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TABLE OF CONTENTS
| | | | Volume 8, February 2017 | | In this issue Corrigendum News and Commentaries Original Articles | | | | | Advertisement | | Online-only and open access, Cell Death Discovery publishes scientifically sound research at the intersection of cell death and medicine. Increasing the reproducibility of research, the journal fosters a dynamic dialogue with a focus on cancer, neurobiology and inflammation research.
Submit your manuscript >> | | | | | | Corrigendum | Top | | Constitutive p53 heightens mitochondrial apoptotic priming and favors cell death induction by BH3 mimetic inhibitors of BCL-xLJ Le Pen, L Maillet, K Sarosiek, C Vuillier, F Gautier, S Montessuit, J C Martinou, A Letaï, F Braun and P P Juin Cell Death Dis 2017 8: e2596; 10.1038/cddis.2016.127 Full Text | | News and Commentaries | Top | | Arginylation: a new regulator of mRNA stability and heat stress responseKamalakshi Deka and Sougata Saha Cell Death Dis 2017 8: e2604; 10.1038/cddis.2016.353 Full Text | | | | A novel proinflammatory role for granzyme AJacqueline A van Eck, Liling Shan, Jan Meeldijk, C Erik Hack and Niels Bovenschen Cell Death Dis 2017 8: e2630; 10.1038/cddis.2017.56 Full Text | | Original Articles | Top | | Augmented trophoblast cell death in preeclampsia can proceed via ceramide-mediated necroptosisLiane Jennifer Bailey, Sruthi Alahari, Andrea Tagliaferro, Martin Post and Isabella Caniggia Cell Death Dis 2017 8: e2590; 10.1038/cddis.2016.483 Abstract | Full Text | | | | Knockdown of long non-coding RNA HOTAIR increases miR-454-3p by targeting Stat3 and Atg12 to inhibit chondrosarcoma growthXing Bao, Tingting Ren, Yi Huang, Kunkun Sun, Shidong Wang, Kuisheng Liu, Bingxin Zheng and Wei Guo Cell Death Dis 2017 8: e2605; 10.1038/cddis.2017.31 Abstract | Full Text | | | | Critical role of reactive oxygen species (ROS) for synergistic enhancement of apoptosis by vemurafenib and the potassium channel inhibitor TRAM-34 in melanoma cellsDaniel Bauer, Felix Werth, Ha An Nguyen, Felix Kiecker and Jürgen Eberle Cell Death Dis 2017 8: e2594; 10.1038/cddis.2017.6 Abstract | Full Text | | | | Epigenetic regulation of HGF/Met receptor axis is critical for the outgrowth of bone metastasis from breast carcinomaPaola Bendinelli, Paola Maroni, Emanuela Matteucci and Maria Alfonsina Desiderio Cell Death Dis 2017 8: e2578; 10.1038/cddis.2016.403 Abstract | Full Text | | | | NGS-based transcriptome profiling reveals biomarkers for companion diagnostics of the TGF-β receptor blocker galunisertib in HCCYuan Cao, Rahul Agarwal, Francesco Dituri, Luigi Lupo, Paolo Trerotoli, Serena Mancarella, Peter Winter and Gianluigi Giannelli Cell Death Dis 2017 8: e2634; 10.1038/cddis.2017.44 Abstract | Full Text | | | | Inactivation of Lsd1 triggers senescence in trophoblast stem cells by induction of Sirt4Josefina Castex, Dominica Willmann, Toufike Kanouni, Laura Arrigoni, Yan Li, Marcel