Monday, March 13, 2017

Nature Reviews Microbiology contents April 2017 Volume 15 Number 4 pp 193-254

Nature Reviews Microbiology


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TABLE OF CONTENTS
 
April 2017 Volume 15 Number 4
Nature Reviews Microbiology cover
2015 2-year Impact Factor 24.727 Journal Metrics 2-year Median 19.5
In this issue
Research Highlights
News and Analysis
Progress
Reviews

Also this month
Article series:
Vector-borne diseases
 Featured article:
Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need
Mark C. Field, David Horn, Alan H. Fairlamb, Michael A. J. Ferguson, David W. Gray, Kevin D. Read, Manu De Rycker, Leah S. Torrie, Paul G. Wyatt, Susan Wyllie & Ian H. Gilbert


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RESEARCH HIGHLIGHTS
Top

Bacterial physiology: Treadmilling runs bacterial division
p193 | doi:10.1038/nrmicro.2017.24
Two new studies show that FtsZ treadmilling controls and organizes cell wall synthesis to drive bacterial cell division.

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Bacterial physiology: Persisters running out of energy
p194 | doi:10.1038/nrmicro.2017.19
This study shows that ATP depletion lowers the antibiotic target activity and thus functions as a general mechanism for the formation of persisters.

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IN THE NEWS
CRISPR patent results

p194 | doi:10.1038/nrmicro.2017.21
The CRISPR-Cas9 patents filed by the Broad Institute are upheld by the US Patent and Trademark Office

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Symbiosis: Wolbachia's matchmaking secret revealed
p194 | doi:10.1038/nrmicro.2017.25
Two new studies identify the basis of cytoplasmic incompatibility, a process by which obligate intracellular Wolbachia bacteria favour their inheritance in their female insect hosts.

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Bacterial pathogenesis: Hitching a ride with DCs
p195 | doi:10.1038/nrmicro.2017.18
Pseudogenization of a single Salmonella effector protein gene facilitates pathogen hijacking of dendritic cells for systemic spread.

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NEWS AND ANALYSIS
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GENOME WATCH
Bringing Treponema into the spotlight
Isobel Everall & Leonor Sanchez-Buso
p196 | doi:10.1038/nrmicro.2017.23
This month's Genome Watch highlights how culture-independent selective enrichment approaches coupled to whole-genome sequencing enable the analysis of unculturable microorganisms.


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PROGRESS
Top
The β-barrel assembly machinery in motion
Nicholas Noinaj, James C. Gumbart & Susan K. Buchanan
p197 | doi:10.1038/nrmicro.2016.191
In this Progress article, Buchanan and colleagues discuss recent studies that have advanced our understanding of the structure of the fully assembled β-barrel assembly machinery (BAM) complex and the interactions between the individual components. They also detail the mechanistic insights that have been gained and explore two emerging models for BAM-mediated outer membrane protein biogenesis in bacteria.

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REVIEWS
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Virus–host interactions and their roles in coral reef health and disease
Rebecca Vega Thurber, Jérôme P. Payet, Andrew R. Thurber & Adrienne M. S. Correa
p205 | doi:10.1038/nrmicro.2016.176
Coral reefs are complex ecosystems that are populated by diverse microorganisms. In this Review, Vega Thurber et al. summarize the diversity of reef viruses that infect corals and their associated microbiota, and highlight their roles in coral disease and reef decline.
Abstract | Full Text | PDF

Article series: Vector-borne diseases
Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need
Mark C. Field, David Horn, Alan H. Fairlamb, Michael A. J. Ferguson, David W. Gray, Kevin D. Read, Manu De Rycker, Leah S. Torrie, Paul G. Wyatt, Susan Wyllie & Ian H. Gilbert
p217 | doi:10.1038/nrmicro.2016.193
Trypanosomatid parasites can cause life-threatening diseases, such as human African trypanosomiasis, leishmaniasis and Chagas disease. In this Review, Gilbert and colleagues discuss the drug discovery landscape and describe some of the challenges that are involved in the development of new drugs to treat these diseases.
Abstract | Full Text | PDF

Timing the day: what makes bacterial clocks tick?
Carl Hirschie Johnson, Chi Zhao, Yao Xu & Tetsuya Mori
p232 | doi:10.1038/nrmicro.2016.196
Circadian rhythms enable cells to anticipate cyclic changes in their environment. In this Review, Johnson et al. explore timekeeping systems that range from prototypical circadian clocks to hourglass timers and their role in different bacteria, including cyanobacteria and members of the microbiota.
Abstract | Full Text | PDF

Mimivirus: leading the way in the discovery of giant viruses of amoebae
Philippe Colson, Bernard La Scola, Anthony Levasseur, Gustavo Caetano-Anollés & Didier Raoult
p243 | doi:10.1038/nrmicro.2016.197
The discovery of the giant amoebal virus mimivirus, in 2003, opened up a new area of virology. Extended studies, including those of mimiviruses, have since revealed that these viruses have genetic, proteomic and structural features that are more complex than those of conventional viruses.
Abstract | Full Text | PDF | Supplementary information

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