Nature Reviews Immunology Contents April 2017 Volume 17 Number 4 pp 215-275

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TABLE OF CONTENTS
April 2017 Volume 17 Number 4		Advertisement
2015 2-year Impact Factor 39.416 Journal Metrics 2-year Median 31	In this issue Research Highlights Reviews Also this month Article series: Cell death and immunity  Featured article: Dysbiosis and the immune system Maayan Levy, Aleksandra A. Kolodziejczyk, Christoph A. Thaiss & Eran Elinav	Nature Reviews Immunology and Nature Reviews Molecular Cell Biology: Poster on Bone marrow niches and HSC fates This poster shows the signalling pathways between stromal and haematopoietic cells of the bone marrow niche that direct the fate of haematopoietic stem cells.  Download Produced with support from STEMCELL Technologies
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RESEARCH HIGHLIGHTS Top T cells: Successful checkpoint blockade requires positive co-stimulation p215 | doi:10.1038/nri.2017.32 PD1 inhibits T cell activation by suppressing co-stimulation through CD28, and anti-PD1 therapy requires CD28 stimulation for therapeutic efficacy. PDF Innate lymphoid cells: Circulating precursor for human ILCs p216 | doi:10.1038/nri.2017.29 James Di Santo and colleagues identify a circulating multipotent precursor for human innate lymphoid cells. PDF Viral infection: The mother of all viruses p216 | doi:10.1038/nri.2017.30 Pregnant mice show weaker immune responses to pandemic strains of influenza virus than non-pregnant mice, and this leads to the emergence of more virulent strains of influenza. PDF Immune regulation: Immune cell social networks p216 | doi:10.1038/nri.2017.31 High-resolution proteomics analysis of human immune cells reveals new social networks and establishes a framework for future study of intercellular communication. PDF JOURNAL CLUB Immunometabolism and the land of milk and honey p217 | doi:10.1038/nri.2017.22 Luke O'Neill describes a 2010 study by Connie Krawczyk, Ed Pearce and colleagues that introduced the Warburg effect to immunologists. PDF HIV: Marking the HIV hideout p218 | doi:10.1038/nri.2017.33 CD32a is a cell surface marker for HIV-infected latent CD4+ T cells. PDF Viral infections: Reinvigorating exhausted T cells in hepatitis B infection p218 | doi:10.1038/nri.2017.35 PDF Nature Reviews Immunology JOBS of the week PhD Scientist – Immunology Vedanta BioSciences Associate Managing Editor - Infectious Diseases, Immunology and Rheumatology EBSCO Health/Dynamed Postdoctoral Position in Cancer Immunology / Immunotherapy Biomedicine, University Hospital Basel Senior Scientist, Immuno Biologics - Immunology Takeda Pharmaceuticals Immunology Research Faculty University of Chicago More Science jobs from Nature Reviews Immunology EVENT Tumor Immunology & Immunotherapy 22.10.17 Suzhou, China More science events from
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REVIEWS		Top
Dysbiosis and the immune system Maayan Levy, Aleksandra A. Kolodziejczyk, Christoph A. Thaiss & Eran Elinav p219 | doi:10.1038/nri.2017.7 An increasing number of multifactorial diseases have been linked to intestinal dysbiosis — that is, changes in the composition and function of the gut microbiome. Here, the authors explore the causes and consequences of dysbiosis, and discuss implications for the aetiology and treatment of many common immune-mediated diseases. Abstract | Full Text | PDF
Immune regulation by glucocorticoids Derek W. Cain & John A. Cidlowski p233 | doi:10.1038/nri.2017.1 In this Review, the authors discuss the effects of glucocorticoids on both innate and adaptive immunity. They explain the mechanistic basis of glucocorticoid-mediated immunosuppression and highlight the less well-appreciated roles of glucocorticoids in enhancing immune responses. Abstract | Full Text | PDF
Neutrophils as protagonists and targets in chronic inflammation Oliver Soehnlein, Sabine Steffens, Andres Hidalgo & Christian Weber p248 | doi:10.1038/nri.2017.10 Neutrophils are rapidly recruited to tissues in response to injury or infection, and they have mainly been studied in the context of acute inflammation. However, neutrophils can also be important contributors to chronic tissue inflammation. This Review discusses neutrophil function in the context of chronic inflammation and considers the potential of targeting these cells in chronic diseases. Abstract | Full Text | PDF
Article series: Cell death and immunity Dying cells actively regulate adaptive immune responses Nader Yatim, Sean Cullen & Matthew L. Albert p262 | doi:10.1038/nri.2017.9 This Review provides an overview of the cross-presentation of antigens derived from dead cells and describes how immunological signals from dying cells influence T cell cross-priming. The authors propose a novel classification of the immunogenic signals that arise from dying cells and discuss how different forms of cell death may influence the outcome of cross-presentation. Abstract | Full Text | PDF
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