Ecology: A helping habitat for bumblebees A study showing the effects of land-use quality on the productivity of bumblebee colonies highlights the importance of resource availability across space and time in promoting survival over generations.
Hiv: Finding latent needles in a haystack Antiretroviral therapy can keep HIV at bay, but a few cells remain infected, so the disease cannot be cured. The discovery of a protein that marks out these infected cells will facilitate crucial studies of this latent viral reservoir.
MC4R-dependent suppression of appetite by bone-derived lipocalin 2 Osteoblast-derived LCN2 activates the melanocortin 4 receptor in neurons of the paraventricular nucleus of the hypothalamus to suppress appetite, regulates insulin secretion and increases insulin sensitivity and glucose tolerance. Ioanna Mosialou, Steven Shikhel, Jian-Min Liu et al.
Molecular basis of ancestral vertebrate electroreception Detection of weak electrical signals by skates relies on functional coupling of specific calcium and potassium channels, which mediates oscillations in electrosensory cell membrane voltage. Nicholas W. Bellono, Duncan B. Leitch, David Julius
Global warming and recurrent mass bleaching of corals Aerial and underwater survey data combined with satellite-derived measurements of sea surface temperature over the past two decades show that multiple mass-bleaching events have expanded to encompass virtually all of the Great Barrier Reef. Terry P. Hughes, James T. Kerry, Mariana Álvarez-Noriega et al.
Integrated genomic and molecular characterization of cervical cancer This paper describes molecular subtypes of cervical cancers, including squamous cell carcinoma and adenocarcinoma clusters defined by HPV status and molecular features, and distinct molecular pathways that are activated in cervical carcinomas caused by different somatic alterations and HPV types. The Cancer Genome Atlas Research Network
Paleoproterozoic sterol biosynthesis and the rise of oxygen Steranes in ancient rocks have been used as ‘molecular fossils’, but the very earliest records of steranes have been shown to be contaminants; here, the presence of two key sterol biosynthesis enzymes in eukaryotes and bacteria suggests at least one gene transfer between bacteria and the earliest eukaryotes occurred some 2.3 billion years ago. David A. Gold, Abigail Caron, Gregory P. Fournier et al.
SZT2 dictates GATOR control of mTORC1 signalling SZT2 recruits GATOR1 and GATOR2 to form a SZT2-orchestrated GATOR (SOG) complex at the lysosome that is essential for GATOR- and SESN-dependent nutrient sensing and mTORC1 regulation. Min Peng, Na Yin, Ming O. Li
Hutchinson Centre Research Institute of South Africa
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