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Visit our open access funding page or contact openaccess@nature.com to learn more about APC funding. | | | | | | Latest Editorial | View all Editorials | | | | | Fostering reproducible fMRI research OPEN | | | The validity of conclusions drawn from functional MRI research has been questioned for some time now. Nature Neuroscience and Nature Communications are committed to working with neuroimaging researchers to improve the robustness and reproducibility of their work. | | | 23 February 2017 | doi: 10.1038/ncomms14748 | | | | | | | | Latest Articles | View all Articles | | | |
| The spatial organization of intra-tumour heterogeneity and evolutionary trajectories of metastases in hepatocellular carcinoma OPEN | | | Weiwei Zhai, Tony Kiat-Hon Lim, Tong Zhang, Su-Ting Phang, Zenia Tiang, Peiyong Guan, Ming-Hwee Ng, Jia Qi Lim, Fei Yao, Zheng Li, Poh Yong Ng, Jie Yan, Brian K. Goh, Alexander Yaw-Fui Chung, Su-Pin Choo, Chiea Chuen Khor, Wendy Wei-Jia Soon, Ken Wing-Kin Sung, Roger Sik-Yin Foo and Pierce Kah-Hoe Chow et al. | | | Hepatocellular carcinoma has one of the poorest survival rates amongst cancers. Here, the authors highlight the intra-tumour heterogeneity of this disease, finding that spatially closer tumour sectors are genetically more similar and that intra-hepatic metastasis is accompanied by rapid genetic diversification. | | | 27 February 2017 | doi: 10.1038/ncomms14565 | | |
| Intensity-dependent modulation of optically active signals in a chiral metamaterial OPEN | | | Sean P. Rodrigues, Shoufeng Lan, Lei Kang, Yonghao Cui, Patrick W. Panuski, Shengxiang Wang, Augustine M. Urbas and Wenshan Cai | | | Here Rodrigues et al. report an optical metamaterial with tailored chiroptical effects in the nonlinear regime, which exhibits a pronounced shift in its circular dichroism spectrum under a modest level of excitation power. | | | 27 February 2017 | doi: 10.1038/ncomms14602 | | |
| Edge states and skyrmion dynamics in nanostripes of frustrated magnets OPEN | | | A. O. Leonov and M. Mostovoy | | | The interaction between electric currents and magnetic textures in frustrated magnetic materials leads to rich nonlinear dynamics. Here, the authors show how currents can be used to control topology of edge states in nanostripes by inducing the emission and absorption of skyrmions. | | | 27 February 2017 | doi: 10.1038/ncomms14394 | | |
| Canonical free-energy barrier of particle and polymer cluster formation OPEN | | | Johannes Zierenberg, Philipp Schierz and Wolfhard Janke | | | Droplet formation processes are ubiquitous in nature and accompanied by a free-energy barrier. Here, the authors present a numerical approach for a shape-free determination of free-energy barriers and demonstrate on this level an analogy between particle condensation and polymer aggregation. | | | 27 February 2017 | doi: 10.1038/ncomms14546 | | |
| Superconducting parity effect across the Anderson limit OPEN | | | Sergio Vlaic, Stéphane Pons, Tianzhen Zhang, Alexandre Assouline, Alexandre Zimmers, Christophe David, Guillemin Rodary, Jean-Christophe Girard, Dimitri Roditchev and Hervé Aubin | | | How quantum size effects affect superconductivity has been predicted, but it has never been verified. Here, Vlaic et al. report superconducting parity effect as a function of lead nanocrystal volume, unambiguously validating the Anderson criterion. | | | 27 February 2017 | doi: 10.1038/ncomms14549 | | |
| Metamaterial bricks and quantization of meta-surfaces OPEN | | | Gianluca Memoli, Mihai Caleap, Michihiro Asakawa, Deepak R. Sahoo, Bruce W. Drinkwater and Sriram Subramanian | | | Controlling acoustic fields is of interest for diverse applications. Here the authors develop metasurfaces using a small set of pre-manufactured three-dimensional unit cells, quantized in both the spatial and phase domains, achieving with them acoustic levitation. | | | 27 February 2017 | doi: 10.1038/ncomms14608 | | |
| A tailored double perovskite nanofiber catalyst enables ultrafast oxygen evolution OPEN | | | Bote Zhao, Lei Zhang, Dongxing Zhen, Seonyoung Yoo, Yong Ding, Dongchang Chen, Yu Chen, Qiaobao Zhang, Brian Doyle, Xunhui Xiong and Meilin Liu | | | The design of efficient and stable oxygen evolution catalysts has implications for water splitting and metal-air battery technology. Here, the authors fabricate double perovskite nanofibers and demonstrate the favourable effects of co-doping and nanostructuring on oxygen evolution performance. | | | 27 February 2017 | doi: 10.1038/ncomms14586 | | |
| Connecting genetic risk to disease end points through the human blood plasma proteome OPEN | | | Karsten Suhre, Matthias Arnold, Aditya Mukund Bhagwat, Richard J. Cotton, Rudolf Engelke, Johannes Raffler, Hina Sarwath, Gaurav Thareja, Annika Wahl, Robert Kirk DeLisle, Larry Gold, Marija Pezer, Gordan Lauc, Mohammed A. El-Din Selim, Dennis O. Mook-Kanamori, Eman K. Al-Dous, Yasmin A. Mohamoud, Joel Malek, Konstantin Strauch, Harald Grallert et al. | | | Individual genetic variation can affect the levels of protein in blood, but detailed data sets linking these two types of data are rare. Here, the authors carry out a genome-wide association study of levels of over a thousand different proteins, and describe many new SNP-protein interactions. | | | 27 February 2017 | doi: 10.1038/ncomms14357 | | |
