Friday, January 27, 2017

Nature Reviews Cancer contents February 2017 Volume 17 Number 2 pp75-140

Nature Reviews Cancer

Nature Outlook: Kidney Cancer

Kidney cancer has long flown under the radar despite being one of the top-ten cancer killers worldwide. It remains hard to detect, difficult to treat and poorly understood. But that is starting to change as researchers dig into the mysteries surrounding the disease. 

Access the Outlook free online for six months

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February 2017 Volume 17 Number 2
Nature Reviews Cancer cover
Impact Factor 34.244 *
In this issue
Research Highlights

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 Featured article:
Consensus molecular subtypes and the evolution of precision medicine in colorectal cancer
Rodrigo Dienstmann, Louis Vermeulen, Justin Guinney, Scott Kopetz, Sabine Tejpar & Josep Tabernero

Unexplored opportunities in the druggable human genome

This poster presents a categorization of human proteins based on the amount of data on them, highlighting a knowledge deficit and indicating novel drug discovery opportunities. 

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Illuminating the Druggable Genome Knowledge Management Center 

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An online-only, open access, multidisciplinary journal dedicated to publishing high-quality original research articles, reviews, editorials, commentaries, and hypothesis generating observations on all areas of breast cancer research.

Part of the Nature Partner Journals series, published in partnership with the Breast Cancer Research Foundation.

Now open for submissions >>

Metastasis: Planting metastasis early
p75 | doi:10.1038/nrc.2017.4
Two papers demonstrate that early disseminated cancer cells (DCCs) from HER2+ breast cancer are more likely to seed metastasis than those from established tumours.

Oncogenes: Coping with stress
p76 | doi:10.1038/nrc.2017.1
Grabocka and Bar-Sagi have shown that cells expressing mutant KRAS upregulate SGs in response to stress, and that this enhances the survival of both KRAS-mutant and wild-type cells.

Metastasis: The fat controller
p76 | doi:10.1038/nrc.2017.3
Salvador Aznar Benitah and colleagues have identified a subpopulation of cells with high metastatic potential that express high levels of the fatty acid receptor CD36 in human oral carcinoma samples.

Tumour metabolism: Packed full of protein!
p77 | doi:10.1038/nrc.2017.2
Davidson et al. used an implantable microdevice to show that pancreatic tumours in vivo catabolize proteins in their local environment, by macropinocytosis, to derive amino acids for cell growth.

JOBS of the week
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Open for Submissions

npj Precision Oncology is a new open access, online-only, peer-reviewed journal committed to publishing cutting-edge scientific research in all aspects of precision oncology from basic science to translational applications, to clinical medicine. The journal is part of the Nature Partner Journals series and published in partnership with The Hormel Institute, University of Minnesota.

Explore the benefits of submitting your manuscript.
Consensus molecular subtypes and the evolution of precision medicine in colorectal cancer
Rodrigo Dienstmann, Louis Vermeulen, Justin Guinney, Scott Kopetz, Sabine Tejpar & Josep Tabernero
p79 | doi:10.1038/nrc.2016.126
In this Review, Dienstmann et al. analyse the complex nature of colorectal cancer and the different subtypes in which this disease can be classified, advocating for a 'multi-molecular' perspective for the development of therapies to treat it.
Abstract | Full Text | PDF

Cell cycle proteins as promising targets in cancer therapy
Tobias Otto & Piotr Sicinski
p93 | doi:10.1038/nrc.2016.138
Proteins regulating cell cycle progression are involved in the formation of most cancer types. This Review discusses the role of cell cycle proteins in cancer, the rationale for targeting them in cancer treatment, results of clinical trials, as well as future therapeutic potential of various cell cycle inhibitors.
Abstract | Full Text | PDF | Supplementary information

The recurrent architecture of tumour initiation, progression and drug sensitivity
Andrea Califano & Mariano J. Alvarez
p116 | doi:10.1038/nrc.2016.124
This Opinion article discusses the recurring regulatory architecture that is both necessary and sufficient to maintain tumour cell state. Considering this architecture provides a valuable reductionist framework to study the genetic heterogeneity of human disease and to drive key translational applications.
Abstract | Full Text | PDF

Cancer cell motility: lessons from migration in confined spaces
Colin D. Paul, Panagiotis Mistriotis & Konstantinos Konstantopoulos
p131 | doi:10.1038/nrc.2016.123
This Opinion article discusses the various migration modes used by cancer cells in confining microenvironments and explains how understanding confined cancer cell motility in vivo through the application of engineered in vitro models could help to develop therapeutic approaches to prevent metastases.
Abstract | Full Text | PDF

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