Wednesday, March 29, 2017

Nature contents: 30 March 2017

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  journal cover  
Nature Volume 543 Issue 7647
This Week  
Trump’s pipeline permit is bad for both the US economy and the environment
The US president’s approval of a controversial oil pipeline offers a disturbing glimpse of the future. But he will struggle to get things all his own way.
Forensics: Germany considers wider use of DNA evidence in criminal cases
The country may lift its ban on the analysis of gene-coding regions in DNA samples.
An early start on tackling childhood cancers
The most vulnerable cancer patients are drawing the attention they deserve.
World View  
Brexit must preserve advisory networks
Policymakers in charge of the United Kingdom’s withdrawal from the European Union have a duty to maintain benefits of collaboration, says James Wilsdon.
Seven Days  
Brexit triggered, preprint push and a stem-cell first
The week in science: 24–30 March 2017.
Research Highlights  
Animal behaviour: Playful call makes parrots merry | Planetary Science: Titan's electrified dunes | Molecular Biology: Drug stalls protein translation | Evolution: Diet drives primate brain size | Ageing: Senescent cells cleared out | Cancer: How fat boosts breast cancer | Astronomy: Landslides cause comet eruptions | Seismology: Quake shows rare complexity | Virology: What makes bird flu jump species?
News in Focus
Battle between quantum and thermodynamic laws heats up
Physicists try to rebuild the laws of heat and energy for processes at a quantum scale.
Davide Castelvecchi
  Canada budget falls flat with scientists
Emphasis on innovation overshadowed by funding freeze for key research councils.
Nicola Jones
Gates Foundation announces open-access publishing venture
Global health charity is latest funder to start its own publishing ‘channel’ — and the European Commission is considering its own service.
Declan Butler
  How Brexit is changing the lives of eight researchers
The months between the Brexit vote and this week's triggering of Article 50 have been a turbulent time for scientists — and things show no sign of calming.
Alison Abbott, Ewen Callaway, Daniel Cressey et al.
Election chaos at Russian Academy of Sciences
Beleaguered institution cancels presidential election two days before vote, and appoints acting chief.
Olga Dobrovidova
  Biological underpinnings of chronic fatigue syndrome begin to emerge
Gut bacteria and altered metabolic pathways are suspects in mysterious disease.
Amy Maxmen
How giant marine reptiles terrorized the ancient seas
Ichthyosaurs were some of the largest and most mysterious predators to ever prowl the oceans. Now they are giving up their secrets.
Traci Watson
Cruel fusion: What a young man’s death means for childhood cancer
Epigenetic discoveries are fuelling renewed interest in the fusion proteins that have bedevilled cancer biologists.
Heidi Ledford
Nature Podcast: 30 March 2017
This week, mapping sound in the brain, dwindling groundwater, and giving common iron uncommon properties.
Nature Extra: Backchat March 2017
A sting operation finds several predatory journals offered to employ a fictional, unqualified academic as an editor. Plus, the Great Barrier Reef in hot water, and trying to explain 'time crystals'.

