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Nature Cell Biology contents: April 2017 Volume 19 Number 4, pp 259 - 407

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April 2017 Volume 19, Issue 4

News and Views
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On data availability, reproducibility and reuse   p259
Data sharing is an inherent principle of research publication, and information on how data may be accessed is key for the replication and furthering of scientific findings. Here we revisit the policies of Nature Cell Biology on data availability.

News and Views


Demystifying blood stem cell fates   pp261 - 263
Fiona K. Hamey and Berthold Göttgens
Determining the differentiation potential of stem and progenitor cells is essential for understanding their function, yet our ability to do so is limited by the restrictions of experimental assays. Based on single-cell functional and molecular profiling experiments, a new computational approach shows how lineage commitment may occur in human haematopoiesis.

See also: Article by Velten et al.

PARL paves the way to apoptosis   pp263 - 265
Naotada Ishihara and Katsuyoshi Mihara
Although the mitochondrial inner membrane rhomboid peptidase PARL is known to participate in critical signalling cascades, its role in apoptosis has remained unclear. PARL is now shown to process the mitochondrial pro-apoptotic protein Smac (also known as DIABLO) for its subsequent release into the cytosol where it antagonizes XIAP-mediated caspase inhibition to promote apoptosis.

See also: Article by Saita et al.

Talin gets SHANKed in the fight for integrin activation   pp265 - 267
Paul Atherton and Christoph Ballestrem
Genetic mutations in the SHANK family of proteins are linked to multiple neuropsychiatric disorders including autism spectrum disorders. A study now elucidates critical roles for SHANK in regulating integrin-mediated cell-extracellular matrix adhesion, by sequestering integrin activators.

See also: Article by Lilja et al.

Hippo interferes with antiviral defences   pp267 - 269
Natalia Muñoz-Wolf and Ed C. Lavelle
The Hippo pathway responds to environmental factors including nutrient availability, cell density and substrate stiffness to regulate organ size. This pathway is now shown to also regulate antiviral defence by modulating the TBK1-mediated control of interferon production.

See also: Article by Zhang et al.

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Human haematopoietic stem cell lineage commitment is a continuous process   pp271 - 281
Lars Velten, Simon F. Haas, Simon Raffel, Sandra Blaszkiewicz, Saiful Islam et al.
Velten et al. use single-cell transcriptomics and functional data to map the early lineage commitment of human haematopoietic stem cells as a continuous process of cells passing through transitory states rather than demarcating discrete progenitors.

See also: News and Views by Hamey & Göttgens

Genomic instability during reprogramming by nuclear transfer is DNA replication dependent   pp282 - 291
Gloryn Chia, Judith Agudo, Nathan Treff, Mark V. Sauer, David Billing et al.
Chia et al. show that developmental arrest after human nuclear transfer is associated with genetic instability, including DNA damage, which occurs during DNA replication and is influenced by the developmental origin of the transferred nucleus.

SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras   pp292 - 305
Johanna Lilja, Thomas Zacharchenko, Maria Georgiadou, Guillaume Jacquemet, Nicola De Franceschi et al.
Lilja et al. find that SHANK proteins inhibit the signalling of Ras and Rap G-proteins by restricting their availability at the plasma membrane. This leads to restricted integrin activation, affecting cell spreading, migration and invasion.

See also: News and Views by Atherton & Ballestrem

Friction forces position the neural anlage   pp306 - 317
Michael Smutny, Zsuzsa Ákos, Silvia Grigolon, Shayan Shamipour, Verena Ruprecht et al.
Zebrafish neuroectoderm morphogenesis is influenced by the mesoderm germ layer. Smutny et al. now show that friction forces between cells moving in opposite directions, mediated by E-cadherin adhesion, determine the position of the neural anlage.

PARL mediates Smac proteolytic maturation in mitochondria to promote apoptosis   pp318 - 328
Shotaro Saita, Hendrik Nolte, Kai Uwe Fiedler, Hamid Kashkar, A. Saskia Venne et al.
Saita et al. show that PARL cleaves Smac (also known as DIABLO) to generate an IAP-binding motif required for its apoptotic activity, identifying PARL-mediated Smac processing as a pro-apoptotic mitochondrial pathway.

