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Advertisement |  | | | | | | | | | | | | | Latest Correspondence | | | | | | | | | | | | Latest Articles | View all Articles | | | | | Clustering of 770,000 genomes reveals post-colonial population structure of North America OPEN | | | Eunjung Han, Peter Carbonetto, Ross E. Curtis, Yong Wang, Julie M. Granka, Jake Byrnes, Keith Noto, Amir R. Kermany, Natalie M. Myres, Mathew J. Barber, Kristin A. Rand, Shiya Song, Theodore Roman, Erin Battat, Eyal Elyashiv, Harendra Guturu, Eurie L. Hong, Kenneth G. Chahine and Catherine A. Ball | | | Genetic data has led to great advances in our understanding of human evolution and dispersal, but information on more recent events is limited. Here, the authors analyse genotypes from 770,000 US individuals to map the fine-scale population structure of North America after European settlement. | | | 07 February 2017 | doi: 10.1038/ncomms14238 | | |
| Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent OPEN | | | Anren Song, Yujin Zhang, Leng Han, Gennady G. Yegutkin, Hong Liu, Kaiqi Sun, Angelo D’Alessandro, Jessica Li, Harry Karmouty-Quintana, Takayuki Iriyama, Tingting Weng, Shushan Zhao, Wei Wang, Hongyu Wu, Travis Nemkov, Andrew W. Subudhi, Sonja Jameson-Van Houten, Colleen G. Julian, Andrew T. Lovering, Kirk C. Hansen et al. | | | Humans that reach high altitude soon after the first ascent show faster adaptation to hypoxia. Song et al. show that this adaptive response relies on decreased red blood cell uptake of plasma adenosine due to reduced levels of nucleoside transporter ENT1 resulting from coordinated adenosine generation by ectonucleotidase CD73 and activation of A2B receptors. | | | 07 February 2017 | doi: 10.1038/ncomms14108 | | |
| A unique Pd-catalysed Heck arylation as a remote trigger for cyclopropane selective ring-opening OPEN | | | Sukhdev Singh, Jeffrey Bruffaerts, Alexandre Vasseur and Ilan Marek | | | Functionalizing multiple, distant sites across a molecule is a challenge. Here the authors report a remote functionalization strategy, whereby an initial Heck reaction leads to chain-walking of palladium across a molecule, ring-opening cyclopropanes while retaining the stereochemistry in the product. | | | 07 February 2017 | doi: 10.1038/ncomms14200 | | |
| Hotspots of aberrant enhancer activity punctuate the colorectal cancer epigenome OPEN | | | Andrea J. Cohen, Alina Saiakhova, Olivia Corradin, Jennifer M. Luppino, Katreya Lovrenert, Cynthia F. Bartels, James J. Morrow, Stephen C. Mack, Gursimran Dhillon, Lydia Beard, Lois Myeroff, Matthew F. Kalady, Joseph Willis, James E. Bradner, Ruth A. Keri, Nathan A. Berger, Shondra M. Pruett-Miller, Sanford D. Markowitz and Peter C. Scacheri | | | Active enhancers are defined by the presence of post-translational modifications of histones. Here, the authors use these marks to identify enhancers recurrently activated in colorectal cancer and find that these enhancers turn on oncogenes and are associated with known risk loci for developing the disease. | | | 07 February 2017 | doi: 10.1038/ncomms14400 | | |
| Armc5 deletion causes developmental defects and compromises T-cell immune responses OPEN | | | Yan Hu, Linjiang Lao, Jianning Mao, Wei Jin, Hongyu Luo, Tania Charpentier, Shijie Qi, Junzheng Peng, Bing Hu, Mieczyslaw Martin Marcinkiewicz, Alain Lamarre and Jiangping Wu | | | Mutations in ARMC5 are associated with risk of primary macronodular adrenal gland hyperplasia. Here the authors show that mice lacking Armc5 have adrenal gland hyperplasia and defective T-cell proliferation, differentiation, survival and in vivo T-cell-mediated immune responses. | | | 07 February 2017 | doi: 10.1038/ncomms13834 | | |
| A substrate-bound structure of cyanobacterial biliverdin reductase identifies stacked substrates as critical for activity OPEN | | | Haruna Takao, Kei Hirabayashi, Yuki Nishigaya, Haruna Kouriki, Tetsuko Nakaniwa, Yoshinori Hagiwara, Jiro Harada, Hideaki Sato, Toshimasa Yamazaki, Yoichi Sakakibara, Masahito Suiko, Yujiro Asada, Yasuhiro Takahashi, Ken Yamamoto, Keiichi Fukuyama, Masakazu Sugishima and Kei Wada | | | Biliverdin reductase (BVR) catalyses the last step in haem degradation. Here the authors present the crystal structure of cyanobacterial BVR bound to its substrate biliverdin and oxidised cofactor NADP+, which was used to propose the catalytic mechanism of this enzyme. | | | 07 February 2017 | doi: 10.1038/ncomms14397 | | |
