Scientific Reports Biology Table of Contents e-alert: 6 December 2016

If you are unable to see the message below, click here to view.

06 December 2016      • Visit Scientific Reports • Submit your manuscript to Scientific Reports     Welcome to your Table of Contents e-alert for Scientific Reports       Biological Sciences               Identification of heterotic loci associated with grain yield and its components using two CSSL test populations in maize ▶     Hongqiu Wang, Xiangge Zhang, Huili Yang et al.     Heterosis has widely been used to increase grain yield and quality. In this study, the genetic basis of heterosis on grain yield and its main components in maize were examined …             Refined purification strategy for reliable proteomic profiling of HDL2/3: Impact on proteomic complexity ▶     Michael Holzer, Sabine Kern, Ruth Birner-Grünberger et al.     Proteomics have extended the list of high-density lipoprotein (HDL) associated proteins to about 90. One of the major issues of global protein characterization is establishing …             Catalytic Conversion of Lipophilic Substrates by Phase constrained Enzymes in the Aqueous or in the Membrane Phase ▶     Marcus Cebula, Ilke Simsek Turan, Birgitta Sjödin et al.     Both soluble and membrane-bound enzymes can catalyze the conversion of lipophilic substrates. The precise substrate access path, with regard to phase, has however, until now …             Blood-borne phagocytes internalize urate microaggregates and prevent intravascular NETosis by urate crystals ▶     Elmar Pieterse, Ivica Jeremic, Christine Czegley et al.     Hyperuricemia is strongly linked to cardiovascular complications including atherosclerosis and thrombosis. In individuals with hyperuricemia, needle-shaped monosodium urate …             13-Methylberberine, a berberine analogue with stronger anti-adipogenic effects on mouse 3T3-L1 cells ▶     Yit-Lai Chow, Mami Sogame, Fumihiko Sato     Lipid metabolism modulation is a main focus of metabolic syndrome research, an area in which many natural and synthetic chemicals are constantly being screened for in vitro and …             c-MET as a Potential Therapeutic Target in Ovarian Clear Cell Carcinoma ▶     Ha-Jeong Kim, Aera Yoon, Ji-Yoon Ryu et al.     In this study, we investigated the therapeutic effects of c-MET inhibition in ovarian clear cell carcinoma (OCCC). Expression levels of c-MET in the epithelial ovarian cancers …             A century of temporal stability of genetic diversity in wild bumblebees ▶     Kevin Maebe, Ivan Meeus, Sarah Vray et al.     Since the 1950s, bumblebee (Bombus) species are showing a clear decline worldwide. Although many plausible drivers have been hypothesized, the cause(s) of this phenomenon remain …             Global DNA methylation variations after short-term heat shock treatment in cultured microspores of Brassica napus cv. Topas ▶     Jun Li, Qian Huang, Mengxiang Sun et al.     Heat stress can induce the cultured microspores into embryogenesis. In this study, whole genome bisulphite sequencing was employed to study global DNA methylation variations …             The effects of light exposure during incubation on embryonic development and hatchling traits in lizards ▶     Yong-Pu Zhang, Shu-Ran Li, Jun Ping et al.     Light is an environmental factor that is known to profoundly affect embryonic development in some oviparous vertebrates, but such effects are unstudied in reptiles. We …             Comparison of cell behavior on pva/pva-gelatin electrospun nanofibers with random and aligned configuration ▶     Chen-Yu Huang, Keng-Hsiang Hu, Zung-Hang Wei     Electrospinning technique is able to create nanofibers with specific orientation. Poly(vinyl alcohol) (PVA) have good mechanical stability but poor cell adhesion property due to …             Regional variations in the diversity and predicted metabolic potential of benthic prokaryotes in coastal northern Zhejiang, East China Sea ▶     Kai Wang, Xiansen Ye, Huajun Zhang et al.     Knowledge about the drivers of benthic prokaryotic diversity and metabolic potential in interconnected coastal sediments at regional scales is limited. We collected surface …             Umbilical Cord-derived Mesenchymal Stem Cells Instruct Monocytes Towards an IL10-producing Phenotype by Secreting IL6 and HGF ▶     Yinan Deng, Yingcai Zhang, Linsen Ye et al.     Human UC-MSCs are regarded as an attractive alternative to BM-MSCs for clinical applications due to their easy preparation, higher proliferation and lower immunogenicity. …             Basigin can be a therapeutic target to restore the retinal vascular barrier function in the mouse model of diabetic retinopathy ▶     Mitsuru Arima, Dan Cui, Tokuhiro Kimura et al.     Despite the advance in medical technology, diabetic retinopathy (DR) is still an intractable disease which leads to the damage of retinal cells and finally the visual loss. …             Vessel wall differences between middle cerebral artery and basilar artery plaques on magnetic resonance imaging ▶     Peng-Peng Niu, Yao Yu, Hong-Wei Zhou et al.     