Tuesday, February 21, 2017

Scientific Reports Biology Table of Contents e-alert: 21 February 2017

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  21 February 2017   
 
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Welcome to your Table of Contents e-alert for Scientific Reports

 
 
 
 
 
 
 
 
 
 
 
 
 
Biological Sciences
 
 
 
 
 
 
 

Expression and distribution of extensins and AGPs in susceptible and resistant banana cultivars in response to wounding and Fusarium oxysporum

 
 

Yunli Wu, Wei Fan, Xiaoquan Li et al.

 
 

Banana Fusarium wilt caused by Fusarium oxysporum f. sp. cubense (Foc) is soil-borne disease of banana (Musa spp.) causing significant economic losses. Extensins and …

 
 
 
 
 
 

Long-term satellite tracking reveals variable seasonal migration strategies of basking sharks in the north-east Atlantic

 
 

P. D. Doherty, J. M. Baxter, F. R. Gell et al.

 
 

Animal migration is ubiquitous in nature with individuals within a population often exhibiting varying movement strategies. The basking shark (Cetorhinus maximus) is the world’s …

 
 
 
 
 
 

A 3′-5′ exonuclease activity embedded in the helicase core domain of Candida albicans Pif1 helicase

 
 

Xiao-Bin Wei, Bo Zhang, Nicolas Bazeille et al.

 
 

3′-5′ exonucleases are frequently found to be associated to polymerases or helicases domains in the same enzyme or could function as autonomous entities. Here we uncovered that

 
 
 
 
 
 

Shared mechanism for emotion processing in adolescents with and without autism

 
 

Christina Ioannou, Marwa El Zein, Valentin Wyart et al.

 
 

Although, the quest to understand emotional processing in individuals with Autism Spectrum Disorders (ASD) has led to an impressive number of studies, the picture that emerges …

 
 
 
 
 
 

Calcium spikes, waves and oscillations in a large, patterned epithelial tissue

 
 

Ramya Balaji, Christina Bielmeier, Hartmann Harz et al.

 
 

While calcium signaling in excitable cells, such as muscle or neurons, is extensively characterized, calcium signaling in epithelial tissues is little understood. Specifically, …

 
 
 
 
 
 

Proteomic analysis of exported chaperone/co-chaperone complexes of P. falciparum reveals an array of complex protein-protein interactions

 
 

Qi Zhang, Cheng Ma, Alexander Oberli et al.

 
 

Malaria parasites modify their human host cell, the mature erythrocyte. This modification is mediated by a large number of parasite proteins that are exported to the host cell, …

 
 
 
 
 
 

A novel HRM assay for the simultaneous detection and differentiation of eight poxviruses of medical and veterinary importance

 
 

Esayas Gelaye, Lukas Mach, Jolanta Kolodziejek et al.

 
 

Poxviruses belonging to the Orthopoxvirus, Capripoxvirus and Parapoxvirus genera share common host species and create a challenge for diagnosis. Here, we developed a novel …

 
 
 
 
 
 

Resveratrol treatment reveals a novel role for HMGB1 in regulation of the type 1 interferon response in dengue virus infection

 
 

Nurhafiza Zainal, Chih-Peng Chang, Yi-Lin Cheng et al.

 
 

Dengue is one of the most significant mosquito-borne virus diseases worldwide, particularly in tropical and subtropical regions. This study sought to examine the antiviral …

 
 
 
 
 
 

CRISPR knockout rat cytochrome P450 3A1/2 model for advancing drug metabolism and pharmacokinetics research

 
 

Jian Lu, Yanjiao Shao, Xuan Qin et al.

 
 

Cytochrome P450 (CYP) 3A accounts for nearly 30% of the total CYP enzymes in the human liver and participates in the metabolism of over 50% of clinical drugs. Moreover, CYP3A …

 
 
 
 
 
 

Discovery of the first dual inhibitor of the 5-lipoxygenase-activating protein and soluble epoxide hydrolase using pharmacophore-based virtual screening

 
 

Veronika Temml, Ulrike Garscha, Erik Romp et al.

 
 

Leukotrienes (LTs) are pro-inflammatory lipid mediators derived from arachidonic acid (AA) with roles in inflammatory and allergic diseases. The biosynthesis of LTs is initiated …

 
 
 
 
 
 

The importance of pollen chemistry in evolutionary host shifts of bees

 
 

Maryse Vanderplanck, Nicolas J. Vereecken, Laurent Grumiau et al.

 
 

Although bee-plant associations are generally maintained through speciation processes, host shifts have occurred during evolution. Understanding shifts between both …

 
 
 
 
 
 

Matrix attachment region combinations increase transgene expression in transfected Chinese hamster ovary cells

 
 

Chun-Peng Zhao, Xiao Guo, Si-Jia Chen et al.

 
 

Matrix attachment regions (MARs) are cis-acting DNA elements that can increase transgene expression levels in a CHO cell expression system. To investigate the effects of MAR …

 
 
 
 
 
 

Interleukin 10 inhibits pro-inflammatory cytokine responses and killing of Burkholderia pseudomallei

 
 

Bianca Kessler, Darawan Rinchai, Chidchamai Kewcharoenwong et al.

 
 

Melioidosis, caused by Burkholderia pseudomallei, is endemic in northeastern Thailand and Northern Australia. Severe septicemic melioidosis is associated with high levels of …

 
 
 
 
 
 

An adaptive decorrelation method removes Illumina DNA base-calling errors caused by crosstalk between adjacent clusters

 
 

Bo Wang, Lin Wan, Anqi Wang et al.

 
 

Base-calling accuracy is crucial for high-throughput DNA sequencing and downstream analysis such as read mapping and genome assembly. Accordingly, we made an endeavor to reduce …

 
 
 
 
 
 

Ubiquitination and dynactin regulate TMEPAI lysosomal trafficking

 
 

Shenheng Luo, Lei Jing, Tian Zhao et al.

 
 

The transmembrane prostate androgen-induced protein (TMEPAI) has been reported to be elevated in various tumor cells, is localized to the lysosome and promotes lysosome …

 
 
 
 
 
 

Natural and laboratory mutations in kuzbanian are associated with zinc stress phenotypes in Drosophila melanogaster

 
 

Hung Le Manh, Lain Guio, Miriam Merenciano et al.

 
 

Organisms must cope with altered environmental conditions such as high concentrations of heavy metals. Stress response to heavy metals is mediated by the metal-responsive …

 
 
 
 
 
 

Genome-wide primary transcriptome analysis of H2-producing archaeon Thermococcus onnurineus NA1

 
 

Suhyung Cho, Min-Sik Kim, Yujin Jeong et al.

 
 

In spite of their pivotal roles in transcriptional and post-transcriptional processes, the regulatory elements of archaeal genomes are not yet fully understood. Here, we …

 
 
 
 
 
 

Rapid and sensitive diagnoses of dry root rot pathogen of chickpea (Rhizoctonia bataticola (Taub.) Butler) using loop-mediated isothermal amplification assay

 
 

Raju Ghosh, Avijit Tarafdar, Mamta Sharma

 
 

Dry root rot (DRR) caused by the fungus Rhizoctonia bataticola (Taub.) Butler, is an emerging disease in chickpea. The disease is often mistaken with other root rots like Fusarium

 
 
 
 
 
 

Hyperthermia and chemotherapy using Fe(Salen) nanoparticles might impact glioblastoma treatment

 
 

Makoto Ohtake, Masanari Umemura, Itaru Sato et al.

 
 

We previously reported that μ-oxo N,N’-bis(salicylidene)ethylenediamine iron [Fe(Salen)], a magnetic organic compound, has direct anti-tumor activity, and generates heat in an …

 
 
 
 
 
 

Thymoquinone: An IRAK1 inhibitor with in vivo and in vitro anti-inflammatory activities

 
 

Muhammad Jahangir Hossen, Woo Seok Yang, Daewon Kim et al.

 
 

Thymoquinone (TQ) is a bioactive component of black seed (Nigella sativa) volatile oil and has been shown to have anti-oxidative, anti-inflammatory, and anti-cancer properties. …

 
 
 
 
 
 

Floating of the lobes of mosquito (Aedes togoi) larva for respiration

 
 

Seung Chul Lee, Jun Ho Kim, Sang Joon Lee

 
 

Mosquito (Aedes togoi) larva has to float its siphon on the water surface to breathe air. To elucidate the floating mechanism of the siphon, morphological structures, especially …

 
 
 
 
 
 

Mutations underlying Episodic Ataxia type-1 antagonize Kv1.1 RNA editing

 
 

Elizabeth A. Ferrick-Kiddie, Joshua J. C. Rosenthal, Gregory D. Ayers et al.

 
 

Adenosine-to-inosine RNA editing in transcripts encoding the voltage-gated potassium channel Kv1.1 converts an isoleucine to valine codon for amino acid 400, speeding channel …

 
 
 
 
 
 

Suramin interacts with the positively charged region surrounding the 5-fold axis of the EV-A71 capsid and inhibits multiple enterovirus A

 
 

Peijun Ren, Yimei Zheng, Wenqi Wang et al.

 
 

Suramin was previously shown to bind to the EV-A71 capsid through its naphthalenetrisulfonic acid groups, thereby reducing virus-cell binding and inhibiting viral replication. …

 
 
 
 
 
 

CD8+ T cells promote proliferation of benign prostatic hyperplasia epithelial cells under low androgen level via modulation of CCL5/STAT5/CCND1 signaling pathway

 
 

Yang Yang, Shuai Hu, Jie Liu et al.

 
 

Previous studies by our group have shown that low intra-prostatic dihydrotestosterone (DHT) induced BPH epithelial cells (BECs) to recruit CD8+ T cells. However, the influence of …

 
 
 
 
 
 

A pan-cancer analysis of secreted Frizzled-related proteins: re-examining their proposed tumour suppressive function

 
 

Krista Marie Vincent, Lynne-Marie Postovit

 
 

Secreted frizzled-related proteins (SFRPs), containing five family members (SFRPs 1–5) are putative extracellular Wnt inhibitors. Given their abilities to inhibit Wnt signalling, …

 
 
 
 
 
 

A combination of mutational and computational scanning guides the design of an artificial ligand-binding controlled lipase

 
 

Marco Kaschner, Oliver Schillinger, Timo Fettweiss et al.

 
 

Allostery, i.e. the control of enzyme activity by a small molecule at a location distant from the enzyme’s active site, represents a mechanism essential for sustaining life. The …

 
 
 
 
 
 

STIM1 Phosphorylation at Y361 Recruits Orai1 to STIM1 Puncta and Induces Ca2+ Entry

 
 

Pascal Yazbeck, Mohammad Tauseef, Kevin Kruse et al.

 
 

Store-operated Ca2+ entry (SOCE) mediates the increase in intracellular calcium (Ca2+) in endothelial cells (ECs) that regulates several EC functions including tissue-fluid …

 
 
 
 
 
 

miR-203 enhances let-7 biogenesis by targeting LIN28B to suppress tumor growth in lung cancer

 
 

Yong Zhou, Hongwei Liang, Zhicong Liao et al.

 
 

Human cancers often exhibit increased microRNA (miRNA) biogenesis and global aberrant expression of miRNAs; thus, targeting the miRNA biogenesis pathway represents a novel …

 
 
 
 
 
 

Dual mechanisms regulate the nucleocytoplasmic localization of human DDX6

 
 

Jo-Hsi Huang, Wei-Chi Ku, Yen-Chun Chen et al.

 
 

DDX6 is a conserved DEAD-box protein (DBP) that plays central roles in cytoplasmic RNA regulation, including processing body (P-body) assembly, mRNA decapping, and translational …

 
 
 
 
 
 

The CUL3-SPOP-DAXX axis is a novel regulator of VEGFR2 expression in vascular endothelial cells

 
 

Tomohisa Sakaue, Iori Sakakibara, Takahiro Uesugi et al.

 
 

Vascular endothelial cell growth factor receptor 2 (VEGFR2) is an essential receptor for the homeostasis of endothelial cells. In this study, we showed that NEDD8-conjugated …

 
 
 
 
 
 

S 38093, a histamine H3 antagonist/inverse agonist, promotes hippocampal neurogenesis and improves context discrimination task in aged mice

 
 

Jean-Philippe Guilloux, Benjamin A. Samuels, Indira Mendez-David et al.

 
 

Strategies designed to increase adult hippocampal neurogenesis (AHN) may have therapeutic potential for reversing memory impairments. H3 receptor antagonists/inverse agonists …

 
 
 
 
 
 

Multi-Constituent Simulation of Thrombus Deposition

 
 

Wei-Tao Wu, Megan A. Jamiolkowski, William R. Wagner et al.

 
 

In this paper, we present a spatio-temporal mathematical model for simulating the formation and growth of a thrombus. Blood is treated as a multi-constituent mixture comprised of …

 
 
 
 
 
 

The interaction between the proliferating macroalga Asparagopsis taxiformis and the coral Astroides calycularis induces changes in microbiome and metabolomic fingerprints

 
 

Stéphane Greff, Tânia Aires, Ester A. Serrão et al.

 
 

Mediterranean Sea ecosystems are considered as hotspots of biological introductions, exposed to possible negative effects of non–indigenous species. In such temperate marine …

 
 
 
 
 
 

Trapping of ivermectin by a pentameric ligand-gated ion channel upon open-to-closed isomerization

 
 

Nurit Degani-Katzav, Moshe Klein, Moran Har-Even et al.

 
 

Ivermectin (IVM) is a broad-spectrum anthelmintic drug used to treat human parasitic diseases like river blindness and lymphatic filariasis. By activating invertebrate pentameric …

 
 
 
 
 
 

Massively augmented hippocampal dentate granule cell activation accompanies epilepsy development

 
 

Christopher G. Dengler, Cuiyong Yue, Hajime Takano et al.

 
 

In a mouse model of temporal lobe epilepsy, multicellular calcium imaging revealed that disease emergence was accompanied by massive amplification in the normally sparse, …

 
 
 
 
 
 

Vinculin variant M94I identified in sudden unexplained nocturnal death syndrome decreases cardiac sodium current

 
 

Jianding Cheng, John W. Kyle, Brandi Wiedmeyer et al.

