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February 2017 Volume 17 Number 2 | ||||||||||||||||||||||||||||||||||||||||
In this issue Research Highlights Reviews Perspectives
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REVIEWS | Top | |||||||||||||||||||||||||||||||||||||||
Consensus molecular subtypes and the evolution of precision medicine in colorectal cancer Rodrigo Dienstmann, Louis Vermeulen, Justin Guinney, Scott Kopetz, Sabine Tejpar & Josep Tabernero p79 | doi:10.1038/nrc.2016.126 In this Review, Dienstmann et al. analyse the complex nature of colorectal cancer and the different subtypes in which this disease can be classified, advocating for a 'multi-molecular' perspective for the development of therapies to treat it. Abstract | Full Text | PDF | ||||||||||||||||||||||||||||||||||||||||
Cell cycle proteins as promising targets in cancer therapy Tobias Otto & Piotr Sicinski p93 | doi:10.1038/nrc.2016.138 Proteins regulating cell cycle progression are involved in the formation of most cancer types. This Review discusses the role of cell cycle proteins in cancer, the rationale for targeting them in cancer treatment, results of clinical trials, as well as future therapeutic potential of various cell cycle inhibitors. Abstract | Full Text | PDF | Supplementary information | ||||||||||||||||||||||||||||||||||||||||
PERSPECTIVES | Top | |||||||||||||||||||||||||||||||||||||||
OPINION The recurrent architecture of tumour initiation, progression and drug sensitivity Andrea Califano & Mariano J. Alvarez p116 | doi:10.1038/nrc.2016.124 This Opinion article discusses the recurring regulatory architecture that is both necessary and sufficient to maintain tumour cell state. Considering this architecture provides a valuable reductionist framework to study the genetic heterogeneity of human disease and to drive key translational applications. Abstract | Full Text | PDF | ||||||||||||||||||||||||||||||||||||||||
OPINION Cancer cell motility: lessons from migration in confined spaces Colin D. Paul, Panagiotis Mistriotis & Konstantinos Konstantopoulos p131 | doi:10.1038/nrc.2016.123 This Opinion article discusses the various migration modes used by cancer cells in confining microenvironments and explains how understanding confined cancer cell motility in vivo through the application of engineered in vitro models could help to develop therapeutic approaches to prevent metastases. Abstract | Full Text | PDF | ||||||||||||||||||||||||||||||||||||||||
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*2014 Journal Citation Report (Thomson Reuters, 2015) |
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