This year's Frontiers in Biology Insight features Reviews on how genomics is helping to uncover the peopling of the world, the interplay between morphogens and morphogenesis in determining organismal shape, the factors that influence the immune response to cancer, advances in single-cell genomics, and the effects of base modifications in messenger RNA.
This computational course will provide an introduction to network analysis and in-depth training in the main modelling approaches used in systems biology by combining lectures, hands-on computational practical sessions, and group activities. Application deadline: 24 March
ELECTRON MICROSCOPY FOR MATERIALS - THE NEXT TEN YEARS Presented by: Zhejiang University | Nature | Nature Materials
The conference will feature sessions on nanomaterials, functional materials, structural material, soft matter and biomaterials, and techniques development.
Unearthing worm replication origins pp195 - 196 Takayo Sasaki and David M Gilbert doi:10.1038/nsmb.3385 Unlike in animals in which gastrulation marks the onset of zygotic transcription and a transition from random to site-specific localization of replication origins, transcription and origin specification in Caenorhabditis elegans are in place before gastrulation. Nonetheless, origin-site redistribution takes place after gastrulation, and is coordinated with changes in the sites of active transcription.
Cotranslational folding of spectrin domains via partially structured states pp221 - 225 Ola B Nilsson, Adrian A Nickson, Jeffrey J Hollins, Stephan Wickles, Annette Steward et al. doi:10.1038/nsmb.3355 Using a family of spectrin domain variants and a combination of structural, biochemical and biophysical approaches, it is shown that cotranslational folding cannot be predicted on the basis of the folding behavior of isolated proteins.
Eukaryotic Rad50 functions as a rod-shaped dimer pp248 - 257 Young Bong Park, Marcel Hohl, Michal Padjasek, Eunyoung Jeong, Kyeong Sik Jin et al. doi:10.1038/nsmb.3369 Structural, biochemical and in vivo analyses reveal that Rad50 zinc-hook and coiled-coil domains form a novel dimerization interface essential for Mre11-complex function in DNA damage response and repair.
Structural basis of the specificity of USP18 toward ISG15 pp270 - 278 Anja Basters, Paul P Geurink, Annika Rocker, Katharina F Witting, Roya Tadayon et al. doi:10.1038/nsmb.3371 The specificity of USP18's deconjugating activity toward ISG15, a ubiquitin-like protein induced by interferon, is revealed by structural and biochemistry studies of the mouse proteins.
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