Quantifying the shifting landscape of B cell immunodominance pp367 - 368 Gordon A Dale, Jessica R Shartouny and Joshy Jacob doi:10.1038/ni.3695 Antibodies to neutralizing epitopes on hemagglutinin exhibit reproducible dynamic immunodominance patterns over time. Early responses target largely the Cb site, followed by Sb dominance and a concomitant rise in the diversity of neutralizing-antibody specificities.
THEMIS-tery is solved pp368 - 370 David L Wiest doi:10.1038/ni.3708 THEMIS, the enigmatic regulator of T cell selection in the thymus, controls selection by oxidizing and suppressing the activity of the tyrosine phosphatase SHP-1.
γδ T cells get adaptive pp370 - 372 Bruno Silva-Santos and Jessica Strid doi:10.1038/ni.3705 Throughout ontogeny, the γδ TCR repertoire in human blood becomes less diverse and more focused, yet is private in nature, and specific adult γδ T cell subsets undergo substantial clonal expansion after challenge with cytomegalovirus.
Ontogeny and homeostasis of CNS myeloid cells pp385 - 392 Marco Prinz, Daniel Erny and Nora Hagemeyer doi:10.1038/ni.3703 Microglia are by far the best-characterized macrophages in the CNS, but non-parenchymal populations, such as those found in the meninges, are being increasingly studied. Prinz et al. review the ontogeny and functions of both parenchymal macrophages and non-parenchymal macrophages the CNS.
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Defining B cell immunodominance to viruses pp456 - 463 Davide Angeletti, James S Gibbs, Matthew Angel, Ivan Kosik, Heather D Hickman et al. doi:10.1038/ni.3680 Antigenic epitopes differ in their immunogenicity. Yewdell and colleagues show that B cell and antibody responses to influenza A virus infection display reproducible dynamic immunodominance hierarchies to viral hemagglutinin epitopes.
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