| Nur77 suppresses hepatocellular carcinoma via switching glucose metabolism toward gluconeogenesis through attenuating phosphoenolpyruvate carboxykinase sumoylation OPEN | | | Xue-li Bian, Hang-zi Chen, Peng-bo Yang, Ying-ping Li, Fen-na Zhang, Jia-yuan Zhang, Wei-jia Wang, Wen-xiu Zhao, Sheng Zhang, Qi-tao Chen, Yu Zheng, Xiao-yu Sun, Xiao-min Wang, Kun-Yi Chien and Qiao Wu | | | Gluconeogenesis is downregulated in hepatocellular carcinoma. Here, the authors show that nuclear receptor Nur77 acts as a tumour suppressor sustaining gluconeogenesis by enhancing phosphoenolpyruvate carboxykinase (PEPCK1) stability via regulating its interaction with the SUMO-conjugating enzyme Ubc9. | | | 27 February 2017 | doi: 10.1038/ncomms14420 | | |
| Amotl1 mediates sequestration of the Hippo effector Yap1 downstream of Fat4 to restrict heart growth OPEN | | | Chiara V. Ragni, Nicolas Diguet, Jean-François Le Garrec, Marta Novotova, Tatiana P. Resende, Sorin Pop, Nicolas Charon, Laurent Guillemot, Lisa Kitasato, Caroline Badouel, Alexandre Dufour, Jean-Christophe Olivo-Marin, Alain Trouvé, Helen McNeill and Sigolène M Meilhac | | | Growth of the mammalian heart is controlled by Hippo signalling but how this is regulated is unclear. Here, the authors show that Fat4 (an atypical cadherin) acts upstream of Hippo signalling and Fat4 mutant mice have thicker myocardium, which is mediated by the scaffold Amot1 and transcription factor Yap1. | | | 27 February 2017 | doi: 10.1038/ncomms14582 | | |
| DNA damage response inhibition at dysfunctional telomeres by modulation of telomeric DNA damage response RNAs OPEN | | | Francesca Rossiello, Julio Aguado, Sara Sepe, Fabio Iannelli, Quan Nguyen, Sethuramasundaram Pitchiaya, Piero Carninci and Fabrizio d’Adda di Fagagna | | | The DNA damage response (DDR) involves site-specific small non-coding RNAs. Here the authors show that telomere dysfunction induces transcription of telomeric DNA damage response RNAs that are necessary for DDR activation, which can be specifically muted by antisense inhibitory oligonucleotides. | | | 27 February 2017 | doi: 10.1038/ncomms13980 | | |
| Transcending the slow bimolecular recombination in lead-halide perovskites for electroluminescence OPEN | | | Guichuan Xing, Bo Wu, Xiangyang Wu, Mingjie Li, Bin Du, Qi Wei, Jia Guo, Edwin K. L. Yeow, Tze Chien Sum and Wei Huang | | | Slow bimolecular recombination in three-dimensional halide perovskites represents a fundamental limitation for electroluminescence efficiency. Using time-resolved spectroscopy Xing et al. demonstrate that this limitation can be overcome by employing van-der-Waals-coupled multiple quantum well structures. | | | 27 February 2017 | doi: 10.1038/ncomms14558 | | |
| Timing and nature of AMOC recovery across Termination 2 and magnitude of deglacial CO2 change OPEN | | | Emily L. Deaney, Stephen Barker and Tina van de Flierdt | | | Differences in the sequence and timing of ocean circulation changes across glacial terminations could affect the magnitude of deglacial atmospheric CO2 rise. Here, the authors argue that late ocean circulation recovery during the penultimate deglaciation (T2) led to a larger rise in CO2 compared with T1. | | | 27 February 2017 | doi: 10.1038/ncomms14595 | | |
| Identifying electron transfer coordinates in donor-bridge-acceptor systems using mode projection analysis OPEN | | | Xunmo Yang, Theo Keane, Milan Delor, Anthony J. H. M. Meijer, Julia Weinstein and Eric R. Bittner | | | Manipulating chemical reactions using laser pulses to control electron transfer is an attractive goal, however much of the underlying physics remains unexplored. Here the authors analyse and explain the intramolecular electronic transfer occurring during charge-separation in acetylene, a model donor-bridge-acceptor molecule. | | | 24 February 2017 | doi: 10.1038/ncomms14554 | | |
| Rosin-enabled ultraclean and damage-free transfer of graphene for large-area flexible organic light-emitting diodes OPEN | | | Zhikun Zhang, Jinhong Du, Dingdong Zhang, Hengda Sun, Lichang Yin, Laipeng Ma, Jiangshan Chen, Dongge Ma, Hui-Ming Cheng and Wencai Ren | | | Ultraclean and damage-free transfer of graphene over large areas is crucial for the future development of flexible electronics and optoelectronics. Using a rosin-assisted method, the authors transfer graphene with an ultraclean surface and uniform small sheet resistance—a 4-inch monolithic organic light-emitting diode is demonstrated. | | | 24 February 2017 | doi: 10.1038/ncomms14560 | | |
| The role of alternative polyadenylation in the antiviral innate immune response OPEN | | | Xin Jia, Shaochun Yuan, Yao Wang, Yonggui Fu, Yong Ge, Yutong Ge, Xihong Lan, Yuchao Feng, Feifei Qiu, Peiyi Li, Shangwu Chen and Anlong Xu | | | RNA processing by alternative polyadenylation (APA) can result in 3′UTR diversity and regulation of target RNA function. Here the authors survey APA in viral infection of macrophages. | | | 24 February 2017 | doi: 10.1038/ncomms14605 | | |
