Scientific Reports Biology Table of Contents e-alert: 10 January 2017

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10 January 2017      • Visit Scientific Reports • Submit your manuscript to Scientific Reports     Welcome to your Table of Contents e-alert for Scientific Reports       Biological Sciences               Drug Response Prediction as a Link Prediction Problem ▶     Zachary Stanfield, Mustafa Coşkun, Mehmet Koyutürk     Drug response prediction is a well-studied problem in which the molecular profile of a given sample is used to predict the effect of a given drug on that sample. Effective …             Stromal Cell Subsets Directing Neonatal Spleen Regeneration ▶     Jonathan K. H. Tan, Takeshi Watanabe     Development of lymphoid tissue is determined by interactions between stromal lymphoid tissue organiser (LTo) and hematopoietic lymphoid tissue inducer (LTi) cells. A failure for …             OsMYC2, an essential factor for JA-inductive sakuranetin production in rice, interacts with MYC2-like proteins that enhance its transactivation ability ▶     Satoshi Ogawa, Koji Miyamoto, Keiichirou Nemoto et al.     Biosynthesis of sakuranetin, a flavonoid anti-fungal phytoalexin that occurs in rice, is highly dependent on jasmonic acid (JA) signalling and induced by a variety of …             Two-Step Amyloid Aggregation: Sequential Lag Phase Intermediates ▶     Fabio Castello, Jose M. Paredes, Maria J. Ruedas-Rama et al.     The self-assembly of proteins into fibrillar structures called amyloid fibrils underlies the onset and symptoms of neurodegenerative diseases, such as Alzheimer’s and …             Adeno-associated virus serotype rh.10 displays strong muscle tropism following intraperitoneal delivery ▶     Jianzhong Ai, Jia Li, Dominic J. Gessler et al.     Recombinant adeno-associated virus (rAAV) is an attractive tool for basic science and translational medicine including gene therapy, due to the versatility in its cell and organ …             DynOmics to identify delays and co-expression patterns across time course experiments ▶     Jasmin Straube, Bevan Emma Huang, Kim-Anh Lê Cao     Dynamic changes in biological systems can be captured by measuring molecular expression from different levels (e.g., genes and proteins) across time. Integration of such data …             The mechanism of catalysis by type-II NADH:quinone oxidoreductases ▶     James N. Blaza, Hannah R. Bridges, David Aragão et al.     Type II NADH:quinone oxidoreductase (NDH-2) is central to the respiratory chains of many organisms. It is not present in mammals so may be exploited as an antimicrobial drug …             Corrigendum: Premature changes in neuronal excitability account for hippocampal network impairment and autistic-like behavior in neonatal BTBR T+tf/J mice ▶     Giada Cellot, Laura Maggi, Maria Amalia Di Castro et al.                 Free flight odor tracking in Drosophila: Effect of wing chemosensors, sex and pheromonal gene regulation ▶     Benjamin Houot, Vincent Gigot, Alain Robichon et al.     The evolution of powered flight in insects had major consequences for global biodiversity and involved the acquisition of adaptive processes allowing individuals to disperse to …             Efficient implementation of a real-time estimation system for thalamocortical hidden Parkinsonian properties ▶     Shuangming Yang, Bin Deng, Jiang Wang et al.     Real-time estimation of dynamical characteristics of thalamocortical cells, such as dynamics of ion channels and membrane potentials, is useful and essential in the study of the …             Validation of reference genes for cryopreservation studies with the gorgonian coral endosymbiont Symbiodinium ▶     Gabriella Chong, Fu-Wen Kuo, Sujune Tsai et al.     Quantification by real-time RT-PCR requires a stable internal reference known as a housekeeping gene (HKG) for normalising the mRNA levels of target genes. The present study …             Weak functional connectivity in the human fetal brain prior to preterm birth ▶     Moriah E. Thomason, Dustin Scheinost, Janessa H. Manning et al.     It has been suggested that neurological problems more frequent in those born preterm are expressed prior to birth, but owing to technical limitations, this has been difficult to …             Dopamine-functionalized mesoporous onion-like silica as a new matrix for immobilization of lipase Candida sp. 99-125 ▶     Junkai Gao, Yanjun Jiang, Jinshu Lu et al.     Dopmine functionalized mesoporous onion-like silica (DPMS) was synthesized via a biomimetic coating, and lipase Candida sp. 99-125 (LCS) was immobilized in DPMS (LCS@DPMS) by …             Spatial competition dynamics between reef corals under ocean acidification ▶     Rael Horwitz, Mia O. Hoogenboom, Maoz Fine     Climate change, including ocean acidification (OA), represents a major threat to coral-reef ecosystems. Although previous experiments have shown that OA can negatively affect the …             Development of a Recombinase Polymerase Amplification Assay for Detection of Epidemic Human Noroviruses ▶     Matthew D. Moore, Lee-Ann Jaykus     Human norovirus is a leading cause of viral gastroenteritis worldwide. Rapid detection could facilitate control, however widespread point-of-care testing is infrequently done due …             Topography-associated thermal gradient predicts warming effects on woody plant structural diversity in a subtropical forest ▶     Siyan He, Yonglin Zhong, Yudan Sun et al.     Understanding global warming effects on forest ecosystems will help policy-makers and forest managers design forest management and biodiversity conservation strategies. We …             Polypurine reverse-Hoogsteen (PPRH) oligonucleotides can form triplexes with their target sequences even under conditions where they fold into G-quadruplexes ▶     Anna Solé, Emmanuelle Delagoutte, Carlos J. Ciudad et al.     Polypurine reverse-Hoogsteen (PPRH) oligonucleotides are non-modified DNA molecules composed of two mirror-symmetrical polypurine stretches linked by a five-thymidine loop. They …             Chimeric virus-like particles containing influenza HA antigen and GPI-CCL28 induce long-lasting mucosal immunity against H3N2 viruses ▶     Teena Mohan, Zachary Berman, Yuan Luo et al.     Influenza virus is a significant cause of morbidity and mortality, with worldwide seasonal epidemics. The duration and quality of humoral immunity and generation of immunological …             Supra-operonic clusters of functionally related genes (SOCs) are a source of horizontal gene co-transfers ▶     Tin Yau Pang, Martin J. Lercher     Adaptation of bacteria occurs predominantly via horizontal gene transfer (HGT). While it is widely recognized that horizontal acquisitions frequently encompass multiple genes, it …             Tubules of plant reoviruses exploit tropomodulin to regulate actin-based tubule motility in insect vector ▶     Qian Chen, Linghua Zhang, Yanshuang Zhang et al.     Plant reoviruses are known to exploit virion-packaging tubules formed by virus-encoding non-structural proteins for viral spread in insect vectors. Tubules are propelled by …             Regulation of FADS2 transcription by SREBP-1 and PPAR-α influences LC-PUFA biosynthesis in fish ▶     Xiaojing Dong, Peng Tan, Zuonan Cai et al.     The present study was conducted to explore the mechanisms leading to differences among fishes in the ability to biosynthesize long-chain polyunsaturated fatty acids (LC-PUFAs). …             Autophagy-related protein MoAtg14 is involved in differentiation, development and pathogenicity in the rice blast fungus Magnaporthe oryzae ▶     Xiao-Hong Liu, Ya-Hui Zhao, Xue-Ming Zhu et al.     Autophagy is the major intracellular degradation system by which cytoplasmic materials are delivered to and degraded in the vacuole/lysosome in eukaryotic cells. MoAtg14 in M. …             Di2-ethylhexyl phthalate disrupts thyroid hormone homeostasis through activating the Ras/Akt/TRHr pathway and inducing hepatic enzymes ▶     Hanfeng Ye, Mei Ha, Min Yang et al.     Di(2-ethylhexyl) phthalate (DEHP), as a widespread environmental pollutant and an endocrine disruptor, can disturb the homeostasis of thyroid hormones (THs). In order to …             Variant Ionotropic Receptors in the Malaria Vector Mosquito Anopheles gambiae Tuned to Amines and Carboxylic Acids ▶     R. Jason Pitts, Stephen L. Derryberry, Zhiwei Zhang et al.     The principal Afrotropical human malaria vector mosquito, Anopheles gambiae, remains a significant threat to global health. A critical component in the transmission of malaria is …             Transcription regulator TRIP-Br2 mediates ER stress-induced brown adipocytes dysfunction ▶     Guifen Qiang, Hyerim Whang Kong, Victoria Gil et al.     In contrast to white adipose tissue, brown adipose tissue (BAT) is known to play critical roles for both basal and inducible energy expenditure. Obesity is associated with …             The in vivo efficacy of neuraminidase inhibitors cannot be determined from the decay rates of influenza viral titers observed in treated patients ▶     John Palmer, Hana M. Dobrovolny, Catherine A. A. Beauchemin     Antiviral therapy is a first line of defence against new influenza strains. Current pandemic preparations involve stock- piling oseltamivir, an oral neuraminidase inhibitor …             Enhanced tumor-targeting selectivity by modulating bispecific antibody binding affinity and format valence ▶     Yariv Mazor, Kris F. Sachsenmeier, Chunning Yang et al.     Bispecific antibodies are considered attractive bio-therapeutic agents owing to their ability to target two distinct disease mediators. Cross-arm avidity targeting of antigen …             A novel chimeric lysin with robust antibacterial activity against planktonic and biofilm methicillin-resistant Staphylococcus aureus ▶     Hang Yang, Huaidong Zhang, Jing Wang et al.     Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most threatening pathogens due to its multi-drug resistance (MDR) and strong biofilm-forming capacity. Here, we …             Redundant functions of I-BAR family members, IRSp53 and IRTKS, are essential for embryonic development ▶     Ai Mei Chou, Kai Ping Sem, Wei Jun Lam et al.     The insulin receptor substrate of 53 kDa, IRSp53, is an adaptor protein that works with activated GTPases, Cdc42 and Rac, to modulate actin dynamics and generate membrane …             Orientation toward humans predicts cognitive performance in orang-utans ▶     Laura A. Damerius, Sofia I. F. Forss, Zaida K. Kosonen et al.     Non-human animals sometimes show marked intraspecific variation in their cognitive abilities that may reflect variation in external inputs and experience during the developmental …             Proteomic analysis of Cry2Aa-binding proteins and their receptor function in Spodoptera exigua ▶     Lin Qiu, Boyao Zhang, Lang Liu et al.     The bacterium Bacillus thuringiensis produces Crystal (Cry) proteins that are toxic to a diverse range of insects. Transgenic crops that produce Bt Cry proteins are grown …             KANK1 inhibits cell growth by inducing apoptosis though regulating CXXC5 in human malignant peripheral nerve sheath tumors ▶     Zhibin Cui, Yingjia Shen, Kenny H. Chen et al.     Malignant peripheral nerve sheath tumors (MPNSTs) are a type of rare sarcomas with a poor prognosis due to its highly invasive nature and limited treatment options. Currently …             Sec16A is critical for both conventional and unconventional secretion of CFTR ▶     He Piao, Jiyoon Kim, Shin Hye Noh et al.     CFTR is a transmembrane protein that reaches the cell surface via the conventional Golgi mediated secretion pathway. Interestingly, ER-to-Golgi blockade or ER stress induces …             Perceptual similarity and the neural correlates of geometrical illusions in human brain structure ▶     Vadim Axelrod, D. Samuel Schwarzkopf, Sharon Gilaie-Dotan et al.     Geometrical visual illusions are an intriguing phenomenon, in which subjective perception consistently misjudges the objective, physical properties of the visual stimulus. …             Increase in α-tubulin modifications in the neuronal processes of hippocampal neurons in both kainic acid-induced epileptic seizure and Alzheimer’s disease ▶     Hang Thi Vu, Hiroyasu Akatsu, Yoshio Hashizume et al.     Neurodegeneration includes acute changes and slow-developing alterations, both of which partly involve common cellular machinery. During neurodegeneration, neuronal processes are …             Unusual respiratory capacity and nitrogen metabolism in a Parcubacterium (OD1) of the Candidate Phyla Radiation ▶     Cindy J. Castelle, Christopher T. Brown, Brian C. Thomas et al.     The Candidate Phyla Radiation (CPR) is a large group of bacteria, the scale of which approaches that of all other bacteria. CPR organisms are inferred to depend on other …             Neuregulin 1-ErbB module in C-bouton synapses on somatic motor neurons: molecular compartmentation and response to peripheral nerve injury ▶     Anna Casanovas, Sara Salvany, Víctor Lahoz et al.     