Wednesday, March 15, 2017

Nature Reviews Genetics Contents April 2017 Volume 18 Number 4 pp209-267

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Nature Reviews Genetics

April 2017 Volume 18 Number 4Advertisement

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2015 2–year Impact Factor 35.898 Journal Metrics 2–year Median 32
In this issue
Research Highlights

Also this month
Article series:
Study designs
Single-cell omics
Translational genetics
 Featured article:
Evolving health care through personal genomics
Heidi L. Rehm

A new open access journal dedicated to publishing the most important scientific advances in all aspects of genomics and its application in the practice of medicine. Part of the Nature Partner Journals series, the journal is published in partnership with the Center of Excellence in Genomic Medicine Research.
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Epigenetics: Rich pore methods for DNA methylation detection
p209 | doi:10.1038/nrg.2017.18

Genetic variation: HSP90 shapes human genetic variation
p210 | doi:10.1038/nrg.2017.16

Complex traits: Selecting against schooling
p210 | doi:10.1038/nrg.2017.9

Technique: Barcoding the nucleus
p211 | doi:10.1038/nrg.2017.11

Cancer genomics: ECdetect hunts extrachromosomal DNA
p212 | doi:10.1038/nrg.2017.13

Non-coding RNA: Exosomal microRNAs as novel adipokines
p212 | doi:10.1038/nrg.2017.14

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Assistant & Associate Investigator / Professors: Cancer Genetics, Epigenetics and Biomarkers
Faculty Position – Department of Genetics and Genome Sciences
Case Western Reserve University, School of Medicine
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Postdoctoral Fellowship in Sleep, Chronobiology, Aging, Cognition and Genetics at GIGA-Cyclotron Research Center / In Vivo Imaging
Postdoctoral Position in Developmental Genetics : Institut Curie, Paris, France
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Article series: Study designs
The evolution of tumour phylogenetics: principles and practice
Russell Schwartz & Alejandro A. Schäffer
p213 | doi:10.1038/nrg.2016.170
The use of phylogenetics in cancer genomics is increasing owing to a growing appreciation of the importance of evolutionary theory to cancer progression. The authors provide guidance on the design and analysis of tumour phylogeny studies by surveying the range of phylogenetic methods and tools available to the cancer researcher and discussing their key applications and the unsolved problems in the field.
Abstract | Full Text | PDF | Supplementary information

Article series: Single-cell omics
Building a lineage from single cells: genetic techniques for cell lineage tracking
Mollie B. Woodworth, Kelly M. Girskis & Christopher A. Walsh
p230 | doi:10.1038/nrg.2016.159
Lineage analyses of multicellular organisms provide key insights into developmental mechanisms and how these developmental trajectories go awry in diverse diseases. This Review discusses the features, technical challenges and latest opportunities of an evolving range of sophisticated genetic techniques for tracking cell lineages in organisms. These strategies include methods for prospective tracking using engineered genetic constructs, as well as retrospective tracking based on naturally occurring somatic mutations.
Abstract | Full Text | PDF

Limb development: a paradigm of gene regulation
Florence Petit, Karen E. Sears & Nadav Ahituv
p245 | doi:10.1038/nrg.2016.167
Here, the authors review the complex gene regulatory mechanisms that underlie limb development and that determine forelimb versus hindlimb identity. They explain how the modification of these regulatory elements leads to morphological evolution, acquired regeneration capacity or limb malformations in diverse species, including humans.
Abstract | Full Text | PDF

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Article series: Translational genetics
Evolving health care through personal genomics
Heidi L. Rehm
p259 | doi:10.1038/nrg.2016.162
The advent of genomic technologies is changing health care systems, with genomic data increasingly being applied to guide individual patient care. In this Essay, Rehm discusses how genomics is becoming an essential part of clinical care and the existing challenges that must be surmounted to take full advantage of personal genomic information.
Abstract | Full Text | PDF

An online-only, open access, multidisciplinary journal dedicated to publishing high-quality original research articles, reviews, editorials, commentaries, and hypothesis generating observations on all areas of breast cancer research. Part of the Nature Partner Journals series, published in partnership with the Breast Cancer Research Foundation.

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