A recent study showed that posterior circulation plaques have a greater capacity for positive remodeling in a non-Asian population. We aimed to investigate if the features of …             ECAT1 is essential for human oocyte maturation and pre-implantation development of the resulting embryos ▶     Changyu Liu, Min Li, Tianjie Li et al.     ECAT1 is a subunit of the subcortical maternal complex that is required for cell cycle progression during pre-implantation embryonic development; however, its exact function …             Clonal spread of mcr-1 in PMQR-carrying ST34 Salmonella isolates from animals in China ▶     Xing-Ping Li, Liang-Xing Fang, Jia-Qi Song et al.     Since initial identification in China, the widespread geographical occurrence of plasmid-mediated colistin resistance gene mcr-1 in Enterobacteriaceae has been of great concern. …             A high-throughput fluorimetric microarray with enhanced fluorescence and suppressed “coffee-ring” effects for the detection of calcium ions in blood ▶     Yanjun Ding, Jiang Ling, Yuchun Qiao et al.     A rapid, ultrasensitive, and high-throughput fluorimetric microarray method has been developed using hydrophobic pattern as the microarray substrate and …             Characteristics of NH4+ and NO3− fluxes in tea (Camellia sinensis) roots measured by scanning ion-selective electrode technique ▶     Li Ruan, Kang Wei, Liyuan Wang et al.     As a vital beverage crop, tea has been extensively planted in tropical and subtropical regions. Nitrogen (N) levels and forms are closely related to tea quality. Based on …             Xylanase Treatment Suppresses Light- and Heat-Induced Yellowing of Pulp ▶     Daolei Zhang, Xuezhi Li, Meimei Wang et al.     Xylanase is commonly applied in pulp and paper industries to ease cost-related and environmental pressures. The effect of xylanase treatment on pulp bleaching is …             Astragaloside IV ameliorates allergic inflammation by inhibiting key initiating factors in the initial stage of sensitization ▶     Kai-fan Bao, Xi Yu, Xiao Wei et al.     To illuminate the anti-allergy mechanism of astragaloside IV (AS-IV), we assessed its effects in a murine model of allergic contact dermatitis (ACD). AS-IV administered in the …             Glycoprotein 130 is associated with adverse postoperative clinical outcomes of patients with late-stage non-metastatic gastric cancer ▶     Yifan Cao, Heng Zhang, Hao Liu et al.     The interaction of glycoprotein 130 (gp130) with the cytokines of Interleukin-6 (IL-6) family has proved to play a crucial part in several cancers. Our current study is designed …             Renal Denervation Improves the Baroreflex and GABA System in Chronic Kidney Disease-induced Hypertension ▶     Hsin-Hung Chen, Pei-Wen Cheng, Wen-Yu Ho et al.     Hypertensive rats with chronic kidney disease (CKD) exhibit enhanced gamma-aminobutyric acid (GABA)B receptor function and regulation within the nucleus tractus solitarii (NTS). …             A novel open-type biosensor for the in-situ monitoring of biochemical oxygen demand in an aerobic environment ▶     Takahiro Yamashita, Natsuki Ookawa, Mitsuyoshi Ishida et al.     Biochemical oxygen demand (BOD) is a widely used index of water-quality assessment. Since bioelectrochemical BOD biosensors require anaerobic conditions for anodic reactions, …             Establishment of a gastric cancer subline with high metastatic potential using a novel microfluidic system ▶     Zhe-zhou Chen, Wan-ming Li, Yu Zhang et al.     Metastasis is an important hallmark of malignant tumors. In this study, we developed a microfluidic system to screen highly metastatic sublines via differential resolution of …             DNA intercalation optimized by two-step molecular lock mechanism ▶     Ali A. Almaqwashi, Johanna Andersson, Per Lincoln et al.     The diverse properties of DNA intercalators, varying in affinity and kinetics over several orders of magnitude, provide a wide range of applications for DNA-ligand assemblies. Un…             Exploring experimental cerebral malaria pathogenesis through the characterisation of host-derived plasma microparticle protein content ▶     Natalia Tiberti, Sharissa L. Latham, Stephen Bush et al.     Cerebral malaria (CM) is a severe complication of Plasmodium falciparum infection responsible for thousands of deaths in children in sub-Saharan Africa. CM pathogenesis remains …             Association of MTDH immunohistochemical expression with metastasis and prognosis in female reproduction malignancies: a systematic review and meta-analysis ▶     Yongbin Hou, Lihua Yu, Yonghua Mi et al.     Various literatures have demonstrated that overexpression of Metadherin (MTDH) is correlated with tumor metastasis and it can predict poor survival outcomes in female …             A closer look into the α-helix basin ▶     Boris Haimov, Simcha Srebnik     α-Helices are the most abundant structures found within proteins and play an important role in the determination of the global structure of proteins and their function. …             Inhibition of alpha-synuclein aggregation by multifunctional dopamine agonists assessed by a novel in vitro assay and an in vivo Drosophila synucleinopathy model ▶     Deepthi Yedlapudi, Gnanada S. Joshi, Dan Luo et al.     