Thursday, February 23, 2017

Nature Reviews Cancer contents March 2017 Volume 17 Number 3 pp141-204

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Nature Reviews Cancer

March 2017 Volume 17 Number 3Advertisement
Nature Reviews Cancer cover
2015 2-year Impact Factor 34.244 Journal Metrics 2-year Median 27
In this issue
Research Highlights

Also this month
 Featured article:
A chemical probe toolbox for dissecting the cancer epigenome
Jake Shortt, Christopher J. Ott, Ricky W. Johnstone & James E. Bradner

Nature Insight Frontiers in Biology

This year's Frontiers in Biology Insight features Reviews on how genomics is helping to uncover the peopling of the world, the interplay between morphogens and morphogenesis in determining organismal shape, the factors that influence the immune response to cancer, advances in single-cell genomics, and the effects of base modifications in messenger RNA.

Recommend to library

Tumour evolution: Epigenetic and genetic heterogeneity in metastasis
p141 | doi:10.1038/nrc.2017.11
How similar are metastases to the primary tumour and other metastases in the same patient? And what does that tell us about the evolution of metastatic ability? Two papers investigated these questions in pancreatic ductal adenocarcinoma (PDAC).

Early detection: The algorithm will see you now
p142 | doi:10.1038/nrc.2017.10
Esteva et al. have developed an artificial intelligence algorithm which recognises and classifies skin cancers as accurately as specialist clinicians, thereby automating diagnosis.

Tumorigenesis: Fitness penalties of aneuploidy
p142 | doi:10.1038/nrc.2017.9
Sheltzer et al. find that single-chromosome gains can prevent tumorigenesis relative to genetically matched euploid cells, but that these aneuploid cells can evolve over time to have improved fitness.

Tumorigenesis: Extra! Extra! Read all about it!
p143 | doi:10.1038/nrc.2017.12
Two papers demonstrate that centrosome amplification can cause cancer in mammals and that a PIDDosome–p53-dependent control mechanism acts to prevent cell proliferation in the presence of extra centrosomes.

JOBS of the week
Postdoctoral Fellows: Cancer Genetics, Epigenetics and Biomarkers
Baylor Scott & White Research Institute
Director, UT Health San Antonio MD Anderson Cancer Center
UT Health Science Center San Antonio
Postdoctoral Fellow - Cancer Biology - Kong lab
City of Hope
Postdoctoral position: RNA, Stem Cell and Cancer Biology
Lund University
Tumor Immunology / Immunotherapy / Tumor Microenvironment in Pediatric Cancer
Children's Cancer Research Institute; St. Anna Kinderkrebsforschung
More Science jobs from
3rd World Congress on Cancer and Prevention Methods
Barcelona, Spain
More science events from
Notch as a tumour suppressor
Craig S. Nowell & Freddy Radtke
p145 | doi:10.1038/nrc.2016.145
In this Review, Nowell and Radtke outline the accumulating evidence that Notch functions as a tumour suppressor in a range of cancers, and present potential mechanisms by which loss of Notch signalling could promote tumorigenesis.
Abstract | Full Text | PDF

A chemical probe toolbox for dissecting the cancer epigenome
Jake Shortt, Christopher J. Ott, Ricky W. Johnstone & James E. Bradner
p160 | doi:10.1038/nrc.2016.148
This review summarizes the state of the art in chemical probes targeting molecular processes operating at the chromatin interface in cancer cells. It seeks to provide a chemical toolbox for use by scientists to dissect epigenetic vulnerabilities of tumour biology.
Abstract | Full Text | PDF | Supplementary information

SUMO and the robustness of cancer
Jacob-Sebastian Seeler & Anne Dejean
p184 | doi:10.1038/nrc.2016.143
Sumoylation is an important mechanism in cellular responses to stress, and appears to be upregulated in many cancers. This Review argues that sumoylation protects the stability and functionality of otherwise easily misregulated gene expression programmes and signalling pathways of cancer cells.
Abstract | Full Text | PDF

Precision diagnostics: moving towards protein biomarker signatures of clinical utility in cancer
Carl A. K. Borrebaeck
p199 | doi:10.1038/nrc.2016.153
This Opinion article focuses on the trends and progress being made in identifying protein biomarker signatures of clinical utility in cancer using, in particular, blood-based proteomics.
Abstract | Full Text | PDF

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