Nature Biotechnology Contents: Volume 35 pp 97 - 180

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TABLE OF CONTENTS February 2017 Volume 35, Issue 2 Editorial News Correction Bioentrepreneur Opinion and Comment Features News and Views Research Careers and Recruitment Advertisement Unexplored opportunities in the druggable human genome This poster presents a categorization of human proteins based on the amount of data on them, highlighting a knowledge deficit and indicating novel drug discovery opportunities.  Download the Poster free online Produced with support from: Illuminating the Druggable Genome Knowledge Management Center  (IDG KMC) Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement Nature Outlook: Regenerative Medicine  Sometimes, a drug can remedy a chemical imbalance or surgery can repair a structural failure, but there are times when there is no substitute for replacing a part with human tissue or an entire organ. Rapid advances in regenerative medicine are bringing that possibility closer to reality.  Access the Outlook Produced with support from  Translational Research Informatics Center(TRI)  Clio, Inc.  Sapporo Medical University CYBERDYNE,INC.      Advertisement BIOPHARMA DEALMAKERS Company Profiles and Partnering Opportunities   Advertisement CRISPR Calendar 2017 To celebrate the continuing rise to fame of the CRISPR system, the Nature Reviews Genetics 2017 CRISPR calendar highlights the underlying biology of CRISPR, as well as its diverse range of exciting potential applications in genetic research, biotechnology and therapeutics. Download the calendar free online Produced with support from  OriGene   Editorial Top The problem with neoantigen prediction   p97 doi:10.1038/nbt.3800 Personalized immunotherapy is all the rage, but neoantigen discovery and validation remains a daunting problem. News Top Spinal muscular atrophy approval boosts antisense drugs   pp99 - 100 Elie Dolgin doi:10.1038/nbt0217-99 Roche breaks with PacBio, opts for Genia   p100 doi:10.1038/nbt0217-100 Grail to pour $1 billion into blood test to detect early cancer   pp101 - 102 Cormac Sheridan doi:10.1038/nbt0217-101 Shire divests mRNA platform to RaNa   p103 doi:10.1038/nbt0217-103b Jun Wang's iCarbonX heads consortium using AI in health and wellness   pp103 - 105 David Cyranoski doi:10.1038/nbt0217-103a AACR makes public 19,000 cancer genomes   p104 doi:10.1038/nbt0217-104 Correction Top Correction   p105 doi:10.1038/nbt0217-105a News Top GE to boost yields with Synpromics' synthetic promoters   p105 doi:10.1038/nbt0217-105b Novartis snaps up Selexys for sickle cell   p106 Chris Morrison doi:10.1038/nbt0217-106 Data Page Drug pipeline: 4Q16   p107 Laura DeFrancesco doi:10.1038/nbt.3797 News Feature Fresh from the biotech pipeline—2016   pp108 - 112 Chris Morrison doi:10.1038/nbt.3783 Despite last year's sharp decline in approvals, registrations of two RNA drugs offer a window into the current state and possible future of drug development. Looking forward, the sector seeks greater clarity on the new presidential administration's priorities and the impact of new healthcare legislation. Chris Morrison reports. Advertisement Confident Protein/Peptide Sequencing  Shimadzu's protein sequencers offer increased sensitivity to enable the study of longer protein sequences, more stable retention times, and reduced liquid waste/running costs. New software enables compliance with FDA 21 CFR Part 11 guidelines, while easy-to-use data analysis functions simplify operation, data processing and reporting. Learn more. Bioentrepreneur Top Building a business So you want to be a student entrepreneur?   