Aggregation of alpha synuclein (α-syn) leading to dopaminergic neuronal death has been recognized as one of the main pathogenic factors in the initiation and progression of …             Chemical Imaging of Platinum-Based Drugs and their Metabolites ▶     Xin Liu, Amanda B. Hummon     Platinum-based drugs (cisplatin, carboplatin, and oxaliplatin) are widely used therapeutic agents for cancer treatment. Even though the platinum (Pt)-drugs are routinely used …             RCANs regulate the convergent roles of NFATc1 in bone homeostasis ▶     Jung Ha Kim, Kabsun Kim, Inyoung Kim et al.     Activation of calcineurin-dependent nuclear factor of activated T cells c1 (NFATc1) is convergent for normal bone homeostasis. NFATc1 regulates both osteoclastogenesis and …             T cells mediate autoantibody-induced cutaneous inflammation and blistering in epidermolysis bullosa acquisita ▶     Katja Bieber, Mareike Witte, Shijie Sun et al.     T cells are key players in autoimmune diseases by supporting the production of autoantibodies. However, their contribution to the effector phase of antibody-mediated autoimmune …             Comparative phylogenomic analysis provides insights into TCP gene functions in Sorghum ▶     Aleena Francis, Namrata Dhaka, Mohit Bakshi et al.     Sorghum is a highly efficient C4 crop with potential to mitigate challenges associated with food, feed and fuel. TCP proteins are of particular interest for crop improvement …             Incomplete and delayed Sox2 deletion defines residual ear neurosensory development and maintenance ▶     Martina Dvorakova, Israt Jahan, Iva Macova et al.     The role of Sox2 in neurosensory development is not yet fully understood. Using mice with conditional Islet1-cre mediated deletion of Sox2, we explored the function of Sox2 in …             Distinct epigenomes in CD4+ T cells of newborns, middle-ages and centenarians ▶     Ming Zhao, Jian Qin, Hanqi Yin et al.     Age-related variations in genes and microRNAs expression and DNA methylation have been reported respectively; however, their interactions during aging are unclear. We therefore …             Soluble Amyloid-beta Aggregates from Human Alzheimer’s Disease Brains ▶     Thomas J. Esparza, Norelle C. Wildburger, Hao Jiang et al.     Soluble amyloid-beta (Aβ) aggregates likely contribute substantially to the dementia that characterizes Alzheimer’s disease. However, despite intensive study of in vitro …             Biomarker MicroRNAs for Diagnosis, Prognosis and Treatment of Hepatocellular Carcinoma: A Functional Survey and Comparison ▶     Sijia Shen, Yuxin Lin, Xuye Yuan et al.     Hepatocellular Carcinoma (HCC) is one of the most common malignant tumors with high incidence and mortality rate. Precision and effective biomarkers are therefore urgently needed …             OsSGL, a novel pleiotropic stress-related gene enhances grain length and yield in rice ▶     Manling Wang, Xuedan Lu, Guoyun Xu et al.     Abiotic stress seriously affects the yield of rice (Oryza sativa L.). Grain yield in rice is multiplicatively determined by the number of panicles, number of grains per panicle, …             Colonic luminal microbiota and bacterial metabolite composition in pregnant Huanjiang mini-pigs: effects of food composition at different times of pregnancy ▶     Xiang-feng Kong, Yu-jiao Ji, Hua-wei Li et al.     The gut harbours diverse and complex microbiota, which influence body health including nutrient metabolism, immune development, and protection from pathogens. Pregnancy is …             Distinct and Shared Determinants of Cardiomyocyte Contractility in Multi-Lineage Competent Ethnically Diverse Human iPSCs ▶     Martin L. Tomov, Zachary T. Olmsted, Haluk Dogan et al.     The realization of personalized medicine through human induced pluripotent stem cell (iPSC) technology can be advanced by transcriptomics, epigenomics, and bioinformatics that …             Relocation of active site carboxylates in major facilitator superfamily multidrug transporter LmrP reveals plasticity in proton interactions ▶     Asha V. Nair, Himansha Singh, Sagar Raturi et al.     The expression of polyspecific membrane transporters is one important mechanism by which cells can obtain resistance to structurally different antibiotics and cytotoxic agents. …             The Core Subunit of A Chromatin-Remodeling Complex, ZmCHB101, Plays Essential Roles in Maize Growth and Development ▶     Xiaoming Yu, Lili Jiang, Rui Wu et al.     ATP-dependent chromatin remodeling complexes play essential roles in the regulation of diverse biological processes by formulating a DNA template that is accessible to the …             Biogenic synthesis of Zinc oxide nanostructures from Nigella sativa seed: Prospective role as food packaging material inhibiting broad-spectrum quorum sensing and biofilm ▶     Nasser A. Al-Shabib, Fohad Mabood Husain, Faheem Ahmed et al.     