Complete Cell Solutions for Cancer Research from ATCC
ATCC provides scientists with a complete set of solutions for tumor biology, metastasis, and cancer immunology studies. Our new drug screening tools include a high-throughput angiogenesis assay, gene-edited isogenic cells, and PBMCs. Let ATCC supply the cell lines, primary cells, stem cells, and cell-based services you need for your experiments. Learn more >>
Now is the time to enter Nikon's Small World Photo and Video Competitions. April 30th is the deadline to submit your images and movies taken through the light microscope. In celebration of Nikon's 100th anniversary, the grand prizewinners will receive $3000 and a trip to Japan. The lucky winners will also receive a private tour of Nikon's glass and lens manufacturing facilities.
The National Eye Institute (NEI) is sponsoring a challenge to spur development of a robust 3-D retina organoid system for modeling retina diseases and testing new therapies. Do you have what it takes to accelerate the development of new retinal therapies? All expertise welcome!
Sometimes, a drug can remedy a chemical imbalance or surgery can repair a structural failure, but there are times when there is no substitute for replacing a part with human tissue or an entire organ. Rapid advances in regenerative medicine are bringing that possibility closer to reality.
On data availability, reproducibility and reuse p259 doi:10.1038/ncb3506 Data sharing is an inherent principle of research publication, and information on how data may be accessed is key for the replication and furthering of scientific findings. Here we revisit the policies of Nature Cell Biology on data availability.
Demystifying blood stem cell fates pp261 - 263 Fiona K. Hamey and Berthold Göttgens doi:10.1038/ncb3494 Determining the differentiation potential of stem and progenitor cells is essential for understanding their function, yet our ability to do so is limited by the restrictions of experimental assays. Based on single-cell functional and molecular profiling experiments, a new computational approach shows how lineage commitment may occur in human haematopoiesis.
PARL paves the way to apoptosis pp263 - 265 Naotada Ishihara and Katsuyoshi Mihara doi:10.1038/ncb3504 Although the mitochondrial inner membrane rhomboid peptidase PARL is known to participate in critical signalling cascades, its role in apoptosis has remained unclear. PARL is now shown to process the mitochondrial pro-apoptotic protein Smac (also known as DIABLO) for its subsequent release into the cytosol where it antagonizes XIAP-mediated caspase inhibition to promote apoptosis.
Talin gets SHANKed in the fight for integrin activation pp265 - 267 Paul Atherton and Christoph Ballestrem doi:10.1038/ncb3501 Genetic mutations in the SHANK family of proteins are linked to multiple neuropsychiatric disorders including autism spectrum disorders. A study now elucidates critical roles for SHANK in regulating integrin-mediated cell-extracellular matrix adhesion, by sequestering integrin activators.
Hippo interferes with antiviral defences pp267 - 269 Natalia Muñoz-Wolf and Ed C. Lavelle doi:10.1038/ncb3502 The Hippo pathway responds to environmental factors including nutrient availability, cell density and substrate stiffness to regulate organ size. This pathway is now shown to also regulate antiviral defence by modulating the TBK1-mediated control of interferon production.
Human haematopoietic stem cell lineage commitment is a continuous process pp271 - 281 Lars Velten, Simon F. Haas, Simon Raffel, Sandra Blaszkiewicz, Saiful Islam et al. doi:10.1038/ncb3493 Velten et al. use single-cell transcriptomics and functional data to map the early lineage commitment of human haematopoietic stem cells as a continuous process of cells passing through transitory states rather than demarcating discrete progenitors.
Friction forces position the neural anlage pp306 - 317 Michael Smutny, Zsuzsa Ákos, Silvia Grigolon, Shayan Shamipour, Verena Ruprecht et al. doi:10.1038/ncb3492 Zebrafish neuroectoderm morphogenesis is influenced by the mesoderm germ layer. Smutny et al. now show that friction forces between cells moving in opposite directions, mediated by E-cadherin adhesion, determine the position of the neural anlage.
Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact firstname.lastname@example.org
You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/myaccount (You will need to log in to be recognised as a nature.com registrant)