| Comparative influenza protein interactomes identify the role of plakophilin 2 in virus restriction OPEN | | | Lingyan Wang, Bishi Fu, Wenjun Li, Girish Patil, Lin Liu, Martin E. Dorf and Shitao Li | | | Protein interaction networks can identify host proteins that affect virus replication. Here, the authors compare the protein interactomes of several influenza A virus strains and identify plakophilin 2 as a restriction factor that inhibits formation of the viral polymerase complex. | | | 07 February 2017 | doi: 10.1038/ncomms13876 | | |
| CRISPR–Cas9-targeted fragmentation and selective sequencing enable massively parallel microsatellite analysis OPEN | | | GiWon Shin, Susan M. Grimes, HoJoon Lee, Billy T. Lau, Li C. Xia and Hanlee P. Ji | | | Microsatellite genotyping is a common molecular method of for identification but current methods have restricted throughput. The authors demonstrate STR-Seq, which combines next generation sequencing with targeted in vitro CRISPR-Cas9 fragmentation to enable massively parallel analysis in the thousands. | | | 07 February 2017 | doi: 10.1038/ncomms14291 | | |
| Two factor-based reprogramming of rodent and human fibroblasts into Schwann cells OPEN | | | Pietro Giuseppe Mazzara, Luca Massimino, Marta Pellegatta, Giulia Ronchi, Alessandra Ricca, Angelo Iannielli, Serena Gea Giannelli, Marco Cursi, Cinzia Cancellieri, Alessandro Sessa, Ubaldo Del Carro, Angelo Quattrini, Stefano Geuna, Angela Gritti, Carla Taveggia and Vania Broccoli | | | Schwann cells (SCs) myelinate peripheral nerve axons and offer opportunities for the treatment of injuries and demyelinating diseases but reliable and renewable sources of these cells are hard to come by. Here the authors reprogram rat, mouse and human fibroblasts into Schwann cells using two transcription factors. | | | 07 February 2017 | doi: 10.1038/ncomms14088 | | |
| Molecular determinant of the effects of hydrostatic pressure on protein folding stability OPEN | | | Calvin R. Chen and George I. Makhatadze | | | Proteins can be both stabilized and destabilized by pressure. Here the authors analyse the factors contributing to both negative and positive protein volume change upon denaturation, and shed light on the molecular determinants allowing proteins to be stable at high pressures. | | | 07 February 2017 | doi: 10.1038/ncomms14561 | | |
| Small-molecule-biased formyl peptide receptor agonist compound 17b protects against myocardial ischaemia-reperfusion injury in mice OPEN | | | Cheng Xue Qin, Lauren T. May, Renming Li, Nga Cao, Sarah Rosli, Minh Deo, Amy E. Alexander, Duncan Horlock, Jane E. Bourke, Yuan H. Yang, Alastair G. Stewart, David M. Kaye, Xiao-Jun Du, Patrick M. Sexton, Arthur Christopoulos, Xiao-Ming Gao and Rebecca H. Ritchie | | | G Protein-Coupled Receptors (GPCRs) can adopt different conformations, each linked to distinct cellular outcomes. Here the authors show that compound 17b, a novel agonist of the GPCR family member FPR, robustly activates cardioprotective but not detrimental FPR signalling, showing beneficial therapeutic effect in a mouse model of cardiac infarction. | | | 07 February 2017 | doi: 10.1038/ncomms14232 | | |
| Nanoscale π–π stacked molecules are bound by collective charge fluctuations OPEN | | | Jan Hermann, Dario Alfè and Alexandre Tkatchenko | | | Attractive, non-covalent interactions between aromatic rings—termed π−π stacking—is common in chemistry but difficult to model. Here the authors report a quantum-mechanical model to show the importance of collective charge fluctuations for understanding pi-stacked supramolecular systems. | | | 07 February 2017 | doi: 10.1038/ncomms14052 | | |
| DEK-targeting DNA aptamers as therapeutics for inflammatory arthritis OPEN | | | Nirit Mor-Vaknin, Anjan Saha, Maureen Legendre, Carmelo Carmona-Rivera, M Asif Amin, Bradley J. Rabquer, Marta J. Gonzales-Hernandez, Julie Jorns, Smriti Mohan, Srilakshmi Yalavarthi, Dave A. Pai, Kristine Angevine, Shelley J. Almburg, Jason S. Knight, Barbara S. Adams, Alisa E. Koch, David A. Fox, David R. Engelke, Mariana J. Kaplan and David M. Markovitz et al. | | | DEK is a secreted protein abundant in the synovia of patients with juvenile idiopathic arthritis. Here the authors show DEK is important for neutrophil extracellular trap formation and joint inflammation, and demonstrate therapeutic efficacy of DEK-targeting aptamers in a mouse model of arthritis. | | | 06 February 2017 | doi: 10.1038/ncomms14252 | | |