See also: News and Views by Ishihara & Mihara

Altering the threshold of an excitable signal transduction network changes cell migratory modes   pp329 - 340
Yuchuan Miao, Sayak Bhattacharya, Marc Edwards, Huaqing Cai, Takanari Inoue et al.
Miao et al. show through imaging and mathematical simulations that changing the activation thresholds in an excitable PIP2-Ras-Rap signal transduction network can alter the types of protrusions formed in migrating Dictyostelium cells.

The TDH-GCN5L1-Fbxo15-KBP axis limits mitochondrial biogenesis in mouse embryonic stem cells   pp341 - 351
Valerio Donato, Massimo Bonora, Daniele Simoneschi, Davide Sartini, Yasusei Kudo et al.
Donato et al. show that Fbxo15 targets acetylated KBP for degradation to limit mitochondrial expansion, whereas KBP accumulation promotes mitochondrial biogenesis in a Kif1Bα-dependent manner.

Endocytic proteins are partitioned at the edge of the clathrin lattice in mammalian cells   pp352 - 361
Kem A. Sochacki, Andrea M. Dickey, Marie-Paule Strub and Justin W. Taraska
Using large-scale, super-resolution microscopy, Sochacki et al. define the spatial organization of 19 proteins within clathrin-coated pits during distinct stages of clathrin-mediated endocytosis.

Hippo signalling governs cytosolic nucleic acid sensing through YAP/TAZ-mediated TBK1 blockade   pp362 - 374
Qian Zhang, Fansen Meng, Shasha Chen, Steven W. Plouffe, Shiying Wu et al.
Zhang et al. show that YAP and TAZ suppress nucleic acid sensing and antiviral responses by inhibiting the TBK1 kinase. Conversely, Hippo pathway activity inactivates YAP/TAZ to relieve TBK1 suppression and enhance antiviral defence in zebrafish.

See also: News and Views by Munoz-Wolf & Lavelle



Basolateral protrusion and apical contraction cooperatively drive Drosophila germ-band extension   pp375 - 383
Zijun Sun, Christopher Amourda, Murat Shagirov, Yusuke Hara, Timothy E. Saunders et al.
Sun et al. show that during Drosophila germ-band extension basolateral rosette formation does not depend on apical contractility, but is driven by Rac1-mediated protrusion and active cell migration and requires Src42A as a regulator.

The tetrameric kinesin Kif25 suppresses pre-mitotic centrosome separation to establish proper spindle orientation   pp384 - 390
Justin Decarreau, Michael Wagenbach, Eric Lynch, Aaron R. Halpern, Joshua C. Vaughan et al.
Decarreau and colleagues demonstrate that the minus-directed kinesin Kif25 acts to prevent both premature centrosome separation and mis-positioning of the nucleus and mitotic spindle.

Tubulin acetylation protects long-lived microtubules against mechanical ageing   pp391 - 398
Didier Portran, Laura Schaedel, Zhenjie Xu, Manuel Théry and Maxence V. Nachury
Acetylation of α-tubulin on lysine 40 is associated with microtubule stability. In vitro experiments by Portran et al. show that tubulin acetylation reduces lateral interactions, increasing microtubule flexibility and resistance to mechanical stress.

Endoplasmic-reticulum-mediated microtubule alignment governs cytoplasmic streaming   pp399 - 406
Kenji Kimura, Alexandre Mamane, Tohru Sasaki, Kohta Sato, Jun Takagi et al.
Through imaging and theoretical modelling, Kimura et al. discover that endoplasmic reticulum flow determines microtubule alignment to promote cytoplasmic streaming of yolk granules in Caenorhabditis elegans zygotes.



Erratum: Tissue-scale coordination of cellular behaviour promotes epidermal wound repair in live mice   p407
Sangbum Park, David G. Gonzalez, Boris Guirao, Jonathan D. Boucher, Katie Cockburn et al.

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