| Ensemble forecast of human West Nile virus cases and mosquito infection rates OPEN | | | Nicholas B. DeFelice, Eliza Little, Scott R. Campbell and Jeffrey Shaman | | | Since its introduction to the US in 1999, the West Nile virus (WNV) has become endemic in the Americas. Here, the authors develop a model of WNV transmission dynamics between birds, mosquitoes and humans, which they integrate in conjunction with data assimilation methods, mosquito infection data and reported human cases in a New York county to show its utility for forecasting infection rates. | | | 24 February 2017 | doi: 10.1038/ncomms14592 | | |
| Spectroelectrochemical analysis of the mechanism of (photo)electrochemical hydrogen evolution at a catalytic interface OPEN | | | Ernest Pastor, Florian Le Formal, Matthew T. Mayer, S. David Tilley, Laia Francàs, Camilo A. Mesa, Michael Grätzel and James R. Durrant | | | Understanding reaction mechanisms in heterogeneous (photo)electrochemical catalysts is key to improving solar-to-fuel conversion efficiencies. Here the authors compare the mechanism of hydrogen evolution on ruthenium oxide as an electrocatalyst and as part of a photocathode via an optical/electrochemical approach. | | | 24 February 2017 | doi: 10.1038/ncomms14280 | | |
| PEGylated graphene oxide elicits strong immunological responses despite surface passivation OPEN | | | Nana Luo, Jeffrey K. Weber, Shuang Wang, Binquan Luan, Hua Yue, Xiaobo Xi, Jing Du, Zaixing Yang, Wei Wei, Ruhong Zhou and Guanghui Ma | | | Polyethylene glycol has been widely utilized to functionalize nanomaterials in order to improve their biocompatibility. Here, the authors demonstrate that PEGylated nano-graphene oxide can elicit an inflammatory response, contradicting current literature. | | | 24 February 2017 | doi: 10.1038/ncomms14537 | | |
| Sponge-associated bacteria mineralize arsenic and barium on intracellular vesicles OPEN | | | Ray Keren, Boaz Mayzel, Adi Lavy, Iryna Polishchuk, Davide Levy, Sirine C. Fakra, Boaz Pokroy and Micha Ilan | | | The marine sponge Theonella swinhoei accumulates toxic arsenic and barium. Here the authors show that these toxic elements are actually accumulated and mineralized within vesicles inside bacteria that live within the sponge tissues. | | | 24 February 2017 | doi: 10.1038/ncomms14393 | | |
| Hyperactivation of Nrf2 in early tubular development induces nephrogenic diabetes insipidus OPEN | | | Takafumi Suzuki, Shiori Seki, Keiichiro Hiramoto, Eriko Naganuma, Eri H. Kobayashi, Ayaka Yamaoka, Liam Baird, Nobuyuki Takahashi, Hiroshi Sato and Masayuki Yamamoto | | | Nrf2 regulates oxidative and electrophilic stress responses by modulating the expression of enzymes involved in detoxification pathways. Here Suzuki et al. show that Nrf2 activation in early tubular development promotes nephrogenic diabetes insipidus by regulating aquaporin 2 expression and trafficking and water permeability. | | | 24 February 2017 | doi: 10.1038/ncomms14577 | | |
| Feasibility and coexistence of large ecological communities OPEN | | | Jacopo Grilli, Matteo Adorisio, Samir Suweis, György Barabás, Jayanth R. Banavar, Stefano Allesina and Amos Maritan | | | A central question in theoretical ecology is how diverse species can coexist in communities, and how that coexistence depends on network properties. Here, Grilli et al. quantify the extent of feasible coexistence of empirical networks, showing that it is smaller for trophic than mutualism networks. | | | 24 February 2017 | doi: 10.1038/ncomms14389 | | |
| Direct experimental determination of the topological winding number of skyrmions in Cu2OSeO3 OPEN | | | S. L. Zhang, G. van der Laan and T. Hesjedal | | | Experimental demonstrations of topologically nontrivial states in magnetic films currently rely on indirect comparisons of theoretical models with microscopic images. Here the authors show that resonant X-ray scattering provides direct information on the topology of magnetic textures. | | | 24 February 2017 | doi: 10.1038/ncomms14619 | | |
| RD26 mediates crosstalk between drought and brassinosteroid signalling pathways OPEN | | | Huaxun Ye, Sanzhen Liu, Buyun Tang, Jiani Chen, Zhouli Xie, Trevor M. Nolan, Hao Jiang, Hongqing Guo, Hung-Ying Lin, Lei Li, Yanqun Wang, Hongning Tong, Mingcai Zhang, Chengcai Chu, Zhaohu Li, Maneesha Aluru, Srinivas Aluru, Patrick S. Schnable and Yanhai Yin | | | Brassinosteroid (BR) signalling regulates plant development via the BES1/BZR1 family of transcription factors. Here the authors show that BES1 activity can be modified by the drought-responsive RD26 transcription factor providing a molecular basis for the interaction between drought and BR signalling. | | | 24 February 2017 | doi: 10.1038/ncomms14573 | | |
| IFN-γ is required for cytotoxic T cell-dependent cancer genome immunoediting OPEN | | | Kazuyoshi Takeda, Masafumi Nakayama, Yoshihiro Hayakawa, Yuko Kojima, Hiroaki Ikeda, Naoko Imai, Kouetsu Ogasawara, Ko Okumura, David M. Thomas and Mark J. Smyth | | | T cell mediated anti-tumour immune responses result in the emergence of an immune-resistant population in a process called immunoediting. Here, the authors show that immunoediting is associated with an increase in genomic rearrangements of tumour cells that requires both cytotoxic T cells and IFNγ exposure. | | | 24 February 2017 | doi: 10.1038/ncomms14607 | | |