Friedrich, Michael Schleicher, Simon Wöhrle, Mark Pearson, Norbert Kraut, Michaël Méret, Thomas Manke, Eric Metzger, Roland Schüle and Thomas Günther Cell Death Dis 2017 8: e2631; 10.1038/cddis.2017.48 Abstract | Full Text | | | | Increase in the radioresistance of normal skin fibroblasts but not tumor cells by mechanical injuryZelin Chen, Xin Wang, Taotao Jin, Yu Wang, Christopher S Hong, Li Tan, Tingyu Dai, Liao Wu, Zhengping Zhuang and Chunmeng Shi Cell Death Dis 2017 8: e2573; 10.1038/cddis.2016.416 Abstract | Full Text | | | | Dicer promotes tumorigenesis by translocating to nucleus to promote SFRP1 promoter methylation in cholangiocarcinoma cellsWenlong Cheng, Yongqiang Qi, Li Tian, Bing Wang, Wenhua Huang and Yongjun Chen Cell Death Dis 2017 8: e2628; 10.1038/cddis.2017.57 Abstract | Full Text | | | | In situ generated D‐peptidic nanofibrils as multifaceted apoptotic inducers to target cancer cellsXuewen Du, Jie Zhou, Huainin Wang, Junfeng Shi, Yi Kuang, Wu Zeng, Zhimou Yang and Bing Xu Cell Death Dis 2017 8: e2614; 10.1038/cddis.2016.466 Abstract | Full Text | | | | Prenatal alcohol exposure impairs autophagy in neonatal brain cortical microvesselsVirginie Girault, Vianney Gilard, Florent Marguet, Céline Lesueur, Michelle Hauchecorne, Yasmina Ramdani, Annie Laquerrière, Stéphane Marret, Sylvie Jégou, Bruno Jose Gonzalez, Carole Brasse-Lagnel and Soumeya Bekri Cell Death Dis 2017 8: e2610; 10.1038/cddis.2017.29 Abstract | Full Text | | | | RASAL2, a RAS GTPase-activating protein, inhibits stemness and epithelial–mesenchymal transition via MAPK/SOX2 pathway in bladder cancerKe Hui, Yang Gao, Jun Huang, Shan Xu, Bin Wang, Jin Zeng, Jinhai Fan, Xinyang Wang, Yangyang Yue, Shiqi Wu, Jer-Tsong Hsieh, Dalin He and Kaijie Wu Cell Death Dis 2017 8: e2600; 10.1038/cddis.2017.9 Abstract | Full Text | | | | RIPK1/RIPK3 promotes vascular permeability to allow tumor cell extravasation independent of its necroptotic functionKay Hänggi, Lazaros Vasilikos, Aida Freire Valls, Rosario Yerbes, Janin Knop, Lisanne M Spilgies, Kristy Rieck, Tvisha Misra, John Bertin, Peter J Gough, Thomas Schmidt, Carmen Ruiz de Almodòvar and W Wei-Lynn Wong Cell Death Dis 2017 8: e2588; 10.1038/cddis.2017.20 Abstract | Full Text | | | | Coordinate activities of BRD4 and CDK9 in the transcriptional elongation complex are required for TGFβ-induced Nox4 expression and myofibroblast transdifferentiationTalha Ijaz, Mohammad Jamaluddin, Yingxin Zhao, Yueqing Zhang, Jayson Jay, Celeste C Finnerty, David N Herndon, Ronald G Tilton and Allan R Brasier Cell Death Dis 2017 8: e2606; 10.1038/cddis.2016.434 Abstract | Full Text | | | | Opposite effects of HDAC5 and p300 on MRTF-A-related neuronal apoptosis during ischemia/reperfusion injury in ratsNa Li, Qiong Yuan, Xiao-Lu Cao, Ying Zhang, Zhen-Li Min, Shi-Qiang Xu, Zhi-Jun Yu, Jing Cheng, Chunxiang Zhang and Xia-Min Hu Cell Death Dis 2017 8: e2624; 10.1038/cddis.2017.16 Abstract | Full Text | | | | Proteasome-associated deubiquitinase ubiquitin-specific protease 14 regulates prostate cancer proliferation by deubiquitinating and stabilizing androgen receptorYuning Liao, Ningning Liu, Xianliang Hua, Jianyu Cai, Xiaohong Xia, Xuejun Wang, Hongbiao Huang and Jinbao Liu Cell Death Dis 2017 8: e2585; 10.1038/cddis.2016.477 Abstract | Full Text | | | | NLRP3 inflammasome activation mediates radiation-induced pyroptosis in bone marrow-derived macrophagesYan-gang Liu, Ji-kuai Chen, Zi-teng Zhang, Xiu-juan Ma, Yong-chun Chen, Xiu-ming Du, Hong Liu, Ying Zong and Guo-cai Lu Cell Death Dis 2017 8: e2579; 10.1038/cddis.2016.460 Abstract | Full Text | | | | CALCB splice region pathogenic variants leading to plasma cell neurotropic enrichment in type 1 autoimmune pancreatitisQi-cai Liu, Falin Chen, Chao-yang Wu, Feng Gao, Ze-hao Zhuang, Jin-tong Chen, Bin Cai, Tianming Zhang, Ling Guo, Li-qing Lin, Cheng-fei Zhao and Xin-hua Lin Cell Death Dis 2017 8: e2591; 10.1038/cddis.2017.32 Abstract | Full Text | | | | BNIP3 upregulation via stimulation of ERK and JNK activity is required for the protection of keratinocytes from UVB-induced apoptosisMariko Moriyama, Hiroyuki Moriyama, Junki Uda, Hirokazu Kubo, Yuka Nakajima, Arisa Goto, Takashi Morita and Takao Hayakawa Cell Death Dis 2017 8: e2576; 10.1038/cddis.2017.4 Abstract | Full Text | | | | Colon cancer cell treatment with rose bengal generates a protective immune response via immunogenic cell deathJianzhong Qin, Nicholas Kunda, Guilin Qiao, Jed F Calata, Krunal Pardiwala, Bellur S Prabhakar and Ajay V Maker Cell Death Dis 2017 8: e2584; 10.1038/cddis.2016.473 Abstract | Full Text | | | | MCM7 promotes cancer progression through cyclin D1-dependent signaling and serves as a prognostic marker for patients with hepatocellular carcinomaKai Qu, Zhixin Wang, Haining Fan, Juan Li, Jie Liu, Pingping Li, Zheyong Liang, Hongli An, Yina Jiang, Qiushi Lin, Xiaoqun Dong, Peijun Liu and Chang Liu Cell Death Dis 2017 8: e2603; 10.1038/cddis.2016.352 Abstract | Full Text | | | | RIPK3 interactions with MLKL and CaMKII mediate oligodendrocytes death in the developing brainYi Qu, Jun Tang, Huiqing Wang, Shiping Li, Fengyan Zhao, Li Zhang, Q Richard Lu and Dezhi Mu Cell Death Dis 2017 8: e2629; 10.1038/cddis.2017.54 Abstract | Full Text | | | | TAK1 regulates resident macrophages by protecting lysosomal integrityYosuke Sakamachi, Sho Morioka, September R Mihaly, Giichi Takaesu, Julie F Foley, Michael B Fessler and Jun Ninomiya-Tsuji Cell Death Dis 2017 8: e2598; 10.1038/cddis.2017.23 Abstract | Full Text | | | | ErbB4 signaling stimulates pro-inflammatory macrophage apoptosis and limits colonic inflammationMichael A Schumacher, Matija Hedl, Clara Abraham, Jessica K Bernard, Patricia R Lozano, Jonathan J Hsieh, Dana Almohazey, Edie B Bucar, Shivesh Punit, Peter J Dempsey and Mark R Frey Cell Death Dis 2017 8: e2622; 10.1038/cddis.2017.42 Abstract | Full Text | | | | CARMA2sh