Nature Reviews Molecular Cell Biology contents March 2017 Volume 18 Number 3 pp 137-210

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TABLE OF CONTENTS
March 2017 Volume 18 Number 3		Advertisement
2015 2-year Impact Factor 38.602 Journal Metrics 2-year Median 30	In this issue Research Highlights Reviews Perspectives Also this month Article series: RNA processing and modifications  Featured article: Histone chaperone networks shaping chromatin function Colin M. Hammond, Caroline B. Strømme, Hongda Huang, Dinshaw J. Patel & Anja Groth	nature.com webcasts Pixels to data: Quantitative cell biology using high-content imaging and analysis. Date: Tuesday 28 February 2017 Time: 8AM PST, 11AM EST, 4PM GMT, 5PM CET  Register  Sponsor:  PerkinElmer
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RESEARCH HIGHLIGHTS Top Stem cells: A key to totipotency p137 | doi:10.1038/nrm.2017.9 The microRNA mir-34a has a key role in restricting the developmental potential of mouse pluripotent stem cells to embryonic cell types. PDF Epigenetics: Maternal TRIM28 for male embryos p138 | doi:10.1038/nrm.2017.13 In mice, the absence of maternal Trim28 expression in early male embryos causes loss of DNA methylation and derepression of a non-imprinted gene, which results in lethality. PDF DNA repair: Histones have got to go p138 | doi:10.1038/nrm.2017.2 DNA damage-induced histone degradation results in decreased nucleosome occupancy, which promotes homologous recombination by enhancing the dynamicity of chromatin. PDF Organelle dynamics: Connections, connections, connections p139 | doi:10.1038/nrm.2017.14 Three independent studies in human cell lines reveal new functions of membrane contact sites between the endoplasmic reticulum (ER) and mitochondria and between the ER and peroxisomes. PDF JOURNAL CLUB What holds epigenetic memory? p140 | doi:10.1038/nrm.2017.15 Caroline Dean discusses the mechanisms underlying the storage and inheritance of epigenetic memory. PDF Chromosome biology: TZAP trims telomeres p140 | doi:10.1038/nrm.2017.8 A zinc finger protein is shown to bind to telomeres and mediate telomere trimming, thereby preventing potentially detrimental telomere lengthening. PDF Molecular Cell Biology JOBS of the week Staff Scientist / Assistant Professors New York Blood Center Group Leader / Senior Research Scientist, Immunology Kleo Pharmaceuticals Postdoctoral Fellow Tulane University, Department of Cell and Mol. Biology Postdoctoral Research Fellow (m / f) MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE (MDC). Postdoctoral Position Cold Spring Harbor Laboratory (CSHL) More Science jobs from Molecular Cell Biology EVENT Molecular Mechanisms of Immune Cell Development & Function 30.07.17 Snowmass, USA More science events from
REVIEWS		Top
Histone chaperone networks shaping chromatin function Colin M. Hammond et al. p141 | doi:10.1038/nrm.2016.159 Histone chaperones safeguard the chromatin template and shield histones from promiscuous interactions to ensure their proper storage, transport, post-translational modification, nucleosome assembly and turnover. Abstract | Full Text | PDF
Glucocorticoid receptor control of transcription: precision and plasticity via allostery Emily R. Weikum, Matthew T. Knuesel, Eric A. Ortlund & Keith R. Yamamoto p159 | doi:10.1038/nrm.2016.152 In response to steroid ligands, glucocorticoid receptor (GR) activates or represses gene expression in a highly context-specific manner. New evidence suggests that the conformation of GR is allosterically modulated by contextual signals, including DNA sequences, ligands, post-translational modifications and other transcription regulators, and that this supports the assembly of distinct transcription complexes. Abstract | Full Text | PDF | Supplementary information
Telomeres in cancer: tumour suppression and genome instability John Maciejowski & Titia de Lange p175 | doi:10.1038/nrm.2016.171 Telomere shortening and loss of telomere protection can have a tumour-suppressive effect by mediating proliferation arrest. Ultimately, however, these processes can cause a state of extensive genome instability known as telomere crisis, which can facilitate tumorigenesis by causing oncogenic chromosomal rearrangements, including chromothripsis, kataegis and tetraploidization. Abstract | Full Text | PDF
Mitotic spindle assembly in animal cells: a fine balancing act Suzanna L. Prosser & Laurence Pelletier p187 | doi:10.1038/nrm.2016.162 Three microtubule nucleation pathways – initiated from centrosomes, chromatin and existing spindle microtubules – contribute to the assembly of a functional mitotic spindle in animal cells to ensure accurate chromosome segregation. Recent findings have shed light on their relative contributions to building the spindle and on adaptation of the spindle to variations in cell size and shape. Abstract | Full Text | PDF | Supplementary information
PERSPECTIVES		Top
OPINION Article series: RNA processing and modifications RNA modifications and structures cooperate to guide RNA-protein interactions Cole J.T. Lewis, Tao Pan & Auinash Kalsotra p202 | doi:10.1038/nrm.2016.163 The chemical modifications and structural features of mRNAs are highly dynamic. Together, they regulate the composition and function of the transcriptome by shaping RNA-protein interactions at different stages of the gene expression process. Abstract | Full Text | PDF
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*2015 Journal Citation Reports (Thomson Reuters, 2016)

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