The EDGE

Halfway there: the past, present and future of haploidentical transplantation

M Slade, B Fakhri, B N Savani and R Romee

Bone Marrow Transplant 2017 52: 1-6; advance online publication, July 25, 2016; 10.1038/bmt.2016.190

Reviews

Gut microbiota and hematopoietic stem cell transplantation: where do we stand?

D Zama, E Biagi, R Masetti, P Gasperini, A Prete, M Candela, P Brigidi and A Pession

Bone Marrow Transplant 2017 52: 7-14; advance online publication, June 27, 2016; 10.1038/bmt.2016.173

Sixty as the new forty: considerations on older related stem cell donors

P Anderlini

Bone Marrow Transplant 2017 52: 15-19; advance online publication, August 8, 2016; 10.1038/bmt.2016.201

Original Articles

ACUTE LEUKEMIA

Multi-center analysis of the effect of T-cell acute lymphoblastic leukemia subtype and minimal residual disease on allogeneic stem cell transplantation outcomes

J E Brammer, R M Saliba, J L Jorgensen, C Ledesma, S Gaballa, M Poon, R T Maziarz, R E Champlin, C Hosing and P Kebriaei

Bone Marrow Transplant 2017 52: 20-27; advance online publication, September 12, 2016; 10.1038/bmt.2016.194

CHRONIC LEUKEMIA

Bendamustine added to allogeneic conditioning improves long-term outcomes in patients with CLL

I F Khouri, D Sui, E J Jabbour, B I Samuels, F Turturro, G Alatrash, P Anderlini, S Ahmed, B Oran, S O Ciurea, D Marin, A Olson, K K Patel, U R Popat, C Ledesma, T M Kadia, A Ferrajoli, J A Burger, J L Jorgensen, L J Medeiros, R L Bassett and A M Gulbis

Bone Marrow Transplant 2017 52: 28-33; advance online publication, September 5, 2016; 10.1038/bmt.2016.204

PLASMA CELL DISORDERS

The impact of induction regimen on transplant outcome in newly diagnosed multiple myeloma in the era of novel agents

R Chakraborty, E Muchtar, S Kumar, F K Buadi, D Dingli, A Dispenzieri, S R Hayman, W J Hogan, P Kapoor, M Q Lacy, N Leung and M A Gertz

Bone Marrow Transplant 2017 52: 34-40; advance online publication, August 22, 2016; 10.1038/bmt.2016.214

APLASTIC ANEMIA

The Latin American experience of allografting patients with severe aplastic anaemia: real-world data on the impact of stem cell source and ATG administration in HLA-identical sibling transplants

D Gómez-Almaguer, A Vázquez-Mellado, J R Navarro-Cabrera, V Abello-Polo, V Milovic, J García, A L Basquiera, S Saba, G Balladares, J Vela-Ojeda, S Gómez, A Karduss-Aurueta, A Bustinza-Álvarez, A Requejo, L Feldman, J C Jaime-Pérez, S Yantorno, G Kusminsky, C H Gutiérrez-Aguirre, J Arbelbide, J Martinez-Rolon, G Jarchum, G Jaimovich, L Riera, E Pedraza-Mesa, L Villamizar-Gómez, M Á Herrera-Rojas, M M Gamboa-Alonso, C Foncuberta, G Rodríguez-González, M A García Ruiz-Esparza, E Hernández-Maldonado, M Paz-Infanzón, E González-López and G J Ruiz-Argüelles

Bone Marrow Transplant 2017 52: 41-46; advance online publication, August 22, 2016; 10.1038/bmt.2016.212

Immunosuppressive therapy versus alternative donor hematopoietic stem cell transplantation for children with severe aplastic anemia who lack an HLA-matched familial donor

Y B Choi, E S Yi, J W Lee, K W Sung, H H Koo and K H Yoo

Bone Marrow Transplant 2017 52: 47-52; advance online publication, September 26, 2016; 10.1038/bmt.2016.223

AUTOIMMUNE DISORDERS

Autologous hematopoietic stem cell transplantation has better outcomes than conventional therapies in patients with rapidly progressive systemic sclerosis

