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TABLE OF CONTENTS |
April 2017 Volume 35, Issue 4 |
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| Editorial News Opinion and Comment Features News and Views Research Careers and Recruitment
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nature.com webcasts Nature Cell Biology, Nature Reviews Clinical Oncology and the cancer editorial community of the Nature journals present a webcast on: Cancer Evolution Date: Friday, April 28th, 2017 Time: 12:00pm EDT Register for FREE Sponsored by: EMD Serono | | |
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Nature Protocols: Poster on the production of Chimeric Antigen Receptor T-cells This poster overviews the production of (CAR) T-cells, discussing the significant and unique challenges of the production process Available to download free Produced with support from STEMCELL Technologies | | |
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Editorial | Top |
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A futile cycle in cell therapy p291 doi:10.1038/nbt.3857 Should a cell therapy for heart disease with scant evidence of efficacy continue to be tested in humans?
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News | Top |
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Trade groups laud Gottlieb FDA choice, silent on NIH cutback pp293 - 294 Mark Ratner doi:10.1038/nbt0417-293
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'Tinder' for startups p294 Andrew Marshall doi:10.1038/nbt0417-294
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National Academies relax stance on germline edits pp295 - 296 Cormac Sheridan doi:10.1038/nbt0417-295
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Allergan dives into CRISPR-Cas9 p296 doi:10.1038/nbt0417-296
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Top heart-failure contender serelaxin flops p297 doi:10.1038/nbt0417-297b
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Real world points to SGLT-2 blockers advantage p297 doi:10.1038/nbt0417-297c
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Oncologists await historic first: a pan-tumor predictive marker, for immunotherapy pp297 - 298 Ken Garber doi:10.1038/nbt0417-297a
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Biotech startups woo increasing numbers of crowdfunders pp299 - 300 Nuala Moran doi:10.1038/nbt0417-299
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Around the world in a month p300 doi:10.1038/nbt0417-300
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Drugmakers accused of exploiting orphan drug incentives, fueling price problem p301 Brady Huggett doi:10.1038/nbt0417-301
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Opinion and Comment | Top |
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Correspondence |
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Elevating the conversation about GE crops pp302 - 304 Fred Gould, Richard M Amasino, Dominique Brossard, C Robin Buell, Richard A Dixon et al. doi:10.1038/nbt.3841
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National Academies report has broad support pp304 - 306 Paul Vincelli, Douglas Jackson-Smith, Michael Holsapple, Michael A Grusak, Matthew Harsh et al. doi:10.1038/nbt.3842
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Response to Gould et al. and Vincelli et al. pp306 - 308 doi:10.1038/nbt.3844
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Remote detection of buried landmines using a bacterial sensor pp308 - 310 Shimshon Belkin, Sharon Yagur-Kroll, Yossef Kabessa, Victor Korouma, Tali Septon et al. doi:10.1038/nbt.3791
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Robotic crowd biology with Maholo LabDroids pp310 - 312 Nozomu Yachie, Tohru Natsume, Koichi Takahashi, Toshiaki Katayama, Takeshi Sakurada et al. doi:10.1038/nbt.3758
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With all due respect to Maholo, lab automation isn't anthropomorphic pp312 - 314 David W McClymont and Paul S Freemont doi:10.1038/nbt.3795
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Toil enables reproducible, open source, big biomedical data analyses pp314 - 316 John Vivian, Arjun Arkal Rao, Frank Austin Nothaft, Christopher Ketchum, Joel Armstrong et al. doi:10.1038/nbt.3772
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Nextflow enables reproducible computational workflows pp316 - 319 Paolo Di Tommaso, Maria Chatzou, Evan W Floden, Pablo Prieto Barja, Emilio Palumbo et al. doi:10.1038/nbt.3820
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Reproducible RNA-seq analysis using recount2 pp319 - 321 Leonardo Collado-Torres, Abhinav Nellore, Kai Kammers, Shannon E Ellis, Margaret A Taub et al. doi:10.1038/nbt.3838
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Features | Top |
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Nature Biotechnology's academic spinouts of 2016 pp322 - 333 Aaron Bouchie, Laura DeFrancesco, Cormac Sheridan and Sarah Webb doi:10.1038/nbt.3847 Our annual survey highlights several academic startups developing immunotherapies as well as ventures focusing on microbiomes, proteostasis, integrin biology, nucleic acid delivery and subcellular imaging.
