Nature Reviews Genetics Contents March 2017 Volume 18 Number 3 pp143-208

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TABLE OF CONTENTS
March 2017 Volume 18 Number 3
2015 2–year Impact Factor 35.898 Journal Metrics 2–year Median 32	In this issue Research Highlights Reviews Also this month Article series: Disease mechanisms Epigenetics  Featured article: Ground rules of the pluripotency gene regulatory network Mo Li & Juan Carlos Izpisua Belmonte
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RESEARCH HIGHLIGHTS Top Gene expression: Host-pathogen duels revealed by dual RNA-seq in vivo p143 | doi:10.1038/nrg.2017.10 PDF Genetic variation: Giving context to phenotype prediction p144 | doi:10.1038/nrg.2017.3 PDF Technique: SMiLE-seq illuminates transcription factor motifs p144 | doi:10.1038/nrg.2017.5 PDF Non-coding RNA: Pri-miRNA processing: structure is key p145 | doi:10.1038/nrg.2017.6 PDF Metagenomics: Uncultivated microbes reveal new CRISPR-Cas systems p146 | doi:10.1038/nrg.2017.1 PDF Cancer genomics: Keeping score with immunotherapy response p146 | doi:10.1038/nrg.2017.2 PDF
REVIEWS		Top
Article series: Disease mechanisms Down syndrome and the complexity of genome dosage imbalance Stylianos E. Antonarakis p147 | doi:10.1038/nrg.2016.154 In this article, the author reviews the current understanding of the genetic basis for Down syndrome phenotypes, including congenital heart defects, Alzheimer disease and leukaemia. The potential for Down syndrome therapies is discussed in light of recent progress in the field. Abstract | Full Text | PDF | Supplementary information
Transcriptional architecture of the mammalian circadian clock Joseph S. Takahashi p164 | doi:10.1038/nrg.2016.150 Next-generation sequencing approaches have yielded new insights into circadian function. Here, Takahashi reviews genome-wide analyses of the clock transcriptional feedback loop in mammals, which reveal a global circadian regulation of transcription factor occupancy, RNA polymerase II recruitment and initiation, nascent transcription and chromatin remodelling. Abstract | Full Text | PDF
Ground rules of the pluripotency gene regulatory network Mo Li & Juan Carlos Izpisua Belmonte p180 | doi:10.1038/nrg.2016.156 In this article, the authors review the mechanisms by which the pluripotency gene regulatory network governs the acquisition, maintenance and dissolution of the pluripotent state, including the interaction of these networks with chromatin-mediated and RNA-mediated regulatory mechanisms. They discuss recent evidence for alternative pluripotency states and the factors that affect transitions between these states. Abstract | Full Text | PDF
Article series: Epigenetics Chromatin dynamics during the cell cycle at centromeres Sebastian Muller & Genevieve Almouzni p192 | doi:10.1038/nrg.2016.157 During the cell cycle, the centromeres of chromosomes have important roles and face key challenges, such as mediating successful chromosome segregation during mitosis and faithfully propagating their chromatin state to daughter chromosomes during S phase. This Review describes cell cycle-related features of centromeres, focusing on the nature and dynamics of centromeric chromatin, how it is intricately regulated and the potential implications for disease when these processes are disrupted. Abstract | Full Text | PDF
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