Bacterial spoilage of food products is regulated by density dependent communication system called quorum sensing (QS). QS control biofilm formation in numerous food pathogens and …             Submillimetre Network Formation by Light-induced Hybridization of Zeptomole-level DNA ▶     Takuya Iida, Yushi Nishimura, Mamoru Tamura et al.     Macroscopic unique self-assembled structures are produced via double-stranded DNA formation (hybridization) as a specific binding essential in biological systems. However, a …             Biodiversity in models of cyclic dominance is preserved by heterogeneity in site-specific invasion rates ▶     Attila Szolnoki, Matjaž Perc     Global, population-wide oscillations in models of cyclic dominance may result in the collapse of biodiversity due to the accidental extinction of one species in the loop. …             Modular Architecture and Unique Teichoic Acid Recognition Features of Choline-Binding Protein L (CbpL) Contributing to Pneumococcal Pathogenesis ▶     Javier Gutiérrez-Fernández, Malek Saleh, Martín Alcorlo et al.     The human pathogen Streptococcus pneumoniae is decorated with a special class of surface-proteins known as choline-binding proteins (CBPs) attached to phosphorylcholine (PCho) …             Utility of real-time prospective motion correction (PROMO) on 3D T1-weighted imaging in automated brain structure measurements ▶     Keita Watanabe, Shingo Kakeda, Natsuki Igata et al.     PROspective MOtion correction (PROMO) can prevent motion artefacts. The aim of this study was to determine whether brain structure measurements of motion-corrected images with …             New Insights into Molecular Organization of Human Neuraminidase-1: Transmembrane Topology and Dimerization Ability ▶     Pascal Maurice, Stéphanie Baud, Olga V. Bocharova et al.     Neuraminidase 1 (NEU1) is a lysosomal sialidase catalyzing the removal of terminal sialic acids from sialyloconjugates. A plasma membrane-bound NEU1 modulating a plethora of …             NIPTRIC: an online tool for clinical interpretation of non-invasive prenatal testing (NIPT) results ▶     Birgit Sikkema-Raddatz, Lennart F. Johansson, Eddy N. de Boer et al.     To properly interpret the result of a pregnant woman’s non-invasive prenatal test (NIPT), her a priori risk must be taken into account in order to obtain her personalised a …             Optical imaging of MMP-12 active form in inflammation and aneurysm ▶     Mahmoud Razavian, Thomas Bordenave, Dimitris Georgiadis et al.     Matrix metalloproteinase (MMP)-12 plays a key role in the development of aneurysm. Like other members of MMP family, MMP-12 is produced as a proenzyme, mainly by macrophages, and …             Small molecules increase direct neural conversion of human fibroblasts ▶     Ulrich Pfisterer, Fredrik Ek, Stefan Lang et al.     The generation of human induced neurons (hiNs) via exogenous delivery of neural transcription factors represents a novel technique to obtain disease and patient specific neurons. …             Purslane (Portulaca oleracea) Seed Consumption And Aerobic Training Improves Biomarkers Associated with Atherosclerosis in Women with Type 2 Diabetes (T2D) ▶     Firouzeh Dehghan, Rahman Soori, Khadijeh Gholami et al.     The aim of this study was to investigate the responses of atherosclerosis plaque biomarkers to purslane seed consumption and aerobic training in women with T2D. 196 women with …             Self-cleaning of Surfaces: the Role of Surface Wettability and Dust Types ▶     Yun-Yun Quan, Li-Zhi Zhang, Rong-Hui Qi et al.     The self-cleaning property is usually connected to superhydrophobic surfaces (SHSs) where the dust particles can be easily removed by the rolling motion of droplets. It seems …             Novel human mutation and CRISPR/Cas genome-edited mice reveal the importance of C-terminal domain of MSX1 in tooth and palate development ▶     Silvia Naomi Mitsui, Akihiro Yasue, Kiyoshi Masuda et al.     Several mutations, located mainly in the MSX1 homeodomain, have been identified in non-syndromic tooth agenesis predominantly affecting premolars and third molars. We identified …             Heterotrophy promotes the re-establishment of photosynthate translocation in a symbiotic coral after heat stress ▶     Pascale Tremblay, Andrea Gori, Jean François Maguer et al.     Symbiotic scleractinian corals are particularly affected by climate change stress and respond by bleaching (losing their symbiotic dinoflagellate partners). Recently, the …             Ubiquitin Ligase NEDD4 Regulates PPARγ Stability and Adipocyte Differentiation in 3T3-L1 Cells ▶     Jing Jing Li, Ruishan Wang, Rati Lama et al.     Peroxisome proliferator–activated receptor-γ (PPARγ) is a ligand-activated nuclear receptor which controls lipid and glucose metabolism. It is also the master regulator of …             Functional complexity emerging from anatomical constraints in the brain: the significance of network modularity and rich-clubs ▶     Gorka Zamora-López, Yuhan Chen, Gustavo Deco et al.     