Friday, January 27, 2017

Nature Reviews Cancer contents February 2017 Volume 17 Number 2 pp75-140

Nature Reviews Cancer


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TABLE OF CONTENTS
 
February 2017 Volume 17 Number 2
Nature Reviews Cancer cover
Impact Factor 34.244 *
In this issue
Research Highlights
Reviews
Perspectives

Also this month
 Featured article:
Consensus molecular subtypes and the evolution of precision medicine in colorectal cancer
Rodrigo Dienstmann, Louis Vermeulen, Justin Guinney, Scott Kopetz, Sabine Tejpar & Josep Tabernero



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An online-only, open access, multidisciplinary journal dedicated to publishing high-quality original research articles, reviews, editorials, commentaries, and hypothesis generating observations on all areas of breast cancer research.

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RESEARCH HIGHLIGHTS
Top

Metastasis: Planting metastasis early
p75 | doi:10.1038/nrc.2017.4
Two papers demonstrate that early disseminated cancer cells (DCCs) from HER2+ breast cancer are more likely to seed metastasis than those from established tumours.
PDF


Oncogenes: Coping with stress
p76 | doi:10.1038/nrc.2017.1
Grabocka and Bar-Sagi have shown that cells expressing mutant KRAS upregulate SGs in response to stress, and that this enhances the survival of both KRAS-mutant and wild-type cells.
PDF


Metastasis: The fat controller
p76 | doi:10.1038/nrc.2017.3
Salvador Aznar Benitah and colleagues have identified a subpopulation of cells with high metastatic potential that express high levels of the fatty acid receptor CD36 in human oral carcinoma samples.
PDF


Tumour metabolism: Packed full of protein!
p77 | doi:10.1038/nrc.2017.2
Davidson et al. used an implantable microdevice to show that pancreatic tumours in vivo catabolize proteins in their local environment, by macropinocytosis, to derive amino acids for cell growth.
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Cancer
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REVIEWS
Top
Consensus molecular subtypes and the evolution of precision medicine in colorectal cancer
Rodrigo Dienstmann, Louis Vermeulen, Justin Guinney, Scott Kopetz, Sabine Tejpar & Josep Tabernero
p79 | doi:10.1038/nrc.2016.126
In this Review, Dienstmann et al. analyse the complex nature of colorectal cancer and the different subtypes in which this disease can be classified, advocating for a 'multi-molecular' perspective for the development of therapies to treat it.
Abstract | Full Text | PDF

Cell cycle proteins as promising targets in cancer therapy
Tobias Otto & Piotr Sicinski
p93 | doi:10.1038/nrc.2016.138
Proteins regulating cell cycle progression are involved in the formation of most cancer types. This Review discusses the role of cell cycle proteins in cancer, the rationale for targeting them in cancer treatment, results of clinical trials, as well as future therapeutic potential of various cell cycle inhibitors.
Abstract | Full Text | PDF | Supplementary information

 
PERSPECTIVES
Top
OPINION
The recurrent architecture of tumour initiation, progression and drug sensitivity
Andrea Califano & Mariano J. Alvarez
p116 | doi:10.1038/nrc.2016.124
This Opinion article discusses the recurring regulatory architecture that is both necessary and sufficient to maintain tumour cell state. Considering this architecture provides a valuable reductionist framework to study the genetic heterogeneity of human disease and to drive key translational applications.
Abstract | Full Text | PDF

OPINION
Cancer cell motility: lessons from migration in confined spaces
Colin D. Paul, Panagiotis Mistriotis & Konstantinos Konstantopoulos
p131 | doi:10.1038/nrc.2016.123
This Opinion article discusses the various migration modes used by cancer cells in confining microenvironments and explains how understanding confined cancer cell motility in vivo through the application of engineered in vitro models could help to develop therapeutic approaches to prevent metastases.
Abstract | Full Text | PDF

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