The electric activity of lower motor neurons (MNs) appears to play a role in determining cell-vulnerability in MN diseases. MN excitability is modulated by cholinergic inputs …             Widespread temporo-occipital lobe dysfunction in amyotrophic lateral sclerosis ▶     Kristian Loewe, Judith Machts, Jörn Kaufmann et al.     Recent studies suggest that amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) lie on a single clinical continuum. However, previous neuroimaging studies have …             C. elegans-on-a-chip for in situ and in vivo Ag nanoparticles’ uptake and toxicity assay ▶     Jin Ho Kim, Seung Hwan Lee, Yun Jeong Cha et al.     Nanomaterials are extensively used in consumer products and medical applications, but little is known about their environmental and biological toxicities. Moreover, the toxicity …             Spatio-temporal patterns of proportions of influenza B cases ▶     Daihai He, Alice P. Y. Chiu, Qianying Lin et al.     We studied the spatio-temporal patterns of the proportions of influenza B cases out of all typed cases, with data from 139 countries and regions downloaded from the FluNet …             Effects of plant species richness on 13C assimilate partitioning in artificial grasslands of different established ages ▶     Longhua Xu, Buqing Yao, Wenying Wang et al.     Artificial grasslands play a role in carbon storage on the Qinghai–Tibetan Plateau. The artificial grasslands exhibit decreased proportions of graminate and increased species …             Gastroprotective [6]-Gingerol Aspirinate as a Novel Chemopreventive Prodrug of Aspirin for Colon Cancer ▶     Yingdong Zhu, Fang Wang, Yantao Zhao et al.     A growing body of research suggests daily low-dose aspirin (ASA) reduces heart diseases and colorectal cancers. However, the major limitation to the use of aspirin is its side …             Analytical studies on ascosin, candicidin and levorin multicomponent antifungal antibiotic complexes. The stereostructure of ascosin A2 ▶     Paweł Szczeblewski, Tomasz Laskowski, Bartosz Kubacki et al.     In the class of polyene macrolides, there is a subgroup of aromatic heptaenes, which exhibit the highest antifungal activity within this type of antibiotics. Yet, due to their …             Computational and biochemical characterization of two partially overlapping interfaces and multiple weak-affinity K-Ras dimers ▶     Priyanka Prakash, Abdallah Sayyed-Ahmad, Kwang-Jin Cho et al.     Recent studies found that membrane-bound K-Ras dimers are important for biological function. However, the structure and thermodynamic stability of these complexes remained …             Fluorescent Gold Nanoclusters for Selective Detection of Dopamine in Cerebrospinal fluid ▶     Saravanan Govindaraju, Seshadri Reddy Ankireddy, Buddolla Viswanath et al.     Since the last two decades, protein conjugated fluorescent gold nanoclusters (NCs) owe much attention in the field of medical and nanobiotechnology due to their excellent photo …             Effect of hierarchically aligned fibrin hydrogel in regeneration of spinal cord injury demonstrated by tractography: A pilot study ▶     Zhenxia Zhang, Shenglian Yao, Sheng Xie et al.     Some studies have reported that scaffold or cell-based transplantation may improve functional recovery following SCI, but no imaging information regarding regeneration has been …             Quantifying influences of physiographic factors on temperate dryland vegetation, Northwest China ▶     Ziqiang Du, Xiaoyu Zhang, Xiaoming Xu et al.     Variability in satellite measurements of terrestrial greenness in drylands is widely observed in land surface processes and global change studies. Yet the underlying causes …             SDF-1/CXCR4 axis induces human dental pulp stem cell migration through FAK/PI3K/Akt and GSK3β/β-catenin pathways ▶     Mingwei Li, Xuefei Sun, Liang Ma et al.     SDF-1 (stromal cell derived factor-1) has been found to be widely expressed during dental pulp inflammation, while hDPSCs (human dental pulp stem cells) contribute to the repair …             Oleanolic acid ameliorates high glucose-induced endothelial dysfunction via PPARδ activation ▶     Zihui Zhang, Manli Jiang, Xinya Xie et al.     Oleanolic acid (3β-hydroxyolean-12-en-28-oic acid, OA) is a pentacyclic triterpenes widely distributed in food, medicinal plants and nutritional supplements. OA exhibits various …             Gomisin N inhibits adipogenesis and prevents high-fat diet-induced obesity ▶     Min-Kyung Jang, Ye-Rang Yun, Ji-Hyun Kim et al.     Gomisin N (GN) is a physiological lignan derived from Schisandra chinensis. In the present study, we investigated the inhibitory effects of GN on differentiation of 3T3-L1 …             Gut Microbiota Mediates Protection Against Enteropathy Induced by Indomethacin ▶     Xue Xiao, Geicho Nakatsu, Ye Jin et al.     Non-steroidal anti-inflammatory drugs (NSAIDs) can cause significant small bowel injuries. The role of gut microbiota in this NSAID-induced enteropathy is poorly understood. We …             Weissella cibaria WIKIM28 ameliorates atopic dermatitis-like skin lesions by inducing tolerogenic dendritic cells and regulatory T cells in BALB/c mice ▶     Seul Ki Lim, Min-Sung Kwon, Jieun Lee et al.     The occurrence of atopic dermatitis (AD), a chronic inflammatory skin disease, has been increasing steadily in children and adults in recent decades. In this study, we evaluated …             Glucose-6-Phosphate Isomerase (G6PI) Mediates Hypoxia-Induced Angiogenesis in Rheumatoid Arthritis ▶     Ying Lu, Shan-Shan Yu, Ming Zong et al.     The higher level of Glucose-6-phosphate isomerase (G6PI) has been found in both synovial tissue and synovial fluid of rheumatoid arthritis (RA) patients, while the function of …             Smartphone-based low light detection for bioluminescence application ▶     Huisung Kim, Youngkee Jung, Iyll-Joon Doh et al.     We report a smartphone-based device and associated imaging-processing algorithm to maximize the sensitivity of standard smartphone cameras, that can detect the presence of …             Serelaxin treatment reverses vascular dysfunction and left ventricular hypertrophy in a mouse model of Type 1 diabetes ▶     Hooi Hooi Ng, Chen Huei Leo, Darnel Prakoso et al.     Serelaxin prevents endothelial dysfunction in the mouse aorta ex vivo and inhibits apoptosis in cardiomyocytes under acute hyperglycaemia. Less is known about the effects of …             The autophagy elongation complex (ATG5-12/16L1) positively regulates HCV replication and is required for wild-type membranous web formation ▶     Ahmed M. Fahmy, Patrick Labonté     Hepatitis C virus (HCV) infection induces intracellular membrane rearrangements, thus forming a membranous web (MW) in which HCV replication and assembly occur. The HCV-induced …             A Novel and Conserved Plasmodium Sporozoite Membrane Protein SPELD is Required for Maturation of Exo-erythrocytic Forms ▶     Faisal Mohammed Abdul Al-Nihmi, Surendra Kumar Kolli, Segireddy Rameswara Reddy et al.     Plasmodium sporozoites are the infective forms of malaria parasite to vertebrate host and undergo dramatic changes in their transcriptional repertoire during maturation in …             Impaired novelty acquisition and synaptic plasticity in congenital hyperammonemia caused by hepatic glutamine synthetase deficiency ▶     Aisa N. Chepkova, Olga A. Sergeeva, Boris Görg et al.     Genetic defects in ammonia metabolism can produce irreversible damage of the developing CNS causing an impairment of cognitive and motor functions. We investigated alterations in …             Multiomics reveal non-alcoholic fatty liver disease in rats following chronic exposure to an ultra-low dose of Roundup herbicide ▶     Robin Mesnage, George Renney, Gilles-Eric Séralini et al.     The impairment of liver function by low environmentally relevant doses of glyphosate-based herbicides (GBH) is still a debatable and unresolved matter. Previously we have shown …             Association of Polymorphisms in three pri-miRNAs that Target Pepsinogen C with the Risk and Prognosis of Gastric Cancer ▶     Ye-feng Wu, Qian Xu, Cai-yun He et al.     We aimed to explore the associations of polymorphisms in three microRNAs (miRNAs) (let-7e rs8111742, miR-365b rs121224 and miR-4795 rs1002765) that target PGC with the risk and …             Hampering Effect of Cholesterol on the Permeation of Reactive Oxygen Species through Phospholipids Bilayer: Possible Explanation for Plasma Cancer Selectivity ▶     Jonas Van der Paal, Claudia Verheyen, Erik C. Neyts et al.     In recent years, the ability of cold atmospheric pressure plasmas (CAPS) to selectively induce cell death in cancer cells has been widely established. This selectivity has been …             Predictive screening of M1 and M2 macrophages reveals the immunomodulatory effectiveness of post spinal cord injury azithromycin treatment ▶     John C. Gensel, Timothy J. Kopper, Bei Zhang et al.     Spinal cord injury (SCI) triggers a heterogeneous macrophage response that when experimentally polarized toward alternative forms of activation (M2 macrophages) promotes tissue …             Identification and functional characterisation of 5-HT4 receptor in sea cucumber Apostichopus japonicus (Selenka) ▶     Tianming Wang, Zhen Yang, Naiming Zhou et al.     Serotonin (5-HT) is an important neurotransmitter and neuromodulator that controls a variety of sensory and motor functions through 5-HT receptors (5-HTRs). The 5-HT4R subfamily …             An on-chip imaging droplet-sorting system: a real-time shape recognition method to screen target cells in droplets with single cell resolution ▶     Mathias Girault, Hyonchol Kim, Hisayuki Arakawa et al.     A microfluidic on-chip imaging cell sorter has several advantages over conventional cell sorting methods, especially to identify cells with complex morphologies such as clusters. …             Influenza virus exploits tunneling nanotubes for cell-to-cell spread ▶     Amrita Kumar, Jin Hyang Kim, Priya Ranjan et al.     Tunneling nanotubes (TNTs) represent a novel route of intercellular communication. While previous work has shown that TNTs facilitate the exchange of viral or prion proteins from …             Non-invasive, Focused Ultrasound-Facilitated Gene Delivery for Optogenetics ▶     Shutao Wang, Tara Kugelman, Amanda Buch et al.     Optogenetics, a widely used technique in neuroscience research, is often limited by its invasive nature of application. Here, we present a noninvasive, ultrasound-based technique …             Rapidly discriminate commercial medicinal Pulsatilla chinensis (Bge.) Regel from its adulterants using ITS2 barcoding and specific PCR-RFLP assay ▶     Yuhua Shi, Mingming Zhao, Hui Yao et al.     Pulsatillae radix is a conventional traditional Chinese medicine (TCM) with common name Baitouweng, and has notable effects on inflammation and dysentery. Pulsatilla chinensis …             Disulfide isomerase-like protein AtPDIL1–2 is a good candidate for trichlorophenol phytodetoxification ▶     Ri-He Peng, Jin Qiu, Yong-Sheng Tian et al.     Trichlorophenol (TCP) is a widely used and persistent environmentally toxic compound that poses a carcinogenic risk to humans. Phytoremediation is a proficient cleanup technology …             Study on relationship between pollen exine ornamentation pattern and germplasm evolution in flowering crabapple ▶     Wang-Xiang Zhang, Ming-Ming Zhao, Jun-Jun Fan et al.     Pollen ornamentation patterns are important in the study of plant genetic evolution and systematic taxonomy. However, they are normally difficult to quantify. Based on …             C-terminus of HSC70-Interacting Protein (CHIP) Inhibits Adipocyte Differentiation via Ubiquitin- and Proteasome-Mediated Degradation of PPARγ ▶     Jung-Hoon Kim, Soyeon Shin, Jinho Seo et al.     PPARγ (Peroxisome proliferator-activated receptor γ) is a nuclear receptor involved in lipid homeostasis and related metabolic diseases. Acting as a transcription factor, PPARγ …             Cellulose Nanofibril Based-Aerogel Microreactors: A High Efficiency and Easy Recoverable W/O/W Membrane Separation System ▶     Fang Zhang, Hao Ren, Jing Dou et al.     Hereby we report a novel cellulose nanofirbril aerogel-based W/O/W microreactor system that can be used for fast and high efficient molecule or ions extraction and separation. …             NMR reveals a dynamic allosteric pathway in thrombin ▶     Lindsey D. Handley, Brian Fuglestad, Kyle Stearns et al.     Although serine proteases are found ubiquitously in both eukaryotes and prokaryotes, and they comprise the largest of all of the peptidase families, their dynamic motions remain …             Omics for understanding synergistic action of validamycin A and Trichoderma asperellum GDFS1009 against maize sheath blight pathogen ▶     Qiong Wu, Lida Zhang, Hai Xia et al.     