Nature Immunology Contents: April 2017 Volume 18 pp 365 - 474

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Advertisement Nature Reviews Immunology and Nature Reviews Molecular Cell Biology: Poster on Bone marrow niches and HSC fates This poster shows the signalling pathways between stromal and haematopoietic cells of the bone marrow niche that direct the fate of haematopoietic stem cells.  Download Produced with support from  STEMCELL Technologies TABLE OF CONTENTS April 2017 Volume 18, Issue 4 News and Views Research Highlights Reviews Articles Resource Corrigenda Errata Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement Looking to recruit? Limited time offer from Naturejobs:  Get a 20% discount on our Premium job posting package when you buy before March 31, 2017. Reach a potential audience of 10.8 million users* via nature.com Be seen first by candidates — your position will appear at the top of related searches for 60 days and be displayed prominently on the Naturejobs home page as Job of the Week. Plus appear as 'Featured' in search results Post a job now. * Publisher data 2016     News and Views Top To B-1 or not to B-1   pp365 - 366 Henry H Wortis doi:10.1038/ni.3715 The transcription factor Bhlhe41 determines the survival and repertoire of B-1a cells. See also: Article by Kreslavsky et al. Quantifying the shifting landscape of B cell immunodominance   pp367 - 368 Gordon A Dale, Jessica R Shartouny and Joshy Jacob doi:10.1038/ni.3695 Antibodies to neutralizing epitopes on hemagglutinin exhibit reproducible dynamic immunodominance patterns over time. Early responses target largely the Cb site, followed by Sb dominance and a concomitant rise in the diversity of neutralizing-antibody specificities. See also: Article by Angeletti et al. THEMIS-tery is solved   pp368 - 370 David L Wiest doi:10.1038/ni.3708 THEMIS, the enigmatic regulator of T cell selection in the thymus, controls selection by oxidizing and suppressing the activity of the tyrosine phosphatase SHP-1. See also: Article by Choi et al. γδ T cells get adaptive   pp370 - 372 Bruno Silva-Santos and Jessica Strid doi:10.1038/ni.3705 Throughout ontogeny, the γδ TCR repertoire in human blood becomes less diverse and more focused, yet is private in nature, and specific adult γδ T cell subsets undergo substantial clonal expansion after challenge with cytomegalovirus. See also: Article by Ravens et al. Immunology JOBS of the week Post-Doctoral Research Fellow, Statistical Methods Development Fred Hutchinson Cancer Research Center Experienced International Researcher LE STUDIUM LOIRE VALLEY INSTITUTE FOR ADVANCED STUDIES PostDoc Investigating Ladderane Lipid Biosynthesis Max Planck Institute for Medical Research Postdoctoral Fellow Vacancy - Interfacial Lab King Abdullah University of Science and Technology (KAUST) Senior Scientist Computational Toxicologist-Toxicokinetics Philip Morris International (PMI) More Science jobs from Immunology EVENT NETTAB 2017 Methods, tools & platforms for Personalized Medicine in the Big Data Era 16.10.17 Palermo, Italy More science events from Research Highlights Top CD6 targeting | Maintaining TRM cells | Importing material | Atherosclerosis-prone HSCs | Antimicrobial IL-22 | Adipose-tissue ILCs Reviews Top Mechanisms and consequences of Jak-STAT signaling in the immune system   pp374 - 384 Alejandro V Villarino, Yuka Kanno and John J O'Shea doi:10.1038/ni.3691 O/'Shea and colleagues review recent advances in Jak–STAT biology, focusing on immune cell function, disease etiology and therapeutic intervention, as well as broader principles of gene regulation and signal-dependent transcription factors. Ontogeny and homeostasis of CNS myeloid cells   pp385 - 392 Marco Prinz, Daniel Erny and Nora Hagemeyer doi:10.1038/ni.3703 Microglia are by far the best-characterized macrophages in the CNS, but non-parenchymal populations, such as those found in the meninges, are being increasingly studied. Prinz et al. review the ontogeny and functions of both parenchymal macrophages and non-parenchymal macrophages the CNS. Advertisement An open access, online-only, multidisciplinary research journal dedicated to publishing the most important scientific advances in the life sciences, physical sciences, and engineering fields that are facilitated by spaceflight and analogue platforms.   Explore the benefits of submitting your next research article.   