pp113 - 116 Charles H Jones and Andrew Hill doi:10.1038/nbt.3778 Opinion and Comment Top Correspondence Industrializing rare disease therapy discovery and development   pp117 - 118 Sean Ekins doi:10.1038/nbt.3787 Features Top Patents Situating brain regions among patent rights and moral risks   pp119 - 121 Dylan Roskams-Edris, Stacey Anderson-Redick, Zelma H Kiss and Judy Illes doi:10.1038/nbt.3782 What is the ethical value of awarding patent rights that implicate regions of the brain? Recent patents in single-cell analysis and microfluidics   p122 doi:10.1038/nbt.3792 Advertisement nature.com webcasts Pixels to data: Quantitative cell biology using high-content imaging and analysis. Date: Tuesday 28 February 2017 Time: 8AM PST, 11AM EST, 4PM GMT, 5PM CET  Register Sponsor: PerkinElmer News and Views Top Core promoters across the genome   pp123 - 124 Nevena Cvetesic and Boris Lenhard doi:10.1038/nbt.3788 Promoter strength is measured genome-wide with two high-throughput reporter assays. See also: Research by Arnold et al. | Research by van Arensbergen et al. Exploring protein sequence-function landscapes   pp125 - 126 Tyler N Starr and Joseph W Thornton doi:10.1038/nbt.3786 The effects of sequence variation on function are elucidated by a study of protein evolution. See also: Research by Hopf et al. Research Highlights   p127 doi:10.1038/nbt.3785 Stretching sensors by confinement   p127 Irene Jarchum doi:10.1038/nbt.3789 Biotechnology JOBS of the week Research and Teaching Fellow / Postdoc Position TU Dresden Postdoctoral Fellow Washington University School of Medicine Exciting PhD Positions in Modern Biology VBC PhD Programme Postdoctoral Fellow Icahn School of Medicine at Mount Sinai PhD Student Systems Biology German Cancer Research Center (DKFZ). More Science jobs from Biotechnology EVENT Plant Genomes Biotechnology November 29, 2017 Cold Spring Harbor, USA More science events from Research Top Analysis Mutation effects predicted from sequence co-variation   pp128 - 135 Thomas A Hopf, John B Ingraham, Frank J Poelwijk, Charlotta P I Scharfe, Michael Springer et al. doi:10.1038/nbt.3769 The global effects of epistasis on protein and RNA function are revealed by an unsupervised model of amino acid co-conservation in evolutionary sequence variation. See also: News and Views by Starr & Thornton Articles Genome-wide assessment of sequence-intrinsic enhancer responsiveness at single-base-pair resolution   pp136 - 144 Cosmas D Arnold, Muhammad A Zabidi, Michaela Pagani, Martina Rath, Katharina Schernhuber et al. doi:10.1038/nbt.3739 STAP-seq quantifies the ability of genomic DNA sequences to convert enhancer activities into transcription initiation events. See also: News and Views by Cvetesic & Lenhard Genome-wide mapping of autonomous promoter activity in human cells   pp145 - 153 Joris van Arensbergen, Vincent D FitzPatrick, Marcel de Haas, Ludo Pagie, Jasper Sluimer et al. doi:10.1038/nbt.3754 The intrinsic strength of promoter sequences in driving transcription is measured across the human genome. See also: News and Views by Cvetesic & Lenhard Combined small-molecule inhibition accelerates the derivation of functional cortical neurons from human pluripotent stem cells   pp154 - 163 Yuchen Qi, Xin-Jun Zhang, Nicolas Renier, Zhuhao Wu, Talia Atkin et al. doi:10.1038/nbt.3777 Cortical neurons are rapidly derived from human pluripotent stem cells using a cocktail of small molecules. Influence of node abundance on signaling network state and dynamics analyzed by mass cytometry   pp164 - 172 Xiao-Kang Lun, Vito R T Zanotelli, James D Wade, Denis Schapiro, Marco Tognetti et al. doi:10.1038/nbt.3770 Mass-cytometry analysis reveals how signaling networks respond to changes in the abundance of their nodes. Letter Lipid production in Yarrowia lipolytica is maximized by engineering cytosolic redox metabolism   pp173 - 177 Kangjian Qiao, Thomas M Wasylenko, Kang Zhou, Peng Xu and Gregory Stephanopoulos doi:10.1038/nbt.3763 Cytosolic redox metabolism is rewired to improve lipid yield and productivity in the industrial yeast Yarrowia lipolytica Errata Erratum: Innovative academic startups 2016   p178 Brady Huggett doi:10.1038/nbt0217-178a Erratum: Multiplex gene editing by CRISPR-Cpf1 using a single crRNA array   p178 Bernd Zetsche, Matthias Heidenreich, Prarthana Mohanraju, Iana Fedorova, Jeroen Kneppers et al. doi:10.1038/nbt0217-178b Erratum: The cancer bloodhounds   p178 Sarah Webb doi:10.1038/nbt0217-178c Careers and Recruitment Top Fourth-quarter biotech job picture   p179 Michael Francisco doi:10.1038/nbt.3794 People People   p180 doi:10.1038/nbt.3793 Top Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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