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Cell Death and Disease - Table of Contents alert Volume 8, February 2017

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Cell Death and Disease

Cell Death & Disease is an online-only, open access journal seeking to promote diverse and integrated areas of experimental and internal medicine with its specialities, including cancer, cancer metabolism, immunity and neuroscience.

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Volume 8, February 2017

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Original Articles
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Online-only and open access, Cell Death Discovery publishes scientifically sound research at the intersection of cell death and medicine. Increasing the reproducibility of research, the journal fosters a dynamic dialogue with a focus on cancer, neurobiology and inflammation research.

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Constitutive p53 heightens mitochondrial apoptotic priming and favors cell death induction by BH3 mimetic inhibitors of BCL-xL

J Le Pen, L Maillet, K Sarosiek, C Vuillier, F Gautier, S Montessuit, J C Martinou, A Letaï, F Braun and P P Juin

Cell Death Dis 2017 8: e2596; 10.1038/cddis.2016.127

Full Text

News and Commentaries


Arginylation: a new regulator of mRNA stability and heat stress response

Kamalakshi Deka and Sougata Saha

Cell Death Dis 2017 8: e2604; 10.1038/cddis.2016.353

Full Text

A novel proinflammatory role for granzyme A

Jacqueline A van Eck, Liling Shan, Jan Meeldijk, C Erik Hack and Niels Bovenschen

Cell Death Dis 2017 8: e2630; 10.1038/cddis.2017.56

Full Text

Original Articles


Augmented trophoblast cell death in preeclampsia can proceed via ceramide-mediated necroptosis

Liane Jennifer Bailey, Sruthi Alahari, Andrea Tagliaferro, Martin Post and Isabella Caniggia

Cell Death Dis 2017 8: e2590; 10.1038/cddis.2016.483

Abstract | Full Text

Knockdown of long non-coding RNA HOTAIR increases miR-454-3p by targeting Stat3 and Atg12 to inhibit chondrosarcoma growth

Xing Bao, Tingting Ren, Yi Huang, Kunkun Sun, Shidong Wang, Kuisheng Liu, Bingxin Zheng and Wei Guo

Cell Death Dis 2017 8: e2605; 10.1038/cddis.2017.31

Abstract | Full Text

Critical role of reactive oxygen species (ROS) for synergistic enhancement of apoptosis by vemurafenib and the potassium channel inhibitor TRAM-34 in melanoma cells

Daniel Bauer, Felix Werth, Ha An Nguyen, Felix Kiecker and Jürgen Eberle

Cell Death Dis 2017 8: e2594; 10.1038/cddis.2017.6

Abstract | Full Text

Epigenetic regulation of HGF/Met receptor axis is critical for the outgrowth of bone metastasis from breast carcinoma

Paola Bendinelli, Paola Maroni, Emanuela Matteucci and Maria Alfonsina Desiderio

Cell Death Dis 2017 8: e2578; 10.1038/cddis.2016.403

Abstract | Full Text

NGS-based transcriptome profiling reveals biomarkers for companion diagnostics of the TGF-β receptor blocker galunisertib in HCC

Yuan Cao, Rahul Agarwal, Francesco Dituri, Luigi Lupo, Paolo Trerotoli, Serena Mancarella, Peter Winter and Gianluigi Giannelli

Cell Death Dis 2017 8: e2634; 10.1038/cddis.2017.44

Abstract | Full Text

Inactivation of Lsd1 triggers senescence in trophoblast stem cells by induction of Sirt4

Josefina Castex, Dominica Willmann, Toufike Kanouni, Laura Arrigoni, Yan Li, Marcel Friedrich, Michael Schleicher, Simon Wöhrle, Mark Pearson, Norbert Kraut, Michaël Méret, Thomas Manke, Eric Metzger, Roland Schüle and Thomas Günther

Cell Death Dis 2017 8: e2631; 10.1038/cddis.2017.48

Abstract | Full Text

Increase in the radioresistance of normal skin fibroblasts but not tumor cells by mechanical injury