Sheath blight, causes by Rhizoctonia spp., threaten maize yield every year throughout the world. Trichoderma could degrade Rhizoctonia solani on maize mainly via competition and …             An exploratory study of predisposing genetic factors for DiGeorge/velocardiofacial syndrome ▶     Laia Vergés, Francesca Vidal, Esther Geán et al.     DiGeorge/velocardiofacial syndrome (DGS/VCFS) is a disorder caused by a 22q11.2 deletion mediated by non-allelic homologous recombination (NAHR) between low-copy repeats (LCRs). …             A derivatization-enhanced detection strategy in mass spectrometry: analysis of 4-hydroxybenzoates and their metabolites after keratinocytes are exposed to UV radiation ▶     Yi-Hsuan Lee, Ying-Chi Lin, Chia-Hsien Feng et al.     4-Hydroxybenzoate is a phenolic derivative of alkyl benzoates and is a widely used preservative in cosmetic and pharmaceutical products. The presence of 4-hydroxybenzoates in the …             Tyrosine kinase c-Abl regulates the survival of plasma cells ▶     Yan-Feng Li, Shengli Xu, Yuhan Huang et al.     Tyrosine kinase c-Abl plays an important role in early B cell development. Its deletion leads to reduced pro- and pre-B cell generation in mice. However, its function in B cell …             Conserved role of Ovo in germline development in mouse and Drosophila ▶     Makoto Hayashi, Yuko Shinozuka, Shuji Shigenobu et al.     Ovo, which encodes a transcription factor with Zn-finger domains, is evolutionarily conserved among animals. In Drosophila, in addition to its zygotic function for egg …             The driving force of prophages and CRISPR-Cas system in the evolution of Cronobacter sakazakii ▶     Haiyan Zeng, Jumei Zhang, Chensi Li et al.     Cronobacter sakazakii is an important foodborne pathogens causing rare but life-threatening diseases in neonates and infants. CRISPR-Cas system is a new prokaryotic defense …             In ovo injection of betaine alleviates corticosterone-induced fatty liver in chickens through epigenetic modifications ▶     Yun Hu, Qinwei Sun, Jie Liu et al.     Betaine alleviates high-fat diet-induced fatty liver and prenatal betaine programs offspring hepatic lipid metabolism. Excessive corticosterone (CORT) exposure causes fatty liver …             Further characterization of Maize chlorotic mottle virus and its synergistic interaction with Sugarcane mosaic virus in maize ▶     Qiang Wang, Chao Zhang, Chunyan Wang et al.     Maize chlorotic mottle virus (MCMV) was first reported in maize in China in 2009. In this study we further analyzed the epidemiology of MCMV and corn lethal necrosis disease …             Deficiency of the eIF4E isoform nCBP limits the cell-to-cell movement of a plant virus encoding triple-gene-block proteins in Arabidopsis thaliana ▶     Takuya Keima, Yuka Hagiwara-Komoda, Masayoshi Hashimoto et al.     One of the important antiviral genetic strategies used in crop breeding is recessive resistance. Two eukaryotic translation initiation factor 4E family genes, eIF4E and eIFiso4E, …             The OPRM1 A118G polymorphism modulates the descending pain modulatory system for individual pain experience in young women with primary dysmenorrhea ▶     Shyh-Yuh Wei, Li-Fen Chen, Ming-Wei Lin et al.     The mu-opioid receptor (OPRM1) A118G polymorphism underpins different pain sensitivity and opioid-analgesic outcome with unclear effect on the descending pain modulatory system …             Membrane translocation of t-SNARE protein syntaxin-4 abrogates ground-state pluripotency in mouse embryonic stem cells ▶     Natsumi Hagiwara-Chatani, Kota Shirai, Takumi Kido et al.     Embryonic stem (ES) and induced pluripotent stem (iPS) cells are attractive tools for regenerative medicine therapies. However, aberrant cell populations that display flattened …             Pyruvic oxime dioxygenase from heterotrophic nitrifier Alcaligenes faecalis is a nonheme Fe(II)-dependent enzyme homologous to class II aldolase ▶     Shuhei Tsujino, Chisato Uematsu, Hideo Dohra et al.     Pyruvic oxime dioxygenase (POD), a key enzyme in heterotrophic nitrification, was purified from Alcaligenes faecalis, and the molecular and catalytic characteristics were …             Single cell time-lapse analysis reveals that podoplanin enhances cell survival and colony formation capacity of squamous cell carcinoma cells ▶     Tomoyuki Miyashita, Youichi Higuchi, Motohiro Kojima et al.     Tumor initiating cells (TICs) are characterized by high clonal expansion capacity. We previously reported that podoplanin is a TIC-specific marker for the human squamous cell …             IFN type I and II induce BAFF secretion from human decidual stromal cells ▶     Anna-Carin Lundell, Inger Nordström, Kerstin Andersson et al.     B cell activating factor (BAFF) is a critical cytokine for maturation of immature B cells. In murine lymph nodes, BAFF is mainly produced by podoplanin-expressing stromal cells. …             Cigarette smoke extract profoundly suppresses TNFα-mediated proinflammatory gene expression through upregulation of ATF3 in human coronary artery endothelial cells ▶     Jack E. Teasdale, Georgina G. J. Hazell, Alasdair M. G. Peachey et al.     Endothelial dysfunction caused by the combined action of disturbed flow, inflammatory mediators and oxidants derived from cigarette smoke is known to promote coronary …             Isolation of cell type-specific apoptotic bodies by fluorescence-activated cell sorting ▶     Georgia K. Atkin-Smith, Stephanie Paone, Damien J. Zanker et al.     Apoptotic bodies (ApoBDs) are membrane-bound extracellular vesicles that can mediate intercellular communication in physiological and pathological settings. By combining recently …             Comparison of sputum microbiome of legionellosis-associated patients and other pneumonia patients: indications for polybacterial infections ▶     Hila Mizrahi, Avi Peretz, René Lesnik et al.     Bacteria of the genus Legionella cause water-based infections resulting in severe pneumonia. Here we analyze and compare the bacterial microbiome of sputum samples from pneumonia …             Mapping Post-Glacial expansions: The Peopling of Southwest Asia ▶     Daniel E. Platt, Marc Haber, Magda Bou Dagher-Kharrat et al.     Archaeological, palaeontological and geological evidence shows that post-glacial warming released human populations from their various climate-bound refugia. Yet specific …             A late-lineage murine neutrophil precursor population exhibits dynamic changes during demand-adapted granulopoiesis ▶     Min-Hyeok Kim, Dongchan Yang, Mirang Kim et al.     Homeostasis of neutrophils—the blood cells that respond first to infection and tissue injury—is critical for the regulation of immune responses and regulated through …             4,3-α-Glucanotransferase, a novel reaction specificity in glycoside hydrolase family 70 and clan GH-H ▶     Joana Gangoiti, Sander S. van Leeuwen, Gerrit J. Gerwig et al.     Lactic acid bacteria possess a diversity of glucansucrase (GS) enzymes that belong to glycoside hydrolase family 70 (GH70) and convert sucrose into α-glucan polysaccharides with …             Neuronal apoptosis inhibitory protein (NAIP) localizes to the cytokinetic machinery during cell division ▶     Francisco Abadía-Molina, Virginia Morón-Calvente, Stephen D. Baird et al.     The neuronal apoptosis inhibitory protein (NAIP) is a constituent of the inflammasome and a key component of the innate immune system. Here we use immunofluorescence to position …             Transcriptome profiles reveal gene regulation of peanut (Arachis hypogaea L.) nodulation ▶     Ze Peng, Fengxia Liu, Liping Wang et al.     The molecular mechanisms of symbiosis in cultivated peanut with a ‘crack entry’ infection process are largely understudied. In this study, we investigated the root …             Insights into the Mechanistic Basis of Plasmid-Mediated Colistin Resistance from Crystal Structures of the Catalytic Domain of MCR-1 ▶     Philip Hinchliffe, Qiu E. Yang, Edward Portal et al.     The polymixin colistin is a “last line” antibiotic against extensively-resistant Gram-negative bacteria. Recently, the mcr-1 gene was identified as a plasmid-mediated resistance …             Prediction of N-Methyl-D-Aspartate Receptor GluN1-Ligand Binding Affinity by a Novel SVM-Pose/SVM-Score Combinatorial Ensemble Docking Scheme ▶     Max K. Leong, Ren-Guei Syu, Yi-Lung Ding et al.     The glycine-binding site of the N-methyl-D-aspartate receptor (NMDAR) subunit GluN1 is a potential pharmacological target for neurodegenerative disorders. A novel combinatorial …             A Markov State-based Quantitative Kinetic Model of Sodium Release from the Dopamine Transporter ▶     Asghar M. Razavi, George Khelashvili, Harel Weinstein     The dopamine transporter (DAT) belongs to the neurotransmitter:sodium symporter (NSS) family of membrane proteins that are responsible for reuptake of neurotransmitters from the …             TRIM14 is a Putative Tumor Suppressor and Regulator of Innate Immune Response in Non-Small Cell Lung Cancer ▶     Josephine Hai, Chang-Qi Zhu, Tao Wang et al.     Non-small-cell lung carcinoma (NSCLC) accounts for 85% of malignant lung tumors and is the leading cause of cancer deaths. Our group previously identified Tripartite Motif 14 (…             Dysregulation of WTI (−KTS) is Associated with the Kidney-Specific Effects of the LMX1B R246Q Mutation ▶     Gentzon Hall, Brandon Lane, Megan Chryst-Ladd et al.     Mutations in the LIM homeobox transcription factor 1-beta (LMX1B) are a cause of nail patellar syndrome, a condition characterized by skeletal changes, glaucoma and focal …             Biotic and abiotic factors investigated in two Drosophila species – evidence of both negative and positive effects of interactions on performance ▶     Michael Ørsted, Mads Fristrup Schou, Torsten Nygaard Kristensen     Multiple environmental factors acting in concert can interact and strongly influence population fitness and ecosystem composition. Studies investigating interactions usually …             A simple and rapid flow cytometry-based assay to identify a competent embryo prior to embryo transfer ▶     Eva Pallinger, Zoltan Bognar, Jozsef Bodis et al.     Multiple pregnancy is a risk for prematurity and preterm birth. The goal of assisted reproduction is to achieve a single pregnancy, by transferring a single embryo. This requires …             A novel role for the DNA repair gene Rad51 in Netrin-1 signalling ▶     K. A. Glendining, D. Markie, R. J. M. Gardner et al.     Mutations in RAD51 have recently been linked to human Congenital Mirror Movements (CMM), a developmental disorder of the motor system. The only gene previously linked to CMM …             Phosphoproteomic comparison of Pik3ca and Pten signalling identifies the nucleotidase NT5C as a novel AKT substrate ▶     Larissa S. Moniz, Silvia Surinova, Essam Ghazaly et al.     To identify novel effectors and processes regulated by PI3K pathway activation, we performed an unbiased phosphoproteomic screen comparing two common events of PI3K deregulation …             Establishment of an accurate and fast detection method using molecular beacons in loop-mediated isothermal amplification assay ▶     Wei Liu, Simo Huang, Ningwei Liu et al.     This study established a constant-temperature fluorescence quantitative detection method, combining loop-mediated isothermal amplification (LAMP) with molecular beacons. The …             Meprin β contributes to collagen deposition in lung fibrosis ▶     V. Biasin, M. Wygrecka, L. M. Marsh et al.     Lung fibrosis is a severe disease characterized by epithelial cell injury, inflammation and collagen deposition. The metalloproteases meprinα and meprinβ have been shown to …             Pseudorabies virus infection inhibits autophagy in permissive cells in vitro ▶     Mingxia Sun, Linlin Hou, Yan-dong Tang et al.     A large number of studies have demonstrated that autophagy is involved in the infection processes of different pathogens. Autophagy is now recognized as an essential component of …             The molecular sensory machinery of a Chagas disease vector: expression changes through imaginal moult and sexually dimorphic features ▶     Jose Manuel Latorre-Estivalis, Hugh M. Robertson, Kimberly K. O. Walden et al.     The triatomine bug Rhodnius prolixus is a main vector of Chagas disease, which affects several million people, mostly in Latin-America. Host searching, pheromone communication, …             Atypical developmental trajectory of local spontaneous brain activity in autism spectrum disorder ▶     Xiaonan Guo, Heng Chen, Zhiliang Long et al.     