| Functional roles of Aves class-specific cis-regulatory elements on macroevolution of bird-specific features OPEN | | | Ryohei Seki, Cai Li, Qi Fang, Shinichi Hayashi, Shiro Egawa, Jiang Hu, Luohao Xu, Hailin Pan, Mao Kondo, Tomohiko Sato, Haruka Matsubara, Namiko Kamiyama, Keiichi Kitajima, Daisuke Saito, Yang Liu, M. Thomas P. Gilbert, Qi Zhou, Xing Xu, Toshihiko Shiroishi, Naoki Irie et al. | | | The transition from non-avian dinosaurs to birds capable of powered flight represents a major evolutionary transition. Here the authors analyse 48 bird genomes and identify avian-specific highly conserved elements with roles in avian limb development. | | | 06 February 2017 | doi: 10.1038/ncomms14229 | | |
| Major sulfonate transporter Soa1 in Saccharomyces cerevisiae and considerable substrate diversity in its fungal family OPEN | | | Sylvester Holt, Harish Kankipati, Stijn De Graeve, Griet Van Zeebroeck, Maria R. Foulquié-Moreno, Stinus Lindgreen and Johan M. Thevelein | | | Sulfonates are a major source of sulphur for soil microbes but their cellular uptake is still not fully understood. Here the authors show that Saccharomyces cerevisiae YIL166C(SOA1) encodes for an inorganic sulphur transporter that can also function as a sulfonate and choline sulphate transporter. | | | 06 February 2017 | doi: 10.1038/ncomms14247 | | |
| Structure of the homodimeric androgen receptor ligand-binding domain OPEN | | | Marta Nadal, Stefan Prekovic, Nerea Gallastegui, Christine Helsen, Montserrat Abella, Karolina Zielinska, Marina Gay, Marta Vilaseca, Marta Taulès, Adriaan B. Houtsmuller, Martin E. van Royen, Frank Claessens, Pablo Fuentes-Prior and Eva Estébanez-Perpiñá | | | The androgen receptor is crucial for the development and physiology of reproductive organs. Here the authors present the structure of the androgen receptor ligand-binding domain bound to dihydrotestosterone, identifying a homodimerization interface that is crucial for receptor activity in vivo. | | | 06 February 2017 | doi: 10.1038/ncomms14388 | | |
| A CAF40-binding motif facilitates recruitment of the CCR4-NOT complex to mRNAs targeted by Drosophila Roquin OPEN | | | Annamaria Sgromo, Tobias Raisch, Praveen Bawankar, Dipankar Bhandari, Ying Chen, Duygu Kuzuoğlu-Öztürk, Oliver Weichenrieder and Elisa Izaurralde | | | Roquin proteins downregulate target mRNA expression by recruiting effectors such as the CCR4-NOT deadenylase complex. Here the authors provide molecular details of how Roquin proteins recruit the CCR4-NOT complex to repress the expression of its targets. | | | 06 February 2017 | doi: 10.1038/ncomms14307 | | |
| Angle resolved photoemission spectroscopy reveals spin charge separation in metallic MoSe2 grain boundary OPEN | | | Yujing Ma, Horacio Coy Diaz, José Avila, Chaoyu Chen, Vijaysankar Kalappattil, Raja Das, Manh-Huong Phan, Tilen Čadež, José M. P. Carmelo, Maria C. Asensio and Matthias Batzill | | | Line defects are 1D structures often embedded within 2D materials. Here, the authors use angle resolved photoemission spectroscopy to unveil the 1D nature of electron behaviour in such defects in atomically thin MoS2, providing evidence for spin- and charge-separation. | | | 06 February 2017 | doi: 10.1038/ncomms14231 | | |
| Dissection of goadsporin biosynthesis by in vitro reconstitution leading to designer analogues expressed in vivo OPEN | | | Taro Ozaki, Kona Yamashita, Yuki Goto, Morito Shimomura, Shohei Hayashi, Shumpei Asamizu, Yoshinori Sugai, Haruo Ikeda, Hiroaki Suga and Hiroyasu Onaka | | | Goadsporin is an antibacterial peptide highly customized by multiple post-translational modifying enzymes. Here, the authors dissect its biosynthetic pathway by in vitro reconstitution and use their insights to produce goadsporin analogues in vitro and in vivo. | | | 06 February 2017 | doi: 10.1038/ncomms14207 | | |
| Cryptic bioactivity capacitated by synthetic hybrid plant peptides OPEN | | | Yuki Hirakawa, Hidefumi Shinohara, Kai Welke, Stephan Irle, Yoshikatsu Matsubayashi, Keiko U. Torii and Naoyuki Uchida | | | Peptide hormones play versatile roles in plant development and environmental responses. Here the authors report the engineering of a synthetic plant peptide that acts on meristems through interaction with both the CLV1 and TDR/PXY receptors of Arabidopsis thaliana. | | | 06 February 2017 | doi: 10.1038/ncomms14318 | | |
| Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia OPEN | | | Philip J. Law, Sonja I. Berndt, Helen E. Speedy, Nicola J. Camp, Georgina P. Sava, Christine F. Skibola, Amy Holroyd, Vijai Joseph, Nicola J. Sunter, Alexandra Nieters, Silvia Bea, Alain Monnereau, David Martin-Garcia, Lynn R. Goldin, Guillem Clot, Lauren R. Teras, Inés Quintela, Brenda M. Birmann, Sandrine Jayne, Wendy Cozen et al. | | | Chronic lymphocytic leukaemia has a hereditary component, much of which remains to be identified. Here, the authors perform a genome-wide association study and find new risk loci for the disease, which are associated with genes involved in immune function. | | | 06 February 2017 | doi: 10.1038/ncomms14175 | | |
| Identification of BPIFA1/SPLUNC1 as an epithelium-derived smooth muscle relaxing factor OPEN | | | Tongde Wu, Julianne Huang, Patrick J. Moore, Michael S. Little, William G. Walton, Robert C. Fellner, Neil E. Alexis, Y. Peter Di, Matthew R. Redinbo, Stephen L. Tilley and Robert Tarran | | | Asthma is characterized by abnormal airway hyperresponsiveness. Here the authors identify BPIFA1 as a factor secreted by airway epithelial cells, and show that it regulates contractility of airway smooth muscle cells by binding to and regulating the Orai1 Ca2+ channel. | | | 06 February 2017 | doi: 10.1038/ncomms14118 | | |
| Cell fate decisions emerge as phages cooperate or compete inside their host OPEN | | | Jimmy T. Trinh, Tamás Székely, Qiuyan Shao, Gábor Balázsi and Lanying Zeng | | | The bacteriophage lambda and its host Escherichia coli provide a model system to study cell-fate decisions. Here, Trinh et al. develop a four-colour fluorescence system at the single-cell/single-virus/single-viral-DNA level and find phages cooperate during lysogenization and compete during lysis. | | | 06 February 2017 | doi: 10.1038/ncomms14341 | | |
| FAK signalling controls insulin sensitivity through regulation of adipocyte survival OPEN | | | Cynthia T. Luk, Sally Yu Shi, Erica P. Cai, Tharini Sivasubramaniyam, Mansa Krishnamurthy, Jara J. Brunt, Stephanie A. Schroer, Daniel A. Winer and Minna Woo | | | The kinase FAK is important for integrin signalling and promotes cell survival. Here, the authors demonstrate FAK regulates adipocyte survival, and is particularly important for maintaining insulin sensitivity during adipose tissue expansion in the context of a calorie-rich diet. | | | 06 February 2017 | doi: 10.1038/ncomms14360 | | |
| Killing by Type VI secretion drives genetic phase separation and correlates with increased cooperation OPEN | | | Luke McNally, Eryn Bernardy, Jacob Thomas, Arben Kalziqi, Jennifer Pentz, Sam P. Brown, Brian K. Hammer, Peter J. Yunker and William C. Ratcliff | | | The Type VI Secretory System (T6SS) is used by some bacteria to kill non-kin competitors. Here, McNally and colleagues combine mathematical modelling, experiments with Vibrio cholera and phylogenetic analysis to show that by eliminating nearby non-kin the T6SS may also favour cooperation among kin. | | | 06 February 2017 | doi: 10.1038/ncomms14371 | | |
| Proton enhanced dynamic battery chemistry for aprotic lithium–oxygen batteries OPEN | | | Yun Guang Zhu, Qi Liu, Yangchun Rong, Haomin Chen, Jing Yang, Chuankun Jia, Li-Juan Yu, Amir Karton, Yang Ren, Xiaoxiong Xu, Stefan Adams and Qing Wang | | | Water is believed to undermine the performance of aprotic lithium–air batteries. However, the authors here disclose different battery chemistry, showing that both lithium ions and protons are involved in the battery reactions in the presence of water, leading to an unprecedented dynamic product. | | | 06 February 2017 | doi: 10.1038/ncomms14308 | | |
| An unexpected N-terminal loop in PD-1 dominates binding by nivolumab OPEN | | | Shuguang Tan, Hao Zhang, Yan Chai, Hao Song, Zhou Tong, Qihui Wang, Jianxun Qi, Gary Wong, Xiaodong Zhu, William J. Liu, Shan Gao, Zhongfu Wang, Yi Shi, Fuquan Yang, George F. Gao and Jinghua Yan | | | Programmed cell death 1 (PD-1) is a key target for cancer immunotherapy. Here the authors present the crystal structure of the extracellular PD-1 domain with the clinically approved monoclonal antibody nivolumab, which shows that the N-terminal PD-1 loop is crucial for antibody binding. | | | 06 February 2017 | doi: 10.1038/ncomms14369 | | |