The large-scale structural ingredients of the brain and neural connectomes have been identified in recent years. These are, similar to the features found in many other real …             Intravenous hMSCs Ameliorate Acute Pancreatitis in Mice via Secretion of Tumor Necrosis Factor-α Stimulated Gene/Protein 6 ▶     Zhigang He, Jie Hua, Daohai Qian et al.     The administration of mesenchymal stem cells/multipotent mesenchymal stromal cells (MSCs) to enhance tissue repair is currently undergoing clinical trials. Some studies, …             Transcriptome and long noncoding RNA sequencing of three extracellular vesicle subtypes released from the human colon cancer LIM1863 cell line ▶     Maoshan Chen, Rong Xu, Hong Ji et al.     Previously we reported that LIM1863 colorectal cancer (CRC) cells secrete three distinct extracellular vesicle subtypes – two subpopulations of exosomes (apical EpCAM-Exos and …             An integrated modelling framework from cells to organism based on a cohort of digital embryos ▶     Paul Villoutreix, Julien Delile, Barbara Rizzi et al.     We conducted a quantitative comparison of developing sea urchin embryos based on the analysis of five digital specimens obtained by automatic processing of in toto 3D+ time image …             Improved in-cell structure determination of proteins at near-physiological concentration ▶     Teppei Ikeya, Tomomi Hanashima, Saori Hosoya et al.     Investigating three-dimensional (3D) structures of proteins in living cells by in-cell nuclear magnetic resonance (NMR) spectroscopy opens an avenue towards understanding the …             Prior Knowledge Facilitates Mutual Gaze Convergence and Head Nodding Synchrony in Face-to-face Communication ▶     C. Thepsoonthorn, T. Yokozuka, S. Miura et al.     As prior knowledge is claimed to be an essential key to achieve effective education, we are interested in exploring whether prior knowledge enhances communication effectiveness. …             Microtubule stabilising peptides rescue tau phenotypes in-vivo ▶     Shmma Quraishe, Megan Sealey, Louise Cranfield et al.     The microtubule cytoskeleton is a highly dynamic, filamentous network underpinning cellular structure and function. In Alzheimer’s disease, the microtubule cytoskeleton is …             Disentangling the roles of cholesterol and CD59 in intermedilysin pore formation ▶     Courtney M. Boyd, Edward S. Parsons, Richard A. G. Smith et al.     The plasma membrane provides an essential barrier, shielding a cell from the pressures of its external environment. Pore-forming proteins, deployed by both hosts and pathogens …             Genome analysis of Campylobacter concisus strains from patients with inflammatory bowel disease and gastroenteritis provides new insights into pathogenicity ▶     Heung Kit Leslie Chung, Alfred Tay, Sophie Octavia et al.     Campylobacter concisus is an oral bacterium that is associated with inflammatory bowel disease. C. concisus has two major genomospecies, which appear to have different enteric …             Hydrogen overproducing nitrogenases obtained by random mutagenesis and high-throughput screening ▶     Emma Barahona, Emilio Jiménez-Vicente, Luis M. Rubio     When produced biologically, especially by photosynthetic organisms, hydrogen gas (H2) is arguably the cleanest fuel available. An important limitation to the discovery or …             Mal-Lys: prediction of lysine malonylation sites in proteins integrated sequence-based features with mRMR feature selection ▶     Yan Xu, Ya-Xin Ding, Jun Ding et al.     Lysine malonylation is an important post-translational modification (PTM) in proteins, and has been characterized to be associated with diseases. However, identifying …             The mechanism of transactivation regulation due to polymorphic short tandem repeats (STRs) using IGF1 promoter as a model ▶     Holly Y. Chen, Suk Ling Ma, Wei Huang et al.     Functional short tandem repeats (STR) are polymorphic in the population, and the number of repeats regulates the expression of nearby genes (known as expression STR, eSTR). STR …             Zn uptake behavior of rice genotypes and its implication on grain Zn biofortification ▶     Sarah E. Johnson-Beebout, Johnvie Bayang Goloran, Francis H. C. Rubianes et al.     Understanding Zn uptake dynamics is critical to rice grain Zn biofortification. Here we examined soil Zn availability and Zn uptake pathways as affected by genotype (high-grain …             Conditional knockout of N-WASP in mouse fibroblast caused keratinocyte hyper proliferation and enhanced wound closure ▶     Neeraj Jain, Pazhanichamy Kalailingam, Kai Wei Tan et al.     Neural-Wiskott Aldrich Syndrome Protein (N-WASP) is expressed ubiquitously, regulates actin polymerization and is essential during mouse development. We have previously shown …             Calcium ions function as a booster of chromosome condensation ▶     Rinyaporn Phengchat, Hideaki Takata, Kenichi Morii et al.     Chromosome condensation is essential for the faithful transmission of genetic information to daughter cells during cell division. The depletion of chromosome scaffold proteins …             Methylmercury induces the expression of TNF-α selectively in the brain of mice ▶     Miyuki Iwai-Shimada, Tsutomu Takahashi, Min-Seok Kim et al.     