Tuesday, April 11, 2017

Nature Biotechnology Contents: Volume 35 pp 291 - 388

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TABLE OF CONTENTS

April 2017 Volume 35, Issue 4

Editorial
News
Opinion and Comment
Features
News and Views
Research
Careers and Recruitment

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Editorial

Top

A futile cycle in cell therapy   p291
doi:10.1038/nbt.3857
Should a cell therapy for heart disease with scant evidence of efficacy continue to be tested in humans?

News

Top

Trade groups laud Gottlieb FDA choice, silent on NIH cutback   pp293 - 294
Mark Ratner
doi:10.1038/nbt0417-293

'Tinder' for startups   p294
Andrew Marshall
doi:10.1038/nbt0417-294

National Academies relax stance on germline edits   pp295 - 296
Cormac Sheridan
doi:10.1038/nbt0417-295

Allergan dives into CRISPR-Cas9   p296
doi:10.1038/nbt0417-296

Top heart-failure contender serelaxin flops   p297
doi:10.1038/nbt0417-297b

Real world points to SGLT-2 blockers advantage   p297
doi:10.1038/nbt0417-297c

Oncologists await historic first: a pan-tumor predictive marker, for immunotherapy   pp297 - 298
Ken Garber
doi:10.1038/nbt0417-297a

Biotech startups woo increasing numbers of crowdfunders   pp299 - 300
Nuala Moran
doi:10.1038/nbt0417-299

Around the world in a month   p300
doi:10.1038/nbt0417-300

Drugmakers accused of exploiting orphan drug incentives, fueling price problem   p301
Brady Huggett
doi:10.1038/nbt0417-301

Opinion and Comment

Top
Correspondence

Elevating the conversation about GE crops   pp302 - 304
Fred Gould, Richard M Amasino, Dominique Brossard, C Robin Buell, Richard A Dixon et al.
doi:10.1038/nbt.3841

National Academies report has broad support   pp304 - 306
Paul Vincelli, Douglas Jackson-Smith, Michael Holsapple, Michael A Grusak, Matthew Harsh et al.
doi:10.1038/nbt.3842

Response to Gould et al. and Vincelli et al.   pp306 - 308
doi:10.1038/nbt.3844

Remote detection of buried landmines using a bacterial sensor   pp308 - 310
Shimshon Belkin, Sharon Yagur-Kroll, Yossef Kabessa, Victor Korouma, Tali Septon et al.
doi:10.1038/nbt.3791

Robotic crowd biology with Maholo LabDroids   pp310 - 312
Nozomu Yachie, Tohru Natsume, Koichi Takahashi, Toshiaki Katayama, Takeshi Sakurada et al.
doi:10.1038/nbt.3758

With all due respect to Maholo, lab automation isn't anthropomorphic   pp312 - 314
David W McClymont and Paul S Freemont
doi:10.1038/nbt.3795

Toil enables reproducible, open source, big biomedical data analyses   pp314 - 316
John Vivian, Arjun Arkal Rao, Frank Austin Nothaft, Christopher Ketchum, Joel Armstrong et al.
doi:10.1038/nbt.3772

Nextflow enables reproducible computational workflows   pp316 - 319
Paolo Di Tommaso, Maria Chatzou, Evan W Floden, Pablo Prieto Barja, Emilio Palumbo et al.
doi:10.1038/nbt.3820

Reproducible RNA-seq analysis using recount2    pp319 - 321
Leonardo Collado-Torres, Abhinav Nellore, Kai Kammers, Shannon E Ellis, Margaret A Taub et al.
doi:10.1038/nbt.3838


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Features

Top

Nature Biotechnology's academic spinouts of 2016   pp322 - 333
Aaron Bouchie, Laura DeFrancesco, Cormac Sheridan and Sarah Webb
doi:10.1038/nbt.3847
Our annual survey highlights several academic startups developing immunotherapies as well as ventures focusing on microbiomes, proteostasis, integrin biology, nucleic acid delivery and subcellular imaging.

