The EMBO Journal Table of Contents for 15 March 2017; Vol. 36, No. 6

15 March 2017 | Volume 36, Number 6 Submit Table of Contents News & Views Articles Volume 36, Number 6 News & Views No sex please, we're (in)breeding Trait mapping to a pollen‐specific phospholipase elucidates the molecular basis of a widely used shortcut for haploid induction in maize breeding. David Jackson Published online 06.03.2017 Dangerous fusions: a path to cancer for arrested lymphoid progenitors Pax5 fusion proteins exert a gain‐of‐function effect on transcription that contributes to the onset of lymphoblastic leukemia by preventing B‐cell differentiation, thus increasing the risk of oncogenic transformation. Ameera Alsadeq and Hassan Jumaa Published online 08.03.2017 Articles Loss of pollen‐specific phospholipase NOT LIKE DAD triggers gynogenesis in maize The function of the patatin‐like phospholipase A NOT LIKE DAD (NLD) in the sperm cells of maize pollen is necessary for successful fertilization, whereas its disruption promotes the development of haploid embryos, which represent an important plant breeding tool. Laurine M Gilles, Abdelsabour Khaled, Jean‐Baptiste Laffaire, Sandrine Chaignon, Ghislaine Gendrot, Jérôme Laplaige, Hélène Bergès, Genséric Beydon, Vincent Bayle, Pierre Barret, Jordi Comadran, Jean‐Pierre Martinant, Peter M Rogowsky, and Thomas Widiez Published online 22.02.2017 Molecular role of the PAX5‐ETV6 oncoprotein in promoting B‐cell acute lymphoblastic leukemia New mouse models for PAX5 fusion proteins found in acute lymphoblastic leukemia reveal that oncogenesis involves loss of cell cycle inhibitors rather than deregulation of known PAX5 target genes. Leonie Smeenk, Maria Fischer, Sabine Jurado, Markus Jaritz, Anna Azaryan, Barbara Werner, Mareike Roth, Johannes Zuber, Martin Stanulla, Monique L den Boer, Charles G Mullighan, Sabine Strehl, and Meinrad Busslinger Published online 20.02.2017 ZRF1 is a novel S6 kinase substrate that drives the senescence programme Aberrant mTORC1 signalling induces cell senescence via S6 kinase‐mediated phosphorylation of epigenetic factor ZRF1, thereby linking nutritional cues to regulation of cell fitness. Manuela Barilari, Gregory Bonfils, Caroline Treins, Vonda Koka, Delphine De Villeneuve, Sylvie Fabrega, and Mario Pende Published online 27.02.2017 Paired Siglec receptors generate opposite inflammatory responses to a human‐specific pathogen Escherichia coli K1 uses its polysialic acid capsule to interact with Siglec‐11 to escape host immune responses, but this is counteracted by the activating Siglec‐16. Flavio Schwarz, Corinna S Landig, Shoib Siddiqui, Ismael Secundino, Joshua Olson, Nissi Varki, Victor Nizet, and Ajit Varki Published online 18.01.2017 Protein synthesis inhibition and GADD34 control IFN‐β heterogeneous expression in response to dsRNA GADD34 coordinates transcriptional and translational responses to viral dsRNA to optimize type‐I IFN production. Alexandre Dalet, Rafael J Argüello, Alexis Combes, Lionel Spinelli, Sebastien Jaeger, Mathieu Fallet, Thien‐Phong Vu Manh, Andreia Mendes, Jessica Perego, Marisa Reverendo, Voahirana Camosseto, Marc Dalod, Tobias Weil, Manuel A Santos, Evelina Gatti, and Philippe Pierre Published online 18.01.2017 Hsp70 displaces small heat shock proteins from aggregates to initiate protein refolding Small heat shock proteins initially facilitate solubilization of misfolded protein aggregates, but need to be selectively dissociated to facilitate subsequent access of ATP‐dependent refolding chaperones. Szymon Żwirowski, Agnieszka Kłosowska, Igor Obuchowski, Nadinath B Nillegoda, Artur Piróg, Szymon Ziętkiewicz, Bernd Bukau, Axel Mogk, and Krzysztof Liberek Published online 20.02.2017 Mitochondria control store‐operated Ca2+ entry through Na+ and redox signals The activation of mitochondrial Na+/Ca2+ exchanger NCLX controls Orai1 redox state to ensure maintenance of store‐operated calcium entry (SOCE), thus shedding light on how mitochondria are linked to regulation of SOCE. Tsipi Ben‐Kasus Nissim, Xuexin Zhang, Assaf Elazar, Soumitra Roy, Judith A Stolwijk, Yandong Zhou, Rajender K Motiani, Maxime Gueguinou, Nadine Hempel, Michal Hershfinkel, Donald L Gill, Mohamed Trebak, and Israel Sekler Published online 20.02.2017 Conformational change of syntaxin linker region induced by Munc13s initiates SNARE complex formation in synaptic exocytosis Munc13‐1 catalyzes the transition from the Munc18‐1/syntaxin‐1 complex to the SNARE complex critical for synaptic vesicle priming. This study shows that Munc13‐1 induces a local conformational change in the syntaxin‐1 linker region that promotes this transition. Shen Wang, Ucheor B Choi, Jihong Gong, Xiaoyu Yang, Yun Li, Austin L Wang, Xiaofei Yang, Axel T Brunger, and Cong Ma Published online 30.01.2017   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 973 University Avenue * Los Gatos, CA 95032 * U.S.A. Copyright © 2017 by the European Molecular Biology Organisation.