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TABLE OF CONTENTS |
April 2017 Volume 23, Issue 4 |
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| Editorial News Correction Correspondence News and Views Review Brief Communication Articles Letters Analysis Corrigendum Errata
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Nature Reviews Immunology and Nature Reviews Molecular Cell Biology: Poster on Bone marrow niches and HSC fates
This poster shows the signalling pathways between stromal and haematopoietic cells of the bone marrow niche that direct the fate of haematopoietic stem cells.
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Produced with support from STEMCELL Technologies | | | |
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Nature Protocols: Poster on the production of Chimeric Antigen Receptor T-cells This poster overviews the production of (CAR) T-cells, discussing the significant and unique challenges of the production process Available to download free Produced with support from STEMCELL Technologies | | | |
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Editorial | Top |
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Science over speed p397 doi:10.1038/nm.4325
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News | Top |
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Beyond the breath: Exploring sex differences in tuberculosis outside the lungs pp398 - 401 Alla Katsnelson doi:10.1038/nm0417-398
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A curious connection: Teasing apart the link between gut microbes and lung disease pp402 - 404 Shraddha Chakradhar doi:10.1038/nm0417-402
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Correction | Top |
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Correction p404 doi:10.1038/nm0417-404
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Correspondence | Top |
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The Drug Repurposing Hub: a next-generation drug library and information resource pp405 - 408 Steven M Corsello, Joshua A Bittker, Zihan Liu, Joshua Gould, Patrick McCarren et al. doi:10.1038/nm.4306
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News and Views | Top |
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Review | Top |
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Refining strategies to translate genome editing to the clinic pp415 - 423 Tatjana I Cornu, Claudio Mussolino and Toni Cathomen doi:10.1038/nm.4313 In this Review, Cathomen and colleagues present the latest advances, including improvements in nuclease specificity and delivery, that will expedite the clinical translation of genome editing.
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Brief Communication | Top |
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Glucocorticoid hormone-induced chromatin remodeling enhances human hematopoietic stem cell homing and engraftment pp424 - 428 Bin Guo, Xinxin Huang, Scott Cooper and Hal E Broxmeyer doi:10.1038/nm.4298 Glucocorticoid treatment of human cord blood hematopoietic stem cells increases expression of the receptor CXCR4 by chromatin remodeling, thereby enhancing hematopoietic stem cell homing and engraftment.
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Poster on Molecular mechanisms of amyotrophic lateral sclerosis
This poster from Nature Reviews Neuroscience provides an overview of the molecular and cellular mechanisms that have been proposed to contribute to the pathogenesis of amyotrophic lateral sclerosis, which is the most common form of motor neuron disease.
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Funded by a grant from MT Pharma America, Inc | | | |
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Articles | Top |
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Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice pp429 - 438 Pazit Beckerman, Jing Bi-Karchin, Ae Seo Deok Park, Chengxiang Qiu, Patrick D Dummer et al. doi:10.1038/nm.4287 Risk variants of APOL1 associated with human chronic kidney disease have been identified, but causality has been unclear. Transgenic expression in mice now shows that such alleles can indeed cause renal disease.
See also: News and Views by Winkler & Nelson |
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Targeting CASP8 and FADD-like apoptosis regulator ameliorates nonalcoholic steatohepatitis in mice and nonhuman primates pp439 - 449 Pi-Xiao Wang, Yan-Xiao Ji, Xiao-Jing Zhang, Ling-Ping Zhao, Zhen-Zhen Yan et al. doi:10.1038/nm.4290 Targeting CFLAR in mouse and non-human primates ameliorates non-alcoholic steatohepatitis by decreasing JNK signaling in hepatocytes.
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Gpr124 is essential for blood-brain barrier integrity in central nervous system disease pp450 - 460 Junlei Chang, Michael R Mancuso, Carolina Maier, Xibin Liang, Kanako Yuki et al. doi:10.1038/nm.4309 The G-protein-coupled receptor GPR124, acting through the canonical Wnt pathway, is required for the maintenance of blood-brain barrier function in mouse models of stroke and glioblastoma.
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A subset of platinum-containing chemotherapeutic agents kills cells by inducing ribosome biogenesis stress pp461 - 471 Peter M Bruno, Yunpeng Liu, Ga Young Park, Junko Murai, Catherine E Koch et al. doi:10.1038/nm.4291 Whereas cisplatin and carboplatin kill cancer cells by inducing DNA damage, another platinum derivative, oxaliplatin, induces cell death by triggering ribosome biogenesis stress.