Autism spectrum disorder (ASD) is marked by atypical trajectory of brain maturation, yet the developmental abnormalities in brain function remain unclear. The current study …             Synthesis and insecticidal activity of acridone derivatives to Aedes aegypti and Culex quinquefasciatus larvae and non-target aquatic species ▶     Selvaraj Mohana Roopan, Annadurai Bharathi, Naif Abdullah Al-Dhabi et al.     A serious Mosquito borne yellow fever is one of the grave diseases which affect the major population. Since there is no specific treatment for yellow fever, there is a necessity …             An Integrated Miniature Bioprocessing for Personalized Human Induced Pluripotent Stem Cell Expansion and Differentiation into Neural Stem Cells ▶     Haishuang Lin, Qiang Li, Yuguo Lei     Human induced pluripotent stem cells (iPSCs) are ideal cell sources for personalized cell therapies since they can be expanded to generate large numbers of cells and …             Identification of a novel missense mutation of MIP in a Chinese family with congenital cataracts by target region capture sequencing ▶     Bo Jiang, Yanhua chen, Baisheng Xu et al.     Congenital cataract is both clinically diverse and genetically heterogeneous. To investigate the underlying genetic defect in three-generations of a Chinese family with autosomal …             ABCG2-overexpressing H460/MX20 cell xenografts in athymic nude mice maintained original biochemical and cytological characteristics ▶     Wei Zhang, Zhen Chen, Likun Chen et al.     H460/MX20 are derived from large cell lung cancer H460 cell line and then transformed into ABCG2-overexpressing cells by mitoxantrone’s induction, which are widely used in study …             Obtaining control of cell surface functionalizations via Pre-targeting and Supramolecular host guest interactions ▶     Mark T. M. Rood, Silvia J. Spa, Mick M. Welling et al.     The use of mammalian cells for therapeutic applications is finding its way into modern medicine. However, modification or “training” of cells to make them suitable for a specific …             Labeling and in vivo visualization of transplanted adipose tissue-derived stem cells with safe cadmium-free aqueous ZnS coating of ZnS-AgInS2 nanoparticles ▶     Yusuke Ogihara, Hiroshi Yukawa, Tatsuya Kameyama et al.     The facile synthesis of ZnS-AgInS2 (ZAIS) as cadmium-free QDs and their application, mainly in solar cells, has been reported by our groups. In the present study, we investigated …             Genome-wide association study identifies COL2A1 locus involved in the hand development failure of Kashin-Beck disease ▶     Jingcan Hao, Wenyu Wang, Yan Wen et al.     Kashin-Beck disease (KBD) is a chronic osteochondropathy. The pathogenesis of growth and development failure of hand of KBD remains elusive now. In this study, we conducted a …             Enhancement of mosquito trapping efficiency by using pulse width modulated light emitting diodes ▶     Yu-Nan Liu, Yu-Jen Liu, Yi-Chian Chen et al.     In this study, a light-driving bug zapper is presented for well controlling the diseases brought by insects, such as mosquitoes. In order to have the device efficient to trap the …             Online games: a novel approach to explore how partial information influences human random searches ▶     Ricardo Martínez-García, Justin M. Calabrese, Cristóbal López     Many natural processes rely on optimizing the success ratio of a search process. We use an experimental setup consisting of a simple online game in which players have to find a …             Decreased empathy response to other people’s pain in bipolar disorder: evidence from an event-related potential study ▶     Jingyue Yang, Xinglong Hu, Xiaosi Li et al.     Bipolar disorder (BD) patients often demonstrate poor socialization that may stem from a lower capacity for empathy. We examined the associated neurophysiological abnormalities …             SHG-specificity of cellular Rootletin filaments enables naïve imaging with universal conservation ▶     Toshihiro Akiyama, Akihito Inoko, Yuichi Kaji et al.     Despite growing demand for truly naïve imaging, label-free observation of cilium-related structure remains challenging, and validation of the pertinent molecules is …             Splicing imbalances in basal-like breast cancer underpin perturbation of cell surface and oncogenic pathways and are associated with patients’ survival ▶     Filipe Gracio, Brian Burford, Patrycja Gazinska et al.     Despite advancements in the use of transcriptional information to understand and classify breast cancers, the contribution of splicing to the establishment and progression of …             Functional constraints on adaptive evolution of protein ubiquitination sites ▶     Liang Lu, Yang Li, Zhongyang Liu et al.     It is still unclear whether there exist functional constraints on the evolution of protein ubiquitination sites, because most previous studies regarded all protein ubiquitination …             Osseous differentiation of human fat tissue grafts: From tissue engineering to tissue differentiation ▶     Maryna Bondarava, Chiara Cattaneo, Bin Ren et al.     Conventional bone tissue engineering approaches require isolation and in vitro propagation of autologous cells, followed by seeding on a variety of scaffolds. Those protracted …             Alerted default mode: functional connectivity changes in the aftermath of social stress ▶     Benjamin Clemens, Lisa Wagels, Magdalena Bauchmüller et al.     Stress affects the brain at a network level: the salience network is supposedly upregulated, while at the same time the executive control network is downregulated. While …             Ameloblastin induces tumor suppressive phenotype and enhances chemosensitivity to doxorubicin via Src-Stat3 inactivation in osteosarcoma ▶     Toshinori Ando, Yasusei Kudo, Shinji Iizuka et al.     Ameloblastin (AMBN), the most abundant non-amelogenin enamel matrix protein, plays a role in ameloblast differentiation. Previously, we found that AMBN promoted osteogenic …             Jawbone microenvironment promotes periodontium regeneration by regulating the function of periodontal ligament stem cells ▶     Bin Zhu, Wenjia Liu, Yihan Liu et al.     During tooth development, the jawbone interacts with dental germ and provides the development microenvironment. Jawbone-derived mesenchymal stem cells (JBMSCs) maintain this …             Joint QTL mapping and gene expression analysis identify positional candidate genes influencing pork quality traits ▶     Rayner González-Prendes, Raquel Quintanilla, Angela Cánovas et al.     Meat quality traits have an increasing importance in the pig industry because of their strong impact on consumer acceptance. Herewith, we have combined phenotypic and microarray …             Identification of a Drug Targeting an Intrinsically Disordered Protein Involved in Pancreatic Adenocarcinoma ▶     José L. Neira, Jennifer Bintz, María Arruebo et al.     Intrinsically disordered proteins (IDPs) are prevalent in eukaryotes, performing signaling and regulatory functions. Often associated with human diseases, they constitute …             The combined effects of sediment accretion (burial) and nutrient enrichment on the growth and propagation of Phalaris arundinacea ▶     Xinsheng Chen, Yulin Liao, Yonghong Xie et al.     Sediment accretion (burial) and nutrient enrichment occur concurrently in lacustrine wetlands, but the role of these two aspects of sedimentation on macrophyte performance has …             The emergent role of small-bodied herbivores in pre-empting phase shifts on degraded coral reefs ▶     Caitlin D. Kuempel, Andrew H. Altieri     Natural and anthropogenic stressors can cause phase shifts from coral-dominated to algal-dominated states. In the Caribbean, over-fishing of large herbivorous fish and disease …             OsBT1 encodes an ADP-glucose transporter involved in starch synthesis and compound granule formation in rice endosperm ▶     Sanfeng Li, Xiangjin Wei, Yulong Ren et al.     Starch is the main storage carbohydrate in higher plants. Although several enzymes and regulators for starch biosynthesis have been characterized, a complete regulatory network …             An analysis of disease-gene relationship from Medline abstracts by DigSee ▶     Jeongkyun Kim, Jung-jae Kim, Hyunju Lee     Diseases are developed by abnormal behavior of genes in biological events such as gene regulation, mutation, phosphorylation, and epigenetics and post-translational modification. …             Ultra-sensitive detection of kanamycin for food safety using a reduced graphene oxide-based fluorescent aptasensor ▶     Na-Reum Ha, In-Pil Jung, Im-Joung La et al.     Overuse of antibiotics has caused serious problems, such as appearance of super bacteria, whose accumulation in the human body through the food chain is a concern. Kanamycin is a …             Within brain area tractography suggests local modularity using high resolution connectomics ▶     Peter N. Taylor, Yujiang Wang, Marcus Kaiser     Previous structural brain connectivity studies have mainly focussed on the macroscopic scale of around 1,000 or fewer brain areas (network nodes). However, it has recently been …             Kilohertz frequency nerve block enhances anti-inflammatory effects of vagus nerve stimulation ▶     Yogi A. Patel, Tarun Saxena, Ravi V. Bellamkonda et al.     Efferent activation of the cervical vagus nerve (cVN) dampens systemic inflammatory processes, potentially modulating a wide-range of inflammatory pathological conditions. In …             Rapid Recall Ability of Memory T cells is Encoded in their Epigenome ▶     Artem Barski, Suresh Cuddapah, Andrey V. Kartashov et al.     Even though T-cell receptor (TCR) stimulation together with co-stimulation is sufficient for the activation of both naïve and memory T cells, the memory cells are capable of …             Method for Removing Spectral Contaminants to Improve Analysis of Raman Imaging Data ▶     Xun Zhang, Sheng Chen, Zhe Ling et al.     The spectral contaminants are inevitable during micro-Raman measurements. A key challenge is how to remove them from the original imaging data, since they can distort further …             Using the “target constituent removal combined with bioactivity assay” strategy to investigate the optimum arecoline content in charred areca nut ▶     Wei Peng, Yu-Jie Liu, Mei-Bian Hu et al.     Charred areca nut (CAN) is used to treat dyspepsia and abdominal distension in children. However, reports revealed that arecoline, the most important active constituent of CAN, …             Associations among executive function, cardiorespiratory fitness, and brain network properties in older adults ▶     Toshikazu Kawagoe, Keiichi Onoda, Shuhei Yamaguchi     Aging is associated with deterioration in a number of cognitive functions. Previous reports have demonstrated the beneficial effect of physical fitness on cognitive function, …             JNK activation is essential for activation of MEK/ERK signaling in IL-1β-induced COX-2 expression in synovial fibroblasts ▶     Taku Kitanaka, Rei Nakano, Nanako Kitanaka et al.     The proinflammatory cytokine interleukin 1β (IL-1β) induces prostaglandin E2 (PGE2) production via upregulation of cyclooxygenase-2 (COX-2) expression in synovial fibroblasts. …             High Shear Stresses under Exercise Condition Destroy Circulating Tumor Cells in a Microfluidic System ▶     Sagar Regmi, Afu Fu, Kathy Qian Luo     Circulating tumor cells (CTCs) are the primary targets of cancer treatment as they cause distal metastasis. However, how CTCs response to exercise-induced high shear stress is …             HBx promotes cell proliferation by disturbing the cross-talk between miR-181a and PTEN ▶     Yi Tian, Xinqiang Xiao, Xing Gong et al.     Hepatitis B virus X protein (HBx) is involved in the initiation and progression of hepatocellular carcinoma (HCC). However, the mechanism is still needed to be elucidated. In …             Evaluation of 10-Nitro Oleic Acid Bio-Elimination in Rats and Humans ▶     Sonia R. Salvatore, Dario A. Vitturi, Marco Fazzari et al.     Nitrated fatty acids are endogenously present in human and animal tissues, as well as in plant-derived oils. In particular, 10-nitro oleic acid (10-NO2-OA) potently induces …             Overproduction of superoxide dismutase and catalase confers cassava resistance to Tetranychus cinnabarinus ▶     Fuping Lu, Xiao Liang, Hui Lu et al.     To explore the role of protective enzymes in cassava (Manihot esculenta Crantz) resistance to mites, transgenic cassava lines overproducing copper/zinc superoxide dismutase (…             Effect of dietary Astragalus Polysaccharide supplements on testicular miRNA expression profiles and enzymatic changes of breeder cocks ▶     Shengru Wu, Xiaochun Ren, Yulong Li et al.     