| Axon degeneration induces glial responses through Draper-TRAF4-JNK signalling OPEN | | | Tsai-Yi Lu, Jennifer M. MacDonald, Lukas J. Neukomm, Amy E. Sheehan, Rachel Bradshaw, Mary A. Logan and Marc R. Freeman | | | The engulfment receptor Draper is known to promote glial activation and phagocytosis of debris upon axonal injury. Lu et al. identify TNF receptor associated factor 4 (TRAF4) as a binding partner of Draper, and map out the signalling cascade leading to reactive gliosis in Drosophila. | | | 06 February 2017 | doi: 10.1038/ncomms14355 | | |
| mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases OPEN | | | Michela Palmieri, Rituraj Pal, Hemanth R. Nelvagal, Parisa Lotfi, Gary R. Stinnett, Michelle L. Seymour, Arindam Chaudhury, Lakshya Bajaj, Vitaliy V. Bondar, Laura Bremner, Usama Saleem, Dennis Y. Tse, Deepthi Sanagasetti, Samuel M. Wu, Joel R. Neilson, Fred A. Pereira, Robia G. Pautler, George G. Rodney, Jonathan D. Cooper and Marco Sardiello et al. | | | The transcription factor EB (TFEB) is a master regulator of lysosomal biogenesis. Here authors show that trehalose, an mTOR-independent autophagy inducer, alleviates the pathological phenotypes in a mouse model of neurodegenerative disease. Trehalose acts by inhibiting Akt, which normally suppresses TFEB via an mTORC1-independent mechanism. | | | 06 February 2017 | doi: 10.1038/ncomms14338 | | |
| The ancient CYP716 family is a major contributor to the diversification of eudicot triterpenoid biosynthesis OPEN | | | Karel Miettinen, Jacob Pollier, Dieter Buyst, Philipp Arendt, René Csuk, Sven Sommerwerk, Tessa Moses, Jan Mertens, Prashant D Sonawane, Laurens Pauwels, Asaph Aharoni, José Martins, David R. Nelson and Alain Goossens | | | Cytochrome P450 family enzymes have an essential role in the creation of triterpenoid diversity in plants. Here, the authors describe triterpenoid synthesis as mediated by CYP716 enzymes in medicinal plant species, and perform phylogenetic analysis to describe CYP716 molecular evolution in plants. | | | 06 February 2017 | doi: 10.1038/ncomms14153 | | |
| Ultrahigh-resolution imaging of water networks by atomic force microscopy OPEN | | | Akitoshi Shiotari and Yoshiaki Sugimoto | | | The structure of water in the first layer on surfaces is essential to our understanding of various phenomena, such as surface wettability and heterogeneous catalysis. Here, the authors use atomic force microscopy with a CO-functionalized tip to image water defects on copper surface at atomic resolution. | | | 03 February 2017 | doi: 10.1038/ncomms14313 | | |
| Prenatal thalamic waves regulate cortical area size prior to sensory processing OPEN | | | Verónica Moreno-Juan, Anton Filipchuk, Noelia Antón-Bolaños, Cecilia Mezzera, Henrik Gezelius, Belen Andrés, Luis Rodríguez-Malmierca, Rafael Susín, Olivier Schaad, Takuji Iwasato, Roland Schüle, Michael Rutlin, Sacha Nelson, Sebastien Ducret, Miguel Valdeolmillos, Filippo M. Rijli and Guillermina López-Bendito | | | How sensory maps are formed in the brain is only partially understood. Here the authors describe spontaneous calcium waves that propagate across different sensory nuclei in the embryonic thalamus; disrupting the wave pattern triggers thalamic gene expression changes and eventually alters the size of cortical areas. | | | 03 February 2017 | doi: 10.1038/ncomms14172 | | |
| The inverse-trans-influence in tetravalent lanthanide and actinide bis(carbene) complexes OPEN | | | Matthew Gregson, Erli Lu, David P. Mills, Floriana Tuna, Eric J. L. McInnes, Christoph Hennig, Andreas C. Scheinost, Jonathan McMaster, William Lewis, Alexander J. Blake, Andrew Kerridge and Stephen T. Liddle | | | The inverse-trans-influence has been shown to operate in high oxidation state actinide complexes. Here, the authors report tetravalent cerium, uranium and thorium bis(carbene) complexes with trans C=M=C cores where experimental and theoretical data also suggest the presence of an inverse-trans-effect. | | | 03 February 2017 | doi: 10.1038/ncomms14137 | | |
| Disorder enabled band structure engineering of a topological insulator surface OPEN | | | Yishuai Xu, Janet Chiu, Lin Miao, Haowei He, Zhanybek Alpichshev, A. Kapitulnik, Rudro R. Biswas and L. Andrew Wray | | | The surface electrons in a topological insulator are resistant to localization by nonmagnetic disorder, but are affected by lattice disorder. Here, the authors show that resonance states near lattice defects on the surface have significance beyond the localized regime usually associated with impurity bands. | | | 03 February 2017 | doi: 10.1038/ncomms14081 | | |