 
 

Sudden unexplained nocturnal death syndrome (SUNDS) remains an autopsy negative disorder with unclear etiology. Vinculin (VCL) was linked to sudden arrhythmia death in VCL …

 
 
 
 
 
 

Structure and dynamics of Type III periplasmic proteins VcFhuD and VcHutB reveal molecular basis of their distinctive ligand binding properties

 
 

Shubhangi Agarwal, Sanjay Dey, Biplab Ghosh et al.

 
 

Molecular mechanisms of xenosiderophore and heme acquisitions using periplasmic binding protein (PBP) dependent ATP-binding cassette transporters to scavenge the essential …

 
 
 
 
 
 

Plin5 alleviates myocardial ischaemia/reperfusion injury by reducing oxidative stress through inhibiting the lipolysis of lipid droplets

 
 

Pengfei Zheng, Zhonglin Xie, Yuan Yuan et al.

 
 

Myocardial ischaemia-reperfusion (I/R) injury is a complex pathophysiological process. Current research has suggested that energy metabolism disorders, of which the abnormal …

 
 
 
 
 
 

Pneumococcal prophages are diverse, but not without structure or history

 
 

Angela B. Brueggemann, Caroline L. Harrold, Reza Rezaei Javan et al.

 
 

Bacteriophages (phages) infect many bacterial species, but little is known about the diversity of phages among the pneumococcus, a leading global pathogen. The objectives of this …

 
 
 
 
 
 

Mechanistic Investigation on ROS Resistance of Phosphorothioated DNA

 
 

Tingting Wu, Qiang Huang, Xiao-Lei Wang et al.

 
 

Phosphorothioated DNA (PT-DNA) exhibits a mild anti-oxidant property both in vivo and in vitro. It was found that 8-OHdG and ROS levels were significantly lower in dnd+ (i.e. S+)

 
 
 
 
 
 

Effects of U0126 and MK2206 on cell growth and re-growth of endometriotic stromal cells grown on substrates of varying stiffness

 
 

Sachiko Matsuzaki, Jean-Luc Pouly, Michel Canis

 
 

Endometriosis is a common gynecological disorder responsible for infertility and pelvic pain. A complete cure for patients with endometriosis awaits new targets and strategies. …

 
 
 
 
 
 

Extracellular Superoxide Dismutase Expression in Papillary Thyroid Cancer Mesenchymal Stem/Stromal Cells Modulates Cancer Cell Growth and Migration

 
 

Alessia Parascandolo, Francesca Rappa, Francesco Cappello et al.

 
 

Tumor stroma-secreted growth factors, cytokines, and reactive oxygen species (ROS) influence tumor development from early stages to the metastasis phase. Previous studies have …

 
 
 
 
 
 

Graphene-Induced Pore Formation on Cell Membranes

 
 

Guangxin Duan, Yuanzhao Zhang, Binquan Luan et al.

 
 

Examining interactions between nanomaterials and cell membranes can expose underlying mechanisms of nanomaterial cytotoxicity and guide the design of safer nanomedical …

 
 
 
 
 
 

Interaction of Cutibacterium ( formerly Propionibacterium) acnes with bone cells: a step toward understanding bone and joint infection development

 
 

Guillaume Ghislain Aubin, Marc Baud’huin, Jean-Philippe Lavigne et al.

 
 

Cutibacterium acnes (formerly Propionibacterium acnes) is recognized as a pathogen in foreign-body infections (arthroplasty or spinal instrumentation). To date, the direct impact …

 
 
 
 
 
 

The ubiquitin ligase Cullin5SOCS2 regulates NDR1/STK38 stability and NF-κB transactivation

 
 

Indranil Paul, Tanveer S. Batth, Diego Iglesias-Gato et al.

 
 

SOCS2 is a pleiotropic E3 ligase. Its deficiency is associated with gigantism and organismal lethality upon inflammatory challenge. However, mechanistic understanding of SOCS2 …

 
 
 
 
 
 

Multi-institutional study of nuclear KIFC1 as a biomarker of poor prognosis in African American women with triple-negative breast cancer

 
 

Angela Ogden, Chakravarthy Garlapati, Xiaoxian (Bill) Li et al.

 
 

Nuclear KIFC1 (nKIFC1) predicts worse outcomes in breast cancer, but its prognostic value within racially distinct triple-negative breast cancer (TNBC) patients is unknown. Thus, …

 
 
 
 
 
 

Development of in vitro and in vivo rabies virus neutralization assays based on a high-titer pseudovirus system

 
 

Jianhui Nie, Xiaohong Wu, Jian Ma et al.

 
 

Pseudoviruses are useful virological tools because of their safety and versatility; however the low titer of these viruses substantially limits their wider applications. We …

 
 
 
 
 
 

Fractalkine-CX3CR1 signaling is critical for progesterone-mediated neuroprotection in the retina

 
 

Sarah L. Roche, Alice C. Wyse-Jackson, Ana M. Ruiz-Lopez et al.

 
 

Retinitis pigmentosa (RP) encompasses a group of retinal diseases resulting in photoreceptor loss and blindness. We have previously shown in the rd10 mouse model of RP, that rd10 …

 
 
 
 
 
 

Performance, kinetic, and biodegradation pathway evaluation of anaerobic fixed film fixed bed reactor in removing phthalic acid esters from wastewater

 
 

Ehsan Ahmadi, Samira Yousefzadeh, Mohsen Ansari et al.

 
 

Emerging and hazardous environmental pollutants like phthalic acid esters (PAEs) are one of the recent concerns worldwide. PAEs are considered to have diverse endocrine …

 
 
 
 
 
 

Mangiferin from Pueraria tuberosa reduces inflammation via inactivation of NLRP3 inflammasome

 
 

Ramakrishna K. Bulugonda, Kotha Anil kumar, D. Gangappa et al.

 
 

Recent reports have demonstrated the role of phyto-constituents in modulating inflammatory responses. Mangiferin isolated from Mangifera indica is known to induce potent …

 
 
 
 
 
 

CCR7 deficient inflammatory Dendritic Cells are retained in the Central Nervous System

 
 

Benjamin D. Clarkson, Alec Walker, Melissa G. Harris et al.

 
 

Dendritic cells (DC) accumulate in the CNS during neuroinflammation, yet, how these cells contribute to CNS antigen drainage is still unknown. We have previously shown that after …

 
 
 
 
 
 

Decline causes of Koalas in South East Queensland, Australia: a 17-year retrospective study of mortality and morbidity

 
 

Viviana Gonzalez-Astudillo, Rachel Allavena, Allan McKinnon et al.

 
 

Koala populations are in catastrophic decline in certain eastern Australian regions. Spanning from 1997–2013, a database derived from wildlife hospitals in southeast Queensland …

 
 
 
 
 
 

Intraluminal pressure patterns in the human colon assessed by high-resolution manometry

 
 

Ji-Hong Chen, Yuanjie Yu, Zixian Yang et al.

 
 

Assessment of colonic motor dysfunction is rarely done because of inadequate methodology and lack of knowledge about normal motor patterns. Here we report on elucidation of …

 
 
 
 
 
 

Sleep Supports the Slow Abstraction of Gist from Visual Perceptual Memories

 
 

Nicolas D. Lutz, Susanne Diekelmann, Patricia Hinse-Stern et al.

 
 

Sleep benefits the consolidation of individual episodic memories. In the long run, however, it may be more efficient to retain the abstract gist of single, related memories, …

 
 
 
 
 
 

Corrigendum: Harnessing Nature’s Diversity: Discovering organophosphate bioscavenger characteristics among low molecular weight proteins

 
 

Reed B. Jacob, Kenan C. Michaels, Cathy J. Anderson et al.

 
 

 
 
 
 
 
 

The Use of Bright and Dark Types of Humour is Rooted in the Brain

 
 

Ilona Papousek, Willibald Ruch, Christian Rominger et al.

 
 

The ways in which humour can be used are related to the manifold interpersonal functions humour can serve, some of which are positive, and some negative. In the present study, …

 
 
 
 
 
 

Suppression of TAK1 pathway by shear stress counteracts the inflammatory endothelial cell phenotype induced by oxidative stress and TGF-β1

 
 

Ee Soo Lee, Llorenç Solé Boldo, Bernadette O. Fernandez et al.

 
 

Endothelial dysfunction is characterised by aberrant redox signalling and an inflammatory phenotype. Shear stress antagonises endothelial dysfunction by increasing nitric oxide …

 
 
 
 
 
 

Expression profiling of TRIM protein family in THP1-derived macrophages following TLR stimulation

 
 

Mei-Xiu Jiang, Xuan Hong, Bin-Bin Liao et al.

 
 

Activated macrophages play an important role in many inflammatory diseases including septic shock and atherosclerosis. However, the molecular mechanisms limiting macrophage …

 
 
 
 
 
 

Biofilm formation of the black yeast-like fungus Exophiala dermatitidis and its susceptibility to antiinfective agents

 
 

Lisa Kirchhoff , Maike Olsowski, Katrin Zilmans et al.

 
 

Various fungi have the ability to colonize surfaces and to form biofilms. Fungal biofilm-associated infections are frequently refractory to targeted treatment because of …

 
 
 
 
 
 

Molecular Basis of ABHD5 Lipolysis Activation

 
 

Matthew A. Sanders, Huamei Zhang, Ljiljana Mladenovic et al.

 
 

Alpha-beta hydrolase domain-containing 5 (ABHD5), the defective gene in human Chanarin-Dorfman syndrome, is a highly conserved regulator of adipose triglyceride lipase …

 
 
 
 
 
 

Epigenetic and genetic dissections of UV-induced global gene dysregulation in skin cells through multi-omics analyses

 
 

Yao Shen, Milda Stanislauskas, Gen Li et al.

 
 

To elucidate the complex molecular mechanisms underlying the adverse effects UV radiation (UVR) on skin homeostasis, we performed multi-omics studies to characterize UV-induced …

 
 
 
 
 
 

Factors Affecting Leaf Selection by Foregut-fermenting Proboscis Monkeys: New Insight from in vitro Digestibility and Toughness of Leaves

 
 

Ikki Matsuda, Marcus Clauss, Augustine Tuuga et al.

 
 

Free-living animals must make dietary choices in terms of chemical and physical properties, depending on their digestive physiology and availability of food resources. Here we …

 
 
 
 
 
 

Optimization of the production of knock-in alleles by CRISPR/Cas9 microinjection into the mouse zygote

 
 

Aurélien Raveux, Sandrine Vandormael-Pournin, Michel Cohen-Tannoudji

 
 

Microinjection of the CRISPR/Cas9 system in zygotes is an efficient and comparatively fast method to generate genetically modified mice. So far, only few knock-in mice have been …

 
 
 
 
 
 

Pnc1 piggy-back import into peroxisomes relies on Gpd1 homodimerisation

 
 

Nadal A. Al Saryi, John D. Hutchinson, Murtakab Y. Al-hejjaj et al.

 
 

Peroxisomes are eukaryotic organelles that posttranslationally import proteins via one of two conserved peroxisomal targeting signal (PTS1 or 2) mediated pathways. Oligomeric …

 
 
 
 
 
 

Regulation of mRNA splicing by MeCP2 via epigenetic modifications in the brain

 
 

Tian-Lin Cheng, Jingqi Chen, Huida Wan et al.

 
 

Mutations of X-linked gene Methyl CpG binding protein 2 (MECP2) are the major causes of Rett syndrome (RTT), a severe neurodevelopmental disorder. Duplications of MECP2

 
 
 
 
 
 

Video monitoring of brown planthopper predation in rice shows flaws of sentinel methods

 
 

Yi Zou, Joop de Kraker, Felix J. J. A. Bianchi et al.

 
 

Immobilized preys are routinely used in agro-ecological exposure studies to quantify predation of pests under field conditions, but this method has not been validated. Our …

 
 
 
 
 
 

Natural persistence of the coastal plant Glehnia littoralis along temperate sandy coasts

 
 

Hong-Xiao Yang, Jian-Min Chu, Xiao-Shan Liu

 
 

We studied germination behaviors and persistence mechanism of wild Glehnia littoralis, a typical coastal species at temperate sandy coasts of the North Pacific Ocean, and tested …

 
 
 
 
 
 

In vitro and in vivo physiology of low nanomolar concentrations of Zn2+ in artificial cerebrospinal fluid

 
 

Haruna Tamano, Ryusuke Nishio, Yukina Shakushi et al.

 
 

Artificial cerebrospinal fluid (ACSF), i.e., brain extracellular medium, which includes Ca2+ and Mg2+, but not other divalent cations such as Zn2+, has been used for in vitro and

 
 
 
 
 
 

Characterization of celiac disease related oat proteins: bases for the development of high quality oat varieties suitable for celiac patients

 
 

María J. Giménez, Ana Real, M. Dolores García-Molina et al.

 
 

Some studies have suggested that the immunogenicity of oats depends on the cultivar. RP-HPLC has been proposed as a useful technique to select varieties of oats with reduced …

 
 
 
 
 
 

Integration of microRNA and mRNA expression profiles in the skin of systemic sclerosis patients

 
 

Bin Zhou, Xiao Xia Zuo, Yi Sha Li et al.

 
 

MicroRNAs (miRNAs) play important roles in the fibrosis of systemic sclerosis (SSc). However, the underlying miRNA-mRNA regulatory network is not fully understood. A systemic …

 
 
 
 
 
 

Structure and polymorphisms of the major histocompatibility complex in the Oriental stork, Ciconia boyciana

 
 

Hiroki Tsuji, Yukio Taniguchi, Shintaro Ishizuka et al.

 
 

The major histocompatibility complex (MHC) is highly polymorphic and plays a central role in the vertebrate immune system. Despite its functional consistency, the MHC genomic …

 
 
 
 
 
 

Solution of the spatial neutral model yields new bounds on the Amazonian species richness

 
 

Yahav Shem-Tov, Matan Danino, Nadav M. Shnerb

 
 

Neutral models, in which individual agents with equal fitness undergo a birth-death-mutation process, are very popular in population genetics and community ecology. Usually these …

 
 
 
 
 
 

Genetic analysis of 19 X chromosome STR loci for forensic purposes in four Chinese ethnic groups

 
 

Xingyi Yang, Xiaofang Zhang, Junyong Zhu et al.

