Tuesday, March 21, 2017

Nature Immunology Contents: April 2017 Volume 18 pp 365 - 474

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Nature Immunology

Nature Reviews Immunology and Nature Reviews Molecular Cell Biology: Poster on Bone marrow niches and HSC fates

This poster shows the signalling pathways between stromal and haematopoietic cells of the bone marrow niche that direct the fate of haematopoietic stem cells. 


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April 2017 Volume 18, Issue 4

News and Views
Research Highlights

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News and Views


To B-1 or not to B-1   pp365 - 366
Henry H Wortis
The transcription factor Bhlhe41 determines the survival and repertoire of B-1a cells.

See also: Article by Kreslavsky et al.

Quantifying the shifting landscape of B cell immunodominance   pp367 - 368
Gordon A Dale, Jessica R Shartouny and Joshy Jacob
Antibodies to neutralizing epitopes on hemagglutinin exhibit reproducible dynamic immunodominance patterns over time. Early responses target largely the Cb site, followed by Sb dominance and a concomitant rise in the diversity of neutralizing-antibody specificities.

See also: Article by Angeletti et al.

THEMIS-tery is solved   pp368 - 370
David L Wiest
THEMIS, the enigmatic regulator of T cell selection in the thymus, controls selection by oxidizing and suppressing the activity of the tyrosine phosphatase SHP-1.

See also: Article by Choi et al.

γδ T cells get adaptive   pp370 - 372
Bruno Silva-Santos and Jessica Strid
Throughout ontogeny, the γδ TCR repertoire in human blood becomes less diverse and more focused, yet is private in nature, and specific adult γδ T cell subsets undergo substantial clonal expansion after challenge with cytomegalovirus.

See also: Article by Ravens et al.

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Research Highlights


CD6 targeting | Maintaining TRM cells | Importing material | Atherosclerosis-prone HSCs | Antimicrobial IL-22 | Adipose-tissue ILCs



Mechanisms and consequences of Jak-STAT signaling in the immune system   pp374 - 384
Alejandro V Villarino, Yuka Kanno and John J O'Shea
O/'Shea and colleagues review recent advances in Jak–STAT biology, focusing on immune cell function, disease etiology and therapeutic intervention, as well as broader principles of gene regulation and signal-dependent transcription factors.

Ontogeny and homeostasis of CNS myeloid cells   pp385 - 392
Marco Prinz, Daniel Erny and Nora Hagemeyer
Microglia are by far the best-characterized macrophages in the CNS, but non-parenchymal populations, such as those found in the meninges, are being increasingly studied. Prinz et al. review the ontogeny and functions of both parenchymal macrophages and non-parenchymal macrophages the CNS.

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Human γδ T cells are quickly reconstituted after stem-cell transplantation and show adaptive clonal expansion in response to viral infection   pp393 - 401
Sarina Ravens, Christian Schultze-Florey, Solaiman Raha, Inga Sandrock, Melanie Drenker et al.
γδ T cells are generally understood to be innate lymphocytes. Prinz and colleagues show that human γδ T cells reconstituted after bone-marrow transplantation have a distinct repertoire that can be shaped by infection with cytomegalovirus, which suggests features of adaptive immunity.

See also: News and Views by Silva-Santos & Strid

Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells   pp402 - 411
Andrew N Keller, Sidonia B G Eckle, Weijun Xu, Ligong Liu, Victoria A Hughes et al.
Mucosal-associated invariant T cells recognize vitamin-B-derived ligands presented via the major-histocompatibility-complex-like molecule MR1. Rossjohn and colleagues demonstrate that these cells recognize a wide variety of ligands, some derived from common drugs, in an agonist or antagonist manner.

Critical role of IRF1 and BATF in forming chromatin landscape during type 1 regulatory cell differentiation   pp412 - 421
Katarzyna Karwacz, Emily R Miraldi, Maria Pokrovskii, Asaf Madi, Nir Yosef et al.
Tr1 cells have potent regulatory effects in vitro and in vivo. Kuchroo and colleagues comprehensively describe the epigenetic, transcriptional and gene regulatory landscape that is essential for Tr1 cell differentiation.

Early transcriptional and epigenetic regulation of CD8+ T cell differentiation revealed by single-cell RNA sequencing   pp422 - 432
Boyko Kakaradov, Janilyn Arsenio, Christella E Widjaja, Zhaoren He, Stefan Aigner et al.
CD8+ T cells rapidly commence transcriptional changes after antigenic encounter and priming. Yeo and colleagues find substantial transcriptional heterogeneity among responding lymphocytes, particularly at the first division, that influences cell fate.

THEMIS enhances TCR signaling and enables positive selection by selective inhibition of the phosphatase SHP-1   pp433 - 441
Seeyoung Choi, Claude Warzecha, Ekaterina Zvezdova, Jan Lee, Jérémy Argenty et al.
Love and colleagues show that THEMIS enhances the TCR signaling response to low-affinity ligands by inhibiting the tyrosine-phosphatase activity of SHP-1.

See also: News and Views by Wiest

Essential role for the transcription factor Bhlhe41 in regulating the development, self-renewal and BCR repertoire of B-1a cells   pp442 - 455
Taras Kreslavsky, Bojan Vilagos, Hiromi Tagoh, Daniela Kostanova Poliakova, Tanja A Schwickert et al.
B-1a B cells are a distinct subset of mature B cells that provide innate-like protection against pathogens. Busslinger and colleagues identify the transcription factor Bhlhe41 as being essential for B-1a development and self-renewal.

See also: News and Views by Wortis

Defining B cell immunodominance to viruses   pp456 - 463
Davide Angeletti, James S Gibbs, Matthew Angel, Ivan Kosik, Heather D Hickman et al.
Antigenic epitopes differ in their immunogenicity. Yewdell and colleagues show that B cell and antibody responses to influenza A virus infection display reproducible dynamic immunodominance hierarchies to viral hemagglutinin epitopes.

See also: News and Views by Dale et al.

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Defining the antibody cross-reactome directed against the influenza virus surface glycoproteins   pp464 - 473
Raffael Nachbagauer, Angela Choi, Ariana Hirsh, Irina Margine, Sayaka Iida et al.
Antigenic drift and reassortment alters the epitopes of influenza virus. Krammer and colleagues reveal the cross-reactivity of antibody responses to viral hemagglutinin and neuraminidase in humans and several animal models, but the most prominent responses reflect 'original antigenic sin' to viral exposure.



Corrigendum: Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia   p474
Jing Fang, Lyndsey C Bolanos, Kwangmin Choi, Xiaona Liu, Susanne Christie et al.

Corrigendum: Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells   p474
Sylvia Heink, Nir Yogev, Christoph Garbers, Marina Herwerth, Lilian Aly et al.



Erratum: HIV-1 blocks the signaling adaptor MAVS to evade antiviral host defense after sensing of abortive HIV-1 RNA by the host helicase DDX3   p474
Sonja I Gringhuis, Nina Hertoghs, Tanja M Kaptein, Esther M Zijlstra-Willems, Ramin Sarrami-Fooroshani et al.

Erratum: Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment   p474
Yohko Kitagawa, Naganari Ohkura, Yujiro Kidani, Alexis Vandenbon, Keiji Hirota et al.

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