Nature Reviews Immunology Contents March 2017 Volume 17 Number 3 pp 145-214

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TABLE OF CONTENTS
March 2017 Volume 17 Number 3
2015 2-year Impact Factor 39.416 Journal Metrics 2-year Median 31	In this issue Research Highlights Reviews Perspectives Also this month Article series: Cell death and immunity  Featured article: Regulation of muscle growth and regeneration by the immune system James G. Tidball
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RESEARCH HIGHLIGHTS Top Immunometabolism: Powering down leukaemia p145 | doi:10.1038/nri.2017.17 B-lymphoid transcription factors can protect against leukaemic transformation by restricting glucose and energy usage in pre-B cells. PDF Infection: IL-22 controls iron scavenging p146 | doi:10.1038/nri.2017.15 During systemic infection interleukin-22 can limit the availability of iron by promoting increased production of haem scavengers. PDF Mucosal immunology: Rationing AHR ligands p146 | doi:10.1038/nri.2017.8 CYP1 enzymes expressed by intestinal epithelial cells metabolise AHR ligands in the gut to regulate intestinal immune responses. PDF Infectious disease: Hitching a ride with DCs p147 | doi:10.1038/nri.2017.16 Pseudogenization of a single Salmonella effector protein gene facilitates pathogen hijacking of dendritic cells to spread systemically. PDF Macrophages: mTORC1 drives granulomas p148 | doi:10.1038/nri.2017.14 MTORC1-dependent macrophage proliferation and glycolysis drive granuloma formation in sarcoidosis. PDF Fungal infection: JNK inhibitors boost antifungal immunity p148 | doi:10.1038/nri.2017.18 PDF JOURNAL CLUB Multi-dimensional control of clonal evolution p149 | doi:10.1038/nri.2017.6 Michael McHeyzer-Williams describes a 1998 study by Avi Kupfer and colleagues that transformed the view of cognate T helper cell-B cell crosstalk. PDF Nature Reviews Immunology JOBS of the week Postdoc position in Innate Immunology Ecole Polytechnique Fédérale de Lausanne (EPFL) Associate Professor / Assistant Professor in Immunology The Hong Kong Polytechnic University Group Leader / Senior Research Scientist, Immunology Kleo Pharmaceuticals Professor Molecular Immunology Erasmus MC Bioinformatician on Immunology: Osaka, Japan KOTAI Biotechnologies, Inc More Science jobs from Nature Reviews Immunology EVENT Tumor Immunology & Immunotherapy 22.10.17 Suzhou, China More science events from
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REVIEWS		Top
Article series: Cell death and immunity Programmed cell death as a defence against infection Ine Jorgensen, Manira Rayamajhi & Edward A. Miao p151 | doi:10.1038/nri.2016.147 This Review describes how different modes of cell death protect against bacterial and viral infections, and the complex signalling crosstalk between the different pathways during an infection. Abstract | Full Text | PDF | Supplementary information
Regulation of muscle growth and regeneration by the immune system James G. Tidball p165 | doi:10.1038/nri.2016.150 Following muscle injury, changes in the stages of muscle growth coincide with changes in the phenotype and activation status of leukocytes that enter the site of muscle damage. As described in this Review, complex and coordinated crosstalk between immune cells and muscle cells determines the success or failure of muscle regeneration. Abstract | Full Text | PDF
T cell responses in the central nervous system Thomas Korn & Axel Kallies p179 | doi:10.1038/nri.2016.144 This Review focuses on the protective and pathological roles of different T cell subsets in the central nervous system (CNS). The authors explain how effector, memory and regulatory T cell populations are primed and recruited to the CNS, and discuss the plasticity of these populations, particularly in the context of viral infection and autoimmunity. Abstract | Full Text | PDF
Immunobiology of Ebola and Lassa virus infections Joseph B. Prescott et al. p195 | doi:10.1038/nri.2016.138 Severe haemorrhagic fever is a feature of infection with both Ebola and Lassa viruses, but differences in the immune responses induced by infection in each case may have important implications for the development of specific therapies and vaccines. Abstract | Full Text | PDF | Supplementary information
PERSPECTIVES		Top
OPINION Homeostasis-altering molecular processes as mechanisms of inflammasome activation Adrian Liston & Seth L. Masters p208 | doi:10.1038/nri.2016.151 Innate immune responses are triggered in response to the sensing of pathogen-associated molecular patterns (PAMPs) or damage-associated molecular patterns (DAMPs) by pattern recognition receptors (PRRs). An emerging idea is that inflammasome activation may also occur independently of PRR activation following a disturbance in cellular homeostasis. The authors explore this concept and the implications for chronic inflammatory disease in this Opinion article. Abstract | Full Text | PDF
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