and ULK2 control pathogen-associated molecular patterns recognition in human keratinocytes: psoriasis-linked CARMA2sh mutants escape ULK2 censorshipIvan Scudiero, Pellegrino Mazzone, Luca E D'Andrea, Angela Ferravante, Tiziana Zotti, Gianluca Telesio, Gabriele De Rubis, Carla Reale, Maddalena Pizzulo, Shanmugakonar Muralitharan, Pasquale Vito and Romania Stilo Cell Death Dis 2017 8: e2627; 10.1038/cddis.2017.51 Abstract | Full Text | | | | Thioridazine enhances sensitivity to carboplatin in human head and neck cancer cells through downregulation of c-FLIP and Mcl-1 expressionSeung Un Seo, Hyuk Ki Cho, Kyoung-jin Min, Seon Min Woo, Shin Kim, Jong-Wook Park, Sang Hyun Kim, Yung Hyun Choi, Young Sam Keum, Jin Won Hyun, Hyun Ho Park, Sang-Han Lee, Dong Eun Kim and Taeg Kyu Kwon Cell Death Dis 2017 8: e2599; 10.1038/cddis.2017.8 Abstract | Full Text | | | | Hetero-oligomerization between the TNF receptor superfamily members CD40, Fas and TRAILR2 modulate CD40 signallingCristian R Smulski, Marion Decossas, Neila Chekkat, Julien Beyrath, Laure Willen, Gilles Guichard, Raquel Lorenzetti, Marta Rizzi, Hermann Eibel, Pascal Schneider and Sylvie Fournel Cell Death Dis 2017 8: e2601; 10.1038/cddis.2017.22 Abstract | Full Text | | | | Luteolin selectively kills STAT3 highly activated gastric cancer cells through enhancing the binding of STAT3 to SHP-1Shiyu Song, Zhonglan Su, Hui Xu, Mengyuan Niu, Xiufang Chen, Haiyan Min, Bin Zhang, Guibo Sun, Sijing Xie, Hongwei Wang and Qian Gao Cell Death Dis 2017 8: e2612; 10.1038/cddis.2017.38 Abstract | Full Text | | | | Notch activation enhances mesenchymal stem cell sheet osteogenic potential by inhibition of cellular senescenceYe Tian, Ying Xu, Taiyang Xue, Longgang Chen, Bin Shi, Bing Shu, Chao Xie, Massimo Max Morandi, Todd Jaeblon, John V Marymont and Yufeng Dong Cell Death Dis 2017 8: e2595; 10.1038/cddis.2017.2 Abstract | Full Text | | | | Simvastatin-induced cell cycle arrest through inhibition of STAT3/SKP2 axis and activation of AMPK to promote p27 and p21 accumulation in hepatocellular carcinoma cellsSin-Ting Wang, Hsiu J Ho, Jaw-Town Lin, Jeng-Jer Shieh and Chun-Ying Wu Cell Death Dis 2017 8: e2626; 10.1038/cddis.2016.472 Abstract | Full Text | | | | Loss of BRG1 induces CRC cell senescence by regulating p53/p21 pathwayGuihua Wang, Yinjia Fu, Fuqing Hu, Jinqing Lan, Feng Xu, Xi Yang, Xuelai Luo, Jing Wang and Junbo Hu Cell Death Dis 2017 8: e2607; 10.1038/cddis.2017.1 Abstract | Full Text | | | | Starvation at birth impairs germ cell cyst breakdown and increases autophagy and apoptosis in mouse oocytesYong-Yong Wang, Yuan-Chao Sun, Xiao-Feng Sun, Shun-Feng Cheng, Bo Li, Xi-Feng Zhang, Massimo De Felici and Wei Shen Cell Death Dis 2017 8: e2613; 10.1038/cddis.2017.3 Abstract | Full Text | | | | Adipocytes activate mitochondrial fatty acid oxidation and autophagy to promote tumor growth in colon cancerYang-An Wen, Xiaopeng Xing, Jennifer W Harris, Yekaterina Y