 
 

A new 19 X- short tandem repeat (STR) multiplex PCR system has recently been developed, though its applicability in forensic studies has not been thoroughly assessed. In this …

 
 
 
 
 
 

The Enforcement of Moral Boundaries Promotes Cooperation and Prosocial Behavior in Groups

 
 

Brent Simpson, Robb Willer, Ashley Harrell

 
 

The threat of free-riding makes the marshalling of cooperation from group members a fundamental challenge of social life. Where classical social science theory saw the …

 
 
 
 
 
 

Proteomic analysis of urinary extracellular vesicles from high Gleason score prostate cancer

 
 

Kazutoshi Fujita, Hideaki Kume, Kyosuke Matsuzaki et al.

 
 

Extracellular vesicles (EVs) are microvesicles secreted from various cell types. We aimed to discover a new biomarker for high Gleason score (GS) prostate cancer (PCa) in urinary …

 
 
 
 
 
 

Bisphosphonates enhance antitumor effect of EGFR-TKIs in patients with advanced EGFR mutant NSCLC and bone metastases

 
 

Guowei Zhang, Ruirui Cheng, Zengli Zhang et al.

 
 

Whether bisphosphonates could enhance the effect of epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) in non-small-cell lung cancer (NSCLC) patients with …

 
 
 
 
 
 

High-resolution 3D imaging of whole organ after clearing: taking a new look at the zebrafish testis

 
 

Maxence Frétaud, Laurie Rivière, Élodie De Job et al.

 
 

Zebrafish testis has become a powerful model for reproductive biology of teleostean fishes and other vertebrates and encompasses multiple applications in applied and basic …

 
 
 
 
 
 

The attention network changes in breast cancer patients receiving neoadjuvant chemotherapy: Evidence from an arterial spin labeling perfusion study

 
 

Xingui Chen, Xiaoxuan He, Longxiang Tao et al.

 
 

To investigate the neural mechanisms underlying attention deficits that are related to neoadjuvant chemotherapy in combination with cerebral perfusion. Thirty one patients with …

 
 
 
 
 
 

The propensity of the bacterial rodlin protein RdlB to form amyloid fibrils determines its function in Streptomyces coelicolor

 
 

Wen Yang, Joost Willemse, Elizabeth B. Sawyer et al.

 
 

Streptomyces bacteria form reproductive aerial hyphae that are covered with a pattern of pairwise aligned fibrils called rodlets. The presence of the rodlet layer requires two …

 
 
 
 
 
 

Palindromic amplification of the ERBB2 oncogene in primary HER2-positive breast tumors

 
 

Michael Marotta, Taku Onodera, Jeffrey Johnson et al.

 
 

Oncogene amplification confers a growth advantage to tumor cells for clonal expansion. There are several, recurrently amplified oncogenes throughout the human genome. However, it …

 
 
 
 
 
 

Identification of the core regulators of the HLA I-peptide binding process

 
 

Yu-Hang Zhang, Zhihao Xing, Chenglin Liu et al.

 
 

During the display of peptide/human leukocyte antigen (HLA) -I complex for further immune recognition, the cleaved and transported antigenic peptides have to bind to HLA-I …

 
 
 
 
 
 

Effects of strength training on osteogenic differentiation and bone strength in aging female Wistar rats

 
 

Monique Patricio Singulani, Camila Tami Stringhetta-Garcia, Leandro Figueiredo Santos et al.

 
 

The effects of strength training (ST) on the mechanical bone strength and osteogenic differentiation of bone marrow mesenchymal stromal cells (BMSCs) from adult, aged and …

 
 
 
 
 
 

Interference between variants of peach latent mosaic viroid reveals novel features of its fitness landscape: implications for detection

 
 

Pedro Serra, Edson Bertolini, M. Carmen Martínez et al.

 
 

Natural populations of peach latent mosaic viroid (PLMVd) are complex mixtures of variants. During routine testing, TaqMan rtRT-PCR and RNA gel-blot hybridization produced …

 
 
 
 
 
 

Ecology and genetics affect relative invasion success of two Echium species in southern Australia

 
 

Xiaocheng Zhu, Paul A. Weston, Dominik Skoneczny et al.

 
 

Echium plantagineum and E. vulgare are congeneric exotics first introduced to Australia in the early 1800 s. There, E. plantagineum is now highly invasive, whereas E. vulgare has …

 
 
 
 
 
 

Computer-aided designing of immunosuppressive peptides based on IL-10 inducing potential

 
 

Gandharva Nagpal, Salman Sadullah Usmani, Sandeep Kumar Dhanda et al.

 
 

In the past, numerous methods have been developed to predict MHC class II binders or T-helper epitopes for designing the epitope-based vaccines against pathogens. In contrast, …

 
 
 
 
 
 

In vitro differentiation of fertile sperm from cryopreserved spermatogonia of the endangered endemic cyprinid honmoroko (Gnathopogon caerulescens)

 
 

Shogo Higaki, Manami Shimada, Kazuaki Kawamoto et al.

 
 

Many endemic fish species are threatened with extinction. Conservation strategies and the restoration of endemic fish after extinction must therefore be investigated. Although …

 
 
 
 
 
 

Motor phenotype is not associated with vascular dysfunction in symptomatic Huntington’s disease transgenic R6/2 (160 CAG) mice

 
 

A. Di Pardo, A. Carrizzo, A. Damato et al.

 
 

Whereas Huntington’s disease (HD) is unequivocally a neurological disorder, a critical mass of emerging studies highlights the occurrence of peripheral pathology like …

 
 
 
 
 
 

Activating Akt1 mutations alter DNA double strand break repair and radiosensitivity

 
 

S. Oeck, K. Al-Refae, H. Riffkin et al.

 
 

The survival kinase Akt has clinical relevance to radioresistance. However, its contributions to the DNA damage response, DNA double strand break (DSB) repair and apoptosis …

 
 
 
 
 
 

Rabconnectin-3α is required for the morphological maturation of GnRH neurons and kisspeptin responsiveness

 
 

Brooke K. Tata, Carole Harbulot, Zsolt Csaba et al.

 
 

A few hundred hypothalamic neurons form a complex network that controls reproduction in mammals by secreting gonadotropin-releasing hormone (GnRH). Timely postnatal changes in …

 
 
 
 
 
 

Hepatocyte-secreted extracellular vesicles modify blood metabolome and endothelial function by an arginase-dependent mechanism

 
 

Felix Royo, Laura Moreno, Justyna Mleczko et al.

 
 

Hepatocytes release extracellular vesicles (EVs) loaded with signaling molecules and enzymes into the bloodstream. Although the importance of EVs in the intercellular …

 
 
 
 
 
 

Corrigendum: Cytochrome P450-2E1 promotes fast food-mediated hepatic fibrosis

 
 

Mohamed A. Abdelmegeed, Youngshim Choi, Grzegorz Godlewski et al.

 
 

 
 
 
 
 
 

Transient Cannabinoid Receptor 2 Blockade during Immunization Heightens Intensity and Breadth of Antigen-specific Antibody Responses in Young and Aged mice

 
 

Emmanuel Dotsey, Irina Ushach, Egest Pone et al.

 
 

The hallmark of vaccines is their ability to prevent the spread of infectious pathogens and thereby serve as invaluable public health tool. Despite their medical relevance, there …

 
 
 
 
 
 

High-amplitude electrical stimulation can reduce elicited neuronal activity in visual prosthesis

 
 

Alejandro Barriga-Rivera, Tianruo Guo, Chih-Yu Yang et al.

 
 

Retinal electrostimulation is promising a successful therapy to restore functional vision. However, a narrow stimulating current range exists between retinal neuron excitation …

 
 
 
 
 
 

Structure of a LOV protein in apo-state and implications for construction of LOV-based optical tools

 
 

Vladimir Arinkin, Joachim Granzin, Katrin Röllen et al.

 
 

Unique features of Light-Oxygen-Voltage (LOV) proteins like relatively small size (~12–19 kDa), inherent modularity, highly-tunable photocycle and oxygen-independent fluorescence …

 
 
 
 
 
 

Novel Roles for Staufen1 in Embryonal and Alveolar Rhabdomyosarcoma via c-myc-dependent and -independent events

 
 

Tara E. Crawford Parks, Kristen A. Marcellus, Jonathan Langill et al.

 
 

Rhabdomyosarcoma is the most common soft tissue sarcoma in children and young adults. Rhabdomyosarcomas are skeletal muscle-like tumours that typically arise in muscle beds, and …

 
 
 
 
 
 

Structural basis for fragmenting the exopolysaccharide of Acinetobacter baumannii by bacteriophage ΦAB6 tailspike protein

 
 

I-Ming Lee, I-Fan Tu, Feng-Ling Yang et al.

 
 

With an increase in antibiotic-resistant strains, the nosocomial pathogen Acinetobacter baumannii has become a serious threat to global health. Glycoconjugate vaccines containing …

 
 
 
 
 
 

The effect of gut microbiome on tolerance to morphine mediated antinociception in mice

 
 

Minho Kang, Ryan A. Mischel, Sukhada Bhave et al.

 
 

There is growing appreciation for the importance of gastrointestinal microbiota in many physiological and pathophysiological processes. While morphine and other narcotics are the …

 
 
 
 
 
 

Fibulin-6 regulates pro-fibrotic TGF-β responses in neonatal mouse ventricular cardiac fibroblasts

 
 

Arpita Chowdhury, Lisa Hasselbach, Frank Echtermeyer et al.

 
 

Fibulin-6, an essential component of extracellular matrix determines the architecture of cellular junctions in tissues undergoing strain. Increased expression and deposition of …

 
 
 
 
 
 

Molecular Interplay between the Dimer Interface and the Substrate-Binding Site of Human Peptidylarginine Deiminase 4

 
 

Chien-Yun Lee, Chu-Cheng Lin, Yi-Liang Liu et al.

 
 

Our previous studies suggest that the fully active form of Peptidylarginine deiminase 4 (PAD4) should be a dimer and not a monomer. This paper provides a plausible mechanism for …

 
 
 
 
 
 

Antisense miR-132 blockade via the AChE-R splice variant mitigates cortical inflammation

 
 

Nibha Mishra, Lyndon Friedson, Geula Hanin et al.

 
 

MicroRNA (miR)-132 brain-to-body messages suppress inflammation by targeting acetylcholinesterase (AChE), but the target specificity of 3’-AChE splice variants and the signaling …

 
 
 
 
 
 

Ambient Ultrafine Particle Ingestion Alters Gut Microbiota in Association with Increased Atherogenic Lipid Metabolites

 
 

Rongsong Li, Jieping Yang, Arian Saffari et al.

 
 

Ambient particulate matter (PM) exposure is associated with atherosclerosis and inflammatory bowel disease. Ultrafine particles (UFP, dp < 0.1–0.2 μm) are redox active components …

 
 
 
 
 
 

Generation and quantitative proteomics analysis of CK2α/α’(−/−) cells

 
 

Christian Borgo, Cinzia Franchin, Stefano Scalco et al.

 
 

CK2 is a ubiquitous, constitutively active, highly pleiotropic, acidophilic Ser/Thr protein kinase whose holoenzyme is composed of two catalytic (α and/or α’) subunits and a …

 
 
 
 
 
 

RNA-Seq-based transcriptomic and metabolomic analysis reveal stress responses and programmed cell death induced by acetic acid in Saccharomyces cerevisiae

 
 

Yachen Dong, Jingjin Hu, Linlin Fan et al.

 
 

As a typical harmful inhibitor in cellulosic hydrolyzates, acetic acid not only hinders bioethanol production, but also induces cell death in Saccharomyces cerevisiae. Herein, we …

 
 
 
 
 
 

Visualisation of abscisic acid and 12-oxo-phytodienoic acid in immature Phaseolus vulgaris L. seeds using desorption electrospray ionisation-imaging mass spectrometry

 
 

Hirofumi Enomoto, Takuya Sensu, Kei Sato et al.

 
 

The plant hormone abscisic acid (ABA) and the jasmonic acid related-compound 12-oxo-phytodienoic acid (OPDA) play crucial roles in seed development, dormancy, and germination. …

 
 
 
 
 
 

Colonisation in social species: the importance of breeding experience for dispersal in overcoming information barriers

 
 

A. Payo-Payo, M. Genovart, A. Sanz-Aguilar et al.

 
 

Studying colonisation is crucial to understand metapopulations, evolutionary ecology and species resilience to global change. Unfortunately, few empirical data are available …

 
 
 
 
 
 

Soil aggregate mediates the impacts of land uses on organic carbon, total nitrogen, and microbial activity in a Karst ecosystem

 
 

Shuangshuang Xiao, Wei Zhang, Yingying Ye et al.

 
 

Understanding the effect of land use on soil carbon, nitrogen, and microbial activity associated with aggregates is critical for thorough comprehension of the C and N dynamics of …

 
 
 
 
 
 

Zebrafish tracking using convolutional neural networks

 
 

Zhiping XU, Xi En Cheng

 
 

Keeping identity for a long term after occlusion is still an open problem in the video tracking of zebrafish-like model animals, and accurate animal trajectories are the …

 
 
 
 
 
 

The prognostic value of cytotoxic T-lymphocyte antigen 4 in cancers: a systematic review and meta-analysis

 
 

Pingping Hu, Qiqi Liu, Guodong Deng et al.

 
 

The outcomes of studies analyzing the prognostic role of CTLA-4 in cancers are controversial. Therefore, the aim of our meta-analysis was to clarify the correlation between …

 
 
 
 
 
 

25-Hydroxyvitamin D3 induces osteogenic differentiation of human mesenchymal stem cells

 
 

Yan-Ru Lou, Tai Chong Toh, Yee Han Tee et al.

 
 

25-Hydroxyvitamin D3 [25(OH)D3] has recently been found to be an active hormone. Its biological actions are demonstrated in various cell types. 25(OH)D3 deficiency results in …

 
 
 
 
 
 

Possible Involvement of F1F0-ATP synthase and Intracellular ATP in Keratinocyte Differentiation in normal skin and skin lesions

 
 

Xie Xiaoyun, Han Chaofei, Zeng Weiqi et al.