Methylmercury selectively damages the central nervous system (CNS). The tumor necrosis factor (TNF) superfamily includes representative cytokines that participate in the …             Larval diet affects mosquito development and permissiveness to Plasmodium infection ▶     Inbar Linenberg, George K. Christophides, Mathilde Gendrin     The larval stages of malaria vector mosquitoes develop in water pools, feeding mostly on microorganisms and environmental detritus. Richness in the nutrient supply to larvae …             Glial pannexin1 contributes to tactile hypersensitivity in a mouse model of orofacial pain ▶     Regina Hanstein, Menachem Hanani, Eliana Scemes et al.     Drug studies in animal models have implicated pannexin1 (Panx1) in various types of pain, including trigeminal hypersensitivity, neuropathic pain and migraine. However, the …             Biohydrogen production from enzymatic hydrolysis of food waste in batch and continuous systems ▶     Wei Han, Yingting Yan, Yiwen Shi et al.     In this study, the feasibility of biohydrogen production from enzymatic hydrolysis of food waste was investigated. Food waste (solid-to-liquid ratio of 10%, w/v) was first …             Arabidopsis thaliana as a suitable model host for research on interactions between plant and foliar nematodes, parasites of plant shoot ▶     Dong-Wei Wang, Xiao-Fang Peng, Hui Xie et al.     The rice white tip nematode (RWTN), Aphelenchoides besseyi and the chrysanthemum foliar nematode (CFN), Aphelenchoides ritzemabosi are migratory plant parasitic nematodes that …             Bonobo personality traits are heritable and associated with vasopressin receptor gene 1a variation ▶     Nicky Staes, Alexander Weiss, Philippe Helsen et al.     Despite being closely related, bonobos and chimpanzees show remarkable behavioral differences, the proximate origins of which remain unknown. This study examined the link between …             Hyperthermia enhances 17-DMAG efficacy in hepatocellular carcinoma cells with aggravated DNA damage and impaired G2/M transition ▶     Zhizhou Huang, Xueqiong Zhou, Yangfan He et al.     Due to the lack of effective treatment, hepatocellular carcinoma (HCC) is one of the malignancies with low survival rates worldwide. Combination of hyperthermia and chemotherapy …             Novel groups and unique distribution of phage phoH genes in paddy waters in northeast China ▶     Xinzhen Wang, Junjie Liu, Zhenhua Yu et al.     Although bacteriophages are ubiquitous in various environments, their genetic diversity is primarily investigated in pelagic marine environments. Corresponding studies in …             Group benefit associated with polymorphic trichromacy in a Malagasy primate (Propithecus verreauxi) ▶     Carrie C. Veilleux, Clara J. Scarry, Anthony Di Fiore et al.     In some primate lineages, polymorphisms in the X-linked M/LWS opsin gene have produced intraspecific variation in color vision. In these species, heterozygous females exhibit …             Real-time PCR-based serotyping of Streptococcus agalactiae ▶     Kathleen M. Breeding, Bhavana Ragipani, Kun-Uk David Lee et al.     Group B Streptococcus (GBS) is an encapsulated, gram-positive pathogen that is an important cause of neonatal invasive infections, including sepsis and meningitis. There are ten …             Interference with Protease-activated Receptor 1 Alleviates Neuronal Cell Death Induced by Lipopolysaccharide-Stimulated Microglial Cells through the PI3K/Akt Pathway ▶     Yuxin Li, Wuyang Yang, Alfredo Quinones-Hinojosa et al.     Excessive microglial cells activation in response to inflammatory stimuli leads to synaptic loss, dysfunction, and neuronal cell death. Activated microglia are involved in the …             The Association between Physical Activity During the Day and Long-Term Memory Stability ▶     Matthew B. Pontifex, Kathryn L. Gwizdala, Andrew C. Parks et al.     Despite positive associations between chronic physical activity and memory; we have little understanding of how best to incorporate physical activity during the day to facilitate …             Insights into the Phosphoryl Transfer Mechanism of Human Ubiquitous Mitochondrial Creatine Kinase ▶     Quanjie Li, Shuai Fan, Xiaoyu Li et al.     Human ubiquitous mitochondrial creatine kinase (uMtCK) is responsible for the regulation of cellular energy metabolism. To investigate the phosphoryl-transfer mechanism catalyzed …             Learning by Association in Plants ▶     Monica Gagliano, Vladyslav V. Vyazovskiy, Alexander A. Borbély et al.     In complex and ever-changing environments, resources such as food are often scarce and unevenly distributed in space and time. Therefore, utilizing external cues to locate and …             miR-27a attenuates adipogenesis and promotes osteogenesis in steroid-induced rat BMSCs by targeting PPARγ and GREM1 ▶     Chenxi Gu, Yan Xu, Shanfeng Zhang et al.     