Astragalus Polysaccharide (APS) is an important feed additive due to its immunomodulatory functions. Previous studies have proven that miRNAs play important roles in …             Structure of the acetophenone carboxylase core complex: prototype of a new class of ATP-dependent carboxylases/hydrolases ▶     Sina Weidenweber, Karola Schühle, Ulrike Demmer et al.     Degradation of the aromatic ketone acetophenone is initiated by its carboxylation to benzoylacetate catalyzed by acetophenone carboxylase (Apc) in a reaction dependent on the …             Rapamycin Prolongs the Survival of Corneal Epithelial Cells in Culture ▶     Sanaz Gidfar, Farnoud Y. Milani, Behrad Y. Milani et al.     Rapamycin has previously been shown to have anti-aging effects in cells and organisms. These studies were undertaken to investigate the effects of rapamycin on primary human …             The development of support intuitions and object causality in juvenile Eurasian jays (Garrulus glandarius) ▶     Gabrielle Davidson, Rachael Miller, Elsa Loissel et al.     Knowledge about the causal relationship between objects has been studied extensively in human infants, and more recently in adult animals using differential looking time …             Goal attribution to inanimate moving objects by Japanese macaques (Macaca fuscata) ▶     Takeshi Atsumi, Hiroki Koda, Nobuo Masataka     Humans interpret others’ goals based on motion information, and this capacity contributes to our mental reasoning. The present study sought to determine whether Japanese macaques …             Network-Based Approach to Identify Potential Targets and Drugs that Promote Neuroprotection and Neurorepair in Acute Ischemic Stroke ▶     Yiwei Wang, Hailong Liu, Yongzhong Lin et al.     Acute ischemic stroke (AIS) accounts for more than 80% of the approximately 610,000 new stroke cases worldwide every year. Both ischemia and reperfusion can cause death, damage, …             Erratum: Neuroprotective pentapeptide CN-105 improves functional and histological outcomes in a murine model of intracerebral hemorrhage ▶     Beilei Lei, Michael L. James, Ji Liu et al.                 Functional analysis of the ABCs of eye color in Helicoverpa armigera with CRISPR/Cas9-induced mutations ▶     Sher Afzal Khan, Michael Reichelt, David G. Heckel     Many insect pigments are localized in subcellular pigment granules, and transport of pigment precursors from the cytoplasm is accomplished by ABC proteins. Drosophila melanogaster…             Comparative Transcriptome Profiles of Human Blood in Response to the Toll-like Receptor 4 Ligands Lipopolysaccharide and Monophosphoryl Lipid A ▶     Liming Luan, Naeem K. Patil, Yin Guo et al.     Monophosphoryl lipid A (MPLA), a less toxic derivative of lipopolysaccharide (LPS), is employed as a vaccine adjuvant and is under investigation as a non-specific …             Antimicrobial and anti-inflammatory activities of three chensinin-1 peptides containing mutation of glycine and histidine residues ▶     Weibing Dong, Xiaoman Mao, Yue Guan et al.     The natural peptide chensinin-1 doesnot exhibit its desired biological properties. In this study, the mutant MC1-1 was designed by replacing Gly in the chensinin-1 sequence with …             Common Variable Immunodeficiency patients with a phenotypic profile of immunosenescence present with thrombocytopenia ▶     Jan Stuchlý, Veronika Kanderová, Marcela Vlková et al.     Common variable immunodeficiency (CVID) is a heterogeneous group of diseases. Our aim was to define sub-groups of CVID patients with similar phenotypes and clinical …             Identification of Guanosine 5′-diphosphate as Potential Iron Mobilizer: Preventing the Hepcidin-Ferroportin Interaction and Modulating the Interleukin-6/Stat-3 Pathway ▶     Stanzin Angmo, Neha Tripathi, Sheenu Abbat et al.     Hepcidin, a peptide hormone, is a key regulator in mammalian iron homeostasis. Increased level of hepcidin due to inflammatory conditions stimulates the ferroportin (FPN) …             Cyclooxygenase-2 regulates TGFβ-induced cancer stemness in triple-negative breast cancer ▶     Jun Tian, Mahmood Y. Hachim, Ibrahim Y. Hachim et al.     Triple negative breast cancer (TNBC), an aggressive subtype of breast cancer, display poor prognosis and exhibit resistance to conventional therapies, partly due to an enrichment …             The long non-coding RNA NEAT1 is responsive to neuronal activity and is associated with hyperexcitability states ▶     Guy Barry, James A. Briggs, Do Won Hwang et al.     Despite their abundance, the molecular functions of long non-coding RNAs in mammalian nervous systems remain poorly understood. Here we show that the long non-coding RNA, NEAT1, …             Hepatic MiR-291b-3p Mediated Glucose Metabolism by Directly Targeting p65 to Upregulate PTEN Expression ▶     Jun Guo, Lin Dou, Xiangyu Meng et al.     Several studies have suggested an important role of miR-291b-3p in the development of embryonic stem cells. In previous study, we found that the expression of miR-291b-3p was …             Yersinia pestis halotolerance illuminates plague reservoirs ▶     Maliya Alia Malek, Idir Bitam, Anthony Levasseur et al.     The plague agent Yersinia pestis persists for years in the soil. Two millennia after swiping over Europe and North Africa, plague established permanent foci in North Africa but …             Inefficient co-feeding transmission of Borrelia afzelii in two common European songbirds ▶     Dieter J. A. Heylen, Hein Sprong, Aleksandra Krawczyk et al.     The spirochete bacterium Borrelia afzelii is the most common cause of Lyme borreliosis in Europe. This tick-borne pathogen can establish systemic infections in rodents but not in …             Characterization of a model of systemic inflammation in humans in vivo elicited by continuous infusion of endotoxin ▶     D. Kiers, R. M. Koch, L. Hamers et al.     Investigating the systemic inflammatory response in patients with critical illness such as sepsis, trauma and burns is complicated due to uncertainties about the onset, duration …             Phosphorylation impact on Spleen Tyrosine kinase conformation by Surface Enhanced Raman Spectroscopy ▶     Maximilien Cottat, Ryohei Yasukuni, Yo Homma et al.     Spleen Tyrosine Kinase (Syk) plays a crucial role in immune cell signalling and its altered expression or activation are involved in several cancers. Syk activity relies on its …             Nanosecond Pulsed Electric Fields Enhance the Anti-tumour Effects of the mTOR Inhibitor Everolimus against Melanoma ▶     Jie Dai, Shan Wu, Yan Kong et al.     The PI3K/mTOR/AKT pathway is activated in most melanomas, but mTOR inhibitors used singly have limited activity against advanced melanomas. The application of nanosecond pulsed …             Atomic scale chemical tomography of human bone ▶     Brian Langelier, Xiaoyue Wang, Kathryn Grandfield     Human bone is a complex hierarchical material. Understanding bone structure and its corresponding composition at the nanometer scale is critical for elucidating mechanisms of …             Disaggregation of Amylin Aggregate by Novel Conformationally Restricted Aminobenzoic Acid containing α/β and α/γ Hybrid Peptidomimetics ▶     Ashim Paul, Sourav Kalita, Sujan Kalita et al.     Diabetes has emerged as a threat to the current world. More than ninety five per cent of all the diabetic population has type 2 diabetes mellitus (T2DM). Aggregates of Amylin …             Niclosamide reduces glucagon sensitivity via hepatic PKA inhibition in obese mice: Implications for glucose metabolism improvements in type 2 diabetes ▶     Md. Kamrul Hasan Chowdhury, Nigel Turner, Nicholas L. Bentley et al.     Type 2 diabetes (T2D) is a global pandemic. Currently, the drugs used to treat T2D improve hyperglycemic symptom of the disease but the underlying mechanism causing the high …             Comparison of the Pharmacological Profiles of Selective PDE4B and PDE4D Inhibitors in the Central Nervous System ▶     Chong Zhang, Ying Xu, Han-Ting Zhang et al.     Inhibition of cyclic AMP (cAMP)-specific phosphodiesterase 4 (PDE4) has been proposed as a potential treatment for a series of neuropsychological conditions such as depression, …             Natriuretic peptide type C induces sperm attraction for fertilization in mouse ▶     Nana Kong, Xiaoting Xu, Yu Zhang et al.     Mammalian spermatozoa undergo selective movement along the isthmus of the oviduct to the ampulla during ovulation, which is a prerequisite for fertilization. The factor(s) that …             Evaluation of left pulmonary artery sling, associated cardiovascular anomalies, and surgical outcomes using cardiovascular computed tomography angiography ▶     Jiajun Xie, Yu-Hsiang Juan, Qiushi Wang et al.     We evaluated the prevalence, image appearance, associated cardiovascular anomalies, and surgical outcomes of left pulmonary artery sling (LPAS) using cardiovascular computed …             Quorum-quenching limits quorum-sensing exploitation by signal-negative invaders ▶     Mélanie Tannières, Julien Lang, Claudie Barnier et al.     Some bacteria produce and perceive quorum-sensing (QS) signals that coordinate several behaviours, including the costly processes that are exoenzyme production and plasmid …             Aminophylline suppresses stress-induced visceral hypersensitivity and defecation in irritable bowel syndrome ▶     Teita Asano, Ken-ichiro Tanaka, Arisa Tada et al.     Pharmacological therapy for irritable bowel syndrome (IBS) has not been established. In order to find candidate drugs for IBS with diarrhea (IBS-D), we screened a compound …             A sensitive three monoclonal antibodies based automatic latex particle-enhanced turbidimetric immunoassay for Golgi protein 73 detection ▶     Yanyan Xia, Han Shen, Yefei Zhu et al.     Golgi protein 73 (GP73) is a novel and potential marker for diagnosing hepatocellular carcinoma (HCC) that has been found to be abnormally elevated in liver disease. A latex …             Simultaneous high-speed imaging and optogenetic inhibition in the intact mouse brain ▶     Serena Bovetti, Claudio Moretti, Stefano Zucca et al.     Genetically encoded calcium indicators and optogenetic actuators can report and manipulate the activity of specific neuronal populations. However, applying imaging and …             PaPrBaG: A machine learning approach for the detection of novel pathogens from NGS data ▶     Carlus Deneke, Robert Rentzsch, Bernhard Y. Renard     The reliable detection of novel bacterial pathogens from next-generation sequencing data is a key challenge for microbial diagnostics. Current computational tools usually rely on …             ITS non-concerted evolution and rampant hybridization in the legume genus Lespedeza (Fabaceae) ▶     Bo Xu, Xiao-Mao Zeng, Xin-Fen Gao et al.     The internal transcribed spacer (ITS) as one part of nuclear ribosomal DNA is one of the most extensively sequenced molecular markers in plant systematics. The ITS repeats …             Metabolic pathway for a new strain Pseudomonas synxantha LSH-7′: from chemotaxis to uptake of n-hexadecane ▶     Long Meng, Haoshuai Li, Mutai Bao et al.     Bacteria can use n-hexadecane as a carbon source, but it remains incompletely understood whether n-hexadecane is transformed into metabolic intermediates prior to cellular uptake …             Agouti Related Peptide Secreted Via Human Mesenchymal Stem Cells Upregulates Proteasome Activity in an Alzheimer’s Disease Model ▶     Na Kyung Lee, Sang Eon Park, Soo Jin Kwon et al.     The activity of the ubiquitin proteasome system (UPS) is downregulated in aggregation diseases such as Alzheimer’s disease (AD). In this study, we investigated the therapeutic …             Sequence specific sorting of DNA molecules with FACS using 3dPCR ▶     David J. Sukovich, Shea T. Lance, Adam R. Abate     Genetic heterogeneity is an important feature of many biological systems, but introduces technical challenges to their characterization. Even with the best modern instruments, …             Nesting of colon and ovarian cancer cells in the endothelial niche is associated with alterations in glycan and lipid metabolism ▶     Anna Halama, Bella S. Guerrouahen, Jennifer Pasquier et al.     The metabolic phenotype of a cancer cell is determined by its genetic makeup and microenvironment, which dynamically modulates the tumor landscape. The endothelial cells provide …             Erratum: IL-33 Contributes to Schistosoma japonicum-induced Hepatic Pathology through Induction of M2 Macrophages ▶     Hui Peng, Qixian Zhang, Xiaojuan Li et al.                 A four-compartment PBPK heart model accounting for cardiac metabolism - model development and application ▶     Zofia Tylutki, Sebastian Polak     In the field of cardiac drug efficacy and safety assessment, information on drug concentration in heart tissue is desirable. Because measuring drug concentrations in human …             Tissue Microarray Analysis Applied to Bone Diagenesis ▶     Rafael Barrios Mello, Maria Regina Regis Silva, Maria Teresa Seixas Alves et al.     