Patents

Differing diagnoses for European and US patents   pp334 - 335
Brian Amos and Alan D Miller
doi:10.1038/nbt.3839
Medical diagnostic patent applications in the United States and Europe face diverging fates following the Supreme Court's decision in Mayo.

Recent patents in epigenetic targeting   p336
doi:10.1038/nbt.3858

News and Views

Top

mHealth advances clinical research, bit by bit   pp337 - 339
Joseph C Kvedar and Alexander L Fogel
doi:10.1038/nbt.3851
Monitoring the symptoms of a large cohort of asthma patients is made possible by a smartphone app created using Apple ResearchKit.

See also: Research by Chan et al.

Single-minded CRISPR screening   pp339 - 340
Bryan R Lanning and Christopher R Vakoc
doi:10.1038/nbt.3849
Transcriptome-wide effects of gene knockouts are screened at the single-cell level by combining high-throughput, single-cell RNA-seq with lentiviral CRISPR libraries.

Research Highlights   p340
doi:10.1038/nbt.3845

The best spot to park a CAR   p341
Katarzyna Marcinkiewicz
doi:10.1038/nbt.3848

Biotechnology
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Research

Top
Analysis

Reproducibility of computational workflows is automated using continuous analysis   pp342 - 346
Brett K Beaulieu-Jones and Casey S Greene
doi:10.1038/nbt.3780
The application of continuous integration, an approach common in software development, enables the automatic reproduction of computational analyses.

Brief Communications

GuideScan software for improved single and paired CRISPR guide RNA design   pp347 - 349
Alexendar R Perez, Yuri Pritykin, Joana A Vidigal, Sagar Chhangawala, Lee Zamparo et al.
doi:10.1038/nbt.3804
A tool for genome-wide design of CRISPR guide RNAs reduces off-target effects and facilitates targeting of the non-coding genome.

Prediction of potent shRNAs with a sequential classification algorithm   pp350 - 353
Raphael Pelossof, Lauren Fairchild, Chun-Hao Huang, Christian Widmer, Vipin T Sreedharan et al.
doi:10.1038/nbt.3807
The most effective shRNAs to silence a gene are calculated by a machine learning algorithm.

Articles

The Asthma Mobile Health Study, a large-scale clinical observational study using ResearchKit   pp354 - 362
Yu-Feng Yvonne Chan, Pei Wang, Linda Rogers, Nicole Tignor, Micol Zweig et al.
doi:10.1038/nbt.3826
Use of the ResearchKit platform to track symptoms of a large cohort of asthma sufferers over time demonstrates the pros and cons of mobile health applications in large-scale observational studies.

See also: News and Views by Kvedar & Fogel

A FRET sensor enables quantitative measurements of membrane charges in live cells   pp363 - 370
Yuanqing Ma, Yui Yamamoto, Philip R Nicovich, Jesse Goyette, Jeremie Rossy et al.
doi:10.1038/nbt.3828
The electrostatic potential of the plasma membrane of live mammalian cells is measured with a FRET-based sensor.

Letters

Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusions   pp371 - 376
Y Bill Kim, Alexis C Komor, Jonathan M Levy, Michael S Packer, Kevin T Zhao et al.
doi:10.1038/nbt.3803
Genome editing of single bases is made more versatile and accurate with new fusions of mutated Cas9 and cytidine deaminase domains.

Reduction of antinutritional glucosinolates in Brassica oilseeds by mutation of genes encoding transporters   pp377 - 382
Hussam Hassan Nour-Eldin, Svend Roesen Madsen, Steven Engelen, Morten Egevang Jorgensen, Carl Erik Olsen et al.
doi:10.1038/nbt.3823
An antinutritional compound in Brassica seed meal is reduced by knocking out genes encoding transporter proteins.


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Careers and Recruitment

Top

Continuous positive compensation trends indicate a healthy private life sciences sector   pp383 - 386
Bruce Rychlik
doi:10.1038/nbt.3850
Non-founder total target cash compensation in 2016 increased 4.2% year-over-year at private life sciences companies and 6% at private technology companies.

People

People   p388
doi:10.1038/nbt.3856

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