The imbalance between adipogenic and osteogenic differentiation in bone marrow mesenchymal stem cells (BMSCs) plays a significant role in the pathogenesis of steroid-induced …             Ascl3 transcription factor marks a distinct progenitor lineage for non-neuronal support cells in the olfactory epithelium ▶     Pei-Lun Weng, Mridula Vinjamuri, Catherine E. Ovitt     The olfactory epithelium (OE) is composed of olfactory sensory neurons (OSNs), sustentacular supporting cells, and several types of non-neuronal cells. Stem and progenitor cells …             Melanosome transfer to keratinocyte in the chicken embryonic skin is mediated by vesicle release associated with Rho-regulated membrane blebbing ▶     Ryosuke Tadokoro, Hidetaka Murai, Ken-ichiro Sakai et al.     During skin pigmentation in amniotes, melanin synthesized in the melanocyte is transferred to keratinocytes by a particle called the melanosome. Previous studies, mostly using …             High-throughput chinmedomics-based prediction of effective components and targets from herbal medicine AS1350 ▶     Qi Liu, Aihua Zhang, Liang Wang et al.     This work was designed to explore the effective components and targets of herbal medicine AS1350 and its effect on “Kidney-Yang Deficiency Syndrome” (KYDS) based on a …             Genomic variations leading to alterations in cell morphology of Campylobacter spp ▶     Diane Esson, Alison E. Mather, Eoin Scanlan et al.     Campylobacter jejuni, the most common cause of bacterial diarrhoeal disease, is normally helical. However, it can also adopt straight rod, elongated helical and coccoid forms. …             Comprehensive evaluation of molecular enhancers of the isothermal exponential amplification reaction ▶     Ellie Mok, Eugene Wee, Yuling Wang et al.     The exponential amplification reaction (EXPAR) is an emerging isothermal nucleic acid amplification method with high potential for molecular diagnostics due to its isothermal …             Design of a hydroxyapatite-binding antimicrobial peptide with improved retention and antibacterial efficacy for oral pathogen control ▶     Zhi-bin Huang, Xin Shi, Jing Mao et al.     Controlling and reducing the formation of pathogenic biofilm on tooth surface is the key to the prevention and treatment of the biofilm-associated oral diseases. Antimicrobial …             Genome-wide characterisation and expression profile of the grapevine ATL ubiquitin ligase family reveal biotic and abiotic stress-responsive and development-related members ▶     Pietro Ariani, Alice Regaiolo, Arianna Lovato et al.     The Arabidopsis Tóxicos en Levadura (ATL) protein family is a class of E3 ubiquitin ligases with a characteristic RING-H2 Zn-finger structure that mediates diverse physiological …             Superficial vimentin mediates DENV-2 infection of vascular endothelial cells ▶     Jie Yang, Lingyun Zou, Yi Yang et al.     Damage to vascular endothelial cells (VECs) is a critical hallmark of hemorrhagic diseases caused by dengue virus (DENV). However, the precise molecular event involved in DENV …             Engineering of a thermostable esterase Est816 to improve its quorum-quenching activity and the underlying structural basis ▶     Xiwen Liu, Li-chuang Cao, Xin-jiong Fan et al.     N-acyl-homoserine lactones (AHLs) are small diffusible molecules called autoinducers that mediate cell-to-cell communications. Enzymatic degradation of AHLs is a promising …             MicroRNAs modulate adaption to multiple abiotic stresses in Chlamydomonas reinhardtii ▶     Xiang Gao, Fengge Zhang, Jinlu Hu et al.     MicroRNAs play an important role in abiotic stress responses in higher plants and animals, but their role in stress adaptation in algae remains unknown. In this study, the …             In vivo stepwise immunomodulation using chitosan nanoparticles as a platform nanotechnology for cancer immunotherapy ▶     Hee Dong Han, Yeongseon Byeon, Jong-Hwa Jang et al.     Dentritic cell (DC)-based cancer immunotherapy faces challenges in both efficacy and practicality. However, DC-based vaccination requires multiple injections and elaborates ex …             Novel chemoimmunotherapeutic strategy for hepatocellular carcinoma based on a genome-wide association study ▶     Kaku Goto, Dorcas A. Annan, Tomoko Morita et al.     Pharmacotherapeutic options are limited for hepatocellular carcinoma (HCC). Recently, we identified the anti-tumor ligand MHC class I polypeptide-related sequence A (MICA) gene …             Human Mesenchymal stem cells program macrophage plasticity by altering their metabolic status via a PGE2-dependent mechanism ▶     Anoop Babu Vasandan, Sowmya Jahnavi, Chandanala Shashank et al.     Mesenchymal stem cells (MSCs) are speculated to act at macrophage-injury interfaces to mediate efficient repair. To explore this facet in-depth this study evaluates the influence …             Improved bi-allelic modification of a transcriptionally silent locus in patient-derived iPSC by Cas9 nickase ▶     Reto Eggenschwiler, Mohsen Moslem, Mariane Serra Fráguas et al.     