Nature Reviews Cancer contents April 2017 Volume 17 Number 4 pp205-268

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TABLE OF CONTENTS
April 2017 Volume 17 Number 4		Advertisement
2015 2-year Impact Factor 34.244 Journal Metrics 2-year Median 27	In this issue Research Highlights Reviews Perspectives Correspondence Also this month Featured article: Cancer origins  Featured article: Interrogating open issues in cancer precision medicine with patient-derived xenografts Annette T. Byrne, Denis G. Alférez, Frédéric Amant, Daniela Annibali, Joaquín Arribas et al.	Access Free Oncology Journals Click to download sample issues from some of the leading Oncology Journals including: Cancer, CA: A Cancer Journal for Clinicians, Cancer Cytopathology, The Oncologist and The International Journal of Cancer.
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Nature Reviews Clinical Oncology: Poster on Liquid biopsies in the clinic  This poster highlights the emerging developments in the detection and analysis of circulating tumour material, and its use as liquid biopsies at different stages of tumour evolution.  Available to download free online Produced with support from:  Menarini Silicon Biosystems, Inc.
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RESEARCH HIGHLIGHTS Top Cell migration: Shall we travel together? p205 | doi:10.1038/nrc.2017.21 Mechanical coupling of cancer-associated fibroblasts and cancer cells through a heterotypic E-cadherin-N-cadherin adherens junction promotes cancer cell invasion. PDF Immunotherapy: Engineered T cells for all p206 | doi:10.1038/nrc.2017.19 A report in Science Translational Medicine provides the first example of using universal engineered chimeric antigen receptor (CAR) T cells from human leukocyte antigen (HLA)-mismatched donors. PDF Genomics: A different view of the landscape p206 | doi:10.1038/nrc.2017.22 Using data from The Cancer Genome Atlas, Carter et al. find that germline variations can influence tumour sites of origin and somatic mutations. PDF Epigenetics: Addicted to reading p207 | doi:10.1038/nrc.2017.25 Two papers find that the histone acetylation reader function of the YEATS domain of ENL is required to sustain oncogenic transcriptional programmes for the growth and disease maintenance of acute leukaemias. PDF Cancer JOBS of the week Faculty Cancer Biology Wake Forest School of Medicine Post-Doctoral Research Fellow, Pancreatic Cancer Fred Hutchinson Cancer Research Center Assistant Professor / Esophageal Cancer Scientist McGill University Faculty Position in Mechanisms of Genomic Instability and Cellular Aging in Cancer University of Calgary - Cumming School of Medicine Postdoctoral Position in Cancer Immunology / Immunotherapy Biomedicine, University Hospital Basel More Science jobs from Cancer EVENT International Scientific Conference "Normal and cancer stem cells: discovery, diagnosis and therapy 05.10.17 Kyiv, Ukraine More science events from
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MagCapture™ Exosome Isolation Kit PS Wako is has developed an exosome isolation kit using a novel affinity molecule. High yield high purity exosomes can be isolated by PS affinity method. Exosomes can be recovered from culture media containing FBS.
REVIEWS		Top
Targeting neoantigens to augment antitumour immunity Mark Yarchoan et al. p209 | doi:10.1038/nrc.2016.154 In this Review, Yarchoan et al. discuss the potential of targeting tumour-specific antigens (neoantigens) to increase antitumour immunity and present a framework for personalized cancer immunotherapy based on the identification and specific targeting of individual tumour neoantigens. Abstract | Full Text | PDF
Liquid biopsies come of age: towards implementation of circulating tumour DNA Jonathan C. M. Wan et al. p223 | doi:10.1038/nrc.2017.7 Circulating tumour DNA (ctDNA) analysis has the potential to improve prognostication, molecular profiling and disease monitoring in patients with cancer. This Review summarizes recent advances, potential applications in cancer research and personalized oncology, and the introduction of ctDNA into clinical use. Abstract | Full Text | PDF
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PERSPECTIVES		Top
OPINION Article series: Cancer origins Tissue-specific tumorigenesis: context matters Günter Schneider, Marc Schmidt-Supprian, Roland Rad & Dieter Saur p239 | doi:10.1038/nrc.2017.5 In this Opinion article, Schneider et al. outline tissue- and cell type-specific differences in tumorigenesis and the organization of oncogenic signalling pathways, and discuss the implications of our understanding of tissue context on molecularly targeted therapy and clinical trial design. Abstract | Full Text | PDF
OPINION Interrogating open issues in cancer precision medicine with patient-derived xenografts Annette T. Byrne, Denis G. Alférez, Frédéric Amant, Daniela Annibali, Joaquín Arribas, Andrew V. Biankin, Alejandra Bruna, Eva Budinská, Carlos Caldas, David K. Chang, Robert B. Clarke, Hans Clevers, George Coukos, Virginie Dangles-Marie, S. Gail Eckhardt, Eva Gonzalez-Suarez, Els Hermans, Manuel Hidalgo, Monika A. Jarzabek, Steven de Jong, Jos Jonkers, Kristel Kemper, Luisa Lanfrancone, Gunhild Mari Mælandsmo, Elisabetta Marangoni, Jean-Christophe Marine, Enzo Medico, Jens Henrik Norum, Héctor G. Palmer, Daniel S. Peeper, Pier Giuseppe Pelicci, Alejandro Piris-Gimenez, Sergio Roman-Roman, Oscar M. Rueda, Joan Seoane, Violeta Serra, Laura Soucek, Dominique Vanhecke, Alberto Villanueva, Emilie Vinolo, Andrea Bertotti & Livio Trusolino p254 | doi:10.1038/nrc.2016.140 This Opinion article discusses progress and challenges in using patient-derived xenograft (PDX) models in cancer precision medicine. It is primarily co-authored by members of the EurOPDX Consortium and as such highlights the merits of shared PDX resources. Abstract | Full Text | PDF | Supplementary information
Corrigendum: Consensus molecular subtypes and the evolution of precision medicine in colorectal cancer Rodrigo Dienstmann, Louis Vermeulen, Justin Guinney, Scott Kopetz, Sabine Tejpar & Josep Tabernero p268 | doi:10.1038/nrc.2017.24 Full Text | PDF
Corrigendum: A chemical probe toolbox for dissecting the cancer epigenome Jake shortt, Christopher J. Ott, Ricky W. Johnstone & James E. Bradner p268 | doi:10.1038/nrc.2017.26 Full Text | PDF
CORRESPONDENCE		Top
Correspondence: Oncogenic effects of PAFR ligands produced in tumours upon chemotherapy and radiotherapy Roger Chammas, Luciana Nogueira de Sousa Andrade & Sonia Jancar p253 | doi:10.1038/nrc.2017.15 Full Text | PDF
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Reply: Cancer therapy-induced PAFR ligand expression: any role for caspase activity? Gabriel Ichim & Stephen W. G. Tait p253 | doi:10.1038/nrc.2017.16 Full Text | PDF
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