The Gairdner Foundation is pleased to announce the 2017 Canada Gairdner Award laureates. The Canada Gairdner Awards have become widely recognized as one of the most prestigious medical prizes and this years' laureates include a remarkable representation of basic and translational research that is saving millions of lives worldwide.
Remember why we work on cancer
Levi Garraway reflects on the three things that keep his compass true when the going gets tough.
Levi Garraway
Five ways consortia can catalyse open science
An analysis of more than 50 collaborations shows the secrets of success, write Joel Cutcher-Gershenfeld and colleagues from the Stakeholder Alignment Collaborative.
Joel Cutcher-Gershenfeld, Karen S. Baker, Nicholas Berente et al.
Books and Arts  
Natural history: Backstage at the museum
Richard Fortey questions the level of derring-do in an account of the life curatorial.
Richard Fortey
Metascience: Reproducibility blues
Marcus Munafò enjoys a stinging survey of unreliable findings in biomedical research.
Marcus Munafò
Language: Points, grunts and speaks
Mark Pagel weighs up a study claiming that the origins of human language are rooted in gesture.
Mark Pagel
Books in brief
Barbara Kiser reviews five of the week's best science picks.
Barbara Kiser
Science communication: Take rural road trips to promote science
Adam Moreno, Christine S. Olsen
  Humanities: Blind spot in the March for Science
Alex Holznienkemper
Biosafety: National biosafety standards differ
Frank Alexander Hamill
  Animal welfare: Make animal models more meaningful
Garet Lahvis
Diversity: Boost diversity in biomedical research
Michael V. Drake
Kenneth J. Arrow (1921–2017)
One of the most influential thinkers in economic theory.
Kumaraswamy Velupillai
Cancer: Imaging with antibodies
Innovative techniques are giving researchers unprecedented access to the inner workings of the immune system.
Rosie Mestel
Outlook: Animal health  
Animal health
Herb Brody
  Pets: Millennia together
Rosie Mestel
Environment: Hothouse of disease
Emily Sohn
  Perspective: The one-health way
Laura H. Kahn
Microbiome: Puppy power
Sujata Gupta
  Dogs: The riddle of resistance
Michael Eisenstein
Parasites: Kitty carriers
Sarah DeWeerdt
  Climate change: As the ice melts
Elie Dolgin
Ebola: The great ape gamble
Cassandra Willyard
Biomechanics: The aerodynamics buzz from mosquitoes
Mosquitoes flap their long, thin wings four times faster than similarly sized insects. Imaging and computational analysis of mosquito flight illuminates some aerodynamic mechanisms not seen before in animal flight.
In-crystal reaction cycle of a toluene-bound diiron hydroxylase
Crystal structures and DFT calculations suggest a possible mechanism for diiron enzyme arene hydroxylation.
A B12-dependent radical SAM enzyme involved in oxetanocin A biosynthesis
The biosynthesis of oxetanocin A involves OxsB, a B12-dependent S-adenosylmethionine radical enzyme, which catalyses an unusual ring contraction of a 2′-deoxyadenosine phosphate.
Myeloid progenitor cluster formation drives emergency and leukaemic myelopoiesis
During emergency myelopoiesis in mice, clusters of self-renewing granulocyte/macrophage progenitors (GMP) are transiently formed in the bone marrow cavity to produce a burst of myeloid cells; in leukaemia, GMP clusters persist and constantly generate myeloid leukaemia cells.
Postsynaptic synaptotagmins mediate AMPA receptor exocytosis during LTP
Postsynaptic synaptotagmin-1 and synaptotagmin-7 mediate calcium-dependent exocytosis of AMPA receptors during long-term potentiation.
Visualization and targeting of LGR5+ human colon cancer stem cells
Optically excited structural transition in atomic wires on surfaces at the quantum limit
A structural transition in an atomic indium wire on a silicon substrate proceeds as fast as the indium atom vibrations and is facilitated by strong In–Si interface bonds.
Star formation inside a galactic outflow
Star formation at a rate of more than 15 solar masses a year has been observed inside a massive outflow of gas from a nearby galaxy; this could also be happening inside other galactic outflows.
Single-nucleus Hi-C reveals unique chromatin reorganization at oocyte-to-zygote transition
Using a single-nucleus Hi-C protocol, the authors find that spatial organization of chromatin during oocyte-to-zygote transition differs between paternal and maternal nuclei within a single-cell zygote.
DHX9 suppresses RNA processing defects originating from the Alu invasion of the human genome