 
 

The F1F0-ATP synthase, an enzyme complex, is mainly located on the mitochondrial inner membrane or sometimes cytomembrane to generate or hydrolyze ATP, play a role in cell …

 
 
 
 
 
 

Focus on PNA Flexibility and RNA Binding using Molecular Dynamics and Metadynamics

 
 

Massimiliano Donato Verona, Vincenzo Verdolino, Ferruccio Palazzesi et al.

 
 

Peptide Nucleic Acids (PNAs) can efficiently target DNA or RNA acting as chemical tools for gene regulation. Their backbone modification and functionalization is often used to …

 
 
 
 
 
 

The inflammatory cytokine TNF-α promotes the premature senescence of rat nucleus pulposus cells via the PI3K/Akt signaling pathway

 
 

Pei Li, Yibo Gan, Yuan Xu et al.

 
 

Premature senescence of nucleus pulposus (NP) cells and inflammation are two common features of degenerated discs. This study investigated the effects of the inflammatory …

 
 
 
 
 
 

Characterization of biocarbon-source recovery and microbial community shifts from waste activated sludge by conditioning with cornstover: Assessment of cellulosic compositions

 
 

Kaili Wen, Aijuan Zhou, Jiaguang Zhang et al.

 
 

Most studies on the production of volatile fatty acids (VFAs) from waste activated sludge (WAS) digestion have focused on operating conditions, pretreatments and characteristic …

 
 
 
 
 
 

Dissection of genomic features and variations of three pathotypes of Puccinia striiformis through whole genome sequencing

 
 

Kanti Kiran, Hukam C. Rawal, Himanshu Dubey et al.

 
 

Stripe rust of wheat, caused by Puccinia striiformis f. sp. tritici, is one of the important diseases of wheat. We used NGS technologies to generate a draft genome sequence of …

 
 
 
 
 
 

Reversal of the Apoptotic Resistance of Non-Small-Cell Lung Carcinoma towards TRAIL by Natural Product Toosendanin

 
 

Xin Li, Ming You, Yong-jian Liu et al.

 
 

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) selectively triggers cancer cell death via its association with death receptors on the cell membrane, but exerts …

 
 
 
 
 
 

Depth-specific fluctuations of gene expression and protein abundance modulate the photophysiology in the seagrass Posidonia oceanica

 
 

Gabriele Procaccini, Miriam Ruocco, Lázaro Marín-Guirao et al.

 
 

Here we present the results of a multiple organizational level analysis conceived to identify acclimative/adaptive strategies exhibited by the seagrass Posidonia oceanica to the …

 
 
 
 
 
 

PEDF mediates pathological neovascularization by regulating macrophage recruitment and polarization in the mouse model of oxygen-induced retinopathy

 
 

Sha Gao, Changwei Li, Yanji Zhu et al.

 
 

Macrophages have been demonstrated to play a proangiogenic role in retinal pathological vascular growth. Pigment epithelium-derived factor (PEDF) works as a powerful endogenous …

 
 
 
 
 
 

Differential Effects of Hormones on Cellular Metabolism in Keratoconus In Vitro

 
 

Tina B. McKay, Jesper Hjortdal, Henrik Sejersen et al.

 
 

Keratoconus (KC) is a corneal thinning disease with an onset commonly immediately post-puberty and stabilization by 40 to 50 years of age. The role of hormones in regulating …

 
 
 
 
 
 

A data-driven approach for evaluating multi-modal therapy in traumatic brain injury

 
 

Jenny Haefeli, Adam R. Ferguson, Deborah Bingham et al.

 
 

Combination therapies targeting multiple recovery mechanisms have the potential for additive or synergistic effects, but experimental design and analyses of multimodal …

 
 
 
 
 
 

Using DNA metabarcoding to investigate honey bee foraging reveals limited flower use despite high floral availability

 
 

Natasha de Vere, Laura E. Jones, Tegan Gilmore et al.

 
 

Understanding which flowers honey bees (Apis mellifera) use for forage can help us to provide suitable plants for healthy honey bee colonies. Accordingly, honey DNA metabarcoding …

 
 
 
 
 
 

Erratum: Genome analysis of Campylobacter concisus strains from patients with inflammatory bowel disease and gastroenteritis provides new insights into pathogenicity

 
 

Heung Kit Leslie Chung, Alfred Tay, Sophie Octavia et al.

 
 

 
 
 
 
 
 

Quantitative bioassay to identify antimicrobial drugs through drug interaction fingerprint analysis

 
 

Zohar B. Weinstein, Muhammad H. Zaman

 
 

Drug interaction analysis, which reports the extent to which the presence of one drug affects the efficacy of another, is a powerful tool to select potent combinatorial therapies …

 
 
 
 
 
 

PAK4 interacts with p85 alpha: implications for pancreatic cancer cell migration

 
 

Helen King, Kiruthikah Thillai, Andrew Whale et al.

 
 

It has been reported that p21-activated kinase 4 (PAK4) is amplified in pancreatic cancer tissue. PAK4 is a member of the PAK family of serine/threonine kinases, which act as …

 
 
 
 
 
 

A Jurassic stem pleurodire sheds light on the functional origin of neck retraction in turtles

 
 

Jérémy Anquetin, Haiyan Tong, Julien Claude

 
 

Modern turtles are composed of two monophyletic groups, notably diagnosed by divergent neck retraction mechanisms. Pleurodires (side-necked turtles) bend their neck sideways and …

 
 
 
 
 
 

DNA analysis of a 30,000-year-old Urocitellus glacialis from northeastern Siberia reveals phylogenetic relationships between ancient and present-day arctic ground squirrels

 
 

Marina Faerman, Gila Kahila Bar-Gal, Elisabetta Boaretto et al.

 
 

In contrast to the abundant fossil record of arctic ground squirrels, Urocitellus parryii, from eastern Beringia, only a limited number of fossils is known from its western part. …

 
 
 
 
 
 

Effects of miR-146a on the osteogenesis of adipose-derived mesenchymal stem cells and bone regeneration

 
 

Qing Xie, Wei Wei, Jing Ruan et al.

 
 

Increasing evidence has indicated that bone morphogenetic protein 2 (BMP2) coordinates with microRNAs (miRNAs) to form intracellular networks regulating mesenchymal stem cells …

 
 
 
 
 
 

Complement component 5 promotes lethal thrombosis

 
 

Tomohiro Mizuno, Kengo Yoshioka, Masashi Mizuno et al.

 
 

Extracellular histones promote platelet aggregation and thrombosis; this is followed by induction of coagulation disorder, which results in exhaustion of coagulation factors. …

 
 
 
 
 
 

Bribery games on inter-dependent regular networks

 
 

Prateek Verma, Anjan K. Nandi, Supratim Sengupta

 
 

We examine a scenario of social conflict that is manifest during an interaction between government servants providing a service and citizens who are legally entitled to the …

 
 
 
 
 
 

Genome editing reveals dmrt1 as an essential male sex-determining gene in Chinese tongue sole (Cynoglossus semilaevis)

 
 

Zhongkai Cui, Yun Liu, Wenwen Wang et al.

 
 

Chinese tongue sole is a marine fish with ZW sex determination. Genome sequencing suggested that the Z-linked dmrt1 is a putative male determination gene, but direct genetic …

 
 
 
 
 
 

Genomic insights into the population structure and history of the Irish Travellers

 
 

Edmund Gilbert, Shai Carmi, Sean Ennis et al.

 
 

The Irish Travellers are a population with a history of nomadism; consanguineous unions are common and they are socially isolated from the surrounding, ‘settled’ Irish people. …

 
 
 
 
 
 

Risk factors for brain metastases after prophylactic cranial irradiation in small cell lung cancer

 
 

Haiyan Zeng, Peng Xie, Xue Meng et al.

 
 

Despite administration of prophylactic cranial irradiation (PCI), some small cell lung cancer (SCLC) patients still suffer from brain metastases (BM) with unknown risk factors. …

 
 
 
 
 
 

A New Joint-Blade SENSE Reconstruction for Accelerated PROPELLER MRI

 
 

Mengye Lyu, Yilong Liu, Victor B. Xie et al.

 
 

PROPELLER technique is widely used in MRI examinations for being motion insensitive, but it prolongs scan time and is restricted mainly to T2 contrast. Parallel imaging can …

 
 
 
 
 
 

CXCR2 deficient mice display macrophage-dependent exaggerated acute inflammatory responses

 
 

Douglas P. Dyer, Kenneth Pallas, Laura Medina Ruiz et al.

 
 

CXCR2 is an essential regulator of neutrophil recruitment to inflamed and damaged sites and plays prominent roles in inflammatory pathologies and cancer. It has therefore been …

 
 
 
 
 
 

Identification of a novel NAMPT inhibitor by CRISPR/Cas9 chemogenomic profiling in mammalian cells

 
 

David Estoppey, Jeffrey W. Hewett, Chantale T. Guy et al.

 
 

Chemogenomic profiling is a powerful and unbiased approach to elucidate pharmacological targets and the mechanism of bioactive compounds. Until recently, genome-wide, …

 
 
 
 
 
 

Hypoxia-induced angiotensin II by the lactate-chymase-dependent mechanism mediates radioresistance of hypoxic tumor cells

 
 

Guozhu Xie, Ying Liu, Qiwei Yao et al.

 
 

The renin-angiotensin system (RAS) is a principal determinant of arterial blood pressure and fluid and electrolyte balance. RAS component dysregulation was recently found in some …

 
 
 
 
 
 

Association of fronto-temporal function with cognitive ability in schizophrenia

 
 

Shenghong Pu, Kazuyuki Nakagome, Masashi Itakura et al.

 
 

Deficits in neuropsychological performance are common in schizophrenia, but their relationship with the fronto-temporal functional abnormalities associated with this condition …

 
 
 
 
 
 

Dependence On Glycolysis Sensitizes BRAF-mutated Melanomas For Increased Response To Targeted BRAF Inhibition

 
 

Keisha N. Hardeman, Chengwei Peng, Bishal B. Paudel et al.

 
 

Dysregulated metabolism can broadly affect therapy resistance by influencing compensatory signaling and expanding proliferation. Given many BRAF-mutated melanoma patients …

 
 
 
 
 
 

Phylogenetic analysis of eukaryotic NEET proteins uncovers a link between a key gene duplication event and the evolution of vertebrates

 
 

Madhuri A. Inupakutika, Soham Sengupta, Rachel Nechushtai et al.

 
 

NEET proteins belong to a unique family of iron-sulfur proteins in which the 2Fe-2S cluster is coordinated by a CDGSH domain that is followed by the “NEET” motif. They are …

 
 
 
 
 
 

β-globin gene cluster haplotypes in ethnic minority populations of southwest China

 
 

Hao Sun, Hongxian Liu, Kai Huang et al.

 
 

The genetic diversity and relationships among ethnic minority populations of southwest China were investigated using seven polymorphic restriction enzyme sites in the β-globin …

 
 
 
 
 
 

CR-LAAO, an L-amino acid oxidase from Calloselasma rhodostoma venom, as a potential tool for developing novel immunotherapeutic strategies against cancer

 
 

Tássia R. Costa, Danilo L. Menaldo, Karina F. Zoccal et al.

 
 

L-amino acid oxidases from snake venoms have been described to possess various biological functions. In this study, we investigated the inflammatory responses induced in vivo and

 
 
 
 
 
 

A human programmed death-ligand 1-expressing mouse tumor model for evaluating the therapeutic efficacy of anti-human PD-L1 antibodies

 
 

Anfei Huang, Di Peng, Huanhuan Guo et al.

 
 

Huge efforts have been devoted to develop therapeutic monoclonal antibodies targeting human Programmed death-ligand 1 (hPD-L1) for treating various types of human cancers. …

 
 
 
 
 
 

FocusHeuristics – expression-data-driven network optimization and disease gene prediction

 
 

Mathias Ernst, Yang Du, Gregor Warsow et al.

 
 

To identify genes contributing to disease phenotypes remains a challenge for bioinformatics. Static knowledge on biological networks is often combined with the dynamics observed …

 
 
 
 
 
 

Octreotide Attenuates Acute Kidney Injury after Hepatic Ischemia and Reperfusion by Enhancing Autophagy

 
 

Huiping Sun, Shuangfa Zou, Keith A. Candiotti et al.

 
 

Octreotide exerts a protective effect in hepatic ischemia-reperfusion (HIR) injury. However, whether octreotide preconditioning could also reduce acute kidney injury (AKI) after …

 
 
 
 
 
 

Genome-wide DNA-(de)methylation is associated with Noninfectious Bud-failure exhibition in Almond (Prunus dulcis [Mill.] D.A.Webb)

 
 

Jonathan Fresnedo-Ramírez, Helen M. Chan, Dan E. Parfitt et al.

 
 

Noninfectious bud-failure (BF) remains a major threat to almond production in California, particularly with the recent rapid expansion of acreage and as more intensive cultural …

 
 
 
 
 
 

Erratum: Lucky Rhythms in Orbitofrontal Cortex Bias Gambling Decisions in Humans

 
 

Pierre Sacré, Matthew S. D. Kerr, Kevin Kahn et al.

 
 

 
 
 
 
 
 

Identification of a substrate domain that determines system specificity in mycobacterial type VII secretion systems

 
 

Trang H. Phan, Roy Ummels, Wilbert Bitter et al.

 
 

Type VII secretion (T7S) systems are specialized machineries used by mycobacterial pathogens to transport important virulence factors across their highly hydrophobic cell …

 
 
 
 
 
 

Neuronally-directed effects of RXR activation in a mouse model of Alzheimer’s disease

 
 

M. M. Mariani, T. Malm, R. Lamb et al.

 
 

Alzheimer’s disease (AD) is characterized by extensive neuron loss that accompanies profound impairments in memory and cognition. We examined the neuronally directed effects of …

 
 
 
 
 
 

Aurora A regulates expression of AR-V7 in models of castrate resistant prostate cancer

 
 

Dominic Jones, Martin Noble, Steve R. Wedge et al.

 
 

Androgen receptor variants (AR-Vs) provide a mechanism of therapy evasion in castrate-resistant prostate cancer (CRPC), yet mechanisms of regulation remain largely unknown. Here …

 
 
 
 
 
 

Wnt5a is a crucial regulator of neurogenesis during cerebellum development

 
 

Chandramohan Subashini, Sivadasan Bindu Dhanesh, Chih-Ming Chen et al.

