signaling and Cancer
University Health Network (Toronto)
Postdoctoral Research Scientist in Cancer Metabolism
Cancer Research UK Beatson Institute
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The 3rd Conference on Advances in Prevention and Treatment of Cancer (CAPTC 2017)
Hangzhou, China
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NEW JOURNAL! The Annual Review of Cancer Biology, Volume 1 is now available online, and reviews a range of subjects in cancer research representing important and emerging areas in the field. Free online access to this journal is available for six months with access code: CAONL2017.

Visit today to find out more
Microbiota: a key orchestrator of cancer therapy
Soumen Roy & Giorgio Trinchieri
p271 | doi:10.1038/nrc.2017.13
The human microbiota influences a whole range of physiological functions. In this Review, Roy and Trinchieri discuss our current understanding of how the gut microbiota modulates responses to cancer therapy as well as mediating susceptibility to toxic side effects.
Abstract | Full Text | PDF

Prospects for combining targeted and conventional cancer therapy with immunotherapy
Philip Gotwals et al.
p286 | doi:10.1038/nrc.2017.17
Insights into the effects of targeted therapies, conventional chemotherapy and radiation therapy, on the induction of antitumour immunity will help to advance the design of combination strategies that increase the rate of complete and durable clinical responses in patients.
Abstract | Full Text | PDF

Pre-metastatic niches: organ-specific homes for metastases
Héctor Peinado et al.
p302 | doi:10.1038/nrc.2017.6
This Review summarizes the natural progression of pre-metastatic niche formation and evolution, highlighting recent advances and future hurdles.
Abstract | Full Text | PDF

Advances and challenges in targeting FGFR signalling in cancer
Irina S. Babina & Nicholas C. Turner
p318 | doi:10.1038/nrc.2017.8
Deregulation of fibroblast growth factor (FGF) signalling is observed in several types of cancer, which makes this pathway a highly promising potential therapeutic target. However, aberrant FGF receptor (FGFR) signalling can be challenging. In this Review, Babina et al. discuss the differences between diverse mechanisms of oncogenic activation of FGFR, and the factors that determine response and resistance to FGFR targeting.
Abstract | Full Text | PDF

April 2017 marks the 25th Anniversary of Nature Genetics! To celebrate, the editors have selected some past papers which are free to read for a limited time. 

Click here to read!
Leukaemia: 'Gimme shelter'
Nicola McCarthy
p332 | doi:10.1038/nrc.2017.14
Full Text | PDF
Corrigendum: New frontiers in translational control of the cancer genome
Morgan L. Truitt & Davide Ruggero
p332 | doi:10.1038/nrc.2017.30
Full Text | PDF
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