Monday, March 27, 2017

Nature Reviews Immunology Contents April 2017 Volume 17 Number 4 pp 215-275

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Nature Reviews Immunology

Nature Milestones: Antibodies 

Nature Milestones: Antibodies chronicles the history of antibodies from their earliest description in antisera, their structure, generation and function, right through to their recent application in cancer immunotherapy. It also includes a timeline and a collection of seminal papers reproduced from Springer Nature. 

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Cell death and immunity
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Dysbiosis and the immune system
Maayan Levy, Aleksandra A. Kolodziejczyk, Christoph A. Thaiss & Eran Elinav
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T cells: Successful checkpoint blockade requires positive co-stimulation
p215 | doi:10.1038/nri.2017.32
PD1 inhibits T cell activation by suppressing co-stimulation through CD28, and anti-PD1 therapy requires CD28 stimulation for therapeutic efficacy.

Innate lymphoid cells: Circulating precursor for human ILCs
p216 | doi:10.1038/nri.2017.29
James Di Santo and colleagues identify a circulating multipotent precursor for human innate lymphoid cells.

Viral infection: The mother of all viruses
p216 | doi:10.1038/nri.2017.30
Pregnant mice show weaker immune responses to pandemic strains of influenza virus than non-pregnant mice, and this leads to the emergence of more virulent strains of influenza.

Immune regulation: Immune cell social networks
p216 | doi:10.1038/nri.2017.31
High-resolution proteomics analysis of human immune cells reveals new social networks and establishes a framework for future study of intercellular communication.

Immunometabolism and the land of milk and honey

p217 | doi:10.1038/nri.2017.22
Luke O'Neill describes a 2010 study by Connie Krawczyk, Ed Pearce and colleagues that introduced the Warburg effect to immunologists.

HIV: Marking the HIV hideout
p218 | doi:10.1038/nri.2017.33
CD32a is a cell surface marker for HIV-infected latent CD4+ T cells.

Viral infections: Reinvigorating exhausted T cells in hepatitis B infection
p218 | doi:10.1038/nri.2017.35

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Dysbiosis and the immune system
Maayan Levy, Aleksandra A. Kolodziejczyk, Christoph A. Thaiss & Eran Elinav
p219 | doi:10.1038/nri.2017.7
An increasing number of multifactorial diseases have been linked to intestinal dysbiosis — that is, changes in the composition and function of the gut microbiome. Here, the authors explore the causes and consequences of dysbiosis, and discuss implications for the aetiology and treatment of many common immune-mediated diseases.
Abstract | Full Text | PDF
Immune regulation by glucocorticoids
Derek W. Cain & John A. Cidlowski
p233 | doi:10.1038/nri.2017.1
In this Review, the authors discuss the effects of glucocorticoids on both innate and adaptive immunity. They explain the mechanistic basis of glucocorticoid-mediated immunosuppression and highlight the less well-appreciated roles of glucocorticoids in enhancing immune responses.
Abstract | Full Text | PDF
Neutrophils as protagonists and targets in chronic inflammation
Oliver Soehnlein, Sabine Steffens, Andres Hidalgo & Christian Weber
p248 | doi:10.1038/nri.2017.10
Neutrophils are rapidly recruited to tissues in response to injury or infection, and they have mainly been studied in the context of acute inflammation. However, neutrophils can also be important contributors to chronic tissue inflammation. This Review discusses neutrophil function in the context of chronic inflammation and considers the potential of targeting these cells in chronic diseases.
Abstract | Full Text | PDF
Article series: Cell death and immunity
Dying cells actively regulate adaptive immune responses
Nader Yatim, Sean Cullen & Matthew L. Albert
p262 | doi:10.1038/nri.2017.9
This Review provides an overview of the cross-presentation of antigens derived from dead cells and describes how immunological signals from dying cells influence T cell cross-priming. The authors propose a novel classification of the immunogenic signals that arise from dying cells and discuss how different forms of cell death may influence the outcome of cross-presentation.
Abstract | Full Text | PDF
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