 
 

The role of Wnt5a has been extensively explored in various aspects of development but its role in cerebellar development remains elusive. Here, for the first time we unravel the …

 
 
 
 
 
 

TRIM14 regulates cell proliferation and invasion in osteosarcoma via promotion of the AKT signaling pathway

 
 

Guoxing Xu, Yongfei Guo, Dabo Xu et al.

 
 

Recent studies have shown that some members of the tripartite motif-containing protein (TRIM) family serve as important regulators of tumorigenesis. However, the biological role …

 
 
 
 
 
 

Prognostic Value of microRNA Signature in Patients with Gastric Cancers

 
 

Hai-Ting Liu, Ya-Wen Wang, Ai-Yan Xing et al.

 
 

The occurrence of lymph node metastases (LNM) after endoscopic submucosal dissection (ESD) in patients with gastric cancer (GC) leads to poor prognosis. However, few biomarkers …

 
 
 
 
 
 

Engineering a Lys-Asn isopeptide bond into an immunoglobulin-like protein domain enhances its stability

 
 

Hanna Kwon, Paul G. Young, Christopher J. Squire et al.

 
 

The overall stability of globular protein structures is marginal, a balance between large numbers of stabilizing non-covalent interactions and a destabilizing entropic term. …

 
 
 
 
 
 

In Vitro Characterization and Concerted Function of Three Core Enzymes of a Glycyl Radical Enzyme - Associated Bacterial Microcompartment

 
 

Jan Zarzycki, Markus Sutter, Niña Socorro Cortina et al.

 
 

Many bacteria encode proteinaceous bacterial microcompartments (BMCs) that encapsulate sequential enzymatic reactions of diverse metabolic pathways. Well-characterized BMCs …

 
 
 
 
 
 

Corrigendum: A liposomal Gd contrast agent does not cross the mouse placental barrier

 
 

Anil N. Shetty, Robia Pautler, Ketan Ghaghada et al.

 
 

 
 
 
 
 
 

Calpain-1 deletion impairs mGluR-dependent LTD and fear memory extinction

 
 

Guoqi Zhu, Victor Briz, Jeff Seinfeld et al.

 
 

Recent studies indicate that calpain-1 is required for the induction of long-term potentiation (LTP) elicited by theta-burst stimulation in field CA1 of hippocampus. Here we …

 
 
 
 
 
 

Non-reliance of metazoans on stromatolite-forming microbial mats as a food resource

 
 

Gavin M. Rishworth, Renzo Perissinotto, Matthew S. Bird et al.

 
 

Grazing and burrowing organisms usually homogenise microalgal mats that form on benthic sediments of many aquatic ecosystems. In the absence of this disruption, microalgal mats …

 
 
 
 
 
 

Microcin PDI regulation and proteolytic cleavage are unique among known microcins

 
 

Zhe Zhao, Lisa H. Orfe, Jinxin Liu et al.

 
 

Microcin PDI inhibits a diversity of pathogenic Escherichia coli through the action of an effector protein, McpM. In this study we demonstrated that expression of the inhibitory …

 
 
 
 
 
 

Insect herbivory (Choristoneura fumiferana, Tortricidea) underlies tree population structure (Picea glauca, Pinaceae)

 
 

Geneviève J. Parent, Isabelle Giguère, Gaby Germanos et al.

 
 

Variation in insect herbivory can lead to population structure in plant hosts as indicated by defence traits. In annual herbaceous, defence traits may vary between geographic …

 
 
 
 
 
 

Protective Effect of 17β-Estradiol Upon Hippocampal Spine Density and Cognitive Function in an Animal Model of Vascular Dementia

 
 

Ying Zhu, Quanguang Zhang, Wenli Zhang et al.

 
 

The current study examined whether the steroid hormone, 17β-estradiol (E2) can exert long-lasting beneficial effects upon axonal health, synaptic plasticity, dementia-related …

 
 
 
 
 
 

ALD5, PAD1, ATF1 and ATF2 facilitate the catabolism of coniferyl aldehyde, ferulic acid and p-coumaric acid in Saccharomyces cerevisiae

 
 

Peter Temitope Adeboye, Maurizio Bettiga, Lisbeth Olsson

 
 

The ability of Saccharomyces cerevisiae to catabolize phenolic compounds remains to be fully elucidated. Conversion of coniferyl aldehyde, ferulic acid and p-coumaric acid by S. …

 
 
 
 
 
 

Mitochondrial behaviour throughout the lytic cycle of Toxoplasma gondii

 
 

Jana Ovciarikova, Leandro Lemgruber, Krista L. Stilger et al.

 
 

Mitochondria distribution in cells controls cellular physiology in health and disease. Here we describe the mitochondrial morphology and positioning found in the different stages …

 
 
 
 
 
 

Focal adhesion kinase activity is required for actomyosin contractility-based invasion of cells into dense 3D matrices

 
 

Claudia T. Mierke, Tony Fischer, Stefanie Puder et al.

 
 

The focal adhesion kinase (FAK) regulates the dynamics of integrin-based cell adhesions important for motility. FAK’s activity regulation is involved in stress-sensing and …

 
 
 
 
 
 

Cryogel-supported stem cell factory for customized sustained release of bispecific antibodies for cancer immunotherapy

 
 

Roberta Aliperta, Petra B. Welzel, Ralf Bergmann et al.

 
 

Combining stem cells with biomaterial scaffolds provides a promising strategy for the development of drug delivery systems. Here we propose an innovative immunotherapeutic …

 
 
 
 
 
 

The influence of AccD5 on AccD6 carboxyltransferase essentiality in pathogenic and non-pathogenic Mycobacterium

 
 

Jakub Pawelczyk, Albertus Viljoen, Laurent Kremer et al.

 
 

Malonyl-coenzyme A (CoA) is a crucial extender unit for the synthesis of mycolic and other fatty acids in mycobacteria, generated in a reaction catalyzed by acetyl-CoA …

 
 
 
 
 
 

Does Zika virus infection affect mosquito response to repellents?

 
 

Walter S. Leal, Rosângela M. R. Barbosa, Fangfang Zeng et al.

 
 

The World Health Organization (WHO) recommends that people travelling to or living in areas with Zika virus (ZIKV) outbreaks or epidemics adopt prophylactic measures to reduce or …

 
 
 
 
 
 

Mechanisms of Chinese Medicine Xinmailong’s protection against heart failure in pressure-overloaded mice and cultured cardiomyocytes

 
 

Jianyong Qi, Juan Yu, Yafang Tan et al.

 
 

Patients with heart failure (HF) have high mortality and mobility. Xinmailong (XML) injection, a Chinese Medicine, is clinically effective in treating HF. However, the mechanism …

 
 
 
 
 
 

Corrigendum: Inter-individual variability and modeling of electrical activity: a possible new approach to explore cardiac safety?

 
 

Jean-Yves Le Guennec, Jérôme Thireau, Aude Ouillé et al.

 
 

 
 
 
 
 
 

Ontogenetic loops in habitat use highlight the importance of littoral habitats for early life-stages of oceanic fishes in temperate waters

 
 

Patrick Polte, Paul Kotterba, Dorothee Moll et al.

 
 

General concepts of larval fish ecology in temperate oceans predominantly associate dispersal and survival to exogenous mechanisms such as passive drift along ocean currents. …

 
 
 
 
 
 

Leukocyte TLR5 deficiency inhibits atherosclerosis by reduced macrophage recruitment and defective T-cell responsiveness

 
 

Guilielmus H.J.M. Ellenbroek, Gijs H.M. van Puijvelde, Adam A. Anas et al.

 
 

Toll-like receptors (TLR) provide a critical link between innate and adaptive immunity, both important players in atherosclerosis. Since evidence for the role of TLR5 is lacking, …

 
 
 
 
 
 

Epigenetic signatures of invasive status in populations of marine invertebrates

 
 

Alba Ardura, Anastasija Zaiko, Paloma Morán et al.

 
 

Epigenetics, as a DNA signature that affects gene expression and enables rapid reaction of an organism to environmental changes, is likely involved in the process of biological …

 
 
 
 
 
 

Pathways of N removal and N2O emission from a one-stage autotrophic N removal process under anaerobic conditions

 
 

Kai Li, Fang Fang, Han Wang et al.

 
 

To investigate the pathways of nitrogen (N) removal and N2O emission in a one-stage autotrophic N removal process during the non-aeration phase, biofilm from an intermittent …

 
 
 
 
 
 

A postnatal role for embryonic myosin revealed by MYH3 mutations that alter TGFβ signaling and cause autosomal dominant spondylocarpotarsal synostosis

 
 

Jennifer Zieba, Wenjuan Zhang, Jessica X. Chong et al.

 
 

Spondylocarpotarsal synostosis (SCT) is a skeletal disorder characterized by progressive vertebral, carpal and tarsal fusions, and mild short stature. The majority of affected …

 
 
 
 
 
 

Imaging cardiac SCN5A using the novel F-18 radiotracer radiocaine

 
 

Jacob M. Hooker, Martin G. Strebl, Frederick A. Schroeder et al.

 
 

The key function of the heart, a well-orchestrated series of contractions, is controlled by cardiac action potentials. These action potentials are initiated and propagated by a …

 
 
 
 
 
 

Deciphering the distance to antibiotic resistance for the pneumococcus using genome sequencing data

 
 

Fredrick M. Mobegi, Amelieke J. H. Cremers, Marien I. de Jonge et al.

 
 

Advances in genome sequencing technologies and genome-wide association studies (GWAS) have provided unprecedented insights into the molecular basis of microbial phenotypes and …

 
 
 
 
 
 

The tiered-evaluation of the effects of transgenic cry1c rice on Cyrtorhinus lividipennis, a main predator of Nilaparvata lugens

 
 

Yu Han, Fugang Ma, Muhammad Nawaz et al.

 
 

T1C-19, a newly developed transgenic cry1C rice line, expresses cry1C under the control of the maize ubiquitin promoter, and is highly resistant to lepidopteran pests of rice.

 
 
 
 
 
 

Regionalization of Chinese Material Medical Quality Based on Maximum Entropy Model: A case study of Atractylodes lancea

 
 

Zhu Shoudong, Peng Huasheng, Guo Lanping et al.

 
 

Atractylodes is an East-Asiatic endemic genera that distributed in China, Japan and Russian Far Eastern. As an important resource of medicinal plant, atractylodes has long been …

 
 
 
 
 
 

Circulating miR-155, miR-145 and let-7c as diagnostic biomarkers of the coronary artery disease

 
 

Julien Faccini, Jean-Bernard Ruidavets, Pierre Cordelier et al.

 
 

Coronary artery disease (CAD) is the most prevalent cause of mortality and morbidity worldwide and the number of individuals at risk is increasing. To better manage …

 
 
 
 
 
 

The small molecule AUTEN-99 (autophagy enhancer-99) prevents the progression of neurodegenerative symptoms

 
 

Tibor Kovács, Viktor Billes, Marcell Komlós et al.

 
 

Autophagy functions as a main route for the degradation of superfluous and damaged constituents of the cytoplasm. Defects in autophagy are implicated in the development of …

 
 
 
 
 
 

A new primitive Neornithischian dinosaur from the Jurassic of Patagonia with gut contents

 
 

Leonardo Salgado, José I. Canudo, Alberto C. Garrido et al.

 
 

We describe a new species of an ornithischian dinosaur, Isaberrysaura mollensis gen. et sp. nov. The specimen, consisting in an almost complete skull and incomplete postcranium …

 
 
 
 
 
 

New evidence from China for the nature of the pterosaur evolutionary transition

 
 

Xiaoli Wang, Shunxing Jiang, Junqiang Zhang et al.

 
 

Pterosaurs are extinct flying reptiles, the first vertebrates to achieve powered flight. Our understanding of the evolutionary transition between basal, predominantly long-tailed …

 
 
 
 
 
 

Biological motion distorts size perception

 
 

Peter Veto, Wolfgang Einhäuser, Nikolaus F. Troje

 
 

Visual illusions explore the limits of sensory processing and provide an ideal testbed to study perception. Size illusions – stimuli whose size is consistently misperceived – do …

 
 
 
 
 
 

Genomic structure and insertion sites of Helicobacter pylori prophages from various geographical origins

 
 

Filipa F. Vale, Alexandra Nunes, Mónica Oleastro et al.

 
 

Helicobacter pylori genetic diversity is known to be influenced by mobile genomic elements. Here we focused on prophages, the least characterized mobile elements of H. pylori. We …

 
 
 
 
 
 

Nickel biopathways in tropical nickel hyperaccumulating trees from Sabah (Malaysia)

 
 

Antony van der Ent, Damien L. Callahan, Barry N. Noller et al.

 
 

The extraordinary level of accumulation of nickel (Ni) in hyperaccumulator plants is a consequence of specific metal sequestering and transport mechanisms, and knowledge of these …

 
 
 
 
 
 

Genetic polymorphism and evolutionary differentiation of Eastern Chinese Han: a comprehensive and comparative analysis on KIRs

 
 

Caiyong Yin, Li Hu, Huijie Huang et al.

 
 

Killer cell immunoglobulin-like receptor genes, namely KIRs, cluster together within the 160 kb genomic DNA region. In this study, we used PCR-SSP approach and successfully …

 
 
 
 
 
 

Structural environment built by AKAP12+ colon mesenchymal cells drives M2 macrophages during inflammation recovery

 
 

Jun-Mo Yang, Hye Shin Lee, Ji Hae Seo et al.

 
 

Macrophages exhibit phenotypic plasticity, as they have the ability to switch their functional phenotypes during inflammation and recovery. Simultaneously, the mechanical …

 
 
 
 
 
 

Duration of SHIV production by infected cells is not exponentially distributed: Implications for estimates of infection parameters and antiviral efficacy

 
 

Catherine A. A. Beauchemin, Tomoyuki Miura, Shingo Iwami

 
 

The duration of the eclipse phase, from cell infection to the production and release of the first virion progeny, immediately followed by the virus-production phase, from the …

 
 
 
 
 
 

BAR502, a dual FXR and GPBAR1 agonist, promotes browning of white adipose tissue and reverses liver steatosis and fibrosis

 
 

Adriana Carino, Sabrina Cipriani, Silvia Marchianò et al.