N Del Papa, F Onida, E Zaccara, G Saporiti, W Maglione, E Tagliaferri, R Andracco, D Vincenti, T Montemurro, L Mircoli, C Vitali and A Cortelezzi

Bone Marrow Transplant 2017 52: 53-58; advance online publication, August 22, 2016; 10.1038/bmt.2016.211

CONDITIONING

A multicenter trial of myeloablative clofarabine and busulfan conditioning for relapsed or primary induction failure AML not in remission at the time of allogeneic hematopoietic stem cell transplantation

J Magenau, P Westervelt, S Khaled, J McGuirk, P Hari, M Eapen, P S Becker, B Parkin, T Braun, B Logan, H Wang, M Jagasia, S D Rowley, D D H Kim, T Schechter, N Frey, B Scott, T Churay, S Lieland, S Forman and S Mineishi

Bone Marrow Transplant 2017 52: 59-65; advance online publication, July 18, 2016; 10.1038/bmt.2016.188

TRANSPLANT TOXICITIES

Cardiac autonomic functioning is impaired among allogeneic hematopoietic stem cell transplantation survivors: a controlled study

G Deuring, A Kiss, J P Halter, J R Passweg and P Grossman

Bone Marrow Transplant 2017 52: 66-72; advance online publication, July 4, 2016; 10.1038/bmt.2016.176

The fifth epidermal growth factor-like region of thrombomodulin exerts cytoprotective function and prevents SOS in a murine model

T Ikezoe, J Yang, C Nishioka, B Pan, K Xu, M Furihata, K Nakamura, H Yurimoto, Y Sakai, G Honda and A Yokoyama

Bone Marrow Transplant 2017 52: 73-79; advance online publication, July 18, 2016; 10.1038/bmt.2016.195

Prevalence and risk factors of iron overload after hematopoietic stem cell transplantation for childhood acute leukemia: a LEA study

A Sirvent, P Auquier, C Oudin, Y Bertrand, S Bohrer, P Chastagner, M Poirée, J Kanold, S Thouvenin, Y Perel, D Plantaz, M-D Tabone, K Yakouben, V Gandemer, P Lutz, N Sirvent, C Vercasson, J Berbis, H Chambost, G Leverger, A Baruchel and G Michel

Bone Marrow Transplant 2017 52: 80-87; advance online publication, September 5, 2016; 10.1038/bmt.2016.205

GRAFT-VERSUS-HOST DISEASE

Clinical separation of cGvHD and GvL and better GvHD-free/relapse-free survival (GRFS) after unrelated cord blood transplantation for AML

C-C Zheng, X-Y Zhu, B-L Tang, X-H Zhang, L Zhang, L-Q Geng, H-L Liu and Z-M Sun

Bone Marrow Transplant 2017 52: 88-94; advance online publication, July 4, 2016; 10.1038/bmt.2016.182

Novel HLA-DP region susceptibility loci associated with severe acute GvHD

R K Goyal, S J Lee, T Wang, M Trucco, M Haagenson, S R Spellman, M Verneris and R E Ferrell

Bone Marrow Transplant 2017 52: 95-100; advance online publication, September 5, 2016; 10.1038/bmt.2016.210

Long-term safety and efficacy of autologous platelet lysate drops for treatment of ocular GvHD

S Pezzotta, C Del Fante, L Scudeller, G C Rossi, C Perotti, P E Bianchi and E Antoniazzi

Bone Marrow Transplant 2017 52: 101-106; advance online publication, September 5, 2016; 10.1038/bmt.2016.221

INFECTIONS

Patterns of infection and infection-related mortality in patients with steroid-refractory acute graft versus host disease

I García-Cadenas, I Rivera, R Martino, A Esquirol, P Barba, S Novelli, G Orti, J Briones, S Brunet, D Valcarcel and J Sierra

Bone Marrow Transplant 2017 52: 107-113; advance online publication, September 5, 2016; 10.1038/bmt.2016.225

Control of infectious mortality due to carbapenemase-producing Klebsiella pneumoniae in hematopoietic stem cell transplantation