| Evolution of Shh endoderm enhancers during morphological transition from ventral lungs to dorsal gas bladder OPEN | | | Tomoko Sagai, Takanori Amano, Akiteru Maeno, Tetsuaki Kimura, Masatoshi Nakamoto, Yusuke Takehana, Kiyoshi Naruse, Norihiro Okada, Hiroshi Kiyonari and Toshihiko Shiroishi | | | Endoderm enhancer MACS1 of Sonic Hedgehog is conserved in animals with lungs. Here, the authors show that mouse without MACS1 has defective laryngeal development, and use phylogenetic analyses to show association of evolutionary lung-gas bladder transition with change of the enhancer. | | | 03 February 2017 | doi: 10.1038/ncomms14300 | | |
| Bloch surface waves confined in one dimension with a single polymeric nanofibre OPEN | | | Ruxue Wang, Hongyan Xia, Douguo Zhang, Junxue Chen, Liangfu Zhu, Yong Wang, Erchan Yang, Tianyang Zang, Xiaolei Wen, Gang Zou, Pei Wang, Hai Ming, Ramachandram Badugu and Joseph R. Lakowicz | | | Typically nanofibres need to be placed on solid substrates for the next generation of devices, but this prevents light guiding. Here Wang et al. numerically and experimentally demonstrate that when a nanofibre is placed on a dielectric multilayer, it supports a Bloch surface wave confined in one dimension. | | | 03 February 2017 | doi: 10.1038/ncomms14330 | | |
| Molecular basis for protection of ribosomal protein L4 from cellular degradation OPEN | | | Ferdinand M. Huber and André Hoelz | | | Acl4 is a dedicated assembly chaperone for ribosomal protein RpL4 that recognizes RpL4 in the cytoplasm to facilitate its nuclear import. Here the authors reveal the mechanism whereby Acl4 recognizes RpL4 and functions to protect it from Tom1-mediated degradation until RpL4 incorporation into the maturing 60S pre-ribosomal subunit. | | | 02 February 2017 | doi: 10.1038/ncomms14354 | | |
| Cooperative expression of atomic chirality in inorganic nanostructures OPEN | | | Peng-peng Wang, Shang-Jie Yu, Alexander O Govorov and Min Ouyang | | | Cooperative chirality is common in organic and biomolecular systems but is rarely explored in inorganic materials. Here, the authors combine synthesis and theory to uncover cooperative chirality in inorganic nanocrystals, arising from the interplay of independently-controlled crystallographic and morphological chirality. | | | 02 February 2017 | doi: 10.1038/ncomms14312 | | |
| Waveguide-coupled nanopillar metal-cavity light-emitting diodes on silicon OPEN | | | V. Dolores-Calzadilla, B. Romeira, F. Pagliano, S. Birindelli, A. Higuera-Rodriguez, P. J. van Veldhoven, M. K. Smit, A. Fiore and D. Heiss | | | Despite much progress, nanoscale light sources suitable for photonic integration are lacking. Here, the authors present a metal-cavity nanopillar LED on a silicon substrate working at telecommunications wavelengths, which demonstrates compatibility with membrane-on-Si photonic integration platforms. | | | 02 February 2017 | doi: 10.1038/ncomms14323 | | |
| Targeting the latent cytomegalovirus reservoir with an antiviral fusion toxin protein OPEN | | | B. A. Krishna, K. Spiess, E. L. Poole, B. Lau, S. Voigt, T. N. Kledal, M. M. Rosenkilde and J. H. Sinclair | | | Reactivation of human cytomegalovirus in immunosuppressed transplant patients can cause severe complications. Here, Krishna et al. show that a fusion toxin protein that specifically binds the viral surface protein US28 can be used to kill latently infected monocytes and their progenitor cells in vitro. | | | 02 February 2017 | doi: 10.1038/ncomms14321 | | |
| Ellipsoidal analysis of coordination polyhedra OPEN | | | James Cumby and J. Paul Attfield | | | Simple polyhedra in crystalline compounds are often deformed, so methods for analysing their distortions are useful. Here, the authors demonstrate that analysis of the minimum bounding ellipsoid of a coordination polyhedron provides a general method for studying distortion. | | | 01 February 2017 | doi: 10.1038/ncomms14235 | | |
| Neutrophils dominate the immune cell composition in non-small cell lung cancer OPEN | | | Julia Kargl, Stephanie E. Busch, Grace H. Y. Yang, Kyoung-Hee Kim, Mark L. Hanke, Heather E. Metz, Jesse J. Hubbard, Sylvia M. Lee, David K. Madtes, Martin W. McIntosh and A. McGarry Houghton | | | Tumour immune evasion can involve multiple strategies. Here, the authors characterize the immune populations from clinical specimens of lung cancer in conjunction with TCR-β sequencing and show abundant neutrophils affecting cytotoxic T-cell content and the frequent presence of tumour-specific T-cell clones. | | | 01 February 2017 | doi: 10.1038/ncomms14381 | | |