Zelin Chen, Xin Wang, Taotao Jin, Yu Wang, Christopher S Hong, Li Tan, Tingyu Dai, Liao Wu, Zhengping Zhuang and Chunmeng Shi

Cell Death Dis 2017 8: e2573; 10.1038/cddis.2016.416

Abstract | Full Text

Dicer promotes tumorigenesis by translocating to nucleus to promote SFRP1 promoter methylation in cholangiocarcinoma cells

Wenlong Cheng, Yongqiang Qi, Li Tian, Bing Wang, Wenhua Huang and Yongjun Chen

Cell Death Dis 2017 8: e2628; 10.1038/cddis.2017.57

Abstract | Full Text

In situ generated Dpeptidic nanofibrils as multifaceted apoptotic inducers to target cancer cells

Xuewen Du, Jie Zhou, Huainin Wang, Junfeng Shi, Yi Kuang, Wu Zeng, Zhimou Yang and Bing Xu

Cell Death Dis 2017 8: e2614; 10.1038/cddis.2016.466

Abstract | Full Text

Prenatal alcohol exposure impairs autophagy in neonatal brain cortical microvessels

Virginie Girault, Vianney Gilard, Florent Marguet, Céline Lesueur, Michelle Hauchecorne, Yasmina Ramdani, Annie Laquerrière, Stéphane Marret, Sylvie Jégou, Bruno Jose Gonzalez, Carole Brasse-Lagnel and Soumeya Bekri

Cell Death Dis 2017 8: e2610; 10.1038/cddis.2017.29

Abstract | Full Text

RASAL2, a RAS GTPase-activating protein, inhibits stemness and epithelial–mesenchymal transition via MAPK/SOX2 pathway in bladder cancer

Ke Hui, Yang Gao, Jun Huang, Shan Xu, Bin Wang, Jin Zeng, Jinhai Fan, Xinyang Wang, Yangyang Yue, Shiqi Wu, Jer-Tsong Hsieh, Dalin He and Kaijie Wu

Cell Death Dis 2017 8: e2600; 10.1038/cddis.2017.9

Abstract | Full Text

RIPK1/RIPK3 promotes vascular permeability to allow tumor cell extravasation independent of its necroptotic function

Kay Hänggi, Lazaros Vasilikos, Aida Freire Valls, Rosario Yerbes, Janin Knop, Lisanne M Spilgies, Kristy Rieck, Tvisha Misra, John Bertin, Peter J Gough, Thomas Schmidt, Carmen Ruiz de Almodòvar and W Wei-Lynn Wong

Cell Death Dis 2017 8: e2588; 10.1038/cddis.2017.20

Abstract | Full Text

Coordinate activities of BRD4 and CDK9 in the transcriptional elongation complex are required for TGFβ-induced Nox4 expression and myofibroblast transdifferentiation

Talha Ijaz, Mohammad Jamaluddin, Yingxin Zhao, Yueqing Zhang, Jayson Jay, Celeste C Finnerty, David N Herndon, Ronald G Tilton and Allan R Brasier

Cell Death Dis 2017 8: e2606; 10.1038/cddis.2016.434

Abstract | Full Text

Opposite effects of HDAC5 and p300 on MRTF-A-related neuronal apoptosis during ischemia/reperfusion injury in rats

Na Li, Qiong Yuan, Xiao-Lu Cao, Ying Zhang, Zhen-Li Min, Shi-Qiang Xu, Zhi-Jun Yu, Jing Cheng, Chunxiang Zhang and Xia-Min Hu

Cell Death Dis 2017 8: e2624; 10.1038/cddis.2017.16

Abstract | Full Text

Proteasome-associated deubiquitinase ubiquitin-specific protease 14 regulates prostate cancer proliferation by deubiquitinating and stabilizing androgen receptor