A Forcina, R Baldan, V Marasco, P Cichero, A Bondanza, M Noviello, S Piemontese, C Soliman, R Greco, F Lorentino, F Giglio, C Messina, M Carrabba, M Bernardi, J Peccatori, M Moro, A Biancardi, P Nizzero, P Scarpellini, D M Cirillo, N Mancini, C Corti, M Clementi and F Ciceri

Bone Marrow Transplant 2017 52: 114-119; advance online publication, September 26, 2016; 10.1038/bmt.2016.234

CELLULAR THERAPY

First report of pediatric hematopoietic stem cell transplantation activities in the eastern mediterranean region from 1984 to 2011: on behalf of the pediatric cancer working committee of the eastern mediterranean blood and marrow transplantation group

A A Hussein, A A Hamidieh, A Elhaddad, M Ramzi, T B Othman, F Hussain, D Dennison, P Ahmed, M Abboud, A Al-Ahmari, A Wahadneh, J Fathy, M-A Bekadja, S Al-Kindi, S Benchekroun, A Ibrahim, M Behfar, M Samra, S Ladeb, S Adil, H El-Solh, M Ayas, M Aljurf, A Ghavamzadeh, A Al-Seraihy and Pediatric Cancer Working Committee of the Eastern Mediterranean Blood and Marrow Transplantation (EMBMT) Group

Bone Marrow Transplant 2017 52: 120-125; advance online publication, September 12, 2016; 10.1038/bmt.2016.209

Letters To The Editor

Course of IL-2-inducible T-cell kinase deficiency in a family: lymphomatoid granulomatosis, lymphoma and allogeneic bone marrow transplantation in one sibling; and death in the other

D Çağdaş, B Erman, D Hanoğlu, B Tavil, B Kuşkonmaz, B Aydın, C Akyüz, D Uçkan, Ö Sanal and İ Tezcan

Bone Marrow Transplant 2017 52: 126-129; advance online publication, July 25, 2016; 10.1038/bmt.2016.185

Aggressive skin cancers in patients who experienced chronic GvHD after allogeneic bone marrow transplantation

A S Zampaolo, J Kanold, O Tournilhac, F Franck, M Bachelerie and M D'Incan

Bone Marrow Transplant 2017 52: 130-131; advance online publication, July 18, 2016; 10.1038/bmt.2016.187

Comparable outcomes following two or three cycles of high-dose chemotherapy and autologous stem cell transplantation for patients with relapsed/refractory germ cell tumors

Z DeFilipp, C B Rosand, D A Goldstein, V A Master, B C Carthon, W B Harris, O Kucuk, Z Al-Kadhimi, J B Cohen, C R Flowers, M J Lechowicz, A K Nooka, J L Kaufman, A A Langston, Z Chen, J Arora and E K Waller

Bone Marrow Transplant 2017 52: 132-134; advance online publication, July 18, 2016; 10.1038/bmt.2016.189

The calcineurin inhibitor and the intensity of the conditioning regimen may affect the occurrence of polyomavirus-associated hemorrhagic cystitis after haploidentical hematopoietic stem cell transplantation with post-transplant cyclophosphamide

A Rimondo, R Crocchiolo, J El-Cheikh, S Bramanti, A Granata, S Furst, B Sarina, L Morabito, R Devillier, S Harbi, B Mohty, R Mineri, C Faucher, C Chabannon, A Santoro, D Blaise and L Castagna

Bone Marrow Transplant 2017 52: 135-137; advance online publication, July 18, 2016; 10.1038/bmt.2016.193

Severe hepatitis C reactivation as an early complication of hematopoietic cell transplantation

N T Oliver, Y L Nieto, B Blechacz, P Anderlini, E Ariza-Heredia and H A Torres

Bone Marrow Transplant 2017 52: 138-140; advance online publication, July 18, 2016; 10.1038/bmt.2016.196

Treatment of acute fibrinous organizing pneumonia following hematopoietic cell transplantation with etanercept OPEN

G L Simmons, H M Chung, J M McCarty, A A Toor, D Farkas, K Miller and W B Clark

Bone Marrow Transplant 2017 52: 141-143; advance online publication, August 15, 2016; 10.1038/bmt.2016.197

Low bone mineral density in adolescents with leukemia after hematopoietic stem cell transplantation: prolonged steroid therapy for GvHD and endocrinopathy after hematopoietic stem cell transplantation might be major concerns?