In the absence of DHX9, circular RNAs accumulate and transcription and translation are dysregulated—effects that are exacerbated by concomitant depletion of the RNA-editing enzyme ADAR.
CRISPR–Cas systems exploit viral DNA injection to establish and maintain adaptive immunity
Analysis of spacer acquisition in Staphylococcus aureus reveals that type II CRISPR–Cas systems exploit viral DNA injection to ensure a successful CRISPR immune response.
Evolutionary dynamics on any population structure
The authors derive a condition for how natural selection chooses between two competing strategies on any graph for weak selection, elucidating which population structures promote certain behaviours, such as cooperation.
Smart wing rotation and trailing-edge vortices enable high frequency mosquito flight
In addition to generating lift by leading-edge vortices (as used by most insects), mosquitoes also employ trailing-edge vortices and a lift mechanism from wing rotation, which enables them to stay airborne despite having a seemingly unlikely airframe.
Corrigendum: Carcinoma–astrocyte gap junctions promote brain metastasis by cGAMP transfer
News and Views  
Cancer: Tumour stem-cell surprises
Florian R. Greten
Inorganic chemistry: Making iron glow
Felix N. Castellano
In Retrospect: Forty years of cellular clues from worms
Paul W. Sternberg
Seeking truth and pursuing innovation
Publishing Date: Mar 30th, 2016
Marine conservation: How to heal an ocean
Boris Worm
Neuroscience: Auditory landscape on the cognitive map
Jon W. Rueckemann, Elizabeth A. Buffalo
Environmental science: Eating ourselves dry
Maite M. Aldaya
Cancer therapy: The leukaemia epigenome targeted
Julie-Aurore Losman
Planetary science: Reckless orbiting in the Solar System
Helena Morais, Fathi Namouni
Exploiting non-covalent π interactions for catalyst design
Our increasing understanding of non-covalent interactions involving aromatic systems is reviewed, and the use of these insights in the design of small-molecule catalysts and enzymes is surveyed.
Andrew J. Neel, Margaret J. Hilton, Matthew S. Sigman et al.
Using coherence to enhance function in chemical and biophysical systems
Coherence observed in chemical and biological systems suggests that even in the presence of disorder and noise the phenomenon may yield transformative ways for improving function.
Gregory D. Scholes, Graham R. Fleming, Lin X. Chen et al.
Functional materials discovery using energy–structure–function maps
Energy–structure–function maps that describe the possible structures and properties of molecular crystals are developed, and these maps are used to guide the experimental discovery of porous materials with specific functions.
Angeles Pulido, Linjiang Chen, Tomasz Kaczorowski et al.
Capacity shortfalls hinder the performance of marine protected areas globally
Although 71% of marine protected areas are benefiting fish populations, their effects are highly variable, with staff capacity proving to be the most important explanatory variable.
David A. Gill, Michael B. Mascia, Gabby N. Ahmadia et al.
Neural ensemble dynamics underlying a long-term associative memory
Use of a head-mounted miniature microscope in awake, behaving mice reveals that neural ensembles in the basal and lateral amygdala encode associations between conditioned and unconditioned stimuli in a way that matches models of supervised learning.
Benjamin F. Grewe, Jan Gründemann, Lacey J. Kitch et al.
A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer
Ablation of Lgr5+ cancer stem cells does not result in regression of primary colorectal tumours, but prevents the formation and maintenance of metastasis in the liver.
Felipe de Sousa e Melo, Antonina V. Kurtova, Jonathan M. Harnoss et al.
LACTB is a tumour suppressor that modulates lipid metabolism and cell state
LACTB modulates mitochondrial lipid metabolism and changes the differentiation state of breast cancer cells, thereby negatively affecting the growth of various tumorigenic, but not non-tumorigenic, cells both in vitro and in vivo.
Zuzana Keckesova, Joana Liu Donaher, Jasmine De Cock et al.
Ultra-selective high-flux membranes from directly synthesized zeolite nanosheets
A direct synthesis of high-aspect-ratio microporous zeolite nanosheets and the use of such nanosheets in separation membranes are described.
Mi Young Jeon, Donghun Kim, Prashant Kumar et al.
Groundwater depletion embedded in international food trade
Global food consumption drives irrigation for crops, which depletes aquifers in some regions; here we quantify the volumes of groundwater depletion associated with global food production and international trade.