Articles Top Human γδ T cells are quickly reconstituted after stem-cell transplantation and show adaptive clonal expansion in response to viral infection   pp393 - 401 Sarina Ravens, Christian Schultze-Florey, Solaiman Raha, Inga Sandrock, Melanie Drenker et al. doi:10.1038/ni.3686 γδ T cells are generally understood to be innate lymphocytes. Prinz and colleagues show that human γδ T cells reconstituted after bone-marrow transplantation have a distinct repertoire that can be shaped by infection with cytomegalovirus, which suggests features of adaptive immunity. See also: News and Views by Silva-Santos & Strid Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells   pp402 - 411 Andrew N Keller, Sidonia B G Eckle, Weijun Xu, Ligong Liu, Victoria A Hughes et al. doi:10.1038/ni.3679 Mucosal-associated invariant T cells recognize vitamin-B-derived ligands presented via the major-histocompatibility-complex-like molecule MR1. Rossjohn and colleagues demonstrate that these cells recognize a wide variety of ligands, some derived from common drugs, in an agonist or antagonist manner. Critical role of IRF1 and BATF in forming chromatin landscape during type 1 regulatory cell differentiation   pp412 - 421 Katarzyna Karwacz, Emily R Miraldi, Maria Pokrovskii, Asaf Madi, Nir Yosef et al. doi:10.1038/ni.3683 Tr1 cells have potent regulatory effects in vitro and in vivo. Kuchroo and colleagues comprehensively describe the epigenetic, transcriptional and gene regulatory landscape that is essential for Tr1 cell differentiation. Early transcriptional and epigenetic regulation of CD8+ T cell differentiation revealed by single-cell RNA sequencing   pp422 - 432 Boyko Kakaradov, Janilyn Arsenio, Christella E Widjaja, Zhaoren He, Stefan Aigner et al. doi:10.1038/ni.3688 CD8+ T cells rapidly commence transcriptional changes after antigenic encounter and priming. Yeo and colleagues find substantial transcriptional heterogeneity among responding lymphocytes, particularly at the first division, that influences cell fate. THEMIS enhances TCR signaling and enables positive selection by selective inhibition of the phosphatase SHP-1   pp433 - 441 Seeyoung Choi, Claude Warzecha, Ekaterina Zvezdova, Jan Lee, Jérémy Argenty et al. doi:10.1038/ni.3692 Love and colleagues show that THEMIS enhances the TCR signaling response to low-affinity ligands by inhibiting the tyrosine-phosphatase activity of SHP-1. See also: News and Views by Wiest Essential role for the transcription factor Bhlhe41 in regulating the development, self-renewal and BCR repertoire of B-1a cells   pp442 - 455 Taras Kreslavsky, Bojan Vilagos, Hiromi Tagoh, Daniela Kostanova Poliakova, Tanja A Schwickert et al. doi:10.1038/ni.3694 B-1a B cells are a distinct subset of mature B cells that provide innate-like protection against pathogens. Busslinger and colleagues identify the transcription factor Bhlhe41 as being essential for B-1a development and self-renewal. See also: News and Views by Wortis Defining B cell immunodominance to viruses   pp456 - 463 Davide Angeletti, James S Gibbs, Matthew Angel, Ivan Kosik, Heather D Hickman et al. doi:10.1038/ni.3680 Antigenic epitopes differ in their immunogenicity. Yewdell and colleagues show that B cell and antibody responses to influenza A virus infection display reproducible dynamic immunodominance hierarchies to viral hemagglutinin epitopes. See also: News and Views by Dale et al. Advertisement Online-only and open access, npj Primary Care Respiratory Medicine is the only fully-indexed scientific journal devoted to the management of respiratory diseases in primary care. Explore the benefits of submitting your next research article.   Resource Top Defining the antibody cross-reactome directed against the influenza virus surface glycoproteins   pp464 - 473 Raffael Nachbagauer, Angela Choi, Ariana Hirsh, Irina Margine, Sayaka Iida et al. doi:10.1038/ni.3684 Antigenic drift and reassortment alters the epitopes of influenza virus. Krammer and colleagues reveal the cross-reactivity of antibody responses to viral hemagglutinin and neuraminidase in humans and several animal models, but the most prominent responses reflect 'original antigenic sin' to viral exposure. Corrigenda Top Corrigendum: Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia   p474 Jing Fang, Lyndsey C Bolanos, Kwangmin Choi, Xiaona Liu, Susanne Christie et al. doi:10.1038/ni0417-474a Corrigendum: Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells   p474 Sylvia Heink, Nir Yogev, Christoph Garbers, Marina Herwerth, Lilian Aly et al. doi:10.1038/ni0417-474b Errata Top Erratum: HIV-1 blocks the signaling adaptor MAVS to evade antiviral host defense after sensing of abortive HIV-1 RNA by the host helicase DDX3   p474 Sonja I Gringhuis, Nina Hertoghs, Tanja M Kaptein, Esther M Zijlstra-Willems, Ramin Sarrami-Fooroshani et al. doi:10.1038/ni0417-474c Erratum: Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment   p474 Yohko Kitagawa, Naganari Ohkura, Yujiro Kidani, Alexis Vandenbon, Keiji Hirota et al. doi:10.1038/ni0417-474d Top Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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