Cryopreservation technologies support access to an incredible selection of genetically engineered mouse models, but mouse repositories often require restrictive licensing, eligibility requirements, and terms of access. How can you navigate these restrictions and choose the optimal vendor for your research goals?
Track how technology is transforming work Without data on how artificial intelligence is affecting jobs, policymakers will fly blind into the next industrial revolution, warn Tom Mitchell and Erik Brynjolfsson. Tom Mitchell, Erik Brynjolfsson
Animal behaviour: How to build a better dad Oldfield mice and deer mice differ in their parental care, most dramatically in the behaviour of fathers. A study reveals the genetic and neuronal contributions to variation in parental care.
Super-multiplex vibrational imaging Stimulated Raman scattering under electronic pre-resonance conditions, combined with a new palette of probes, enables super-multiplex imaging of molecular targets in living cells with very high vibrational selectivity and sensitivity.
Observed quantization of anyonic heat flow Quasiparticles in strongly interacting fractional quantum Hall systems carry heat according to the same quantization of thermal conductance as for particles in non-interacting systems.
Decarboxylative alkenylation Starting with alkyl carboxylic acids, a simple olefin synthesis using any substitution pattern or geometry, based on amide-bond synthesis with nickel- or iron-based catalysis, is described.
Structural basis for selectivity and diversity in angiotensin II receptors Crystal structures of two complexes of the angiotensin II receptor AT2R with distinct tightly bound ligands reveal an active-like state of the receptor, in which helix VIII adopts a non-canonical position that blocks binding of G proteins and β-arrestins. Haitao Zhang, Gye Won Han, Alexander Batyuk et al.
A temperate rocky super-Earth transiting a nearby cool star An Earth-sized planet is observed orbiting a nearby star within the liquid-water, habitable zone, the atmospheric composition of which could be determined from future observations. Jason A. Dittmann, Jonathan M. Irwin, David Charbonneau et al.
Drivers of salamander extirpation mediated by Batrachochytrium salamandrivorans The authors investigated the disease ecology of the fast-spreading fungal pathogen Batrachochytrium salamandrivorans in fire salamanders; on the basis of their research, they call for Europe-wide monitoring systems and conservation strategies for threatened species. Gwij Stegen, Frank Pasmans, Benedikt R. Schmidt et al.
Neanderthal behaviour, diet, and disease inferred from ancient DNA in dental calculus Analysis of calcified dental plaque (calculus) specimens from Neanderthals shows marked regional differences in diet and microbiota and evidence of self-medication in one individual, and identifies prevalent microorganisms and their divergence between Neanderthals and modern humans. Laura S. Weyrich, Sebastian Duchene, Julien Soubrier et al.
Rad51-mediated double-strand break repair and mismatch correction of divergent substrates DNA repair by break-induced replication begins with the Rad51-mediated invasion of single-stranded DNA into a double-stranded donor template; this study shows that successful recombination between highly mismatched substrates can occur when only five consecutive bases can be paired and that mismatch correction is most efficient near the invading end of the recipient strand. Ranjith Anand, Annette Beach, Kevin Li et al.
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