| Mutualism supports biodiversity when the direct competition is weak OPEN | | | Alberto Pascual-García and Ugo Bastolla | | | Theoretical ecologists have made disparate predictions regarding the relationship between mutualism and stability. Here, Pascual-García and Bastolla develop a theoretical framework showing that model mutualistic interactions promote structural stability when competition is weaker than a threshold depending on network architecture. | | | 24 February 2017 | doi: 10.1038/ncomms14326 | | |
| Genome-wide analyses of non-syndromic cleft lip with palate identify 14 novel loci and genetic heterogeneity OPEN | | | Yanqin Yu, Xianbo Zuo, Miao He, Jinping Gao, Yuchuan Fu, Chuanqi Qin, Liuyan Meng, Wenjun Wang, Yaling Song, Yong Cheng, Fusheng Zhou, Gang Chen, Xiaodong Zheng, Xinhuan Wang, Bo Liang, Zhengwei Zhu, Xiazhou Fu, Yujun Sheng, Jiebing Hao, Zhongyin Liu et al. | | | Non-syndromic cleft lip with palate is a common birth defect of unknown aetiology. Here, the authors discover 14 new genes associated with this condition, and show genetic heterogeneity in this and other non-syndromic orofacial clefting disorders. | | | 24 February 2017 | doi: 10.1038/ncomms14364 | | |
| Dynamic plasmonic colour display OPEN | | | Xiaoyang Duan, Simon Kamin and Na Liu | | | Here Duan et al. demonstrate dynamic plasmonic colour displays using catalytic magnesium metasurfaces. Controlled hydrogenation and dehydrogenation of the constituent nanoparticles, which serve as dynamic pixels, allow plasmonic colour printing, tuning, erasing, restoration of colour and encoding of information. | | | 24 February 2017 | doi: 10.1038/ncomms14606 | | |
| Mutant Kras- and p16-regulated NOX4 activation overcomes metabolic checkpoints in development of pancreatic ductal adenocarcinoma OPEN | | | Huai-Qiang Ju, Haoqiang Ying, Tian Tian, Jianhua Ling, Jie Fu, Yu Lu, Min Wu, Lifeng Yang, Abhinav Achreja, Gang Chen, Zhuonan Zhuang, Huamin Wang, Deepak Nagrath, Jun Yao, Mien-Chie Hung, Ronald A. DePinho, Peng Huang, Rui-Hua Xu and Paul J. Chiao | | | Kras activation and p16 inactivation cooperatively promote pancreatic cancer progression. Here, the authors show that such cooperation depends upon an increased expression of the NAD(P)H oxidase NOX4 achieved through transcription factors independently regulated by the two oncogenic genetic alterations. | | | 24 February 2017 | doi: 10.1038/ncomms14437 | | |
| Breather soliton dynamics in microresonators OPEN | | | Mengjie Yu, Jae K. Jang, Yoshitomo Okawachi, Austin G. Griffith, Kevin Luke, Steven A. Miller, Xingchen Ji, Michal Lipson and Alexander L. Gaeta | | | Breather solitons can be found in both physical and biological nonlinear systems. Here, Yu et al. demonstrate this type of soliton in silicon and silicon nitride microresonators, which advances the understanding of soliton-based comb-generation in microresonators. | | | 24 February 2017 | doi: 10.1038/ncomms14569 | | |
| An intelligent artificial throat with sound-sensing ability based on laser induced graphene OPEN | | | Lu-Qi Tao, He Tian, Ying Liu, Zhen-Yi Ju, Yu Pang, Yuan-Quan Chen, Dan-Yang Wang, Xiang-Guang Tian, Jun-Chao Yan, Ning-Qin Deng, Yi Yang and Tian-Ling Ren | | | The functional integration of sound generation and detection on a single device is required to assist mute people. Here, the authors demonstrate a graphene-based artificial throat capable of detecting and converting diverse throat vibrations into meaningful sound within a single device. | | | 24 February 2017 | doi: 10.1038/ncomms14579 | | |
| Spin-dependent quantum interference in photoemission process from spin-orbit coupled states OPEN | | | Koichiro Yaji, Kenta Kuroda, Sogen Toyohisa, Ayumi Harasawa, Yukiaki Ishida, Shuntaro Watanabe, Chuangtian Chen, Katsuyoshi Kobayashi, Fumio Komori and Shik Shin | | | Spin–orbit coupling produces spin–orbital-entanglement in quasiparticle eigenstates. Here, Yaji et al. present a general description of spin–orbital-entangled states and establish a model for dipole transition based on spin-dependent quantum interference, that permits optical spin control. | | | 24 February 2017 | doi: 10.1038/ncomms14588 | | |
| Oxidation of F-actin controls the terminal steps of cytokinesis OPEN | | | Stéphane Frémont, Hussein Hammich, Jian Bai, Hugo Wioland, Kerstin Klinkert, Murielle Rocancourt, Carlos Kikuti, David Stroebel, Guillaume Romet-Lemonne, Olena Pylypenko, Anne Houdusse and Arnaud Echard | | | Cytokinetic abscission relies on the local constriction after cytoskeleton disassembly, but it is not known how the actin filaments are disassembled. Here, the authors show that the redox enzyme MICAL1 is recruited by Rab35 and induces oxidation-mediated depolymerization of actin, which is required to recruit ESCRT-III and complete abscission. | | | 23 February 2017 | doi: 10.1038/ncomms14528 | | |
