Nature Reviews Neuroscience contents April 2017 Volume 18 Number 4 pp 193 - 259

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Nature Insight: Neurodegenerative Diseases This Insight explores brain ageing and possible rejuvenation and updates our understanding of Alzheimer’s disease, amyotrophic lateral sclerosis and Parkinson’s disease. It also discusses how knowledge from prion disease may apply to more common neurodegenerative disorders and provides a structural perspective on the properties of amyloids. Access the Insight free online Produced with support from:  Eli Lilly and Company
TABLE OF CONTENTS
April 2017 Volume 18 Number 4		Advertisement
2015 2-year Impact Factor 29.298 Journal Metrics 2-year Median 22	In this issue Research Highlights Reviews Perspectives Also this month  Featured article: Integration of optogenetics with complementary methodologies in systems neuroscience Christina K. Kim, Avishek Adhikari & Karl Deisseroth	nature.com webcasts Springer Nature presents a custom webcast on: Advances in neuroscience research utilizing modern in situ RNA gene expression techniques Date: 23rd March 2017 Time: 10AM PDT | 1PM EDT | 5PM GMT | 6PM CET  Register for FREE and discover how Dr Jerold Chun has used RNAscope to investigate the human brain Sponsored by: Advanced Cell Diagnostics
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RESEARCH HIGHLIGHTS Top Neurodegenerative disease: A chimeric approach p193 | doi:10.1038/nrn.2017.38 In a new, chimeric model of Alzheimer disease (AD), in which human neurons were transplanted into an AD mouse model, amyloid-β-related pathology was associated with robust degeneration of the human neurons but no neurofibrillary tangle formation. PDF Cell biology of the neuron: Lightening the load p195 | doi:10.1038/nrn.2017.27 Touch neurons in Caenorhabditis elegans eliminate aggregated or neurotoxic proteins and dysfunctional mitochondria by exporting them in large vesicles called exophers. PDF Pain: A gatekeeper circuit p195 | doi:10.1038/nrn.2017.28 The dissection of a circuit for the descending modulation of pain processing in the spinal cord that is recruited by stress. PDF Learning and memory: Remembering where not to go p195 | doi:10.1038/nrn.2017.37 In rats, CA1 place cells that encode the location of an aversive experience are reactivated during retrieval of the memory of that event. PDF IN BRIEF Sensory processing: The eyes have it | Neural development: Digit development | Sleep: Gaining sleep while losing synapses | Synaptic plasticity: Kainate receptors can LTP PDF Nature Reviews Neuroscience JOBS of the week Positions in Simulation Neuroscience Ecole Polytechnique Fédérale de Lausanne (EPFL) Postdoctoral Fellow - Neurosurgery (Neuroscience - Oncology Research) Houston Methodist Research Institute Post doctoral fellow in Neuroscience Uppsala University Group leader position in Neurobiology of disease and translational Neuroscience Bordeaux Neurocampus Neuroscience Postdoctoral Programme Linköping University (LiU) More Science jobs from Nature Reviews Neuroscience EVENT 24th Annual International STRESS AND BEHAVIOR Neuroscience and Biopsychiatry Conference 16.05.17 St Petersburg, Russian Federation More science events from
REVIEWS		Top
Sense of agency in the human brain Patrick Haggard p196 | doi:10.1038/nrn.2017.14 The experience of controlling our own actions is an important feature of human mental life. The processes giving rise to this experience are thought to be disrupted in some psychiatric disorders. In this article, Haggard describes recent developments in our understanding of the cognitive processes and neural mechanisms underlying the sense of agency. Abstract | Full Text | PDF
Operation and plasticity of hippocampal CA3 circuits: implications for memory encoding Nelson Rebola, Mario Carta & Christophe Mulle p208 | doi:10.1038/nrn.2017.10 The circuitry of the hippocampal CA3 region has long been hypothesized to be well suited to the storage of memories. Mulle and colleagues provide an update on the known types and mechanisms of synaptic plasticity in CA3 and describe evidence for their roles in memory formation and retrieval. Abstract | Full Text | PDF
Integration of optogenetics with complementary methodologies in systems neuroscience Christina K. Kim, Avishek Adhikari & Karl Deisseroth p222 | doi:10.1038/nrn.2017.15 Optogenetics is widely used to study the consequences of neuronal activity with high spatiotemporal precision. In this Review, Kim et al. discuss the integration of this approach with other technological and methodological advances to gain insights into neuronal function that were previously inaccessible. Abstract | Full Text | PDF | Supplementary information
NMDA receptors: linking physiological output to biophysical operation Gary J. Iacobucci & Gabriela K. Popescu p236 | doi:10.1038/nrn.2017.24 Kinetic models of NMDA receptor activation derived from single-molecule observations explain the biologically salient features of the excitatory current as a dynamic sequence of quasi-stable receptor states. In this Review, Iacobucci and Popescu discuss how these models will help to match emerging atomic structures with biologically important functional states. Abstract | Full Text | PDF
PERSPECTIVES		Top
TIMELINE The two-century journey of Parkinson disease research Serge Przedborski p251 | doi:10.1038/nrn.2017.25 The year 2017 marks 200 years since James Parkinson's An Essay on the Shaking Palsy was published. In this Timeline article, Serge Przedborski provides an overview of the various avenues of research into Parkinson disease that have been pursued over these two centuries to better understand this neurodegenerative disorder. Abstract | Full Text | PDF
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