W K Cho, M B Ahn, J-W Lee, N-G Chung, M H Jung, B Cho and B-K Suh

Bone Marrow Transplant 2017 52: 144-146; advance online publication, August 1, 2016; 10.1038/bmt.2016.199

Salvage haploidentical hematopoietic cell transplantation for graft rejection following a prior haploidentical allograft

N Epperla, M Pasquini, K Pierce, W R Drobyski, J D Rizzo, M M Horowitz, W Saber, K Zellner, S Ramirez, K Bartz, R V Raj, P N Hari and M Hamadani

Bone Marrow Transplant 2017 52: 147-150; advance online publication, August 1, 2016; 10.1038/bmt.2016.200

Autoimmune-like hepatitis after allogeneic hematopoietic stem cell transplantation: humoral hepatic GvHD

D Koyama, M Ito, E Yokohata, K Watakabe, K Onodera, T Goto, A Seto, K Watanabe, M Doisaki, Y Ozawa, T Yamaguchi and K Miyamura

Bone Marrow Transplant 2017 52: 151-153; advance online publication, August 15, 2016; 10.1038/bmt.2016.202

Cryotherapy reduces oral mucositis and febrile episodes in myeloma patients treated with high-dose melphalan and autologous stem cell transplant: a prospective, randomized study

F Marchesi, A Tendas, D Giannarelli, C Viggiani, S Gumenyuk, D Renzi, L Franceschini, G Caffarella, M Rizzo, F Palombi, F Pisani, A Romano, A Spadea, E Papa, M Canfora, A Pignatelli, M Cantonetti, W Arcese and A Mengarelli

Bone Marrow Transplant 2017 52: 154-156; advance online publication, August 15, 2016; 10.1038/bmt.2016.207

Safety of repeated un-manipulated peripheral blood stem cell haploidentical transplant for graft failure

H Aboul Nour, N Patil, J H Chewning, A Di Stasi, D Salzman, R Innis-Shelton, L Lamb, S Mineishi and A Saad

Bone Marrow Transplant 2017 52: 157-158; advance online publication, August 15, 2016; 10.1038/bmt.2016.208

Long-term outcome following cyclosporine-related neurotoxicity in paediatric allogeneic haematopoietic stem cell transplantation OPEN

K Straathof, P Anoop, Z Allwood, J Silva, O Nikolajeva, R Chiesa, P Veys, P J Amrolia and K Rao

Bone Marrow Transplant 2017 52: 159-162; advance online publication, September 19, 2016; 10.1038/bmt.2016.232

Autologous stem cell transplantation is still a valid option in good- and intermediate-risk AML: a GITMO survey on 809 patients autografted in first complete remission

F Saraceni, B Bruno, R M Lemoli, G Meloni, W Arcese, M Falda, F Ciceri, E P Alessandrino, G Specchia, R Scimè, R Raimondi, A Bacigalupo, A Bosi, F Onida, A Rambaldi, F Bonifazi and A Olivieri on behalf of the GITMO (Gruppo Italiano Trapianto di Midollo Osseo)

Bone Marrow Transplant 2017 52: 163-166; advance online publication, September 26, 2016; 10.1038/bmt.2016.233

Cryopreservation as a way to maintain extracorporeal photopheresis regimen for GvHD treatment while circumventing patient temporary inability to undergo apheresis

C Pochon, L Reppel, P Halle, A Zang, L Clément, D Michel, A Perrot, G Roth-Guépin, M Detrait, J Kanold, N Rouel, B Donzé, V Décot, S Mathieu-Nafissi, E Merlin and D Bensoussan

Bone Marrow Transplant 2017 52: 167-170; advance online publication, September 19, 2016; 10.1038/bmt.2016.240