Yuning Liao, Ningning Liu, Xianliang Hua, Jianyu Cai, Xiaohong Xia, Xuejun Wang, Hongbiao Huang and Jinbao Liu

Cell Death Dis 2017 8: e2585; 10.1038/cddis.2016.477

Abstract | Full Text

NLRP3 inflammasome activation mediates radiation-induced pyroptosis in bone marrow-derived macrophages

Yan-gang Liu, Ji-kuai Chen, Zi-teng Zhang, Xiu-juan Ma, Yong-chun Chen, Xiu-ming Du, Hong Liu, Ying Zong and Guo-cai Lu

Cell Death Dis 2017 8: e2579; 10.1038/cddis.2016.460

Abstract | Full Text

CALCB splice region pathogenic variants leading to plasma cell neurotropic enrichment in type 1 autoimmune pancreatitis

Qi-cai Liu, Falin Chen, Chao-yang Wu, Feng Gao, Ze-hao Zhuang, Jin-tong Chen, Bin Cai, Tianming Zhang, Ling Guo, Li-qing Lin, Cheng-fei Zhao and Xin-hua Lin

Cell Death Dis 2017 8: e2591; 10.1038/cddis.2017.32

Abstract | Full Text

BNIP3 upregulation via stimulation of ERK and JNK activity is required for the protection of keratinocytes from UVB-induced apoptosis

Mariko Moriyama, Hiroyuki Moriyama, Junki Uda, Hirokazu Kubo, Yuka Nakajima, Arisa Goto, Takashi Morita and Takao Hayakawa

Cell Death Dis 2017 8: e2576; 10.1038/cddis.2017.4

Abstract | Full Text

Colon cancer cell treatment with rose bengal generates a protective immune response via immunogenic cell death

Jianzhong Qin, Nicholas Kunda, Guilin Qiao, Jed F Calata, Krunal Pardiwala, Bellur S Prabhakar and Ajay V Maker

Cell Death Dis 2017 8: e2584; 10.1038/cddis.2016.473

Abstract | Full Text

MCM7 promotes cancer progression through cyclin D1-dependent signaling and serves as a prognostic marker for patients with hepatocellular carcinoma

Kai Qu, Zhixin Wang, Haining Fan, Juan Li, Jie Liu, Pingping Li, Zheyong Liang, Hongli An, Yina Jiang, Qiushi Lin, Xiaoqun Dong, Peijun Liu and Chang Liu

Cell Death Dis 2017 8: e2603; 10.1038/cddis.2016.352

Abstract | Full Text

RIPK3 interactions with MLKL and CaMKII mediate oligodendrocytes death in the developing brain

Yi Qu, Jun Tang, Huiqing Wang, Shiping Li, Fengyan Zhao, Li Zhang, Q Richard Lu and Dezhi Mu

Cell Death Dis 2017 8: e2629; 10.1038/cddis.2017.54

Abstract | Full Text

TAK1 regulates resident macrophages by protecting lysosomal integrity

Yosuke Sakamachi, Sho Morioka, September R Mihaly, Giichi Takaesu, Julie F Foley, Michael B Fessler and Jun Ninomiya-Tsuji

Cell Death Dis 2017 8: e2598; 10.1038/cddis.2017.23

Abstract | Full Text

ErbB4 signaling stimulates pro-inflammatory macrophage apoptosis and limits colonic inflammation

Michael A Schumacher, Matija Hedl, Clara Abraham, Jessica K Bernard, Patricia R Lozano, Jonathan J Hsieh, Dana Almohazey, Edie B Bucar, Shivesh Punit, Peter J Dempsey and Mark R Frey

Cell Death Dis 2017 8: e2622; 10.1038/cddis.2017.42

Abstract | Full Text

CARMA2sh and ULK2 control pathogen-associated molecular patterns recognition in human keratinocytes: psoriasis-linked CARMA2sh mutants escape ULK2 censorship