| Self-surface charge exfoliation and electrostatically coordinated 2D hetero-layered hybrids OPEN | | | Min-Quan Yang, Yi-Jun Xu, Wanheng Lu, Kaiyang Zeng, Hai Zhu, Qing-Hua Xu and Ghim Wei Ho | | | Synthesis of atomically thin 2D hetero-layered structures remains a challenge. Here, the authors report a scalable approach to fabricating 2D hetero-layered metal chalcogenides of various compositions: self-surface charge exfoliation, followed by electrostatic coupling. | | | 01 February 2017 | doi: 10.1038/ncomms14224 | | |
| HOPX hypermethylation promotes metastasis via activating SNAIL transcription in nasopharyngeal carcinoma OPEN | | | Xianyue Ren, Xiaojing Yang, Bin Cheng, Xiaozhong Chen, Tianpeng Zhang, Qingmei He, Bin Li, Yingqin Li, Xinran Tang, Xin Wen, Qian Zhong, Tiebang Kang, Musheng Zeng, Na Liu and Jun Ma | | | HOPX is a transcription factor epigenetically silenced in several cancers. Here the authors, by analysing methylation profiles, identify HOPX as a suppressor of metastasis in nasopharyngeal carcinoma: mechanistically HOPX inhibits SNAIL transcription through deacetylation-mediated silencing. | | | 01 February 2017 | doi: 10.1038/ncomms14053 | | |
| Anisotropically organized three-dimensional culture platform for reconstruction of a hippocampal neural network OPEN | | | So Hyun Kim, Sun-Kyoung Im, Soo-Jin Oh, Sohyeon Jeong, Eui-Sung Yoon, C. Justin Lee, Nakwon Choi and Eun-Mi Hur | | | Alignment or anisotropic organisation within and between cells enables biological function but is challenging to engineer. Here, the authors align collagen fibres in a pre-strained polydimethylsiloxane mould to generate a 3D scaffold that guides hippocampal neuron axon growth to form CA3–CA1 neural circuits. | | | 01 February 2017 | doi: 10.1038/ncomms14346 | | |
| Dendritic cell MST1 inhibits Th17 differentiation OPEN | | | Chunxiao Li, Yujing Bi, Yan Li, Hui Yang, Qing Yu, Jian Wang, Yu Wang, Huilin Su, Anna Jia, Ying Hu, Linian Han, Jiangyuan Zhang, Simin Li, Wufan Tao and Guangwei Liu | | | The differentiation of Th17 cells is central to infection and autoimmunity. Here, the authors show that expression of MST1 by dendritic cells limits IL-6 production and thereby controls Th17 differentiation in immunity to fungal infection and experimental autoimmune encephalomyelitis. | | | 01 February 2017 | doi: 10.1038/ncomms14275 | | |
| Photo-induced oxidant-free oxidative C–H/N–H cross-coupling between arenes and azoles OPEN | | | Linbin Niu, Hong Yi, Shengchun Wang, Tianyi Liu, Jiamei Liu and Aiwen Lei | | | Functionalization of unactivated C–H bonds is an attractive strategy to introduce functionality without the need for pre-functionalized starting materials. Here the authors combine cobalt catalysis with photoredox catalysis, allowing arene-azole cross-coupling under oxidant-free conditions. | | | 01 February 2017 | doi: 10.1038/ncomms14226 | | |
| Ethological principles predict the neuropeptides co-opted to influence parenting OPEN | | | Christopher B. Cunningham, Majors J. Badgett, Richard B. Meagher, Ron Orlando and Allen J. Moore | | | Parental care involves shifts in numerous behaviours related to mating, feeding, aggression and social interaction. Here, the authors show that, in burying beetles, parenting is associated with increased levels of neuropeptides known to mediate these precursor behaviours, suggesting co-option of existing genetic pathways. | | | 01 February 2017 | doi: 10.1038/ncomms14225 | | |
| Dysfunction of ventrolateral striatal dopamine receptor type 2-expressing medium spiny neurons impairs instrumental motivation OPEN | | | Iku Tsutsui-Kimura, Hiroyuki Takiue, Keitaro Yoshida, Ming Xu, Ryutaro Yano, Hiroyuki Ohta, Hiroshi Nishida, Youcef Bouchekioua, Hideyuki Okano, Motokazu Uchigashima, Masahiko Watanabe, Norio Takata, Michael R. Drew, Hiromi Sano, Masaru Mimura and Kenji F. Tanaka | | | D2 receptor-expressing medium spiny neurons (D2-MSNs) are thought to suppress goal-directed behaviours. Here authors ablate D2-MSNs specifically in the ventrolateral striatum, and find that surprisingly, it leads to a reduction in goal-directed motivation in mice. | | | 01 February 2017 | doi: 10.1038/ncomms14304 | | |