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Patents |
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Differing diagnoses for European and US patents pp334 - 335 Brian Amos and Alan D Miller doi:10.1038/nbt.3839 Medical diagnostic patent applications in the United States and Europe face diverging fates following the Supreme Court's decision in Mayo.
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Recent patents in epigenetic targeting p336 doi:10.1038/nbt.3858
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News and Views | Top |
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Research | Top |
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Analysis |
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Reproducibility of computational workflows is automated using continuous analysis pp342 - 346 Brett K Beaulieu-Jones and Casey S Greene doi:10.1038/nbt.3780 The application of continuous integration, an approach common in software development, enables the automatic reproduction of computational analyses.
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Brief Communications |
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GuideScan software for improved single and paired CRISPR guide RNA design pp347 - 349 Alexendar R Perez, Yuri Pritykin, Joana A Vidigal, Sagar Chhangawala, Lee Zamparo et al. doi:10.1038/nbt.3804 A tool for genome-wide design of CRISPR guide RNAs reduces off-target effects and facilitates targeting of the non-coding genome.
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Prediction of potent shRNAs with a sequential classification algorithm pp350 - 353 Raphael Pelossof, Lauren Fairchild, Chun-Hao Huang, Christian Widmer, Vipin T Sreedharan et al. doi:10.1038/nbt.3807 The most effective shRNAs to silence a gene are calculated by a machine learning algorithm.
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Articles |
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The Asthma Mobile Health Study, a large-scale clinical observational study using ResearchKit pp354 - 362 Yu-Feng Yvonne Chan, Pei Wang, Linda Rogers, Nicole Tignor, Micol Zweig et al. doi:10.1038/nbt.3826 Use of the ResearchKit platform to track symptoms of a large cohort of asthma sufferers over time demonstrates the pros and cons of mobile health applications in large-scale observational studies.
See also: News and Views by Kvedar & Fogel
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A FRET sensor enables quantitative measurements of membrane charges in live cells pp363 - 370 Yuanqing Ma, Yui Yamamoto, Philip R Nicovich, Jesse Goyette, Jeremie Rossy et al. doi:10.1038/nbt.3828 The electrostatic potential of the plasma membrane of live mammalian cells is measured with a FRET-based sensor.
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Letters |
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Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusions pp371 - 376 Y Bill Kim, Alexis C Komor, Jonathan M Levy, Michael S Packer, Kevin T Zhao et al. doi:10.1038/nbt.3803 Genome editing of single bases is made more versatile and accurate with new fusions of mutated Cas9 and cytidine deaminase domains.
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Reduction of antinutritional glucosinolates in Brassica oilseeds by mutation of genes encoding transporters pp377 - 382 Hussam Hassan Nour-Eldin, Svend Roesen Madsen, Steven Engelen, Morten Egevang Jorgensen, Carl Erik Olsen et al. doi:10.1038/nbt.3823 An antinutritional compound in Brassica seed meal is reduced by knocking out genes encoding transporter proteins.
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Careers and Recruitment | Top |
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Continuous positive compensation trends indicate a healthy private life sciences sector pp383 - 386 Bruce Rychlik doi:10.1038/nbt.3850 Non-founder total target cash compensation in 2016 increased 4.2% year-over-year at private life sciences companies and 6% at private technology companies.
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People |
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People p388 doi:10.1038/nbt.3856
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| | | | | | Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com | | | | | |
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