Ivan Scudiero, Pellegrino Mazzone, Luca E D'Andrea, Angela Ferravante, Tiziana Zotti, Gianluca Telesio, Gabriele De Rubis, Carla Reale, Maddalena Pizzulo, Shanmugakonar Muralitharan, Pasquale Vito and Romania Stilo

Cell Death Dis 2017 8: e2627; 10.1038/cddis.2017.51

Abstract | Full Text

Thioridazine enhances sensitivity to carboplatin in human head and neck cancer cells through downregulation of c-FLIP and Mcl-1 expression

Seung Un Seo, Hyuk Ki Cho, Kyoung-jin Min, Seon Min Woo, Shin Kim, Jong-Wook Park, Sang Hyun Kim, Yung Hyun Choi, Young Sam Keum, Jin Won Hyun, Hyun Ho Park, Sang-Han Lee, Dong Eun Kim and Taeg Kyu Kwon

Cell Death Dis 2017 8: e2599; 10.1038/cddis.2017.8

Abstract | Full Text

Hetero-oligomerization between the TNF receptor superfamily members CD40, Fas and TRAILR2 modulate CD40 signalling

Cristian R Smulski, Marion Decossas, Neila Chekkat, Julien Beyrath, Laure Willen, Gilles Guichard, Raquel Lorenzetti, Marta Rizzi, Hermann Eibel, Pascal Schneider and Sylvie Fournel

Cell Death Dis 2017 8: e2601; 10.1038/cddis.2017.22

Abstract | Full Text

Luteolin selectively kills STAT3 highly activated gastric cancer cells through enhancing the binding of STAT3 to SHP-1

Shiyu Song, Zhonglan Su, Hui Xu, Mengyuan Niu, Xiufang Chen, Haiyan Min, Bin Zhang, Guibo Sun, Sijing Xie, Hongwei Wang and Qian Gao

Cell Death Dis 2017 8: e2612; 10.1038/cddis.2017.38

Abstract | Full Text

Notch activation enhances mesenchymal stem cell sheet osteogenic potential by inhibition of cellular senescence

Ye Tian, Ying Xu, Taiyang Xue, Longgang Chen, Bin Shi, Bing Shu, Chao Xie, Massimo Max Morandi, Todd Jaeblon, John V Marymont and Yufeng Dong

Cell Death Dis 2017 8: e2595; 10.1038/cddis.2017.2

Abstract | Full Text

Simvastatin-induced cell cycle arrest through inhibition of STAT3/SKP2 axis and activation of AMPK to promote p27 and p21 accumulation in hepatocellular carcinoma cells

Sin-Ting Wang, Hsiu J Ho, Jaw-Town Lin, Jeng-Jer Shieh and Chun-Ying Wu

Cell Death Dis 2017 8: e2626; 10.1038/cddis.2016.472

Abstract | Full Text

Loss of BRG1 induces CRC cell senescence by regulating p53/p21 pathway

Guihua Wang, Yinjia Fu, Fuqing Hu, Jinqing Lan, Feng Xu, Xi Yang, Xuelai Luo, Jing Wang and Junbo Hu

Cell Death Dis 2017 8: e2607; 10.1038/cddis.2017.1

Abstract | Full Text

Starvation at birth impairs germ cell cyst breakdown and increases autophagy and apoptosis in mouse oocytes

Yong-Yong Wang, Yuan-Chao Sun, Xiao-Feng Sun, Shun-Feng Cheng, Bo Li, Xi-Feng Zhang, Massimo De Felici and Wei Shen

Cell Death Dis 2017 8: e2613; 10.1038/cddis.2017.3

Abstract | Full Text

Adipocytes activate mitochondrial fatty acid oxidation and autophagy to promote tumor growth in colon cancer

Yang-An Wen, Xiaopeng Xing, Jennifer W Harris, Yekaterina Y Zaytseva, Mihail I Mitov, Dana L Napier, Heidi L Weiss, B Mark Evers and Tianyan Gao

