Nature Reviews Genetics Contents April 2017 Volume 18 Number 4 pp209-267

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TABLE OF CONTENTS
April 2017 Volume 18 Number 4		Advertisement
2015 2–year Impact Factor 35.898 Journal Metrics 2–year Median 32	In this issue Research Highlights Reviews Perspectives Also this month Article series: Study designs Single-cell omics Translational genetics  Featured article: Evolving health care through personal genomics Heidi L. Rehm	A new open access journal dedicated to publishing the most important scientific advances in all aspects of genomics and its application in the practice of medicine. Part of the Nature Partner Journals series, the journal is published in partnership with the Center of Excellence in Genomic Medicine Research.   Open for submissions >>
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RESEARCH HIGHLIGHTS Top Epigenetics: Rich pore methods for DNA methylation detection p209 | doi:10.1038/nrg.2017.18 PDF Genetic variation: HSP90 shapes human genetic variation p210 | doi:10.1038/nrg.2017.16 PDF Complex traits: Selecting against schooling p210 | doi:10.1038/nrg.2017.9 PDF Technique: Barcoding the nucleus p211 | doi:10.1038/nrg.2017.11 PDF Cancer genomics: ECdetect hunts extrachromosomal DNA p212 | doi:10.1038/nrg.2017.13 PDF Non-coding RNA: Exosomal microRNAs as novel adipokines p212 | doi:10.1038/nrg.2017.14 PDF Genetics JOBS of the week Assistant & Associate Investigator / Professors: Cancer Genetics, Epigenetics and Biomarkers BAYLOR SCOTT & WHITE HEALTH Faculty Position – Department of Genetics and Genome Sciences Case Western Reserve University, School of Medicine 2 PhD Student positions in Cancer Genetics / Biology Klinikum rechts der Isar der Technischen Universität München - II. Medizinische Klinik Postdoctoral Fellowship in Sleep, Chronobiology, Aging, Cognition and Genetics at GIGA-Cyclotron Research Center / In Vivo Imaging GIGA Postdoctoral Position in Developmental Genetics : Institut Curie, Paris, France ERC advanced grant More Science jobs from Genetics EVENT Avian Genetics and Immunity 19.06.17 Surrey, UK More science events from
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REVIEWS		Top
Article series: Study designs The evolution of tumour phylogenetics: principles and practice Russell Schwartz & Alejandro A. Schäffer p213 | doi:10.1038/nrg.2016.170 The use of phylogenetics in cancer genomics is increasing owing to a growing appreciation of the importance of evolutionary theory to cancer progression. The authors provide guidance on the design and analysis of tumour phylogeny studies by surveying the range of phylogenetic methods and tools available to the cancer researcher and discussing their key applications and the unsolved problems in the field. Abstract | Full Text | PDF | Supplementary information
Article series: Single-cell omics Building a lineage from single cells: genetic techniques for cell lineage tracking Mollie B. Woodworth, Kelly M. Girskis & Christopher A. Walsh p230 | doi:10.1038/nrg.2016.159 Lineage analyses of multicellular organisms provide key insights into developmental mechanisms and how these developmental trajectories go awry in diverse diseases. This Review discusses the features, technical challenges and latest opportunities of an evolving range of sophisticated genetic techniques for tracking cell lineages in organisms. These strategies include methods for prospective tracking using engineered genetic constructs, as well as retrospective tracking based on naturally occurring somatic mutations. Abstract | Full Text | PDF
Limb development: a paradigm of gene regulation Florence Petit, Karen E. Sears & Nadav Ahituv p245 | doi:10.1038/nrg.2016.167 Here, the authors review the complex gene regulatory mechanisms that underlie limb development and that determine forelimb versus hindlimb identity. They explain how the modification of these regulatory elements leads to morphological evolution, acquired regeneration capacity or limb malformations in diverse species, including humans. Abstract | Full Text | PDF
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PERSPECTIVES		Top
ESSAY Article series: Translational genetics Evolving health care through personal genomics Heidi L. Rehm p259 | doi:10.1038/nrg.2016.162 The advent of genomic technologies is changing health care systems, with genomic data increasingly being applied to guide individual patient care. In this Essay, Rehm discusses how genomics is becoming an essential part of clinical care and the existing challenges that must be surmounted to take full advantage of personal genomic information. Abstract | Full Text | PDF
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