Thursday, March 23, 2017

Nature Reviews Cancer contents April 2017 Volume 17 Number 4 pp205-268

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Nature Reviews Cancer

7 genomic methods that empower immuno-oncology trials

How can genomics provide new insights and shape the success of your immuno-oncology program? 

Download our complimnetary insight brief to learn how genomics-based biomarker approaches, combined with bioinformatics expertise, enhance immuno-oncology programs.
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Featured article:
Cancer origins
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Interrogating open issues in cancer precision medicine with patient-derived xenografts
Annette T. Byrne, Denis G. Alférez, Frédéric Amant, Daniela Annibali, Joaquín Arribas et al.

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Join us May 6-9, 2017 in Boston, MA for this collaborative meeting that will include presentations pertaining to leukemia, lymphoma, myeloma, myelodysplastic syndrome and myeloproliferative neoplasms, spanning the spectrum of cancer science and medicine, from basic science discoveries to their translation in the clinic.... Learn more
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This poster highlights the emerging developments in the detection and analysis of circulating tumour material, and its use as liquid biopsies at different stages of tumour evolution. 

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Cell migration: Shall we travel together?
p205 | doi:10.1038/nrc.2017.21
Mechanical coupling of cancer-associated fibroblasts and cancer cells through a heterotypic E-cadherin-N-cadherin adherens junction promotes cancer cell invasion.

Immunotherapy: Engineered T cells for all
p206 | doi:10.1038/nrc.2017.19
A report in Science Translational Medicine provides the first example of using universal engineered chimeric antigen receptor (CAR) T cells from human leukocyte antigen (HLA)-mismatched donors.

Genomics: A different view of the landscape
p206 | doi:10.1038/nrc.2017.22
Using data from The Cancer Genome Atlas, Carter et al. find that germline variations can influence tumour sites of origin and somatic mutations.

Epigenetics: Addicted to reading
p207 | doi:10.1038/nrc.2017.25
Two papers find that the histone acetylation reader function of the YEATS domain of ENL is required to sustain oncogenic transcriptional programmes for the growth and disease maintenance of acute leukaemias.

JOBS of the week
Faculty Cancer Biology
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MagCapture™ Exosome Isolation Kit PS

Wako is has developed an exosome isolation kit using a novel affinity molecule. High yield high purity exosomes can be isolated by PS affinity method. Exosomes can be recovered from culture media containing FBS.
Targeting neoantigens to augment antitumour immunity
Mark Yarchoan et al.
p209 | doi:10.1038/nrc.2016.154
In this Review, Yarchoan et al. discuss the potential of targeting tumour-specific antigens (neoantigens) to increase antitumour immunity and present a framework for personalized cancer immunotherapy based on the identification and specific targeting of individual tumour neoantigens.
Abstract | Full Text | PDF

Liquid biopsies come of age: towards implementation of circulating tumour DNA
Jonathan C. M. Wan et al.
p223 | doi:10.1038/nrc.2017.7
Circulating tumour DNA (ctDNA) analysis has the potential to improve prognostication, molecular profiling and disease monitoring in patients with cancer. This Review summarizes recent advances, potential applications in cancer research and personalized oncology, and the introduction of ctDNA into clinical use.
Abstract | Full Text | PDF

NEW JOURNAL! The Annual Review of Cancer Biology, Volume 1 is now available online, and reviews a range of subjects in cancer research representing important and emerging areas in the field. Free online access to this journal is available for six months with access code: CAONL2017.

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Article series: Cancer origins
Tissue-specific tumorigenesis: context matters
Günter Schneider, Marc Schmidt-Supprian, Roland Rad & Dieter Saur
p239 | doi:10.1038/nrc.2017.5
In this Opinion article, Schneider et al. outline tissue- and cell type-specific differences in tumorigenesis and the organization of oncogenic signalling pathways, and discuss the implications of our understanding of tissue context on molecularly targeted therapy and clinical trial design.
Abstract | Full Text | PDF

Interrogating open issues in cancer precision medicine with patient-derived xenografts
Annette T. Byrne, Denis G. Alférez, Frédéric Amant, Daniela Annibali, Joaquín Arribas, Andrew V. Biankin, Alejandra Bruna, Eva Budinská, Carlos Caldas, David K. Chang, Robert B. Clarke, Hans Clevers, George Coukos, Virginie Dangles-Marie, S. Gail Eckhardt, Eva Gonzalez-Suarez, Els Hermans, Manuel Hidalgo, Monika A. Jarzabek, Steven de Jong, Jos Jonkers, Kristel Kemper, Luisa Lanfrancone, Gunhild Mari Mælandsmo, Elisabetta Marangoni, Jean-Christophe Marine, Enzo Medico, Jens Henrik Norum, Héctor G. Palmer, Daniel S. Peeper, Pier Giuseppe Pelicci, Alejandro Piris-Gimenez, Sergio Roman-Roman, Oscar M. Rueda, Joan Seoane, Violeta Serra, Laura Soucek, Dominique Vanhecke, Alberto Villanueva, Emilie Vinolo, Andrea Bertotti & Livio Trusolino
p254 | doi:10.1038/nrc.2016.140
This Opinion article discusses progress and challenges in using patient-derived xenograft (PDX) models in cancer precision medicine. It is primarily co-authored by members of the EurOPDX Consortium and as such highlights the merits of shared PDX resources.
Abstract | Full Text | PDF | Supplementary information

Corrigendum: Consensus molecular subtypes and the evolution of precision medicine in colorectal cancer
Rodrigo Dienstmann, Louis Vermeulen, Justin Guinney, Scott Kopetz, Sabine Tejpar & Josep Tabernero
p268 | doi:10.1038/nrc.2017.24
Full Text | PDF
Corrigendum: A chemical probe toolbox for dissecting the cancer epigenome
Jake shortt, Christopher J. Ott, Ricky W. Johnstone & James E. Bradner
p268 | doi:10.1038/nrc.2017.26
Full Text | PDF

Correspondence: Oncogenic effects of PAFR ligands produced in tumours upon chemotherapy and radiotherapy
Roger Chammas, Luciana Nogueira de Sousa Andrade & Sonia Jancar
p253 | doi:10.1038/nrc.2017.15
Full Text | PDF
Reply: Cancer therapy-induced PAFR ligand expression: any role for caspase activity?
Gabriel Ichim & Stephen W. G. Tait
p253 | doi:10.1038/nrc.2017.16
Full Text | PDF
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