Zaytseva, Mihail I Mitov, Dana L Napier, Heidi L Weiss, B Mark Evers and Tianyan Gao Cell Death Dis 2017 8: e2593; 10.1038/cddis.2017.21 Abstract | Full Text | | | | Protein phosphatase 4 coordinates glial membrane recruitment and phagocytic clearance of degenerating axons in DrosophilaLilly M Winfree, Sean D Speese and Mary A Logan Cell Death Dis 2017 8: e2623; 10.1038/cddis.2017.40 Abstract | Full Text | | | | Photo-activation of the delocalized lipophilic cation D112 potentiates cancer selective ROS production and apoptosisNing Yang, Michael Weinfeld, Hélène Lemieux, Ben Montpetit and Ing Swie Goping Cell Death Dis 2017 8: e2587; 10.1038/cddis.2017.19 Abstract | Full Text | | | | Duodenal GLP-1 signaling regulates hepatic glucose production through a PKC-δ-dependent neurocircuitryMengliu Yang, Jinzhi Wang, Shaobo Wu, Lei Yuan, Xiaodong Zhao, Chaohong Liu, Jing Xie, Yanjun Jia, Yerui Lai, Allan Zijian Zhao, Guenther Boden, Ling Li and Gangyi Yang Cell Death Dis 2017 8: e2609; 10.1038/cddis.2017.28 Abstract | Full Text | | | | Ginsenoside Rg5 increases cardiomyocyte resistance to ischemic injury through regulation of mitochondrial hexokinase-II and dynamin-related protein 1Yi-Lin Yang, Jia Li, Kang Liu, Lei Zhang, Qun Liu, Baolin Liu and Lian-Wen Qi Cell Death Dis 2017 8: e2625; 10.1038/cddis.2017.43 Abstract | Full Text | | | | Oridonin induces autophagy via inhibition of glucose metabolism in p53-mutated colorectal cancer cellsZhuo Yao, Fuhua Xie, Min Li, Zirui Liang, Wenli Xu, Jianhua Yang, Chang Liu, Hongwangwang Li, Hui Zhou and Liang-Hu Qu Cell Death Dis 2017 8: e2633; 10.1038/cddis.2017.35 Abstract | Full Text | | | | Overexpression of SLC34A2 is an independent prognostic indicator in bladder cancer and its depletion suppresses tumor growth via decreasing c-Myc expression and transcriptional activityWen Ye, Cui Chen, Ying Gao, Zou-Shan Zheng, Yi Xu, Miao Yun, Hui-Wen Weng, Dan Xie, Sheng Ye and Jia-Xing Zhang Cell Death Dis 2017 8: e2581; 10.1038/cddis.2017.13 Abstract | Full Text | | | | LincRNA-Gm4419 knockdown ameliorates NF-κB/NLRP3 inflammasome-mediated inflammation in diabetic nephropathyHong Yi, Rui Peng, Lu-yu Zhang, Yan Sun, Hui-min Peng, Han-deng Liu, Li-juan Yu, Ai-ling Li, Ya-juan Zhang, Wen-hao Jiang and Zheng Zhang Cell Death Dis 2017 8: e2583; 10.1038/cddis.2016.451 Abstract | Full Text | | | | Mesenchymal stromal cells inhibit CD25 expression via the mTOR pathway to potentiate T-cell suppressionHyun Seung Yoo, Kyuheon Lee, Kwangmin Na, Yong Xu Zhang, Hyun-Ja Lim, TacGhee Yi, Sun U Song and Myung-Shin Jeon Cell Death Dis 2017 8: e2632; 10.1038/cddis.2017.45 Abstract | Full Text | | | | Star-PAP, a poly(A) polymerase, functions as a tumor suppressor in an orthotopic human breast cancer modelC Yu, Y Gong, H Zhou, M Wang, L Kong, J Liu, T An, H Zhu and Y Li Cell Death Dis 2017 8: e2582; 10.1038/cddis.2016.199 Abstract | Full Text | | | | Tenovin-6 impairs autophagy by inhibiting autophagic