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Targeting c-FOS and DUSP1 abrogates intrinsic resistance to tyrosine-kinase inhibitor therapy in BCR-ABL-induced leukemia pp472 - 482 Meenu Kesarwani, Zachary Kincaid, Ahmed Gomaa, Erika Huber, Sara Rohrabaugh et al. doi:10.1038/nm.4310 The intrinsic resistance of BCR-ABL-expressing chronic myeloid leukemia stem cells to treatment with tyrosine-kinase inhibitors requires growth-factor signaling through the proteins c-Fos and DUSP1. Combined inhibition of BCR-ABL, c-Fos, and DUSP1 eradicated leukemia in vivo, pointing to a new therapeutic strategy for kinase-driven leukemias.
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EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas pp483 - 492 Faizaan Mohammad, Simon Weissmann, Benjamin Leblanc, Deo P Pandey, Jonas W Hojfeldt et al. doi:10.1038/nm.4293 Although mutant H3K27M histones inhibit PRC2 in diffuse intrinsic pontine gliomas, these tumors exhibit significant amounts of PRC2 activity. The repression of several genes, including INK4A, by residual EZH2 activity is required for tumor growth, and EZH2 inhibitors therefore represent potential therapies for these patients.
See also: News and Views by Creasy | Letter by Piunti et al. |
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Letters | Top |
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Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas pp493 - 500 Andrea Piunti, Rintaro Hashizume, Marc A Morgan, Elizabeth T Bartom, Craig M Horbinski et al. doi:10.1038/nm.4296 Nucleosomes containing mutant K27M histones in diffuse intrinsic pediatric gliomas (DIPG) exclude PRC2 binding and recruit BET bromodomain proteins; however, residual PRC2-dependent repression of specific loci, is required for DIPG oncogenesis. These results provide a rationale for targeting these epigenetic regulators in patients.
See also: News and Views by Creasy | Article by Mohammad et al. |
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Autoimmunity against a defective ribosomal insulin gene product in type 1 diabetes pp501 - 507 Maria J L Kracht, Menno van Lummel, Tatjana Nikolic, Antoinette M Joosten, Sandra Laban et al. doi:10.1038/nm.4289 Use of an alternative open reading frame, potentially as a result of cellular stress, drives production of an unconventional insulin epitope that is recognized by cytotoxic T cells from individuals with type 1 diabetes; these T cells kill beta cells in vitro.
See also: News and Views by Wei & Yewdell |
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Deficiency of the hepatokine selenoprotein P increases responsiveness to exercise in mice through upregulation of reactive oxygen species and AMP-activated protein kinase in muscle pp508 - 516 Hirofumi Misu, Hiroaki Takayama, Yoshiro Saito, Yuichiro Mita, Akihiro Kikuchi et al. doi:10.1038/nm.4295 Selenoprotein P is released from the liver and acts through LRP1 in the muscle to contribute to exercise resistance in mouse and man by inhibiting ROS levels via inhibition of AMPK and PGC-1α.
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Analysis | Top |
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HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures pp517 - 525 Helen Davies, Dominik Glodzik, Sandro Morganella, Lucy R Yates, Johan Staaf et al. doi:10.1038/nm.4292 HRDetect represents a model integrating whole-genome sequencing mutation signatures associated with BRCA1 and BRCA2 deficiency. The implementation of this predictor across different tumor types identifies a larger proportion of patients displaying /`BRCAness/' than previously recognized; they might derive benefit from platinum and PARP-inhibitor therapies.
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Corrigendum | Top |
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Corrigendum: Persisting positron emission tomography lesion activity and Mycobacterium tuberculosis mRNA after tuberculosis cure p526 Stephanus T Malherbe, Shubhada Shenai, Katharina Ronacher, Andre G Loxton, Gregory Dolganov et al. doi:10.1038/nm0417-526a
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Errata | Top |
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Erratum: Reply to “Neutrophils are not required for resolution of acute gouty arthritis in mice” p526 Christiane Reinwald, Christine Schauer, Janka Zsofia Csepregi, Deborah Kienhofer, Daniela Weidner et al. doi:10.1038/nm0417-526b
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Erratum: PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer p526 Fara Braso-Maristany, Simone Filosto, Steven Catchpole, Rebecca Marlow, Jelmar Quist et al. doi:10.1038/nm0417-526c
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