Taphonomic processes affecting bone post mortem are important in forensic, archaeological and palaeontological investigations. In this study, the application of tissue microarray …             Ingroup/outgroup membership modulates fairness consideration: neural signatures from ERPs and EEG oscillations ▶     Yiwen Wang, Zhen Zhang, Liying Bai et al.     Previous studies have shown that ingroup/outgroup membership influences individual’s fairness considerations. However, it is not clear yet how group membership influences brain …             The metastasis suppressor RARRES3 as an endogenous inhibitor of the immunoproteasome expression in breast cancer cells ▶     Alison M. Anderson, Murugan Kalimutho, Sarah Harten et al.     In breast cancer metastasis, the dynamic continuum involving pro- and anti-inflammatory regulators can become compromised. Over 600 genes have been implicated in metastasis to …             Protein serine/threonine phosphatase PPEF-1 suppresses genotoxic stress response via dephosphorylation of PDCD5 ▶     Soo-Yeon Park, Jaesung Seo, Hyo-Kyoung Choi et al.     Programmed cell death 5 (PDCD5) is believed to play a crucial role in p53 activation; however, the underlying mechanism of how PDCD5 function is regulated during apoptosis …             Corrigendum: Unique Features of Ethnic Mongolian Gut Microbiome revealed by metagenomic analysis ▶     Wenjun Liu, Jiachao Zhang, Chunyan Wu et al.                 Transgenerational epimutations induced by multi-generation drought imposition mediate rice plant’s adaptation to drought condition ▶     Xiaoguo Zheng, Liang Chen, Hui Xia et al.     Epigenetic mechanisms are crucial mediators of appropriate plant reactions to adverse environments, but their involvement in long-term adaptation is less clear. Here, we …             Progressive induction of hepatocyte progenitor cells in chronically injured liver ▶     Naoki Tanimizu, Norihisa Ichinohe, Masahiro Yamamoto et al.     Differentiated epithelial cells show substantial lineage plasticity upon severe tissue injuries. In chronically injured mouse livers, part of hepatocytes become Sry-HMG box …             Microbial taxa and functional genes shift in degraded soil with bacterial wilt ▶     Hongchun Zhang, Rui Wang, Shu Chen et al.     Soil degradation is a serious global problem, but little is known about how soil microbial communities respond to soil degradation as well as their feedback to ecosystem …             Metal transport protein 8 in Camellia sinensis confers superior manganese tolerance when expressed in yeast and Arabidopsis thaliana ▶     Qinghui Li, Yue Li, Xiayuan Wu et al.     Manganese (Mn) is an important micronutrient element required for plant growth and development, playing catalytic roles in enzymes, membranes and DNA replication. The tea plant (…             Prior knowledge is essential for the beneficial effect of targeted memory reactivation during sleep ▶     Sabine Groch, Thomas Schreiner, Björn Rasch et al.     Prior knowledge speeds up system consolidation and accelerates integration of newly acquired memories into existing neocortical knowledge networks. By using targeted memory …             Population cycles and species diversity in dynamic Kill-the-Winner model of microbial ecosystems ▶     Sergei Maslov, Kim Sneppen     Determinants of species diversity in microbial ecosystems remain poorly understood. Bacteriophages are believed to increase the diversity by the virtue of Kill-the-Winner …             Determining the migration duration of rice leaf folder (Cnaphalocrocis medinalis (Guenée)) moths using a trajectory analytical approach ▶     Feng-Ying Wang, Fan Yang, Ming-Hong Lu et al.     Many moths finish their long distance migration after consecutive nights, but little is known about migration duration and distance. This information is key to predicting …             Pigmentation plasticity enhances crypsis in larval newts: associated metabolic cost and background choice behaviour ▶     Nuria Polo-Cavia, Ivan Gomez-Mestre     In heterogeneous environments, the capacity for colour change can be a valuable adaptation enhancing crypsis against predators. Alternatively, organisms might achieve concealment …             Characterization of globulin storage proteins of a low prolamin cereal species in relation to celiac disease ▶     Gyöngyvér Gell, Krisztina Kovács, Gábor Veres et al.     Brachypodium distachyon, a small annual grass with seed storage globulins as primary protein reserves was used in our study to analyse the toxic nature of non-prolamin seed …             Intercalative DNA binding of the marine anticancer drug variolin B ▶     Albert Canals, Raquel Arribas-Bosacoma, Fernando Albericio et al.     Variolin B is a rare marine alkaloid that showed promising anti-cancer activity soon after its isolation. It acts as a cyclin-dependent kinase inhibitor, although the precise …             HIV-1 Env associates with HLA-C free-chains at the cell membrane modulating viral infectivity ▶     Michela Serena, Francesca Parolini, Priscilla Biswas et al.     HLA-C has been demonstrated to associate with HIV-1 envelope glycoprotein (Env). Virions lacking HLA-C have reduced infectivity and increased susceptibility to neutralizing …             Production of itaconate by whole-cell bioconversion of citrate mediated by expression of multiple cis-aconitate decarboxylase (cadA) genes in Escherichia coli ▶     Junyoung Kim, Hyung-Min Seo, Shashi Kant Bhatia et al.     Itaconate, a C5 unsaturated dicarboxylic acid, is an important chemical building block that is used in manufacturing high-value products, such as latex and superabsorbent …             Mechanisms of Yersinia YopO kinase substrate specificity ▶     Wei Lin Lee, Pavithra Singaravelu, Sheena Wee et al.     Yersinia bacteria cause a range of human diseases, including yersiniosis, Far East scarlet-like fever and the plague. Yersiniae modulate and evade host immune defences through …             Optical High Content Nanoscopy of Epigenetic Marks Decodes Phenotypic Divergence in Stem Cells ▶     Joseph J. Kim, Neal K. Bennett, Mitchel S. Devita et al.     While distinct stem cell phenotypes follow global changes in chromatin marks, single-cell chromatin technologies are unable to resolve or predict stem cell fates. We propose the …             The larvicide pyriproxyfen blamed during the Zika virus outbreak does not cause microcephaly in zebrafish embryos ▶     Stefania Dzieciolowska, Anne-Laure Larroque, Elizabeth-Ann Kranjec et al.     Although the zika virus (ZIKV) has now been strongly correlated with emerging cases of microcephaly in the Americas, suspicions have been raised regarding the use of …             High-Quality Metal–Organic Framework ZIF-8 Membrane Supported on Electrodeposited ZnO/2-methylimidazole Nanocomposite: Efficient Adsorbent for the Enrichment of Acidic Drugs ▶     Mian Wu, Huili Ye, Faqiong Zhao et al.     Metal–organic framework (MOF) membranes have received increasing attention as adsorbents, yet the defects in most membrane structures greatly thwart their capacity performance. …             The hypoparathyroidism-associated mutation in Drosophila Gcm compromises protein stability and glial cell formation ▶     Xiao Xi, Lu Lu, Chun-Chun Zhuge et al.     Differentiated neurons and glia are acquired from immature precursors via transcriptional controls exerted by factors such as proteins in the family of Glial Cells Missing (Gcm). …             Ndfip1 restricts Th17 cell potency by limiting lineage stability and proinflammatory cytokine production ▶     Awo Akosua Kesewa Layman, Stephanie L. Sprout, Dylan Phillips et al.     While Th17 cells can protect against colonization by pathogenic organisms, they also have the potential to become pathogenic and promote autoimmune and inflammatory diseases. …             A Light-Responsive Self-Assembly Formed by a Cationic Azobenzene Derivative and SDS as a Drug Delivery System ▶     Shengyong Geng, Yuzhu Wang, Liping Wang et al.     The structure of a self-assembly formed from a cationic azobenzene derivative, 4-cholesterocarbonyl-4′-(N,N,N-triethylamine butyloxyl bromide) azobenzene (CAB) and surfactant …             Modification of Monolignol Biosynthetic Pathway in Jute: Different Gene, Different Consequence ▶     Farhana Shafrin, Ahlan Sabah Ferdous, Suprovath Kumar Sarkar et al.     Lignin, a cross-linked macromolecule of hydrophobic aromatic structure, provides additional rigidity to a plant cell wall. Although it is an integral part of the plant cell, …             Arabidopsis CBF3 and DELLAs positively regulate each other in response to low temperature ▶     Mingqi Zhou, Hu Chen, Donghui Wei et al.     The C-repeat binding factor (CBF) is crucial for regulation of cold response in higher plants. In Arabidopsis, the mechanism of CBF3-caused growth retardation is still unclear. …             U24 from Roseolovirus interacts strongly with Nedd4 WW Domains ▶     Yurou Sang, Rui Zhang, Walter R. P. Scott et al.     U24 is a protein found in both roseoloviruses Human Herpes Virus type 6 and 7 (HHV-6 and HHV-7), with an N-terminus that is rich in prolines (PY motif in both HHV-6A and 7; PxxP …             A comprehensive custom panel design for routine hereditary cancer testing: preserving control, improving diagnostics and revealing a complex variation landscape ▶     Elisabeth Castellanos, Bernat Gel, Inma Rosas et al.     We wanted to implement an NGS strategy to globally analyze hereditary cancer with diagnostic quality while retaining the same degree of understanding and control we had in …             Piscidin-1-analogs with double L- and D-lysine residues exhibited different conformations in lipopolysaccharide but comparable anti-endotoxin activities ▶     Amit Kumar, Mukesh Mahajan, Bhanupriya Awasthi et al.     To become clinically effective, antimicrobial peptides (AMPs) should be non-cytotoxic to host cells. Piscidins are a group of fish-derived AMPs with potent antimicrobial and …             Metabolic profiling of root exudates from two ecotypes of Sedum alfredii treated with Pb based on GC-MS ▶     Qing Luo, Shiyu Wang, Li-na Sun et al.     Phytoremediation is an effective method to remediate Pb-contaminated soils and root exudates play an important role in this process. Based on gas chromatography-mass spectrometry …             Novel Therapeutics Identification for Fibrosis in Renal Allograft Using Integrative Informatics Approach ▶     Li Li, Ilana Greene, Benjamin Readhead et al.     Chronic allograft damage, defined by interstitial fibrosis and tubular atrophy (IF/TA), is a leading cause of allograft failure. Few effective therapeutic options are available …             Human heart valve-derived scaffold improves cardiac repair in a murine model of myocardial infarction ▶     Long Wan, Yao Chen, Zhenhua Wang et al.     Cardiac tissue engineering using biomaterials with or without combination of stem cell therapy offers a new option for repairing infarcted heart. However, the bioactivity of …             Muscle-specific deletion of BDK amplifies loss of myofibrillar protein during protein undernutrition ▶     Takuya Ishikawa, Yasuyuki Kitaura, Yoshihiro Kadota et al.     Branched-chain amino acids (BCAAs) are essential amino acids for mammals and play key roles in the regulation of protein metabolism. However, the effect of BCAA deficiency on …             Direct coupling: a possible strategy to control fruit production in alternate bearing ▶     Awadhesh Prasad, Kenshi Sakai, Yoshinobu Hoshino     We investigated the theoretical possibility of applying phenomenon of synchronization of coupled nonlinear oscillators to control alternate bearing in citrus. The alternate …             RNA synthesis is associated with multiple TBP-chromatin binding events ▶     Hussain A. Zaidi, David T. Auble, Stefan Bekiranov     Competition ChIP is an experimental method that allows transcription factor (TF) chromatin turnover dynamics to be measured across a genome. We develop and apply a physical model …             Identification of small RNAs in extracellular vesicles from the commensal yeast Malassezia sympodialis ▶     Simon Rayner, Sören Bruhn, Helen Vallhov et al.     Malassezia is the dominant fungus in the human skin mycobiome and is associated with common skin disorders including atopic eczema (AE)/dermatitis. Recently, it was found that …             Reconstruction of Rift Valley fever transmission dynamics in Madagascar: estimation of force of infection from seroprevalence surveys using Bayesian modelling ▶     Marie-Marie Olive, Vladimir Grosbois, Annelise Tran et al.     The force of infection (FOI) is one of the key parameters describing the dynamics of transmission of vector-borne diseases. Following the occurrence of two major outbreaks of …             KRAS-mutation incidence and prognostic value are metastatic site-specific in lung adenocarcinoma: poor prognosis in patients with KRAS mutation and bone metastasis ▶     Zoltan Lohinai, Thomas Klikovits, Judit Moldvay et al.     