Carole Dalin, Yoshihide Wada, Thomas Kastner et al.
Somatic mutations reveal asymmetric cellular dynamics in the early human embryo
Whole-genome sequencing of normal blood cells sampled from 241 adults is used to infer mosaic point mutations that are likely to have arisen during early embryogenesis, providing insight into how early cellular dynamics may affect adult tissues.
Young Seok Ju, Inigo Martincorena, Moritz Gerstung et al.
A retrograde co-orbital asteroid of Jupiter
Asteroid 2015 BZ509 is a retrograde co-orbital asteroid of the planet Jupiter, stably orbiting in a sense opposite to that of Jupiter’s orbit around the Sun for around a million years.
Paul Wiegert, Martin Connors, Christian Veillet
A low-spin Fe(iii) complex with 100-ps ligand-to-metal charge transfer photoluminescence
An iron complex is described that exhibits photoluminescence at room temperature, opening the way to the use of iron-based materials as low-cost, non-toxic light emitters and photosensitizers.
Pavel Chábera, Yizhu Liu, Om Prakash et al.
Transboundary health impacts of transported global air pollution and international trade
The transboundary health impacts of air pollution associated with the international trade of goods and services are greater than those associated with long-distance atmospheric pollutant transport.
Qiang Zhang, Xujia Jiang, Dan Tong et al.
The true tempo of evolutionary radiation and decline revealed on the Hawaiian archipelago
A geologically informed model of the relationship between changing island area and species richness for the Hawaiian archipelago reveals the rates of species richness change for 14 endemic groups over their entire evolutionary histories without the need for fossil data or molecular phylogenies.
Jun Y. Lim, Charles R. Marshall
Mapping of a non-spatial dimension by the hippocampal–entorhinal circuit
Cells in the hippocampal–entorhinal circuit, which fire in response to navigational variables such as location or speed, are shown also to encode continuous, task-relevant but non-spatial variables such as sound frequency.
Dmitriy Aronov, Rhino Nevers, David W. Tank
Antigen presentation profiling reveals recognition of lymphoma immunoglobulin neoantigens
Evidence for the abundant presentation of class II neoantigens by a human B-cell lymphoma.
Michael S. Khodadoust, Niclas Olsson, Lisa E. Wagar et al.
Effective combinatorial immunotherapy for castration-resistant prostate cancer
A new chimaeric mouse model of metastatic castration-resistant prostate cancer to efficiently test combination therapies in an autochthonous setting.
Xin Lu, James W. Horner, Erin Paul et al.
The allosteric inhibitor ABL001 enables dual targeting of BCR–ABL1
The selective allosteric ABL1 inhibitor ABL001 (asciminib) represents a new inhibitory mechanism for BCR–ABL1-driven malignancies, and its efficacy and evolving mechanisms of resistance do not overlap with those of other BCR–ABL1 kinase inhibitors.
Andrew A. Wylie, Joseph Schoepfer, Wolfgang Jahnke et al.
Energy transduction and alternating access of the mammalian ABC transporter P-glycoprotein
Double electron–electron resonance and computer simulations are used to describe conformational dynamics in the ATP-binding cassette transporter Pgp, which has an important role in the clearance of xenobiotics and cancer resistance to chemotherapy.
Brandy Verhalen, Reza Dastvan, Sundarapandian Thangapandian et al.
Corrigendum: The histone H4 lysine 16 acetyltransferase hMOF regulates the outcome of autophagy
Jens Füllgrabe, Melinda A. Lynch-Day, Nina Heldring et al.
Corrigendum: Sliding sleeves of XRCC4–XLF bridge DNA and connect fragments of broken DNA
Ineke Brouwer, Gerrit Sitters, Andrea Candelli et al.
Erratum: Single-cell spatial reconstruction reveals global division of labour in the mammalian liver
Keren Bahar Halpern, Rom Shenhav, Orit Matcovitch-Natan et al.
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Careers & Jobs
Flexible working: Solo scientist
Amber Dance
Career Briefs  
Brexit: Oxford researchers
Competition: Biomedical recruits
Sofer Pete
Evolution in action.
Tom Easton, Michael A. Burstein
  Science jobs of the week


Dean, College of Biosciences


The Scripps Research Institute 


Postdoctoral Research Associate


Rosalind Franklin University of Medicine and Science 


Postdoctoral Fellow


The University of Kentucky 


Postdoctoral Fellow / Physiology


The University of Tennessee Health Science Center 


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