 
 

Non-alcoholic steatohepatitis (NASH) is a highly prevalent chronic liver disease. Here, we have investigated whether BAR502, a non-bile acid, steroidal dual ligand for FXR and …

 
 
 
 
 
 

Erratum: Using the virtual reality device Oculus Rift for neuropsychological assessment of visual processing capabilities

 
 

Rebecca M. Foerster, Christian H. Poth, Christian Behler et al.

 
 

 
 
 
 
 
 

NMR metabolic fingerprints of murine melanocyte and melanoma cell lines: application to biomarker discovery

 
 

Arquimedes Paixão de Santana-Filho, Thiago Jacomasso, Daniel Suss Riter et al.

 
 

Melanoma is the most aggressive type of skin cancer and efforts to improve the diagnosis of this neoplasia are largely based on the use of cell lines. Metabolomics is currently …

 
 
 
 
 
 

Dynamic changes in the transcriptome of Populus hopeiensis in response to abscisic acid

 
 

Zhong Chen, Lexiang Ji, Jia Wang et al.

 
 

Abscisic acid (ABA) plays a fundamental role in plant response and adaptation to abiotic stresses, such as drought, high salinity and low temperature. Populus hopeiensis exhibits …

 
 
 
 
 
 

Cultured corneas show dendritic spread and restrict herpes simplex virus infection that is not observed with cultured corneal cells

 
 

Neel Thakkar, Dinesh Jaishankar, Alex Agelidis et al.

 
 

Herpes simplex virus-1 (HSV-1) causes life-long morbidities in humans. While fever blisters are more common, occasionally the cornea is infected resulting in vision loss. A very …

 
 
 
 
 
 

Polymerase cross-linking spiral reaction (PCLSR) for detection of African swine fever virus (ASFV) in pigs and wild boars

 
 

Grzegorz Woźniakowski, Magdalena Frączyk, Andrzej Kowalczyk et al.

 
 

The study reports the development of a polymerase cross-linking spiral reaction (PCLSR) for the detection of African swine fever virus (ASFV) DNA in blood collected from infected …

 
 
 
 
 
 

Novel characteristics of the avian gyrovirus 2 genome

 
 

Shuai Yao, Xiang Gao, Tianbei Tuo et al.

 
 

Avian gyrovirus 2 (AGV2) was the second member of the viral genus Cyclovirus to be discovered. This virus poses a significant potential threat to humans and poultry due to its …

 
 
 
 
 
 

Influence of FKBP5 polymorphism and DNA methylation on structural changes of the brain in major depressive disorder

 
 

Kyu-Man Han, Eunsoo Won, Youngbo Sim et al.

 
 

A single nucleotide polymorphism of rs1360780 in the FKBP5 gene is associated with a predisposition to developing major depressive disorder (MDD). We investigated the interactive …

 
 
 
 
 
 

miR-2478 inhibits TGFβ1 expression by targeting the transcriptional activation region downstream of the TGFβ1 promoter in dairy goats

 
 

Zhuanjian Li, Xianyong Lan, Ruili Han et al.

 
 

In a previous study, miR-2478 was demonstrated to be up-regulated in dairy goat mammary glands during peak lactation compared with the dry period. However, the detailed …

 
 
 
 
 
 

Hemispheric differences between left and right supramarginal gyrus for pitch and rhythm memory

 
 

Nora K. Schaal, Bettina Pollok, Michael J. Banissy

 
 

Functional brain imaging studies and non-invasive brain stimulation methods have shown the importance of the left supramarginal gyrus (SMG) for pitch memory. The extent to which …

 
 
 
 
 
 

Fatigue-related impairments in oculomotor control are prevented by norepinephrine-dopamine reuptake inhibition

 
 

Charlotte J. W. Connell, Benjamin Thompson, Jason Turuwhenua et al.

 
 

Fatigue-induced reductions in saccade velocity have been reported following acute, prolonged exercise. Interestingly, the detrimental impact of fatigue on oculomotor control can …

 
 
 
 
 
 

An acoustic key to eight languages/dialects: Factor analyses of critical-band-filtered speech

 
 

Kazuo Ueda, Yoshitaka Nakajima

 
 

The peripheral auditory system functions like a frequency analyser, often modelled as a bank of non-overlapping band-pass filters called critical bands; 20 bands are necessary …

 
 
 
 
 
 

Jerantinine A induces tumor-specific cell death through modulation of splicing factor 3b subunit 1 (SF3B1)

 
 

Felicia Fei-Lei Chung, Perry Faith Tze Ming Tan, Vijay Joseph Raja et al.

 
 

Precursor mRNA (pre-mRNA) splicing is catalyzed by a large ribonucleoprotein complex known as the spliceosome. Numerous studies have indicated that aberrant splicing patterns or …

 
 
 
 
 
 

Organic nitrogen rearranges both structure and activity of the soil-borne microbial seedbank

 
 

Márcio F. A. Leite, Yao Pan, Jaap Bloem et al.

 
 

Use of organic amendments is a valuable strategy for crop production. However, it remains unclear how organic amendments shape both soil microbial community structure and …

 
 
 
 
 
 

Undervaluing delayed rewards explains adolescents’ impulsivity in inter-temporal choice: an ERP study

 
 

Yunyun Huang, Ping Hu, Xueting Li

 
 

Adolescence has frequently been characterized as a period of choice impulsivity relative to adulthood. According to the control-integrated valuation model of inter-temporal …

 
 
 
 
 
 

Chilling Affects Phytohormone and Post-Embryonic Development Pathways during Bud Break and Fruit Set in Apple (Malus domestica Borkh.)

 
 

Gulshan Kumar, Khushboo Gupta, Shivalika Pathania et al.

 
 

The availability of sufficient chilling during bud dormancy plays an important role in the subsequent yield and quality of apple fruit, whereas, insufficient chilling …

 
 
 
 
 
 

Pre-encoding gamma-band activity during auditory working memory

 
 

Jochen Kaiser, Maria Rieder, Cornelius Abel et al.

 
 

Previous magnetoencephalography (MEG) studies have revealed gamma-band activity at sensors over parietal and fronto-temporal cortex during the delay phase of auditory spatial and …

 
 
 
 
 
 

Overexpression of FAM83H-AS1 indicates poor patient survival and knockdown impairs cell proliferation and invasion via MET/EGFR signaling in lung cancer

 
 

Jie Zhang, Shumei Feng, Wenmei Su et al.

 
 

Whole transcriptome analyses of next generation RNA sequencing (RNA-Seq) data from human cancer samples reveled thousands of uncharacterized non-coding RNAs including long …

 
 
 
 
 
 

A Mutation Identified in Neonatal Microcephaly Destabilizes Zika Virus NS1 Assembly in Vitro

 
 

Deping Wang, Cheng Chen, Shengnan Liu et al.

 
 

An unprecedented epidemic of Zika virus (ZIKV) infection had spread to South and Central America. ZIKV infection was recently confirmed by CDC (the Centers for Disease Control …

 
 
 
 
 
 

Comparative proteomic analysis of horseweed (Conyza canadensis) biotypes identifies candidate proteins for glyphosate resistance

 
 

Fidel González-Torralva, Adrian P. Brown, Stephen Chivasa

 
 

Emergence of glyphosate-resistant horseweed (Conyza canadensis) biotypes is an example of how unrelenting use of a single mode of action herbicide in agricultural weed control …

 
 
 
 
 
 

A novel orally bioavailable compound KPT-9274 inhibits PAK4, and blocks triple negative breast cancer tumor growth

 
 

Chetan Rane, William Senapedis, Erkan Baloglu et al.

 
 

Breast cancer is a heterogeneous disease consisting of several subtypes. Among these subtypes, triple negative breast cancer is particularly difficult to treat. This is due to a …

 
 
 
 
 
 

MicroRNA-155 Controls Exosome Synthesis and Promotes Gemcitabine Resistance in Pancreatic Ductal Adenocarcinoma

 
 

Manabu Mikamori, Daisaku Yamada, Hidetoshi Eguchi et al.

 
 

The cancer drug gemcitabine (GEM) is a key drug for treating pancreatic ductal adenocarcinoma (PDAC), but PDAC cells develop chemoresistance after long-term administration. Since …

 
 
 
 
 
 

An integrated microfluidic device for rapid and high-sensitivity analysis of circulating tumor cells

 
 

Jianing Jiang, Hui Zhao, Weiliang Shu et al.

 
 

Recently there has been a more focus on the development of an efficient technique for detection of circulating tumor cells (CTCs), due to their significance in prognosis and …

 
 
 
 
 
 

Therapeutic effects of human adipose tissue-derived stem cell (hADSC) transplantation on experimental autoimmune encephalomyelitis (EAE) mice

 
 

Jia Li, Ying Chen, Zhibo Chen et al.

 
 

This study is to investigate the therapeutic effects of human adipose tissue-derived stem cell (hADSC) transplantation on experimental autoimmune encephalomyelitis (EAE) in mice. …

 
 
 
 
 
 

In vitro and in vivo responses of macrophages to magnesium-doped titanium

 
 

Bin Li, Huiliang Cao, Yaochao Zhao et al.

 
 

Modulating immune response to biomaterials through changing macrophage polarization has been proven to be a promising strategy to elicit beneficial outcomes in tissue repair. The …

 
 
 
 
 
 

Ubiquitin C-terminal hydrolase37 regulates Tcf7 DNA binding for the activation of Wnt signalling

 
 

Wonhee Han, Hyeyoon Lee, Jin-Kwan Han

 
 

The Tcf/Lef family of transcription factors mediates the Wnt/β-catenin pathway that is involved in a wide range of biological processes, including vertebrate embryogenesis and …

 
 
 
 
 
 

The TNF-α antagonist etanercept reverses age-related decreases in colonic SERT expression and faecal output in mice

 
 

Bhavik Anil Patel, Sara Fidalgo, Chunfang Wang et al.

 
 

Treatment for chronic constipation in older people is challenging and the condition has a major impact on quality of life. A lack of understanding about the causes of this …

 
 
 
 
 
 

PDI regulates seizure activity via NMDA receptor redox in rats

 
 

Ji Yang Kim, Ah-Rhem Ko, Hye-Won Hyun et al.

 
 

Redox modulation of cysteine residues is one of the post-translational modifications of N-methyl-D-aspartate receptor (NMDAR). Protein disulfide isomerases (PDI), an endoplasmic …

 
 
 
 
 
 

Identification of a novel type III secretion-associated outer membrane-bound protein from Xanthomonas campestris pv. campestris

 
 

Lei Li, Rui-Fang Li, Zhen-Hua Ming et al.

 
 

Many bacterial pathogens employ the type III secretion system (T3SS) to translocate effector proteins into eukaryotic cells to overcome host defenses. To date, most of our …

 
 
 
 
 
 

A screening strategy for the discovery of drugs that reduce C/EBPβ-LIP translation with potential calorie restriction mimetic properties

 
 

Mohamad A. Zaini, Christine Müller, Tobias Ackermann et al.

 
 

An important part of the beneficial effects of calorie restriction (CR) on healthspan and lifespan is mediated through regulation of protein synthesis that is under control of …

 
 
 
 
 
 

Mechanistic insight into the substrate specificity of 1,2-β-oligoglucan phosphorylase from Lachnoclostridium phytofermentans

 
 

Masahiro Nakajima, Nobukiyo Tanaka, Nayuta Furukawa et al.

 
 

Glycoside phosphorylases catalyze the phosphorolysis of oligosaccharides into sugar phosphates. Recently, we found a novel phosphorylase acting on β-1,2-glucooligosaccharides …

 
 
 
 
 
 

The secondary resistome of multidrug-resistant Klebsiella pneumoniae

 
 

Bimal Jana, Amy K. Cain, William T. Doerrler et al.

 
 

Klebsiella pneumoniae causes severe lung and bloodstream infections that are difficult to treat due to multidrug resistance. We hypothesized that antimicrobial resistance can be …

 
 
 
 
 
 

Doxorubicin-loaded platelets as a smart drug delivery system: An improved therapy for lymphoma

 
 

Peipei Xu, Huaqin Zuo, Bing Chen et al.

 
 

Chemotherapy is majorly used for the treatment of many cancers, including lymphoma. However, cytotoxic drugs, utilized in chemotherapy, can induce various side effects on normal …

 
 
 
 
 
 

A cyclometalated iridium(III) complex used as a conductor for the electrochemical sensing of IFN-γ

 
 

Xiangmin Miao, Chung-Nga Ko, Kasipandi Vellaisamy et al.

 
 

A novel iridium(III) complex was prepared and used as a conductor for sensitive and enzyme-free electrochemical detection of interferon gamma (IFN-γ). This assay is based on a …

 
 
 
 
 
 

Quick and inexpensive paraffin-embedding method for dynamic bone formation analyses

 
 

Amy Porter, Regina Irwin, Josselyn Miller et al.

 
 

We have developed a straightforward method that uses paraffin-embedded bone for undemineralized thin sectioning, which is amenable to subsequent dynamic bone formation …

 
 
 
 
 
 

Re-shifting the ecological baseline for the overexploited Mediterranean red coral

 
 

J. Garrabou, E. Sala, C. Linares et al.

 
 

Overexploitation leads to the ecological extinction of many oceanic species. The depletion of historical abundances of large animals, such as whales and sea turtles, is well …

 
 
 
 
 
 

Sublethal doses of imidacloprid disrupt sexual communication and host finding in a parasitoid wasp

 
 

Lars Tappert, Tamara Pokorny, John Hofferberth et al.

 
 

Neonicotinoids are widely used insecticides, but their use is subject of debate because of their detrimental effects on pollinators. Little is known about the effect of …

 
 
 
 
 
 

Bio-functionalized magnetic nanoparticles for the immunoassay of fetal fibronectin: a feasibility study for the prediction of preterm birth

 
 

Chian-Huey Wong, Chie-Pein Chen, Chia-Chen Chang et al.

 
 

Preterm birth is an important cause of perinatal morbidity and mortality. Various biomarkers in cervicovaginal secretions related to preterm birth have been investigated, of …

 
 
 
 
 
 

Dual Electrophoresis Detection System for Rapid and Sensitive Immunoassays with Nanoparticle Signal Amplification

 
 

Fangfang Zhang, Junjie Ma, Junji Watanabe et al.

