Tuesday, February 21, 2017

Nature Reviews Molecular Cell Biology contents March 2017 Volume 18 Number 3 pp 137-210

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Nature Reviews Molecular Cell Biology

Nature Outlook: Regenerative Medicine 

Sometimes, a drug can remedy a chemical imbalance or surgery can repair a structural failure, but there are times when there is no substitute for replacing a part with human tissue or an entire organ. Rapid advances in regenerative medicine are bringing that possibility closer to reality. 

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March 2017 Volume 18 Number 3Advertisement
Nature Reviews Molecular Cell Biology cover

2015 2-year Impact Factor 38.602 Journal Metrics 2-year Median 30

In this issue
Research Highlights

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Article series:
RNA processing and modifications
 Featured article:
Histone chaperone networks shaping chromatin function
Colin M. Hammond, Caroline B. Strømme, Hongda Huang, Dinshaw J. Patel & Anja Groth
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Read the latest featured articles: 
Turning back the clock for aging muscles
Epidermolysis bullosa: Gene-editing offers fix for skin condition

Stem cells: A key to totipotency
p137 | doi:10.1038/nrm.2017.9
The microRNA mir-34a has a key role in restricting the developmental potential of mouse pluripotent stem cells to embryonic cell types.

Epigenetics: Maternal TRIM28 for male embryos
p138 | doi:10.1038/nrm.2017.13
In mice, the absence of maternal Trim28 expression in early male embryos causes loss of DNA methylation and derepression of a non-imprinted gene, which results in lethality.

DNA repair: Histones have got to go
p138 | doi:10.1038/nrm.2017.2
DNA damage-induced histone degradation results in decreased nucleosome occupancy, which promotes homologous recombination by enhancing the dynamicity of chromatin.

Organelle dynamics: Connections, connections, connections
p139 | doi:10.1038/nrm.2017.14
Three independent studies in human cell lines reveal new functions of membrane contact sites between the endoplasmic reticulum (ER) and mitochondria and between the ER and peroxisomes.

What holds epigenetic memory?

p140 | doi:10.1038/nrm.2017.15
Caroline Dean discusses the mechanisms underlying the storage and inheritance of epigenetic memory.

Chromosome biology: TZAP trims telomeres
p140 | doi:10.1038/nrm.2017.8
A zinc finger protein is shown to bind to telomeres and mediate telomere trimming, thereby preventing potentially detrimental telomere lengthening.

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Histone chaperone networks shaping chromatin function
Colin M. Hammond et al.
p141 | doi:10.1038/nrm.2016.159
Histone chaperones safeguard the chromatin template and shield histones from promiscuous interactions to ensure their proper storage, transport, post-translational modification, nucleosome assembly and turnover.
Abstract | Full Text | PDF
Glucocorticoid receptor control of transcription: precision and plasticity via allostery
Emily R. Weikum, Matthew T. Knuesel, Eric A. Ortlund & Keith R. Yamamoto
p159 | doi:10.1038/nrm.2016.152
In response to steroid ligands, glucocorticoid receptor (GR) activates or represses gene expression in a highly context-specific manner. New evidence suggests that the conformation of GR is allosterically modulated by contextual signals, including DNA sequences, ligands, post-translational modifications and other transcription regulators, and that this supports the assembly of distinct transcription complexes.
Abstract | Full Text | PDF | Supplementary information
Telomeres in cancer: tumour suppression and genome instability
John Maciejowski & Titia de Lange
p175 | doi:10.1038/nrm.2016.171
Telomere shortening and loss of telomere protection can have a tumour-suppressive effect by mediating proliferation arrest. Ultimately, however, these processes can cause a state of extensive genome instability known as telomere crisis, which can facilitate tumorigenesis by causing oncogenic chromosomal rearrangements, including chromothripsis, kataegis and tetraploidization.
Abstract | Full Text | PDF
Mitotic spindle assembly in animal cells: a fine balancing act
Suzanna L. Prosser & Laurence Pelletier
p187 | doi:10.1038/nrm.2016.162
Three microtubule nucleation pathways – initiated from centrosomes, chromatin and existing spindle microtubules – contribute to the assembly of a functional mitotic spindle in animal cells to ensure accurate chromosome segregation. Recent findings have shed light on their relative contributions to building the spindle and on adaptation of the spindle to variations in cell size and shape.
Abstract | Full Text | PDF | Supplementary information
Article series: RNA processing and modifications
RNA modifications and structures cooperate to guide RNA-protein interactions
Cole J.T. Lewis, Tao Pan & Auinash Kalsotra
p202 | doi:10.1038/nrm.2016.163
The chemical modifications and structural features of mRNAs are highly dynamic. Together, they regulate the composition and function of the transcriptome by shaping RNA-protein interactions at different stages of the gene expression process.
Abstract | Full Text | PDF
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