Nature Biotechnology Contents: Volume 35 pp 1 - 96

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Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement Nature Outlook: Regenerative Medicine  Sometimes, a drug can remedy a chemical imbalance or surgery can repair a structural failure, but there are times when there is no substitute for replacing a part with human tissue or an entire organ. Rapid advances in regenerative medicine are bringing that possibility closer to reality.  Access the Outlook Produced with support from  Translational Research Informatics Center(TRI)  Clio, Inc.  Sapporo Medical University CYBERDYNE,INC.      Advertisement BIOPHARMA DEALMAKERS Company Profiles and Partnering Opportunities   Advertisement CRISPR Calendar 2017 To celebrate the continuing rise to fame of the CRISPR system, the Nature Reviews Genetics 2017 CRISPR calendar highlights the underlying biology of CRISPR, as well as its diverse range of exciting potential applications in genetic research, biotechnology and therapeutics. Download the calendar free online Produced with support from  OriGene   Editorials Top Concerns over Cures   p1 doi:10.1038/nbt.3773 Provisions in the 21st Century Cures Act related to leadership at the US National Institutes of Health (NIH) may spell trouble ahead. Where are the data?   p1 doi:10.1038/nbt.3774 Nature Biotechnology now requires data availability statements to be supplied with research papers. News Top CRISPR therapeutics push into human testing   pp3 - 5 Cormac Sheridan doi:10.1038/nbt0117-3 BMS in microbiome immuno-oncology deal   p5 doi:10.1038/nbt0117-5a Ganymed's Claudin win   p5 doi:10.1038/nbt0117-5b Obama signs 21st Century Cures Act   p6 doi:10.1038/nbt0117-6a CAR-T's forge ahead, despite Juno deaths   pp6 - 7 Laura DeFrancesco doi:10.1038/nbt0117-6b First mitochondrial DNA transfer go-ahead   p7 doi:10.1038/nbt0117-7 Pancreatic islets find a new transplant home in the omentum   p8 Charles Schmidt doi:10.1038/nbt0117-8 Gut microbiome profiling tests propelled by customer demand   p9 Vijay Shankar doi:10.1038/nbt0117-9 Around the world in a month   p10 doi:10.1038/nbt0117-10a Podcast First Rounders Podcast: Jeremy Levin   p10 doi:10.1038/nbt0117-10b News Feature After Theranos   pp11 - 15 Emily Waltz doi:10.1038/nbt.3761 The implosion of blood diagnostics developer Theranos has raised the question: What is feasibly detectible in a drop of blood? Emily Waltz reports. Advertisement nature.com webcasts Springer Nature presents a custom webcast on: CRISPR/Cas9 strategies for disease modeling and drug discovery Date: Tuesday, 24 January 2017 Time: 8AM PST, 11AM EST, 4PM GMT, 5PM CST  Register for FREE  Sponsored by:  The Jackson Laboratory Bioentrepreneur Top Data Page Innovative academic startups 2016   p16 Brady Huggett doi:10.1038/nbt.3760 Correspondence Top Failure to detect DNA-guided genome editing using Natronobacterium gregoryi Argonaute   pp17 - 18 Seung Hwan Lee, Giandomenico Turchiano, Hirotaka Ata, Somaira Nowsheen, Marianna Romito et al. doi:10.1038/nbt.3753 Should you profit from your genome?   pp18 - 20 Jessica L Roberts, Stacey Pereira and Amy L McGuire doi:10.1038/nbt.3757 Will a Trump administration let sleeping cells lie?   pp20 - 21 Jonathan D Moreno doi:10.1038/nbt.3768 Features Top Patents The rise of the ethical license   pp22 - 24 Christi J Guerrini, Margaret A Curnutte, Jacob S Sherkow and Christopher T Scott doi:10.1038/nbt.3756 The Broad Institute's recent licensing of its gene editing patent portfolio demonstrates how licenses can be used to restrict controversial applications of emerging technologies while society deliberates their implications. Recent patents in metagenomics   p25 doi:10.1038/nbt.3775 Advertisement nature.com webcasts Springer Nature presents a custom webcast on: Liquid biopsy: CTC-based classifier predicts chemo resistance in lung cancer Date: Thursday January 19 2017 Time: 8AM PST, 11AM EST, 4PM GMT, 5PM CET  Register for FREE Sponsored by:  Menarini Silicon Biosystems News and Views Top An optical probe of synaptic plasticity   pp26 - 27 Tal Laviv and Ryohei Yasuda doi:10.1038/nbt.3767 An endogenous protein in the mouse brain is inactivated using a light-sensitive antibody construct. See also: Research by Takemoto et al. Mining ancient proteins for next-generation drugs   pp28 - 29 Robert A Lazarus and Friedrich Scheiflinger doi:10.1038/nbt.3762 Predicting the evolutionary ancestors of a protein drug provides a strategy for optimizing its pharmaceutical properties. See also: Research by Zakas et al. Research Highlights   p30 doi:10.1038/nbt.3759 Photosynthesis gets a boost   p30 Irene Jarchum doi:10.1038/nbt.3764 Biotechnology JOBS of the week Post-doctoral Research Assistant in Cell Biology St. George's University of London Post-doctoral Research Assistant in Cell Biology St. George's University of London Post-Doctoral Researcher Texas A&M University Health Science Center PhD student positions at the Institute of Oncology Research Institute of Oncology Research - Fondazione Linfomi -Ticino Research Associate The University of Manchester More Science jobs from Biotechnology EVENT Biotech France 2017 June 28, 2017 Courbevoie, France More science events from Research Top Brief Communications Multiplex gene editing by CRISPR-Cpf1 using a single crRNA array   pp31 - 34 Bernd Zetsche, Matthias Heidenreich, Prarthana Mohanraju, Iana Fedorova, Jeroen Kneppers et al. doi:10.1038/nbt.3737 Multiplexed genome editing is simplified by harnessing the ability of Cpf1 to process its own pre-crRNA. Enhancing the pharmaceutical properties of protein drugs by ancestral sequence reconstruction   pp35 - 37 Philip M Zakas, Harrison C Brown, Kristopher Knight, Shannon L Meeks, H Trent Spencer et al. doi:10.1038/nbt.3677 The pharmaceutical properties of coagulation factor VIII are improved by reconstructing the protein's ancestral sequence. See also: News and Views by Lazarus & Scheiflinger Articles Optical inactivation of synaptic AMPA receptors erases fear memory   pp38 - 47 Kiwamu Takemoto, Hiroko Iwanari, Hirobumi Tada, Kumiko Suyama, Akane Sano et al. doi:10.1038/nbt.3710 Development of an optical method to inactivate synaptic receptors in mice with temporal precision will enable a better understanding of their roles in cognition. See also: News and Views by Laviv & Yasuda Genome-wide mapping of mutations at single-nucleotide resolution for protein, metabolic and genome engineering   pp48 - 55 Andrew D Garst, Marcelo C Bassalo, Gur Pines, Sean A Lynch, Andrea L Halweg-Edwards et al. doi:10.1038/nbt.3718 An approach called CREATE enables multiplex genome engineering, protein engineering and mapping of mutations in bacterial and yeast cells. Sinoatrial node cardiomyocytes derived from human pluripotent cells function as a biological pacemaker   pp56 - 68 Stephanie I Protze, Jie Liu, Udi Nussinovitch, Lily Ohana, Peter H Backx et al. doi:10.1038/nbt.3745 Cardiomyocytes derived from human stem cells act as a biological pacemaker in the rat heart. Letters Influence of donor age on induced pluripotent stem cells   pp69 - 74 Valentina Lo Sardo, William Ferguson, Galina A Erikson, Eric J Topol, Kristin K Baldwin et al. doi:10.1038/nbt.3749 Induced pluripotent stem cells generated from older individuals have higher levels of epigenetic and genetic abnormalities. MRI measurements of reporter-mediated increases in transmembrane water exchange enable detection of a gene reporter   pp75 - 80 Franz Schilling, Susana Ros, De-En Hu, Paula D'Santos, Sarah McGuire et al. doi:10.1038/nbt.3714 Urea transporter can be used as a sensitive, contrast agent-free gene reporter for magnetic resonance imaging in cells and whole animals. Resources Generation of genome-scale metabolic reconstructions for 773 members of the human gut microbiota   pp81 - 89 Stefania Magnusdottir, Almut Heinken, Laura Kutt, Dmitry A Ravcheev, Eugen Bauer et al. doi:10.1038/nbt.3703 A large set of microbial metabolic models (AGORA) could be applied to better understand the functions of the human gut microbiome. Careers and Recruitment Top The impact of postdoctoral training on early careers in biomedicine   pp90 - 94 Shulamit Kahn and Donna K Ginther doi:10.1038/nbt.3766 While postdocs are necessary for entry into tenure-track jobs, they do not enhance salaries in other job sectors over time. People People   p96 doi:10.1038/nbt.3776 Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. 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