Cell Death Dis 2017 8: e2593; 10.1038/cddis.2017.21

Abstract | Full Text

Protein phosphatase 4 coordinates glial membrane recruitment and phagocytic clearance of degenerating axons in Drosophila

Lilly M Winfree, Sean D Speese and Mary A Logan

Cell Death Dis 2017 8: e2623; 10.1038/cddis.2017.40

Abstract | Full Text

Photo-activation of the delocalized lipophilic cation D112 potentiates cancer selective ROS production and apoptosis

Ning Yang, Michael Weinfeld, Hélène Lemieux, Ben Montpetit and Ing Swie Goping

Cell Death Dis 2017 8: e2587; 10.1038/cddis.2017.19

Abstract | Full Text

Duodenal GLP-1 signaling regulates hepatic glucose production through a PKC-δ-dependent neurocircuitry

Mengliu Yang, Jinzhi Wang, Shaobo Wu, Lei Yuan, Xiaodong Zhao, Chaohong Liu, Jing Xie, Yanjun Jia, Yerui Lai, Allan Zijian Zhao, Guenther Boden, Ling Li and Gangyi Yang

Cell Death Dis 2017 8: e2609; 10.1038/cddis.2017.28

Abstract | Full Text

Ginsenoside Rg5 increases cardiomyocyte resistance to ischemic injury through regulation of mitochondrial hexokinase-II and dynamin-related protein 1

Yi-Lin Yang, Jia Li, Kang Liu, Lei Zhang, Qun Liu, Baolin Liu and Lian-Wen Qi

Cell Death Dis 2017 8: e2625; 10.1038/cddis.2017.43

Abstract | Full Text

Oridonin induces autophagy via inhibition of glucose metabolism in p53-mutated colorectal cancer cells

Zhuo Yao, Fuhua Xie, Min Li, Zirui Liang, Wenli Xu, Jianhua Yang, Chang Liu, Hongwangwang Li, Hui Zhou and Liang-Hu Qu

Cell Death Dis 2017 8: e2633; 10.1038/cddis.2017.35

Abstract | Full Text

Overexpression of SLC34A2 is an independent prognostic indicator in bladder cancer and its depletion suppresses tumor growth via decreasing c-Myc expression and transcriptional activity

Wen Ye, Cui Chen, Ying Gao, Zou-Shan Zheng, Yi Xu, Miao Yun, Hui-Wen Weng, Dan Xie, Sheng Ye and Jia-Xing Zhang

Cell Death Dis 2017 8: e2581; 10.1038/cddis.2017.13

Abstract | Full Text

LincRNA-Gm4419 knockdown ameliorates NF-κB/NLRP3 inflammasome-mediated inflammation in diabetic nephropathy

Hong Yi, Rui Peng, Lu-yu Zhang, Yan Sun, Hui-min Peng, Han-deng Liu, Li-juan Yu, Ai-ling Li, Ya-juan Zhang, Wen-hao Jiang and Zheng Zhang

Cell Death Dis 2017 8: e2583; 10.1038/cddis.2016.451

Abstract | Full Text

Mesenchymal stromal cells inhibit CD25 expression via the mTOR pathway to potentiate T-cell suppression

Hyun Seung Yoo, Kyuheon Lee, Kwangmin Na, Yong Xu Zhang, Hyun-Ja Lim, TacGhee Yi, Sun U Song and Myung-Shin Jeon

Cell Death Dis 2017 8: e2632; 10.1038/cddis.2017.45

Abstract | Full Text

Star-PAP, a poly(A) polymerase, functions as a tumor suppressor in an orthotopic human breast cancer model