| Pairing mechanism in the ferromagnetic superconductor UCoGe OPEN | | | Beilun Wu, Gaël Bastien, Mathieu Taupin, Carley Paulsen, Ludovic Howald, Dai Aoki and Jean-Pascal Brison | | | Experimental identification of pairing mechanism in unconventional superconductors is challenging. Here, Wu et al. show that the field dependence of the pairing strength influences the superconducting upper critical field in UCoGe, suggesting the dominant role of ferromagnetic spin fluctuations. | | | 23 February 2017 | doi: 10.1038/ncomms14480 | | |
| Unraveling the processes shaping mammalian gut microbiomes over evolutionary time OPEN | | | Mathieu Groussin, Florent Mazel, Jon G. Sanders, Chris S. Smillie, Sébastien Lavergne, Wilfried Thuiller and Eric J. Alm | | | Both host diet and phylogeny have been argued to shape mammalian microbiome communities. Here, the authors show that diet predicts the presence of ancient bacterial lineages in the microbiome, but that co-speciation between more recent bacterial lineages and their hosts may drive associations between microbiome composition and phylogeny. | | | 23 February 2017 | doi: 10.1038/ncomms14319 | | |
| Direct observation of oxygen vacancy-driven structural and resistive phase transitions in La2/3Sr1/3MnO3 OPEN | | | Lide Yao, Sampo Inkinen and Sebastiaan van Dijken | | | An in-depth understanding of oxygen vacancy-driven effects is necessary for the development of functional ionic devices. Using simultaneous high-resolution imaging and resistance probing, Yao et al. demonstrate oxygen vacancy-driven structural and resistive transitions between three distinct phases in La2/3Sr1/3MnO3. | | | 23 February 2017 | doi: 10.1038/ncomms14544 | | |
| Compiler-aided systematic construction of large-scale DNA strand displacement circuits using unpurified components OPEN | | | Anupama J. Thubagere, Chris Thachuk, Joseph Berleant, Robert F. Johnson, Diana A. Ardelean, Kevin M. Cherry and Lulu Qian | | | DNA circuits hold promise for advancing information-based molecular technologies, yet it is challenging to design and construct them in practice. Thubagere et al. build DNA strand displacement circuits using unpurified strands whose sequences are automatically generated from a user-friendly compiler. | | | 23 February 2017 | doi: 10.1038/ncomms14373 | | |
| Magnetization switching in ferromagnets by adsorbed chiral molecules without current or external magnetic field OPEN | | | Oren Ben Dor, Shira Yochelis, Anna Radko, Kiran Vankayala, Eyal Capua, Amir Capua, See-Hun Yang, Lech Tomasz Baczewski, Stuart Stephen Papworth Parkin, Ron Naaman and Yossi Paltiel | | | Spin manipulation in memory devices typically requires large electrical currents, limiting performance. Here the authors demonstrate magnetization switching in ferromagnetic films by depositing chiral molecules, making use of a proximity effect without needing magnetic or electric fields. | | | 23 February 2017 | doi: 10.1038/ncomms14567 | | |
| Direct observation of intrinsic twin domains in tetragonal CH3NH3PbI3 OPEN | | | Mathias Uller Rothmann, Wei Li, Ye Zhu, Udo Bach, Leone Spiccia, Joanne Etheridge and Yi-Bing Cheng | | | Using low dose transmission electron microscopy, Rothmann, Li, Zhu et al. report direct evidence for twin domains in tetragonal CH3NH3PbI3 perovskite. The relevant scale and transition temperature of these twin domains could have implications for perovskite solar cells. | | | 23 February 2017 | doi: 10.1038/ncomms14547 | | |
| Broad-scale lake expansion and flooding inundates essential wood bison habitat OPEN | | | Jennifer B. Korosi, Joshua R. Thienpont, Michael F. J. Pisaric, Peter deMontigny, Joelle T. Perreault, Jamylynn McDonald, Myrna J. Simpson, Terry Armstrong, Steven V. Kokelj, John P. Smol and Jules M. Blais | | | Climate change can affect lake water level and nearby landscape. Korosi and colleagues show recent expansion of shallow lakes in the Canadian Northwest Territories is flooding critical habitat for the wood bison, and demonstrate the trickle-down effect of climate change on ecosystem functioning. | | | 23 February 2017 | doi: 10.1038/ncomms14510 | | |
| Dynamical Majorana edge modes in a broad class of topological mechanical systems OPEN | | | Emil Prodan, Kyle Dobiszewski, Alokik Kanwal, John Palmieri and Camelia Prodan | | | Properties of topological insulators can be realized in mechanical systems, opening potential applications of topological mechanics. Here, Prodan et al. report a dynamical topological Majorana edge mode in self-assembled chains of rigid bodies with particle-hole symmetry. | | | 23 February 2017 | doi: 10.1038/ncomms14587 | | |
| Cellular senescence mediates fibrotic pulmonary disease OPEN | | | Marissa J. Schafer, Thomas A. White, Koji Iijima, Andrew J. Haak, Giovanni Ligresti, Elizabeth J. Atkinson, Ann L. Oberg, Jodie Birch, Hanna Salmonowicz, Yi Zhu, Daniel L. Mazula, Robert W. Brooks, Heike Fuhrmann-Stroissnigg, Tamar Pirtskhalava, Y. S. Prakash, Tamara Tchkonia, Paul D. Robbins, Marie Christine Aubry, João F. Passos, James L. Kirkland et al. | | | Removal of senescent cells rejuvenates lungs of aged mice. Here the authors show that elimination of senescent cells using either genetic or pharmacological means improves lung function and physical health in a mouse model of idiopathic pulmonary fibrosis (IPF), suggesting potential therapy for treatment of human IPF. | | | 23 February 2017 | doi: 10.1038/ncomms14532 | | |
