Wednesday, February 15, 2017

Nature Reviews Genetics Contents March 2017 Volume 18 Number 3 pp143-208

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Nature Reviews Genetics

March 2017 Volume 18 Number 3
Nature Reviews Genetics cover
2015 2–year Impact Factor 35.898 Journal Metrics 2–year Median 32
In this issue
Research Highlights

Also this month
Article series:
Disease mechanisms
 Featured article:
Ground rules of the pluripotency gene regulatory network
Mo Li & Juan Carlos Izpisua Belmonte

Recommend to library


Gene expression: Host-pathogen duels revealed by dual RNA-seq in vivo
p143 | doi:10.1038/nrg.2017.10

Genetic variation: Giving context to phenotype prediction
p144 | doi:10.1038/nrg.2017.3

Technique: SMiLE-seq illuminates transcription factor motifs
p144 | doi:10.1038/nrg.2017.5

Non-coding RNA: Pri-miRNA processing: structure is key
p145 | doi:10.1038/nrg.2017.6

Metagenomics: Uncultivated microbes reveal new CRISPR-Cas systems
p146 | doi:10.1038/nrg.2017.1

Cancer genomics: Keeping score with immunotherapy response
p146 | doi:10.1038/nrg.2017.2


Article series: Disease mechanisms
Down syndrome and the complexity of genome dosage imbalance
Stylianos E. Antonarakis
p147 | doi:10.1038/nrg.2016.154
In this article, the author reviews the current understanding of the genetic basis for Down syndrome phenotypes, including congenital heart defects, Alzheimer disease and leukaemia. The potential for Down syndrome therapies is discussed in light of recent progress in the field.
Abstract | Full Text | PDF | Supplementary information

Transcriptional architecture of the mammalian circadian clock
Joseph S. Takahashi
p164 | doi:10.1038/nrg.2016.150
Next-generation sequencing approaches have yielded new insights into circadian function. Here, Takahashi reviews genome-wide analyses of the clock transcriptional feedback loop in mammals, which reveal a global circadian regulation of transcription factor occupancy, RNA polymerase II recruitment and initiation, nascent transcription and chromatin remodelling.
Abstract | Full Text | PDF

Ground rules of the pluripotency gene regulatory network
Mo Li & Juan Carlos Izpisua Belmonte
p180 | doi:10.1038/nrg.2016.156
In this article, the authors review the mechanisms by which the pluripotency gene regulatory network governs the acquisition, maintenance and dissolution of the pluripotent state, including the interaction of these networks with chromatin-mediated and RNA-mediated regulatory mechanisms. They discuss recent evidence for alternative pluripotency states and the factors that affect transitions between these states.
Abstract | Full Text | PDF

Article series: Epigenetics
Chromatin dynamics during the cell cycle at centromeres
Sebastian Muller & Genevieve Almouzni
p192 | doi:10.1038/nrg.2016.157
During the cell cycle, the centromeres of chromosomes have important roles and face key challenges, such as mediating successful chromosome segregation during mitosis and faithfully propagating their chromatin state to daughter chromosomes during S phase. This Review describes cell cycle-related features of centromeres, focusing on the nature and dynamics of centromeric chromatin, how it is intricately regulated and the potential implications for disease when these processes are disrupted.
Abstract | Full Text | PDF

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