 
 

An electrophoretic technique was combined with an enzyme-linked immunosorbent assay (ELISA) system to achieve a rapid and sensitive immunoassay. A cellulose acetate filter …

 
 
 
 
 
 

TaWRKY70 transcription factor in wheat QTL-2DL regulates downstream metabolite biosynthetic genes to resist Fusarium graminearum infection spread within spike

 
 

Udaykumar Kage, Kalenahalli N. Yogendra, Ajjamada C. Kushalappa

 
 

A semi-comprehensive metabolomics was used to identify the candidate metabolites and genes to decipher mechanisms of resistance in wheat near-isogenic lines (NILs) containing

 
 
 
 
 
 

Enrichment of circulating head and neck tumour cells using spiral microfluidic technology

 
 

Arutha Kulasinghe, Thao Huynh Phuoc Tran, Tony Blick et al.

 
 

Whilst locoregional control of head and neck cancers (HNCs) has improved over the last four decades, long-term survival has remained largely unchanged. A possible reason for this …

 
 
 
 
 
 

Discovery of genes coding for carbohydrate-active enzyme by metagenomic analysis of lignocellulosic biomasses

 
 

Salvatore Montella, Valeria Ventorino, Vincent Lombard et al.

 
 

In this study, a high-throughput sequencing approach was applied to discover novel biocatalysts for lignocellulose hydrolysis from three dedicated energy crops, Arundo donax, …

 
 
 
 
 
 

Method for Dual Viral Vector Mediated CRISPR-Cas9 Gene Disruption in Primary Human Endothelial Cells

 
 

Haixia Gong, Menglin Liu, Jeff Klomp et al.

 
 

Human endothelial cells (ECs) are widely used to study mechanisms of angiogenesis, inflammation, and endothelial permeability. Targeted gene disruption induced by Clustered …

 
 
 
 
 
 

MIAT Is a Pro-fibrotic Long Non-coding RNA Governing Cardiac Fibrosis in Post-infarct Myocardium

 
 

Xuefeng Qu, Yue Du, You Shu et al.

 
 

A long non-coding RNA (lncRNA), named myocardial infarction associated transcript (MIAT), has been documented to confer risk of myocardial infarction (MI). The aim of this study …

 
 
 
 
 
 

Increased nutrient availability in dense breast tissue of postmenopausal women in vivo

 
 

Annelie Abrahamsson, Anna Rzepecka, Charlotta Dabrosin

 
 

Metabolic reprogramming is a hallmark of cancer. Nutrient availability in the tissue microenvironment determines cellular events and may play a role in breast carcinogenesis. …

 
 
 
 
 
 

Cockroach protease allergen induces allergic airway inflammation via epithelial cell activation

 
 

Sagar L. Kale, Komal Agrawal, Shailendra Nath Gaur et al.

 
 

Protease allergens are known to enhance allergic inflammation but their exact role in initiation of allergic reactions at mucosal surfaces still remains elusive. This study was …

 
 
 
 
 
 

Preliminary evidence for a role of the adrenergic nervous system in generalized anxiety disorder

 
 

Xiaobin Zhang, Joanna Norton, Isabelle Carrière et al.

 
 

Generalized anxiety disorder (GAD) is a common chronic condition that is understudied compared to other psychiatric disorders. An altered adrenergic function has been reported in …

 
 
 
 
 
 

Elevated prevalence of Helicobacter species and virulence factors in opisthorchiasis and associated hepatobiliary disease

 
 

Raksawan Deenonpoe, Eimorn Mairiang, Pisaln Mairiang et al.

 
 

Recent reports suggest that Opisthorchis viverrini serves as a reservoir of Helicobacter and implicate Helicobacter in pathogenesis of opisthorchiasis-associated …

 
 
 
 
 
 

Evaluation of the immunological profile of antibody-functionalized metal-filled single-walled carbon nanocapsules for targeted radiotherapy

 
 

Aritz Perez Ruiz de Garibay, Cinzia Spinato, Rebecca Klippstein et al.

 
 

This study investigates the immune responses induced by metal-filled single-walled carbon nanotubes (SWCNT) under in vitro, ex vivo and in vivo settings. Either empty …

 
 
 
 
 
 

GARP2 accelerates retinal degeneration in rod cGMP-gated cation channel β-subunit knockout mice

 
 

Marci L. DeRamus, Delores A. Stacks, Youwen Zhang et al.

 
 

The Cngb1 locus-encoded β-subunit of rod cGMP-gated cation channel and associated glutamic acid rich proteins (GARPs) are required for phototransduction, disk morphogenesis, and …

 
 
 
 
 
 

Cystinosis (ctns) zebrafish mutant shows pronephric glomerular and tubular dysfunction

 
 

Mohamed A. Elmonem, Ramzi Khalil, Ladan Khodaparast et al.

 
 

The human ubiquitous protein cystinosin is responsible for transporting the disulphide amino acid cystine from the lysosomal compartment into the cytosol. In humans, Pathogenic …

 
 
 
 
 
 

Recombinant vacuolar iron transporter family homologue PfVIT from human malaria-causing Plasmodium falciparum is a Fe2+/H+exchanger

 
 

Paola Labarbuta, Katie Duckett, Catherine H. Botting et al.

 
 

Vacuolar iron transporters (VITs) are a poorly understood family of integral membrane proteins that can function in iron homeostasis via sequestration of labile Fe2+ into …

 
 
 
 
 
 

Identification of Methylation-Driven, Differentially Expressed STXBP6 as a Novel Biomarker in Lung Adenocarcinoma

 
 

Govinda Lenka, Mong-Hsun Tsai, Hsin-Chieh Lin et al.

 
 

DNA methylation is an essential epigenetic marker associated with the silencing of gene expression. Although various genome-wide studies revealed aberrantly methylated gene …

 
 
 
 
 
 

A one-week 5-choice serial reaction time task to measure impulsivity and attention in adult and adolescent mice

 
 

Esther Remmelink, Uyen Chau, August B. Smit et al.

 
 

Many psychiatric disorders emerge during adolescence. The study of executive functions in animal models of these disorders critically requires short-duration tasks measuring …

 
 
 
 
 
 

Investigation of hippocampal synaptic transmission and plasticity in mice deficient in the actin-binding protein Drebrin

 
 

Claudia G. Willmes, Till G. A. Mack, Julia Ledderose et al.

 
 

The dynamic regulation of the actin cytoskeleton plays a key role in controlling the structure and function of synapses. It is vital for activity-dependent modulation of synaptic …

 
 
 
 
 
 

Human IDO-competent, long-lived immunoregulatory dendritic cells induced by intracellular pathogen, and their fate in humanized mice

 
 

Rajeev K. Tyagi, Brodie Miles, Rajesh Parmar et al.

 
 

Targeting of myeloid-dendritic cell receptor DC-SIGN by numerous chronic infectious agents, including Porphyromonas gingivalis, is shown to drive-differentiation of monocytes …

 
 
 
 
 
 

TLR4 signaling induces TLR3 up-regulation in alveolar macrophages during acute lung injury

 
 

Xibing Ding, Shuqing Jin, Yao Tong et al.

 
 

Acute lung injury is a life-threatening inflammatory response caused by severe infection. Toll-like receptors in alveolar macrophages (AMΦ) recognize the molecular constituents …

 
 
 
 
 
 

Sensory augmentation: integration of an auditory compass signal into human perception of space

 
 

Frank Schumann, J. Kevin O’Regan

 
 

Bio-mimetic approaches to restoring sensory function show great promise in that they rapidly produce perceptual experience, but have the disadvantage of being invasive. In …

 
 
 
 
 
 

Arabidopsis thaliana dehydroascorbate reductase 2: Conformational flexibility during catalysis

 
 

Nandita Bodra, David Young, Leonardo Astolfi Rosado et al.

 
 

Dehydroascorbate reductase (DHAR) catalyzes the glutathione (GSH)-dependent reduction of dehydroascorbate and plays a direct role in regenerating ascorbic acid, an essential …

 
 
 
 
 
 

Transcriptome analysis around the onset of strawberry fruit ripening uncovers an important role of oxidative phosphorylation in ripening

 
 

Qing-Hua Wang, Cheng Zhao, Miao Zhang et al.

 
 

Although much progress has been made towards understanding the ripening of non-climacteric fruit using the strawberry as a model plant, the defined molecular mechanisms remain …

 
 
 
 
 
 

Targeted gene knock-in by CRISPR/Cas ribonucleoproteins in porcine zygotes

 
 

Ki-Eun Park, Anne Powell, Shelley E. S. Sandmaier et al.

 
 

The domestic pig is an important “dual purpose” animal model for agricultural and biomedical applications. There is an emerging consensus in the biomedical community for the use …

 
 
 
 
 
 

pH-sensitive micelles for the intracellular co-delivery of curcumin and Pluronic L61 unimers for synergistic reversal effect of multidrug resistance

 
 

Wei Hong, Hong Shi, Mingxi Qiao et al.

 
 

Pluronic L61 unimers, which are biomacromolecular modulators, and curcumin, a small-molecule modulator, were co-formulated into pH-sensitive micelles to reveal the full …

 
 
 
 
 
 

Gas chromatography-mass spectrometry analysis of effects of dietary fish oil on total fatty acid composition in mouse skin

 
 

Peiru Wang, Min Sun, Jianwei Ren et al.

 
 

Altering the fatty acid (FA) composition in the skin by dietary fish oil could provide therapeutic benefits. Although it has been shown that fish oil supplementation enhances EPA …

 
 
 
 
 
 

Spatial assessment of wolf-dog hybridization in a single breeding period

 
 

C. Pacheco, J. V. López-Bao, E. J. García et al.

 
 

Understanding the dynamics of wolf-dog hybridization and delineating evidence-based conservation strategies requires information on the spatial extent of wolf-dog hybridization …

 
 
 
 
 
 

The structural switch of nucleotide-free kinesin

 
 

Luyan Cao, Soraya Cantos-Fernandes, Benoît Gigant

 
 

Kinesin-1 is an ATP-dependent motor protein that moves towards microtubules (+)-ends. Whereas structures of isolated ADP-kinesin and of complexes with tubulin of apo-kinesin and …

 
 
 
 
 
 

How Native and Alien Metal Cations Bind ATP: Implications for Lithium as a Therapeutic Agent

 
 

Todor Dudev, Cédric Grauffel, Carmay Lim

 
 

Adenosine triphosphate (ATP), the major energy currency of the cell, exists in solution mostly as ATP-Mg. Recent experiments suggest that Mg2+ interacts with the highly charged …

 
 
 
 
 
 

Constitutive activation of CREB in mice enhances temporal association learning and increases hippocampal CA1 neuronal spine density and complexity

 
 

Tatsurou Serita, Hotaka Fukushima, Satoshi Kida

 
 

Transcription factor CREB is believed to play essential roles in the formation of long-term memory (LTM), but not in learning and short-term memory (STM). Surprisingly, we …

 
 
 
 
 
 

Harvesting pre-polarized macrophages using thermo-responsive substrates

 
 

Vera Malheiro, Yvonne Elbs-Glatz, Magdalena Obarzanek-Fojt et al.

 
 

In the cell culture environment macrophages are highly adherent cells. Currently used methods to harvest macrophages have the disadvantage of reducing cell viability and their …

 
 
 
 
 
 

Sirtinol, a Sir2 protein inhibitor, affects stem cell maintenance and root development in Arabidopsis thaliana by modulating auxin-cytokinin signaling components

 
 

Sharmila Singh, Alka Singh, Sandeep Yadav et al.

 
 

In Arabidopsis thaliana, besides several key transcription factors and chromatin modifiers, phytohormones auxin and cytokinin play pivotal role in shoot and root meristem …

 
 
 
 
 
 

CRISPR/Cas9-mediated genome editing in wild-derived mice: generation of tamed wild-derived strains by mutation of the a (nonagouti) gene

 
 

Michiko Hirose, Ayumi Hasegawa, Keiji Mochida et al.

 
 

Wild-derived mice have contributed to experimental mouse genetics by virtue of their genetic diversity, which may help increase the chance of identifying novel modifier genes …

 
 
 
 
 
 

Differentiation in drought tolerance mirrors the geographic distributions of alpine plants on the Qinghai-Tibet Plateau and adjacent highlands

 
 

Li-Hua Meng, Jie Yang, Wen Guo et al.

 
 

Climatic tolerance, especially drought tolerance, is one of the major factors shaping the geographic distributions of plant species. Thus, the general decline in rainfall from …

 
 
 
 
 
 

Induction of Invertebrate Larval Settlement; Different Bacteria, Different Mechanisms?

 
 

Marnie L. Freckelton, Brian T. Nedved, Michael G. Hadfield

 
 

Recruitment via settlement of pelagic larvae is critical for the persistence of benthic marine populations. For many benthic invertebrates, larval settlement occurs in response …

 
 
 
 
 
 

Cigarette smoke attenuates phagocytic ability of macrophages through down-regulating Milk fat globule-EGF factor 8 (MFG-E8) expressions

 
 

Yueqin Wang, Guangwei Luo, Jie Chen et al.

 
 

Chronic obstructive pulmonary disease (COPD) is one of the most common inflammatory diseases resulting from habitual smoking. Impaired clearance of apoptotic cell by airway …

 
 
 
 
 
 

Neutrophil-to-lymphocyte ratio as a prognostic biomarker for patients with locally advanced esophageal squamous cell carcinoma treated with definitive chemoradiotherapy

 
 

Xi-Lei Zhou, Yong-Qiang Li, Wei-Guo Zhu et al.

 
 

The present study evaluated the clinical and prognostic value of neutrophil-to-lymphocyte ratio (NLR) in patients with locally advanced esophageal squamous cell carcinoma (ESCC) …

 
 
 
 
 
 

Let-7e modulates the inflammatory response in vascular endothelial cells through ceRNA crosstalk

 
 

Zongwei Lin, Junfeng Ge, Zhe Wang et al.