C Yu, Y Gong, H Zhou, M Wang, L Kong, J Liu, T An, H Zhu and Y Li

Cell Death Dis 2017 8: e2582; 10.1038/cddis.2016.199

Abstract | Full Text

Tenovin-6 impairs autophagy by inhibiting autophagic flux

Hongfeng Yuan, Brandon Tan and Shou-Jiang Gao

Cell Death Dis 2017 8: e2608; 10.1038/cddis.2017.25

Abstract | Full Text

Oncogenic role of rab escort protein 1 through EGFR and STAT3 pathway

Un-Jung Yun, Jee Young Sung, Seog-Yun Park, Sang-Kyu Ye, Jaegal Shim, Jae-Seon Lee, Masahiko Hibi, Young-Ki Bae and Yong-Nyun Kim

Cell Death Dis 2017 8: e2621; 10.1038/cddis.2017.50

Abstract | Full Text

Regulation of glutamate transporter trafficking by Nedd4-2 in a Parkinson’s disease model

Yunlong Zhang, Xiaoliang He, Xingjun Meng, Xiaojuan Wu, Huichun Tong, Xiuping Zhang and Shaogang Qu

Cell Death Dis 2017 8: e2574; 10.1038/cddis.2016.454

Abstract | Full Text

Rapamycin upregulates glutamate transporter and IL-6 expression in astrocytes in a mouse model of Parkinson’s disease

Yunlong Zhang, Xiaoliang He, Xiaojuan Wu, Ming Lei, Zhiyun Wei, Xiuping Zhang, Lei Wen, Pingyi Xu, Shaomin Li and Shaogang Qu

Cell Death Dis 2017 8: e2611; 10.1038/cddis.2016.491

Abstract | Full Text

ID2 promotes survival of glioblastoma cells during metabolic stress by regulating mitochondrial function

Zhonghua Zhang, Gilbert J Rahme, Pranam D Chatterjee, Matthew C Havrda and Mark A Israel

Cell Death Dis 2017 8: e2615; 10.1038/cddis.2017.14

Abstract | Full Text

Knockout of Eva1a leads to rapid development of heart failure by impairing autophagy

Shu Zhang, Xin Lin, Ge Li, Xue Shen, Di Niu, Guang Lu, Xin Fu, Yingyu Chen, Ming Cui and Yun Bai

Cell Death Dis 2017 8: e2586; 10.1038/cddis.2017.17

Abstract | Full Text

Berbamine postconditioning protects the heart from ischemia/reperfusion injury through modulation of autophagy

Yanjun Zheng, Shanshan Gu, Xuxia Li, Jiliang Tan, Shenyan Liu, Yukun Jiang, Caimei Zhang, Ling Gao and Huang-Tian Yang

Cell Death Dis 2017 8: e2577; 10.1038/cddis.2017.7

Abstract | Full Text

MicroRNA-144 is regulated by CP2 and decreases COX-2 expression and PGE2 production in mouse ovarian granulosa cells

Jiawei Zhou, Bin Lei, Huanan Li, Lihua Zhu, Lei Wang, Hu Tao, Shuqi Mei and Fenge Li

Cell Death Dis 2017 8: e2597; 10.1038/cddis.2017.24

Abstract | Full Text

Inhibition of autophagy blocks cathepsins–tBid–mitochondrial apoptotic signaling pathway via stabilization of lysosomal membrane in ischemic astrocytes

Xian-Yong Zhou, Yu Luo, Yong-Ming Zhu, Zhi-He Liu, Thomas A Kent, Jia-Guo Rong, Wei Li, Shi-Gang Qiao, Min Li, Yong Ni, Kazumi Ishidoh and Hui-Ling Zhang

Cell Death Dis 2017 8: e2618; 10.1038/cddis.2017.34

Abstract | Full Text

Tissue transglutaminase (TG2) enables survival of human malignant pleural mesothelioma cells in hypoxia

Sara Zonca, Giulia Pinton, Zhuo Wang, Maria Felicia Soluri, Daniela Tavian, Martin Griffin, Daniele Sblattero and Laura Moro

Cell Death Dis 2017 8: e2592; 10.1038/cddis.2017.30

Abstract | Full Text

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