| Product selectivity in plasmonic photocatalysis for carbon dioxide hydrogenation OPEN | | | Xiao Zhang, Xueqian Li, Du Zhang, Neil Qiang Su, Weitao Yang, Henry O. Everitt and Jie Liu | | | Atmospheric CO2 can be transformed into valuable hydrocarbons by reaction with H2, but CO is the favoured kinetic product. Here, Liu and co-workers show that plasmonic rhodium nanoparticles not only reduce the activation energy for CO2 hydrogenation, but also photo-selectively produce methane. | | | 23 February 2017 | doi: 10.1038/ncomms14542 | | |
| Hierarchical tissue organization as a general mechanism to limit the accumulation of somatic mutations OPEN | | | Imre Derényi and Gergely J. Szöllősi | | | To limit the accumulation of somatic mutations, renewing tissues must minimize the number of times each cell divides during differentiation. Here, the authors analytically derive the lower limit of lifetime divisional load of a tissue, show that hierarchically differentiating tissues can approach this limit, and that this depends on uneven divisional rates across the hierarchy. | | | 23 February 2017 | doi: 10.1038/ncomms14545 | | |
| Drebrin-mediated microtubule–actomyosin coupling steers cerebellar granule neuron nucleokinesis and migration pathway selection OPEN | | | Niraj Trivedi, Daniel R. Stabley, Blake Cain, Danielle Howell, Christophe Laumonnerie, Joseph S. Ramahi, Jamshid Temirov, Ryan A. Kerekes, Phillip R. Gordon-Weeks and David J. Solecki | | | Neuronal migration is vital for neuronal circuit morphogenesis and is thought to rely on microtubule-actomyosin crosstalk. Here, the authors use super-resolution imaging and the drebrin microtubule-actin crosslinking protein to show that microtubule-actomyosin coupling controls the direction of centrosome and somal motility. | | | 23 February 2017 | doi: 10.1038/ncomms14484 | | |
| Differential regulation of the Epr3 receptor coordinates membrane-restricted rhizobial colonization of root nodule primordia OPEN | | | Yasuyuki Kawaharada, Mette W. Nielsen, Simon Kelly, Euan K. James, Kasper R. Andersen, Sheena R. Rasmussen, Winnie Füchtbauer, Lene H. Madsen, Anne B. Heckmann, Simona Radutoiu and Jens Stougaard | | | The Lotus japonicus LysM receptor kinase EPR3 perceives rhizobial exopolysaccharides to initiate infection of the root epidermis. Here the authors show that EPR3 also mediates infection thread progression in the root cortex and show that key transcription factors that regulate symbiosis specify the expression of Epr3. | | | 23 February 2017 | doi: 10.1038/ncomms14534 | | |
| Electrically tunable artificial gauge potential for polaritons OPEN | | | Hyang-Tag Lim, Emre Togan, Martin Kroner, Javier Miguel-Sanchez and Atac Imamoğlu | | | Artificial gauge fields promise a route to controlling topological properties of photonic systems but have only been realized by static design. Here, Lim et al. demonstrate that perpendicular electric and magnetic fields can effect dynamically controlled artificial gauge potentials for polaritons. | | | 23 February 2017 | doi: 10.1038/ncomms14540 | | |
| The critical role of point defects in improving the specific capacitance of δ-MnO2 nanosheets OPEN | | | Peng Gao, Peter Metz, Trevyn Hey, Yuxuan Gong, Dawei Liu, Doreen D. Edwards, Jane Y. Howe, Rong Huang and Scott T. Misture | | | Two-dimensional solids are of interest for energy storage due to their large accessible surface area, enabling rapid charge/discharge. Here, the authors quantify the point defects in oxide nanosheets, demonstrating that intentional introduction of charged point defects improves the charge storage behaviour. | | | 23 February 2017 | doi: 10.1038/ncomms14559 | | |
| Demonstrating the potential of yttrium-doped barium zirconate electrolyte for high-performance fuel cells OPEN | | | Kiho Bae, Dong Young Jang, Hyung Jong Choi, Donghwan Kim, Jongsup Hong, Byung-Kook Kim, Jong-Ho Lee, Ji-Won Son and Joon Hyung Shim | | | Protonic ceramic fuel cells are promising for energy applications, but maintaining high performance with long-term stability is an issue. Here the authors use a stable yttrium-doped barium zirconate electrolyte, achieving a power output one order of magnitude higher than existing protonic ceramic fuel cells. | | | 23 February 2017 | doi: 10.1038/ncomms14553 | | |
| Gel phase formation in dilute triblock copolyelectrolyte complexes OPEN | | | Samanvaya Srivastava, Marat Andreev, Adam E. Levi, David J. Goldfeld, Jun Mao, William T. Heller, Vivek M. Prabhu, Juan J. de Pablo and Matthew V. Tirrell | | | At low concentration, uncharged amphiphilic block copolymers form discrete micelles. Here the authors show that triblock copolyelectrolytes can form phase separated gels at low concentrations, which can be useful in applications, such as, tissue engineering and water purification. | | | 23 February 2017 | doi: 10.1038/ncomms14131 | | |