Current guidelines lack comprehensive information on the metastatic site-specific role of KRAS mutation in lung adenocarcinoma (LADC). We investigated the effect of KRAS mutation …             The histone 3 lysine 9 methyltransferase inhibitor chaetocin improves prognosis in a rat model of high salt diet-induced heart failure ▶     Tomohiko Ono, Naomi Kamimura, Tomohiro Matsuhashi et al.     Histone acetylation has been linked to cardiac hypertrophy and heart failure. However, the pathological implications of changes in histone methylation and the effects of …             Impacts of canine distemper virus infection on the giant panda population from the perspective of gut microbiota ▶     Na Zhao, Meng Li, Jing Luo et al.     The recent increase in infectious disease outbreaks has been directly linked to the global loss of biodiversity and the decline of some endangered species populations. Between …             Deep Transcriptomic Profiling of M1 Macrophages Lacking Trpc3 ▶     Sivarajan Kumarasamy, Sumeet Solanki, Oluwatomisin T. Atolagbe et al.     In previous studies using mice with macrophage-specific loss of TRPC3 we found a significant, selective effect of TRPC3 on the biology of M1, or inflammatory macrophages. Whereas …             Validation of suitable normalizers for miR expression patterns analysis covering tumour heterogeneity ▶     C. Morata-Tarifa, M. Picon-Ruiz, C. Griñan-Lison et al.     Oncogenic microRNAs (miRs) have emerged as diagnostic biomarkers and novel molecular targets for anti-cancer drug therapies. Real-time quantitative PCR (qPCR) is one of the most …             pH is the primary determinant of the bacterial community structure in agricultural soils impacted by polycyclic aromatic hydrocarbon pollution ▶     Yucheng Wu, Jun Zeng, Qinghe Zhu et al.     Acidification and pollution are two major threats to agricultural ecosystems; however, microbial community responses to co-existed soil acidification and pollution remain less …             Global Prioritizing Disease Candidate lncRNAs via a Multi-level Composite Network ▶     Qianlan Yao, Leilei Wu, Jia Li et al.     LncRNAs play pivotal roles in many important biological processes, but research on the functions of lncRNAs in human disease is still in its infancy. Therefore, it is urgent to …             Topological transformations in proteins: effects of heating and proximity of an interface ▶     Yani Zhao, Mateusz Chwastyk, Marek Cieplak     Using a structure-based coarse-grained model of proteins, we study the mechanism of unfolding of knotted proteins through heating. We find that the dominant mechanisms of …             Loss of miR-542-3p enhances IGFBP-1 expression in decidualizing human endometrial stromal cells ▶     Hideno Tochigi, Takeshi Kajihara, Yosuke Mizuno et al.     Endometrial decidualization represents an essential step for the successful implantation of the embryo; however, the molecular mechanism behind this differentiation process …             Mechanically Controlled Electron Transfer in a Single-Polypeptide Transistor ▶     Sheh-Yi Sheu, Dah-Yen Yang     Proteins are of interest in nano-bio electronic devices due to their versatile structures, exquisite functionality and specificity. However, quantum transport measurements …             Cytochrome P450-2E1 promotes fast food-mediated hepatic fibrosis ▶     Mohamed A. Abdelmegeed, Youngshim Choi, Grzegorz Godlewski et al.     Cytochrome P450-2E1 (CYP2E1) increases oxidative stress. High hepatic cholesterol causes non-alcoholic steatohepatitis (NASH) and fibrosis. Thus, we aimed to study the role of …             Universal and reusable virus deactivation system for respiratory protection ▶     Fu-Shi Quan, Ilaria Rubino, Su-Hwa Lee et al.     Aerosolized pathogens are a leading cause of respiratory infection and transmission. Currently used protective measures pose potential risk of primary/secondary infection and …             Evaluation of HDPE and LDPE degradation by fungus, implemented by statistical optimization ▶     Nupur Ojha, Neha Pradhan, Surjit Singh et al.     Plastic in any form is a nuisance to the well-being of the environment. The ‘pestilence’ caused by it is mainly due to its non-degradable nature. With the industrial boom and the …             Elucidating the genetic basis of an oligogenic birth defect using whole genome sequence data in a non-model organism, Bubalus bubalis ▶     Lynsey K. Whitacre, Jesse L. Hoff, Robert D. Schnabel et al.     Recent strong selection for dairy traits in water buffalo has been associated with higher levels of inbreeding, leading to an increase in the prevalence of genetic diseases such …             Relaxation oscillations and hierarchy of feedbacks in MAPK signaling ▶     Marek Kochańczyk, Paweł Kocieniewski, Emilia Kozłowska et al.     We formulated a computational model for a MAPK signaling cascade downstream of the EGF receptor to investigate how interlinked positive and negative feedback loops process EGF …             Erratum: Emergence of human G2P[4] rotaviruses containing animal derived gene segments in the post-vaccine era ▶     Mark Zeller, Valerie Nuyts, Elisabeth Heylen et al.                 Simplifying multidimensional fermentation dataset analysis and visualization: One step closer to capturing high-quality mutant strains ▶     Xiang Zhou, Dan Xu, Ting-Ting Jiang     In this study, we analyzed mutants of Clostridium acetobutylicum, an organism used in a broad range of industrial processes related to biofuel production, to facilitate future …             Personalised proteome analysis by means of protein microarrays made from individual patient samples ▶     Syafrizayanti, Smiths S. Lueong, Cuixia Di et al.     DNA sequencing has advanced to a state that permits studying the genomes of individual patients as nearly a matter of routine. Towards analysing a tissue’s protein content in a …             Local alignment vectors reveal cancer cell-induced ECM fiber remodeling dynamics ▶     Byoungkoo Lee, Jessica Konen, Scott Wilkinson et al.     Invasive cancer cells interact with the surrounding extracellular matrix (ECM), remodeling ECM fiber network structure by condensing, degrading, and aligning these fibers. We …             EColiCore2: a reference network model of the central metabolism of Escherichia coli and relationships to its genome-scale parent model ▶     Oliver Hädicke, Steffen Klamt     Genome-scale metabolic modeling has become an invaluable tool to analyze properties and capabilities of metabolic networks and has been particularly successful for the model …             Batch effects and the effective design of single-cell gene expression studies ▶     Po-Yuan Tung, John D. Blischak, Chiaowen Joyce Hsiao et al.     Single-cell RNA sequencing (scRNA-seq) can be used to characterize variation in gene expression levels at high resolution. However, the sources of experimental noise in scRNA-seq …             Dendritic and Axonal Propagation Delays Determine Emergent Structures of Neuronal Networks with Plastic Synapses ▶     Mojtaba Madadi Asl, Alireza Valizadeh, Peter A. Tass     Spike-timing-dependent plasticity (STDP) modifies synaptic strengths based on the relative timing of pre- and postsynaptic spikes. The temporal order of spikes turned out to be …             The Fall of Sleep K-Complex in Alzheimer Disease ▶     Luigi De Gennaro, Maurizio Gorgoni, Flaminia Reda et al.     Although a slowing of electroencephalographic (EEG) activity during wakefulness and –to some extent- sleep of Alzheimer disease (AD) patients (i.e., increased slow-frequency …             Speed hysteresis and noise shaping of traveling fronts in neural fields: role of local circuitry and nonlocal connectivity ▶     Cristiano Capone, Maurizio Mattia     Neural field models are powerful tools to investigate the richness of spatiotemporal activity patterns like waves and bumps, emerging from the cerebral cortex. Understanding how …             Chrna7 deficient mice manifest no consistent neuropsychiatric and behavioral phenotypes ▶     Jiani Yin, Wu Chen, Hongxing Yang et al.     The alpha7 nicotinic acetylcholine receptor, encoded by the CHRNA7 gene, has been implicated in various psychiatric and behavioral disorders, including schizophrenia, bipolar …             Social harassment induces anxiety-like behaviour in crayfish ▶     Julien Bacqué-Cazenave, Daniel Cattaert, Jean-Paul Delbecque et al.     Social interactions leading to dominance hierarchies often elicit psychological disorders in mammals including harassment and anxiety. Here, we demonstrate that this sequence …             Improved cold tolerance in Elymus nutans by exogenous application of melatonin may involve ABA-dependent and ABA-independent pathways ▶     Juanjuan Fu, Ye Wu, Yanjun Miao et al.     Melatonin is an important secondary messenger that plays a central role in plant growth, as well as abiotic and biotic stress tolerance. However, the underlying physiological and …             The Three-Herb Formula Shuang-Huang-Lian stabilizes mast cells through activation of mitochondrial calcium uniporter ▶     Yuan Gao, Rui Hou, Qiaoling Fei et al.     Mast cells (MCs) are key effector cells of IgE-FcεRI- or MrgprX2-mediated signaling event. Shuang-Huang-Lian (SHL), a herbal formula from Chinese Pharmacopoeia, has been …             Sex-related difference in human white matter volumes studied: Inspection of the corpus callosum and other white matter by VBM ▶     Akihiko Shiino, Yen-wei Chen, Kenji Tanigaki et al.     It has been contended that any observed difference of the corpus callosum (CC) size between men and women is not sex-related but brain-size-related. A recent report, however, …             Methamphetamine and Ovarian Steroid Responsive Cells in the Posteriodorsal Medial Amygdala are Required for Methamphetamine-enhanced Proceptive Behaviors ▶     Katrina M. Williams, Jessica A. Mong     Methamphetamine (Meth) is a psychomotor stimulant strongly associated with increases in sexual drive and impulse in both men and women. These changes in sexual motivation have a …             miRNA and mRNA expression analysis reveals potential sex-biased miRNA expression ▶     Li Guo, Qiang Zhang, Xiao Ma et al.     Recent studies suggest that mRNAs may be differentially expressed between males and females. This study aimed to perform expression analysis of mRNA and its main regulatory …             Bromodomain protein Brd3 promotes Ifnb1 transcription via enhancing IRF3/p300 complex formation and recruitment to Ifnb1 promoter in macrophages ▶     Wenhui Ren, Chunmei Wang, Qinlan Wang et al.     As members of bromodomain and extra-terminal motif protein family, bromodomain-containing proteins regulate a wide range of biological processes including protein scaffolding, …             Chlorogenic acid inhibits glioblastoma growth through repolarizating macrophage from M2 to M1 phenotype ▶     Nina Xue, Qin Zhou, Ming Ji et al.     Glioblastoma is an aggressive tumor that is associated with distinctive infiltrating microglia/macrophages populations. Previous studies demonstrated that chlorogenic acid …             miRsig: a consensus-based network inference methodology to identify pan-cancer miRNA-miRNA interaction signatures ▶     Joseph J. Nalluri, Debmalya Barh, Vasco Azevedo et al.     Decoding the patterns of miRNA regulation in diseases are important to properly realize its potential in diagnostic, prog- nostic, and therapeutic applications. Only a handful of …             Expression of acetylcholinesterase 1 is associated with brood rearing status in the honey bee, Apis mellifera ▶     Young Ho Kim, Ju Hyeon Kim, Kyungmun Kim et al.     Acetylcholinesterase 1 (AmAChE1) of the honey bee, Apis mellifera, has been suggested to have non-neuronal functions. A systematic expression profiling of AmAChE1 over a …             Effects of Elevated β-Estradiol Levels on the Functional Morphology of the Testis - New Insights ▶     Myles Leavy, Matthias Trottmann, Bernhard Liedl et al.     Elevated estradiol levels are correlated with male infertility. Causes of hyperestrogenism include diseases of the adrenal cortex, testis or medications affecting the …             Targeted RNA-Seq profiling of splicing pattern in the DMD gene: exons are mostly constitutively spliced in human skeletal muscle ▶     Anne-Laure Bougé, Eva Murauer, Emmanuelle Beyne et al.     We have analysed the splicing pattern of the human Duchenne Muscular Dystrophy (DMD) NB transcript in normal skeletal muscle. To achieve depth of coverage required for the …             MiR-218 Induces Neuronal Differentiation of ASCs in a Temporally Sequential Manner with Fibroblast Growth Factor by Regulation of the Wnt Signaling Pathway ▶     Feihu Hu, Bo Sun, Peng Xu et al.     