 
 

The inflammatory responses of vascular endothelial cells (VECs) are critical in the development of many cardio-cerebrovascular diseases. Let-7e is an important regulator of …

 
 
 
 
 
 

Dentin Sialoprotein is a Novel Substrate of Matrix Metalloproteinase 9 in vitro and in vivo

 
 

Guohua Yuan, Lei Chen, Junsheng Feng et al.

 
 

Dentin sialoprotein (DSP) is essential for dentinogenesis and processed into fragments in the odontoblast-like cells and the tooth compartments. Matrix metalloproteinase 9 (MMP9) …

 
 
 
 
 
 

NG2 glial cells regulate neuroimmunological responses to maintain neuronal function and survival

 
 

Masayuki Nakano, Yasuhisa Tamura, Masanori Yamato et al.

 
 

NG2-expressing neural progenitor cells (i.e., NG2 glial cells) maintain their proliferative and migratory activities even in the adult mammalian central nervous system (CNS) and …

 
 
 
 
 
 

Lipid droplet dynamics and insulin sensitivity upon a 5-day high-fat diet in Caucasians and South Asians

 
 

Anne Gemmink, Leontine E. H. Bakker, Bruno Guigas et al.

 
 

A 5-day High-Fat High-Calorie diet (HFHC-diet) reduces insulin-stimulated glucose disposal (Rd) in South Asian, but not Caucasian healthy lean males. We aimed to investigate if …

 
 
 
 
 
 

Polymodal Responses in C. elegans Phasmid Neurons Rely on Multiple Intracellular and Intercellular Signaling Pathways

 
 

Wenjuan Zou, Hankui Cheng, Shitian Li et al.

 
 

Animals utilize specialized sensory neurons enabling the detection of a wide range of environmental stimuli from the presence of toxic chemicals to that of touch. However, how …

 
 
 
 
 
 

Mitogen-activated protein kinases (MAPKs) regulate IL-6 over-production during concomitant influenza virus and Staphylococcus aureus infection

 
 

Carolin Klemm, Christin Bruchhagen, Andre van Krüchten et al.

 
 

Bacterial super-infections are a major complication of influenza virus (IV) infections and often lead to severe pneumonia. One hallmark of IV-associated Staphylococcus aureus (S. …

 
 
 
 
 
 

The inhibition of lung cancer cell migration by AhR-regulated autophagy

 
 

Chi-Hao Tsai, Ching-Hao Li, Yu-Wen Cheng et al.

 
 

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that is highly expressed in multiple organs and tissues. Whereas AhR mediates the metabolism of …

 
 
 
 
 
 

Peptoids successfully inhibit the growth of gram negative E. coli causing substantial membrane damage

 
 

Biljana Mojsoska, Gustavo Carretero, Sylvester Larsen et al.

 
 

Peptoids are an alternative approach to antimicrobial peptides that offer higher stability towards enzymatic degradation. It is essential when developing new types of peptoids, …

 
 
 
 
 
 

RNA-seq based detection of differentially expressed genes in the skeletal muscle of Duroc pigs with distinct lipid profiles

 
 

T. F. Cardoso, A. Cánovas, O. Canela-Xandri et al.

 
 

We have used a RNA-seq approach to investigate differential expression in the skeletal muscle of swine (N = 52) with divergent lipid profiles i.e. HIGH (increased intramuscular …

 
 
 
 
 
 

Dynamical footprint of cross-reactivity in a human autoimmune T-cell receptor

 
 

Amit Kumar, Francesco Delogu

 
 

The present work focuses on the dynamical aspects of cross-reactivity between myelin based protein (MBP) self-peptide and two microbial peptides (UL15, PMM) for Hy.1B11 T-cell …

 
 
 
 
 
 

Eda haplotypes in three-spined stickleback are associated with variation in immune gene expression

 
 

Shaun Robertson, Janette E. Bradley, Andrew D. C. MacColl

 
 

Haplotypes underlying local adaptation and speciation are predicted to have numerous phenotypic effects, but few genes involved have been identified, with much work to date …

 
 
 
 
 
 

In patients with chronic aplastic anemia, bone marrow–derived MSCs regulate the Treg/Th17 balance by influencing the Notch/RBP-J/FOXP3/RORγt pathway

 
 

Hongbo Li, Lin Wang, Yan Pang et al.

 
 

The standard treatment for aplastic anemia (AA) in young patients is a matched sibling hematopoietic stem cell transplant. Transfusion of a chronic AA patient with allogeneic …

 
 
 
 
 
 

SUMO regulates the activity of Smoothened and Costal-2 in Drosophila Hedgehog signaling

 
 

Jie Zhang, Yajuan Liu, Kai Jiang et al.

 
 

In Hedgehog (Hh) signaling, the GPCR-family protein Smoothened (Smo) acts as a signal transducer that is regulated by phosphorylation and ubiquitination, which ultimately change …

 
 
 
 
 
 

A novel BK channel-targeted peptide suppresses sound evoked activity in the mouse inferior colliculus

 
 

L. L. Scott, E. J. Brecht, A. Philpo et al.

 
 

Large conductance calcium-activated (BK) channels are broadly expressed in neurons and muscle where they modulate cellular activity. Decades of research support an interest in …

 
 
 
 
 
 

Hematopoietic pannexin 1 function is critical for neuropathic pain

 
 

Janelle L. Weaver, Sanja Arandjelovic, Gregory Brown et al.

 
 

Neuropathic pain symptoms respond poorly to available therapeutics, with most treated patients reporting unrelieved pain and significant impairment in daily life. Here, we show …

 
 
 
 
 
 

Zinc finger protein ZPR9 functions as an activator of AMPK-related serine/threonine kinase MPK38/MELK involved in ASK1/TGF-β/p53 signaling pathways

 
 

Hyun-A Seong, Ravi Manoharan, Hyunjung Ha

 
 

Murine protein serine-threonine kinase 38 (MPK38), an AMP‐activated protein kinase (AMPK)-related kinase, has been implicated in the induction of apoptosis signal-regulating …

 
 
 
 
 
 

Analysis of Craniocardiac Malformations in Xenopus using Optical Coherence Tomography

 
 

Engin Deniz, Stephan Jonas, Michael Hooper et al.

 
 

Birth defects affect 3% of children in the United States. Among the birth defects, congenital heart disease and craniofacial malformations are major causes of mortality and …

 
 
 
 
 
 

Loss of OxyR reduces efficacy of oxygen respiration in Shewanella oneidensis

 
 

Fen Wan, Miaomiao Shi, Haichun Gao

 
 

In many bacteria, OxyR is the major regulator controlling cellular response to H2O2. A common phenotype resulting from OxyR loss is reduced growth rate, but the underlying …

 
 
 
 
 
 

Co-operation, Competition and Crowding: A Discrete Framework Linking Allee Kinetics, Nonlinear Diffusion, Shocks and Sharp-Fronted Travelling Waves

 
 

Stuart T. Johnston, Ruth E. Baker, D. L. Sean McElwain et al.

 
 

Invasion processes are ubiquitous throughout cell biology and ecology. During invasion, individuals can become isolated from the bulk population and behave differently. We …

 
 
 
 
 
 

Molecular dietary analysis of two sympatric felids in the Mountains of Southwest China biodiversity hotspot and conservation implications

 
 

Mengyin Xiong, Dajun Wang, Hongliang Bu et al.

 
 

Dietary information is lacking in most of small to mid-sized carnivores due to their elusive predatory behaviour and versatile feeding habits. The leopard cat (LPC; Prionailurus …

 
 
 
 
 
 

Untargeted metabolomics of colonic digests reveals kynurenine pathway metabolites, dityrosine and 3-dehydroxycarnitine as red versus white meat discriminating metabolites

 
 

Caroline Rombouts, Lieselot Y. Hemeryck, Thomas Van Hecke et al.

 
 

Epidemiological research has demonstrated that the consumption of red meat is an important risk factor for the development of colorectal cancer (CRC), diabetes mellitus and …

 
 
 
 
 
 

Aging and serum exomiR content in women-effects of estrogenic hormone replacement therapy

 
 

Reeta Kangas, Timo Törmäkangas, Vidal Fey et al.

 
 

Exosomes participate in intercellular messaging by transporting bioactive lipid-, protein- and RNA-molecules and -complexes. The contents of the exosomes reflect the …

 
 
 
 
 
 

Humans expect generosity

 
 

Pablo Brañas-Garza, Ismael Rodríguez-Lara, Angel Sánchez

 
 

Mechanisms supporting human ultra-cooperativeness are very much subject to debate. One psychological feature likely to be relevant is the formation of expectations, particularly …

 
 
 
 
 
 

A pupal transcriptomic screen identifies Ral as a target of store-operated calcium entry in Drosophila neurons

 
 

Shlesha Richhariya, Siddharth Jayakumar, Katharine Abruzzi et al.

 
 

Transcriptional regulation by Store-operated Calcium Entry (SOCE) is well studied in non-excitable cells. However, the role of SOCE has been poorly documented in neuronal cells …

 
 
 
 
 
 

Effects of drought on leaf carbon source and growth of European beech are modulated by soil type

 
 

Jian-Feng Liu, Matthias Arend, Wen-Juan Yang et al.

 
 

Drought potentially affects carbon balance and growth of trees, but little is known to what extent soil plays a role in the trade-off between carbon gain and growth investment. …

 
 
 
 
 
 

Energy dissipation in flows through curved spaces

 
 

J.-D. Debus, M. Mendoza, S. Succi et al.

 
 

Fluid dynamics in intrinsically curved geometries is encountered in many physical systems in nature, ranging from microscopic bio-membranes all the way up to general relativity …

 
 
 
 
 
 

The alternative complement pathway is dysregulated in patients with chronic heart failure

 
 

Negar Shahini, Annika E. Michelsen, Per H. Nilsson et al.

 
 

The complement system, an important arm of the innate immune system, is activated in heart failure (HF). We hypothesized that HF patients are characterized by an imbalance of …

 
 
 
 
 
 

New findings of silica nanoparticles induced ER autophagy in human colon cancer cell

 
 

Fujing Wei, Yimin Wang, Zewei Luo et al.

 
 

Nanoparticle-induced autophagy has been extensively studied, however, real time information about the endoplasmic reticulum involved autophagic process (ER autophagy) induced by …

 
 
 
 
 
 

Reproductive strategies of the coral Turbinaria reniformis in the northern Gulf of Aqaba (Red Sea)

 
 

Hanna Rapuano, Itzchak Brickner, Tom Shlesinger et al.

 
 

Here we describe for the first time the reproductive biology of the scleractinian coral Turbinaria reniformis studied during three years at the coral reefs of Eilat and Aqaba. We …

 
 
 
 
 
 

Smoothened is a poor prognosis factor and a potential therapeutic target in glioma

 
 

Yiming Tu, Mingshan Niu, Peng Xie et al.

 
 

Malignant gliomas are associated with a high mortality rate. Thus, there is an urgent need for the development of novel targeted therapeutics. Aberrant Hedgehog signaling has …

 
 
 
 
 
 

TAZ contributes to pulmonary fibrosis by activating profibrotic functions of lung fibroblasts

 
 

Satoshi Noguchi, Akira Saito, Yu Mikami et al.

 
 

Transcriptional coactivator with PDZ-binding motif (TAZ) regulates a variety of biological processes. Nuclear translocation and activation of TAZ are regulated by multiple …

 
 
 
 
 
 

Relationships between motor patterns and intraluminal pressure in the 3-taeniated proximal colon of the rabbit

 
 

Xiaojing Quan, Zixian Yang, Mai Xue et al.

 
 

Manometry is used worldwide to assess motor function of the gastrointestinal tract, and the measured intraluminal pressure patterns are usually equated with contraction patterns. …

 
 
 
 
 
 

Geosmin-producing Species of Coelosphaerium (Synechococcales, Cyanobacteria) in Lake Shinji, Japan

 
 

T. Godo, Y. Saki, Y. Nojiri et al.

 
 

In Lake Shinji, Japan, periodic outbreaks of musty odour have occurred since mid-May 2007. Although the substance responsible for the odour was identified as geosmin, the …

 
 
 
 
 
 

Psychological stress and risk of incident atrial fibrillation in men and women with known atrial fibrillation genetic risk scores

 
 

Thomas Svensson, Mariusz Kitlinski, Gunnar Engström et al.

 
 

Psychological stress has been reported as a possible trigger of atrial fibrillation (AF). No studies have investigated whether any association between stress and AF could be …

 
 
 
 
 
 

Paracingulate Sulcus Asymmetry in the Human Brain: Effects of Sex, Handedness, and Race

 
 

Xuehu Wei, Yan Yin, Menglin Rong et al.

 
 

The anterior cingulate cortex (ACC), which is thought to play a key role in cognitive and affective regulation, has been widely reported to have a high degree of morphological …

 
 
 
 
 
 

Bioproduction, characterization, anticancer and antioxidant activities of extracellular melanin pigment produced by newly isolated microbial cell factories Streptomyces glaucescens NEAE-H

 
 

Noura El-Ahmady El-Naggar, Sara M. El-Ewasy

 
 

In this present study, a newly isolated strain, Streptomyces sp. NEAE-H, capable of producing high amount of black extracellular melanin pigment on peptone-yeast extract iron …

 
 
 
 
 
 

Microglia preconditioned by oxygen-glucose deprivation promote functional recovery in ischemic rats

 
 

Masato Kanazawa, Minami Miura, Masafumi Toriyabe et al.

 
 

Cell-therapies that invoke pleiotropic mechanisms may facilitate functional recovery in stroke patients. We hypothesized that a cell therapy using microglia preconditioned by …

 
 
 
 
 
 

miR302 regulates SNAI1 expression to control mesangial cell plasticity

 
 

L. De Chiara, D. Andrews, A. Watson et al.

 
 

Cell fate decisions are controlled by the interplay of transcription factors and epigenetic modifiers, which together determine cellular identity. Here we elaborate on the role …

 
 
 
 
 
 

Interleukin-1β pre-treated bone marrow stromal cells alleviate neuropathic pain through CCL7-mediated inhibition of microglial activation in the spinal cord

 
 

Jian Li, Guoying Deng, Haowei Wang et al.

 
 

Although neuropathic pain is one of the most intractable diseases, recent studies indicate that systemic or local injection of bone marrow stromal cells (BMSCs) decreases …

 
 
 
 
 
 
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