| Ensemble and single-molecule dynamics of IFT dynein in Caenorhabditis elegans cilia OPEN | | | Jona Mijalkovic, Bram Prevo, Felix Oswald, Pierre Mangeol and Erwin J. G. Peterman | | | Cytoplasmic dynein 2 drives retrograde intraflagellar transport but little is known about its dynamics. Here the authors use fluorescence microscopy to track labelled dynein 2 in C. elegans at the single-molecule level and report diffusion at the ciliary base, and pausing and directional switches along the cilium. | | | 23 February 2017 | doi: 10.1038/ncomms14591 | | |
| Interface confined hydrogen evolution reaction in zero valent metal nanoparticles-intercalated molybdenum disulfide OPEN | | | Zhongxin Chen, Kai Leng, Xiaoxu Zhao, Souradip Malkhandi, Wei Tang, Bingbing Tian, Lei Dong, Lirong Zheng, Ming Lin, Boon Siang Yeo and Kian Ping Loh | | | Interface confined reactions are a viable strategy for achieving stable and selective catalysts. Here, the authors demonstrate that 1T'-enriched lithiated MoS2 can reduce metal ions in situ, forming zero valent platinum nanoparticle-intercalated MoS2, with enhanced hydrogen evolution activity. | | | 23 February 2017 | doi: 10.1038/ncomms14548 | | |
| Allograft inflammatory factor 1 is a regulator of transcytosis in M cells OPEN | | | Sari Kishikawa, Shintaro Sato, Satoshi Kaneto, Shigeo Uchino, Shinichi Kohsaka, Seiji Nakamura and Hiroshi Kiyono | | | M cells are intestinal epithelial cells that are specialized to transcytose antigens and bacteria from the intestinal lumen to antigen presenting cells on the other side. Here the authors show that the actin-binding protein Aif1 is highly expressed by intestinal M cells and regulates this transcytosis. | | | 22 February 2017 | doi: 10.1038/ncomms14509 | | |
| Towards high-resolution laser ionization spectroscopy of the heaviest elements in supersonic gas jet expansion OPEN | | | R. Ferrer, A. Barzakh, B. Bastin, R. Beerwerth, M. Block, P. Creemers, H. Grawe, R. de Groote, P. Delahaye, X. Fléchard, S. Franchoo, S. Fritzsche, L. P. Gaffney, L. Ghys, W. Gins, C. Granados, R. Heinke, L. Hijazi, M. Huyse, T. Kron et al. | | | It is challenging to explore properties of heavy elements as they can only be produced artificially. Here, the authors demonstrate a high resolution spectroscopy method, studying the properties of actinium, which can be extended to the study of other elements located at the end of the periodic table. | | | 22 February 2017 | doi: 10.1038/ncomms14520 | | |
| Post-endocytic sorting of Plexin-D1 controls signal transduction and development of axonal and vascular circuits OPEN | | | Katja Burk, Erik Mire, Anaïs Bellon, Mélanie Hocine, Jeremy Guillot, Filipa Moraes, Yutaka Yoshida, Michael Simons, Sophie Chauvet and Fanny Mann | | | Molecular mechanisms controlling axonal growth cone behaviour are only partially understood. Here the authors reveal a role of an adaptor protein GIPC1 in Plexin-D1 receptor recycling, and show that this process is required for axon track formation and vascular patterning in mice. | | | 22 February 2017 | doi: 10.1038/ncomms14508 | | |
| Abnormal strong burn-in degradation of highly efficient polymer solar cells caused by spinodal donor-acceptor demixing OPEN | | | Ning Li, José Darío Perea, Thaer Kassar, Moses Richter, Thomas Heumueller, Gebhard J. Matt, Yi Hou, Nusret S. Güldal, Haiwei Chen, Shi Chen, Stefan Langner, Marvin Berlinghof, Tobias Unruh and Christoph J. Brabec | | | Li et al. study degradation in organic photovoltaics from a morphological perspective. They find that donor and acceptor phases undergo excessive demixing via spinodal decomposition resulting in a reduction of charge generation. Demixing is due to the inherently low miscibility of both materials. | | | 22 February 2017 | doi: 10.1038/ncomms14541 | | |
| Plasmon-assisted high-harmonic generation in graphene OPEN | | | Joel D. Cox, Andrea Marini and F. Javier García de Abajo | | | High-harmonic generation is a nonlinear optical phenomenon that may be harnessed towards realisation of ultrafast light sources. Here, the authors theoretically show that localized plasmons in graphene nanodisks result in broadband and electrically tunable high-harmonic generation. | | | 22 February 2017 | doi: 10.1038/ncomms14380 | | |
| Episodic release of CO2 from the high-latitude North Atlantic Ocean during the last 135 kyr OPEN | | | Mohamed M. Ezat, Tine L. Rasmussen, Bärbel Hönisch, Jeroen Groeneveld and Peter deMenocal | | | Glacial-interglacial variations in atmospheric pCO2 remain unexplained. Here, the authors show that the Norwegian Sea, an modern area of intense CO2 uptake, acted as a CO2 source during the terminations of Heinrich stadials 1, 4 and 11, sometimes characterized by rapid increases in atmospheric pCO2. | | | 22 February 2017 | doi: 10.1038/ncomms14498 | | |
| Rapid and tunable method to temporally control gene editing based on conditional Cas9 stabilization OPEN | | | Serif Senturk, Nitin H. Shirole, Dawid G. Nowak, Vincenzo Corbo, Debjani Pal, Alexander Vaughan, David A. Tuveson, Lloyd C. Trotman, Justin B. Kinney and Raffaella Sordella | | | CRISPR/Cas9-based genome editing enables specific deletion of target genes. Here, Senturk et al. develop an inducible editing system by fusing a conditional destabilization domain to Cas9 and demonstrate temporal control of gene editing in response to a synthetic ligand. | | | 22 February 2017 | doi: 10.1038/ncomms14370 | | |