fluxHongfeng Yuan, Brandon Tan and Shou-Jiang Gao Cell Death Dis 2017 8: e2608; 10.1038/cddis.2017.25 Abstract | Full Text | | | | Oncogenic role of rab escort protein 1 through EGFR and STAT3 pathwayUn-Jung Yun, Jee Young Sung, Seog-Yun Park, Sang-Kyu Ye, Jaegal Shim, Jae-Seon Lee, Masahiko Hibi, Young-Ki Bae and Yong-Nyun Kim Cell Death Dis 2017 8: e2621; 10.1038/cddis.2017.50 Abstract | Full Text | | | | Regulation of glutamate transporter trafficking by Nedd4-2 in a Parkinson’s disease modelYunlong Zhang, Xiaoliang He, Xingjun Meng, Xiaojuan Wu, Huichun Tong, Xiuping Zhang and Shaogang Qu Cell Death Dis 2017 8: e2574; 10.1038/cddis.2016.454 Abstract | Full Text | | | | Rapamycin upregulates glutamate transporter and IL-6 expression in astrocytes in a mouse model of Parkinson’s diseaseYunlong Zhang, Xiaoliang He, Xiaojuan Wu, Ming Lei, Zhiyun Wei, Xiuping Zhang, Lei Wen, Pingyi Xu, Shaomin Li and Shaogang Qu Cell Death Dis 2017 8: e2611; 10.1038/cddis.2016.491 Abstract | Full Text | | | | ID2 promotes survival of glioblastoma cells during metabolic stress by regulating mitochondrial functionZhonghua Zhang, Gilbert J Rahme, Pranam D Chatterjee, Matthew C Havrda and Mark A Israel Cell Death Dis 2017 8: e2615; 10.1038/cddis.2017.14 Abstract | Full Text | | | | Knockout of Eva1a leads to rapid development of heart failure by impairing autophagyShu Zhang, Xin Lin, Ge Li, Xue Shen, Di Niu, Guang Lu, Xin Fu, Yingyu Chen, Ming Cui and Yun Bai Cell Death Dis 2017 8: e2586; 10.1038/cddis.2017.17 Abstract | Full Text | | | | Berbamine postconditioning protects the heart from ischemia/reperfusion injury through modulation of autophagyYanjun Zheng, Shanshan Gu, Xuxia Li, Jiliang Tan, Shenyan Liu, Yukun Jiang, Caimei Zhang, Ling Gao and Huang-Tian Yang Cell Death Dis 2017 8: e2577; 10.1038/cddis.2017.7 Abstract | Full Text | | | | MicroRNA-144 is regulated by CP2 and decreases COX-2 expression and PGE2 production in mouse ovarian granulosa cellsJiawei Zhou, Bin Lei, Huanan Li, Lihua Zhu, Lei Wang, Hu Tao, Shuqi Mei and Fenge Li Cell Death Dis 2017 8: e2597; 10.1038/cddis.2017.24 Abstract | Full Text | | | | Inhibition of autophagy blocks cathepsins–tBid–mitochondrial apoptotic signaling pathway via stabilization of lysosomal membrane in ischemic astrocytesXian-Yong Zhou, Yu Luo, Yong-Ming Zhu, Zhi-He Liu, Thomas A Kent, Jia-Guo Rong, Wei Li, Shi-Gang Qiao, Min Li, Yong Ni, Kazumi Ishidoh and Hui-Ling Zhang Cell Death Dis 2017 8: e2618; 10.1038/cddis.2017.34 Abstract | Full Text | | | | Tissue transglutaminase (TG2) enables survival of human malignant pleural mesothelioma cells in hypoxiaSara Zonca, Giulia Pinton, Zhuo Wang, Maria Felicia Soluri, Daniela Tavian, Martin Griffin, Daniele Sblattero and Laura Moro Cell Death Dis 2017 8: e2592; 10.1038/cddis.2017.30 Abstract | Full Text | | | | | | | | | | | | | | | Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. 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