Differentiation of neural lineages from mesenchymal stem cells has raised the hope of generating functional cells as seed cells for nerve tissue engineering. As important gene …             Mechanical stress activates NMDA receptors in the absence of agonists ▶     Mohammad Mehdi Maneshi, Bruce Maki, Radhakrishnan Gnanasambandam et al.     While studying the physiological response of primary rat astrocytes to fluid shear stress in a model of traumatic brain injury (TBI), we found that shear stress induced Ca2+ …             Metabolic heterogeneity of activated beige/brite adipocytes in inguinal adipose tissue ▶     Yun-Hee Lee, Sang-Nam Kim, Hyun-Jung Kwon et al.     Sustained β3 adrenergic receptor (ADRB3) activation simultaneously upregulates fatty acid synthesis and oxidation in mouse brown, beige, and white adipose tissues; however, the …             Population genetics of the Manila clam (Ruditapes philippinarum) introduced in North America and Europe ▶     David Cordero, Marina Delgado, Baozhong Liu et al.     Globally, the Manila clam (Ruditapes philippinarum) stands as the second most important bivalve species in fisheries and aquaculture. Native to the Pacific coast of Asia, it is …             Structural characterisation of the fatty acid biosynthesis enzyme FabF from the pathogen Listeria monocytogenes ▶     Tatiana P. Soares da Costa, Jeffrey D. Nanson, Jade K. Forwood     Development of new antimicrobial agents is required against the causative agent for listeriosis, Listeria monocytogenes, as the number of drug resistant strains continues to …             Comparative analysis of DNA methylome and transcriptome of skeletal muscle in lean-, obese-, and mini-type pigs ▶     Yalan Yang, Guoming Liang, Guanglin Niu et al.     DNA methylation plays a pivotal role in biological processes by affecting gene expression. However, how DNA methylation mediates phenotype difference of skeletal muscle between …             Pulsation-limited oxygen diffusion in the tumour microenvironment ▶     Edoardo Milotti, Sabrina Stella, Roberto Chignola     Hypoxia is central to tumour evolution, growth, invasion and metastasis. Mathematical models of hypoxia based on reaction-diffusion equations provide seemingly incomplete …             Testing the controllability of contextual cuing of visual search ▶     David Luque, Miguel A. Vadillo, Francisco J. Lopez et al.     Locating a target among distractors improves when the configuration of distractors consistently cues the target’s location across search trials, an effect called contextual cuing …             Disruption of cell adhesion by an antibody targeting the cell-adhesive intermediate (X-dimer) of human P-cadherin ▶     Shota Kudo, Jose M. M. Caaveiro, Satoru Nagatoishi et al.     Human P-cadherin is a cell adhesion protein of the family of classical cadherins, the overexpression of which is correlated with poor prognosis in various types of cancer. …             Host plant species determines symbiotic bacterial community mediating suppression of plant defenses ▶     Seung Ho Chung, Erin D. Scully, Michelle Peiffer et al.     Herbivore associated bacteria are vital mediators of plant and insect interactions. Host plants play an important role in shaping the gut bacterial community of insects. Colorado …             Corrigendum: Genetic Epidemiology of Glucose-6-Phosphate Dehydrogenase Deficiency in the Arab World ▶     C. George Priya Doss, Dima R. Alasmar, Reem I. Bux et al.                 Interactome of E. piscicida and grouper liver proteins reveals strategies of bacterial infection and host immune response ▶     Hui Li, Qing-feng Zhu, Xuan-xian Peng et al.     The occurrence of infectious diseases is related to heterogeneous protein interactions between a host and a microbe. Therefore, elucidating the host-pathogen interplay is …             A second generation SNP and SSR integrated linkage map and QTL mapping for the Chinese mitten crab Eriocheir sinensis ▶     Gao-Feng Qiu, Liang-Wei Xiong, Zhi-Ke Han et al.     The Chinese mitten crab Eriocheir sinensis is the most economically important cultivated crab species in China, and its genome has a high number of chromosomes (2n = 146). To …             Nucleocapsid Interacts with NPM1 and Protects it from Proteolytic Cleavage, Enhancing Cell Survival, and is Involved in PEDV Growth ▶     Da Shi, Hongyan Shi, Dongbo Sun et al.     Porcine epidemic diarrhea virus (PEDV) replicates in the cytoplasm of infected cells, but its nucleocapsid (N) protein localizes specifically to the nucleolus. The mechanism of …             CTCF interacts with the lytic HSV-1 genome to promote viral transcription ▶     Fengchao Lang, Xin Li, Olga Vladimirova et al.     CTCF is an essential chromatin regulator implicated in important nuclear processes including in nuclear organization and transcription. Herpes Simplex Virus-1 (HSV-1) is a …             Insensitivity to pain induced by a potent selective closed-state Nav1.7 inhibitor ▶     M. Flinspach, Q. Xu, A. D. Piekarz et al.     Pain places a devastating burden on patients and society and current pain therapeutics exhibit limitations in efficacy, unwanted side effects and the potential for drug abuse and …             Soluble OX40L and JAG1 Induce Selective Proliferation of Functional Regulatory T-Cells Independent of canonical TCR signaling ▶     Prabhakaran Kumar, Khaled Alharshawi, Palash Bhattacharya et al.     Regulatory T-cells (Tregs) play a pivotal role in maintaining peripheral tolerance. Increasing Treg numbers/functions has been shown to ameliorate autoimmune diseases. However, …             Comparative genome analyses of Mycobacterium avium reveal genomic features of its subspecies and strains that cause progression of pulmonary disease ▶     Kei-ichi Uchiya, Shuta Tomida, Taku Nakagawa et al.     Pulmonary disease caused by nontuberculous mycobacteria (NTM) is increasing worldwide. Mycobacterium avium is the most clinically significant NTM species in humans and animals, …             High diversity of airborne fungi in the hospital environment as revealed by meta-sequencing-based microbiome analysis ▶     Xunliang Tong, Hongtao Xu, Lihui Zou et al.     Invasive fungal infections acquired in the hospital have progressively emerged as an important cause of life-threatening infection. In particular, airborne fungi in hospitals are …             Conformational transition of FGFR kinase activation revealed by site-specific unnatural amino acid reporter and single molecule FRET ▶     Louis Perdios, Alan R. Lowe, Giorgio Saladino et al.     Protein kinases share significant structural similarity; however, structural features alone are insufficient to explain their diverse functions. Thus, bridging the gap between …             Microvasculature remodeling in the mouse lower gut during inflammaging ▶     Jae-Ho Jeong, KwangSoo Kim, Daejin Lim et al.     Inflammaging is defined as low-grade, chronic, systemic inflammation in aging, in the absence of overt infection. Age-associated deterioration of gastrointestinal function could …             TFP5 peptide, derived from CDK5-activating cofactor p35, provides neuroprotection in early-stage of adult ischemic stroke ▶     Ya-Bin Ji, Pei-Pei Zhuang, Zhong Ji et al.     Cyclin-dependent kinase 5 (CDK5) is a multifaceted protein shown to play important roles in the central nervous system. Abundant evidence indicates that CDK5 hyperactivities …             Nutrition affects insect susceptibility to Bt toxins ▶     Carrie A. Deans, Spencer T. Behmer, Ashley E. Tessnow et al.     Pesticide resistance represents a major challenge to global food production. The spread of resistance alleles is the primary explanation for observations of reduced pesticide …             The cellular magnetic response and biocompatibility of biogenic zinc- and cobalt-doped magnetite nanoparticles ▶     Sandhya Moise, Eva Céspedes, Dalibor Soukup et al.     The magnetic moment and anisotropy of magnetite nanoparticles can be optimised by doping with transition metal cations, enabling their properties to be tuned for different …             Feature selection and classification of urinary mRNA microarray data by iterative random forest to diagnose renal fibrosis: a two-stage study ▶     Le-Ting Zhou, Yu-Han Cao, Lin-Li Lv et al.     Renal fibrosis is a common pathological pathway of progressive chronic kidney disease (CKD). However, kidney function parameters are suboptimal for detecting early fibrosis, and …             Induced pluripotent stem cell generation from a man carrying a complex chromosomal rearrangement as a genetic model for infertility studies ▶     Aurélie Mouka, Vincent Izard, Gérard Tachdjian et al.     Despite progress in human reproductive biology, the cause of male infertility often remains unknown, due to the lack of appropriate and convenient in vitro models of meiosis. …             Building a genetic risk model for bipolar disorder from genome-wide association data with random forest algorithm ▶     Li-Chung Chuang, Po-Hsiu Kuo     A genetic risk score could be beneficial in assisting clinical diagnosis for complex diseases with high heritability. With large-scale genome-wide association (GWA) data, the …             Positive association between physical activity and PER3 expression in older adults ▶     Masaki Takahashi, Atsushi Haraguchi, Yu Tahara et al.     The circadian clock regulates many physiological functions including physical activity and feeding patterns. In addition, scheduled exercise and feeding themselves can affect the …             Corrigendum: A novel mouse model of intrahepatic cholangiocarcinoma induced by liver-specific Kras activation and Pten deletion ▶     Tsuneo Ikenoue, Yumi Terakado, Hayato Nakagawa et al.                 Calpain-dependent disruption of nucleo-cytoplasmic transport in ALS motor neurons ▶     Takenari Yamashita, Hitoshi Aizawa, Sayaka Teramoto et al.     Nuclear dysfunction in motor neurons has been hypothesized to be a principal cause of amyotrophic lateral sclerosis (ALS) pathogenesis. Here, we investigated the mechanism by …             Latitude affects Morningness-Eveningness: evidence for the environment hypothesis based on a systematic review ▶     Christoph Randler, Arash Rahafar     Morningness-eveningness (M/E) is an individual trait related to a person’s sleep-wake cycle and preference for morning or evening hours. The “environment hypothesis” suggests …             Increased Uterine NK cell numbers and perforin expression during the implantation phase in IVF Cycles with GnRH Antagonist Protocol ▶     Bufang Xu, Jingwen Wang, Lan Xia et al.     GnRH antagonist negatively affects endometrial receptivity in in vitro fertilization (IVF) cycles, however, its underlying mechanism remains unclear. To explore its target …             PDLIM5 links kidney anion exchanger 1 (kAE1) to ILK and is required for membrane targeting of kAE1 ▶     Ya Su, Thomas F. Hiemstra, Yahui Yan et al.     Anion exchanger 1 (AE1) mediates Cl−/HCO3− exchange in erythrocytes and kidney intercalated cells where it functions to maintain normal bodily acid-base homeostasis. AE1’s …             Cerebrospinal fluid lens-free microscopy: a new tool for the laboratory diagnosis of meningitis ▶     Robin Delacroix, Sophie Nhu An Morel, Lionel Hervé et al.     Cerebrospinal fluid cytology is performed by operator-dependant light microscopy as part of the routine laboratory work-flow diagnosis of meningitis. We evaluated …             Protective effects of intercalated disk protein afadin on chronic pressure overload-induced myocardial damage ▶     Dimitar P. Zankov, Akio Shimizu, Miki Tanaka-Okamoto et al.     Adhesive intercellular connections at cardiomyocyte intercalated disks (IDs) support contractile force and maintain structural integrity of the heart muscle. Disturbances of the …             Modifying effect of mouse double minute-2 promoter variants on risk of recurrence for patients with squamous cell carcinoma of oropharynx ▶     Yang Zhang, Erich M. Sturgis, Yuncheng Li et al.     Functional mouse double minute-2 (MDM2) promoter variants may alter MDM2 expression and thus affect radiotherapy response and prognosis of squamous cell carcinoma of oropharynx …             Transforming growth factor β-activated kinase 1 transcriptionally suppresses hepatitis B virus replication ▶     Jinke Pang, Geng Zhang, Yong Lin et al.     Hepatitis B Virus (HBV) replication in hepatocytes is restricted by the host innate immune system and related intracellular signaling pathways. Transforming growth factor …             The Molecular Structure of Human Red Blood Cell Membranes from Highly Oriented, Solid Supported Multi-Lamellar Membranes ▶     Sebastian Himbert, Richard J. Alsop, Markus Rose et al.     We prepared highly oriented, multi-lamellar stacks of human red blood cell (RBC) membranes applied on silicon wafers. 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