| Clonal reversal of ageing-associated stem cell lineage bias via a pluripotent intermediate OPEN | | | Martin Wahlestedt, Eva Erlandsson, Trine Kristiansen, Rong Lu, Cord Brakebusch, Irving L. Weissman, Joan Yuan, Javier Martin-Gonzalez and David Bryder | | | Age-associated decline in tissue function has been linked to alterations in adult stem cells, with implications for organ homeostasis and cellular therapy. Here, the authors study the heterogeneity of ageing mouse haematopoietic stem cells (HSCs) and find that the compromised blood cell-forming potential of individual and functionally defined aged HSCs can be reset by reprogramming. | | | 22 February 2017 | doi: 10.1038/ncomms14533 | | |
| Sex differences in microglial CX3CR1 signalling determine obesity susceptibility in mice OPEN | | | Mauricio D. Dorfman, Jordan E. Krull, John D. Douglass, Rachael Fasnacht, Fernando Lara-Lince, Thomas H. Meek, Xiaogang Shi, Vincent Damian, Hong T. Nguyen, Miles E. Matsen, Gregory J. Morton and Joshua P. Thaler | | | Unlike males, female mice are resistant to hypothalamic inflammation and weight gain when fed a high-fat diet. Here, the authors reveal sex-specific regulation of hypothalamic microglial activation through CX3CR1 signalling, providing a potential mechanism for differential susceptibility to diet-induced obesity. | | | 22 February 2017 | doi: 10.1038/ncomms14556 | | |
| Enhanced oxidation resistance of active nanostructures via dynamic size effect OPEN | | | Yun Liu, Fan Yang, Yi Zhang, Jianping Xiao, Liang Yu, Qingfei Liu, Yanxiao Ning, Zhiwen Zhou, Hao Chen, Wugen Huang, Ping Liu and Xinhe Bao | | | Smaller nanostructures often have higher activities, but at the expense of losing chemical stability. Here, the authors find that reducing the size of FeO nanostructures to below 3 nm enhances their resistance to oxidation, and attribute this unexpected observation to a size-dependent, structural dynamics effect. | | | 22 February 2017 | doi: 10.1038/ncomms14459 | | |
| Sequence variant at 8q24.21 associates with sciatica caused by lumbar disc herniation OPEN | | | Gyda Bjornsdottir, Stefania Benonisdottir, Gardar Sveinbjornsson, Unnur Styrkarsdottir, Gudmar Thorleifsson, G. Bragi Walters, Aron Bjornsson, Ingvar H. Olafsson, Elfar Ulfarsson, Arnor Vikingsson, Ragnheidur Hansdottir, Karl O. Karlsson, Thorunn Rafnar, Ingileif Jonsdottir, Michael L. Frigge, Augustine Kong, Asmundur Oddsson, Gisli Masson, Olafur T. Magnusson, Tomas Gudbjartsson et al. | | | Lumbar disc herniation (LDH) can cause persistent sciatica, and in some cases surgery is required to relieve symptoms. Here, the authors carry out a genome-wide association study using microdiscectomy as an indicator of severe LDH, and find a locus on chromosome 8 associated with this condition. | | | 22 February 2017 | doi: 10.1038/ncomms14265 | | |
| Massive production of abiotic methane during subduction evidenced in metamorphosed ophicarbonates from the Italian Alps OPEN | | | Alberto Vitale Brovarone, Isabelle Martinez, Agnès Elmaleh, Roberto Compagnoni, Carine Chaduteau, Cristiano Ferraris and Imène Esteve | | | Alteration of ultramafic rocks plays a role in hydrocarbon production, but little is known about this process at depth. Here, the authors provide evidence that alteration of carbonated ultramafic rocks at high-pressures are an important source of abiotic methanogenesis with implications for deep C mobility. | | | 22 February 2017 | doi: 10.1038/ncomms14134 | | |
| Fluorescence intermittency originates from reclustering in two-dimensional organic semiconductors OPEN | | | Anthony Ruth, Michitoshi Hayashi, Peter Zapol, Jixin Si, Matthew P. McDonald, Yurii V. Morozov, Masaru Kuno and Boldizsár Jankó | | | Fluorescence blinking has been recently observed in two-dimensional graphene oxide systems, yet its origin has so far remained elusive. Here, the authors unveil the nature of such long timescale emission intermittency and link it to the distribution of sp2 carbon domains. | | | 22 February 2017 | doi: 10.1038/ncomms14521 | | | | | | | | | | | | | Latest Corrigenda | | | | |
| | | | | Corrigendum: SIKs control osteocyte responses to parathyroid hormone OPEN | | | Marc N. Wein, Yanke Liang, Olga Goransson, Thomas B. Sundberg, Jinhua Wang, Elizabeth A. Williams, Maureen J. O’Meara, Nicolas Govea, Belinda Beqo, Shigeki Nishimori, Kenichi Nagano, Daniel J. Brooks, Janaina S. Martins, Braden Corbin, Anthony Anselmo, Ruslan Sadreyev, Joy Y. Wu, Kei Sakamoto, Marc Foretz, Ramnik J. Xavier et al. | | | 22 February 2017 | doi: 10.1038/ncomms14745 | | | | | | | | | | Latest Errata | | | | | | Erratum: Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals OPEN | | | Tetsuya Kimura, Shigeyuki Nada, Noriko Takegahara, Tatsusada Okuno, Satoshi Nojima, Sujin Kang, Daisuke Ito, Keiko Morimoto, Takashi Hosokawa, Yoshitomo Hayama, Yuichi Mitsui, Natsuki Sakurai, Hana Sarashina-Kida, Masayuki Nishide, Yohei Maeda, Hyota Takamatsu, Daisuke Okuzaki, Masaki Yamada, Masato Okada and Atsushi Kumanogoh et al. | | | 27 February 2017 | doi: 10.1038/ncomms14711 | | |
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