| Hydraulic hydrogel actuators and robots optically and sonically camouflaged in water OPEN | | | Hyunwoo Yuk, Shaoting Lin, Chu Ma, Mahdi Takaffoli, Nicolas X. Fang and Xuanhe Zhao | | | Hydrogel actuators have been widely developed to be osmotic-driven but many are in fact only capable of producing low forces. Here, the authors developed high speed and high force hydrogel actuators capable of camouflage optically and sonically with low fatigue over multiple cycles. | | | 01 February 2017 | doi: 10.1038/ncomms14230 | | |
| β-arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions OPEN | | | Lu Zhu, Joana Almaça, Prasanna K. Dadi, Hao Hong, Wataru Sakamoto, Mario Rossi, Regina J. Lee, Nicholas C. Vierra, Huiyan Lu, Yinghong Cui, Sara M. McMillin, Nicole A. Perry, Vsevolod V. Gurevich, Amy Lee, Bryan Kuo, Richard D. Leapman, Franz M. Matschinsky, Nicolai M. Doliba, Nikhil M. Urs, Marc G. Caron et al. | | | Beta-arrestins have key roles in development and metabolic functions as euglycaemic control and insulin sentitivity. Here Zhu et al. show that beta-arrestin-2 regulates insulin secretion and glucose tolerance in mice by promoting CAMKII functions in beta cells. | | | 01 February 2017 | doi: 10.1038/ncomms14295 | | |
| A defined syphilis vaccine candidate inhibits dissemination of Treponema pallidum subspecies pallidum OPEN | | | Karen V. Lithgow, Rebecca Hof, Charmaine Wetherell, Drew Phillips, Simon Houston and Caroline E. Cameron | | | There are no vaccines for the prevention of syphilis, a disease caused by the bacterium Treponema pallidum subsp. pallidum. Here, the authors use an animal model of infection to show that immunization with the Tp0751 bacterial protein inhibits the pathogen’s spread within the body. | | | 01 February 2017 | doi: 10.1038/ncomms14273 | | |
| Processable high internal phase Pickering emulsions using depletion attraction OPEN | | | KyuHan Kim, Subeen Kim, Jiheun Ryu, Jiyoon Jeon, Se Gyu Jang, Hyunjun Kim, Dae-Gab Gweon, Won Bin Im, Yosep Han, Hyunjung Kim and Siyoung Q. Choi | | | The fabrication of emulsion droplets stabilized by solid particles adsorbed on the interface is restricted to delicate interfacial conditions. Here, Kim et al. show a general approach to prepare them using the depletion interaction, modified by soluble polymers, between particles and emulsions. | | | 01 February 2017 | doi: 10.1038/ncomms14305 | | |
| Complexion-mediated martensitic phase transformation in Titanium OPEN | | | J. Zhang, C. C. Tasan, M. J. Lai, A. -C. Dippel and D. Raabe | | | One way of tuning mechanical properties of alloys lies in utilizing athermal phase transitions. Here authors report a complexion-mediated martensitic transformation in Ti alloys yielding a nanolaminate structure of martensite bounded by planar complexions, promising new strategies for the design of high strength Ti alloys. | | | 01 February 2017 | doi: 10.1038/ncomms14210 | | |
| Regulation of FT splicing by an endogenous cue in temperate grasses OPEN | | | Zhengrui Qin, Jiajie Wu, Shuaifeng Geng, Nan Feng, Fengjuan Chen, Xingchen Kong, Gaoyuan Song, Kai Chen, Aili Li, Long Mao and Liang Wu | | | The correct timing of transition from the vegetative to reproductive stage is critical during the plant life cycle. Here the authors show that age dependent alternative splicing of FLOWERING LOCUS T mRNA regulates phase transitions in Brachypodium distachyon. | | | 01 February 2017 | doi: 10.1038/ncomms14320 | | |
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| | | | | Corrigendum: Daxx inhibits hypoxia-induced lung cancer cell metastasis by suppressing the HIF-1α/HDAC1/Slug axis OPEN | | | Ching-Wen Lin, Lu-Kai Wang, Shu-Ping Wang, Yih-Leong Chang, Yi-Ying Wu, Hsuan-Yu Chen, Tzu-Hung Hsiao, Wei-Yun Lai, Hsuan-Hsuan Lu, Ya-Hsuan Chang, Shuenn-Chen Yang, Ming-Wei Lin, Chi-Yuan Chen, Tse-Ming Hong and Pan-Chyr Yang | | | 07 February 2017 | doi: 10.1038/ncomms14502 | | | | | | | | | | | | | | Latest Retraction | | | | | | Retraction: Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus OPEN | | | Quanjiang Ji, Peter J. Chen, Guangrong Qin, Xin Deng, Ziyang Hao, Zdzislaw Wawrzak, Won-sik Yeo, Jenny Winjing Quang, Hoonsik Cho, Guan-Zheng Luo, Xiaocheng Weng, Qiancheng You, Chi-Hao Luan, Xiaojing Yang, Taeok Bae, Kunqian Yu, Hualiang Jiang and Chuan He | | | 06 February 2017 | doi: 10.1038/ncomms14331 | | | Biological Sciences Biochemistry Microbiology | | | | | | | | | | | | Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here.
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