Homology directed repair (HDR)-based genome editing via selectable long flanking arm donors can be hampered by local transgene silencing at transcriptionally silent loci. Here, …             Energy metabolism regulated by HDAC inhibitor attenuates cardiac injury in hemorrhagic rat model ▶     Qiyuan Kuai, Chunyan Wang, Yanbing Wang et al.     A disturbance of energy metabolism reduces cardiac function in acute severe hemorrhagic patients. Alternatively, adequate energy supply reduces heart failure and increases …             Antinociceptive Profile of Levo-tetrahydropalmatine in Acute and Chronic Pain Mice Models: Role of spinal sigma-1 receptor ▶     Dong-Wook Kang, Ji-Young Moon, Jae-Gyun Choi et al.     We have recently reported that repeated systemic treatments of extract from Corydalis yanhusuo alleviate neuropathic pain and levo-tetrahydropalmatine (l-THP) is one of active …             The Hha-TomB Toxin-Antitoxin System Shows Conditional Toxicity and Promotes Persister Cell Formation by Inhibiting Apoptosis-Like Death in S. Typhimurium ▶     Sangeeta Jaiswal, Prajita Paul, Chandrashekhar Padhi et al.     Toxin-antitoxin (TA) modules are two component “addictive” genetic elements found on either plasmid or bacterial chromosome, sometimes on both. TA systems perform a wide range of …             Effects of annual influenza vaccination on morbidity and mortality in patients with Systemic Lupus Erythematosus: A Nationwide Cohort Study ▶     Chi-Ching Chang, Yu-Sheng Chang, Wei-Sheng Chen et al.     Studies on the clinical efficacy of influenza vaccination on patients with systemic lupus erythematosus (SLE) are scant. The present study compared the incidence of …             Loss of EGFR-ASAP1 signaling in metastatic and unresectable hepatoblastoma ▶     Sarangarajan Ranganathan, Mylarappa Ningappa, Chethan Ashokkumar et al.     Hepatoblastoma (HBL), the most common childhood liver cancer is cured with surgical resection after chemotherapy or with liver transplantation if local invasion and multifocality …             Sequential information in a great ape utterance ▶     Pawel Fedurek, Klaus Zuberbühler, Christoph D. Dahl     Birdsong is a prime example of acoustically sophisticated vocal behaviour, but its complexity has evolved mainly through sexual selection to attract mates and repel sexual …             Auditory evoked potential could reflect emotional sensitivity and impulsivity ▶     Ji Sun Kim, Sungkean Kim, Wookyoung Jung et al.     Emotional sensitivity and impulsivity could cause interpersonal conflicts and neuropsychiatric problems. Serotonin is correlated with behavioral inhibition and impulsivity. This …             Protein expression from unintegrated HIV-1 DNA introduces bias in primary in vitro post-integration latency models ▶     Pawel Bonczkowski, Marie-Angélique De Scheerder, Eva Malatinkova et al.     To understand the persistence of latently HIV-1 infected cells in virally suppressed infected patients, a number of in vitro models of HIV latency have been developed. In an …             Mutational analysis of PRNP in Alzheimer’s disease and frontotemporal dementia in China ▶     Weiwei Zhang, Bin Jiao, Tingting Xiao et al.     The prion protein (PRNP) gene is associated with prion diseases, whereas variants of the PRNP gene may also explain some cases of Alzheimer disease (AD) and frontotemporal …             Adjuvant radiotherapy for locally advanced upper tract urothelial carcinoma ▶     Yun-Ching Huang, Ying-Hsu Chang, Kuo-Hsiung Chiu et al.     There is relatively little literature on adjuvant radiotherapy after radical nephroureterectomy with bladder cuff excision (RNU) for patients with upper tract urothelial …             The Disinfection Characteristics of Ebola Virus Outbreak Variants ▶     Bradley W. M. Cook, Todd A. Cutts, Aidan M. Nikiforuk et al.     The recent Ebola virus outbreak in West Africa has forced experts to re-evaluate their understanding of how to best disinfect areas contaminated with infectious bodily fluids. …             Intracellular mechanisms of solar water disinfection ▶     María Castro-Alférez, María Inmaculada Polo-López, Pilar Fernández-Ibáñez     Solar water disinfection (SODIS) is a zero-cost intervention measure to disinfect drinking water in areas of poor access to improved water sources, used by more than 6 million …             Protective effects of ginsenoside Rg1 on intestinal ischemia/reperfusion injury-induced oxidative stress and apoptosis via activation of the Wnt/β-catenin pathway ▶     Guo Zu, Jing Guo, Ningwei Che et al.     Ginsenoside Rg1 (Rg1) is one of the major bioactive ingredients in Panax ginseng, and it attenuates inflammation and apoptosis. The aims of our study were to explore the …             BHX Inhibits the Wnt Signaling Pathway by Suppressing β-catenin Transcription in the Nucleus ▶     Fengxia Ding, Meisa Wang, Yibo Du et al.     BHX (N-(4-hydroxybenzyl)-1,3,4-triphenyl-4,5-dihydro-1H-pyrazole-5-carboxamide), a Wnt signaling pathway inhibitor, effectively inhibits tumor cell growth, but the underlying …             Unc-5 homolog B (UNC5B) is one of the key downstream targets of N-α-Acetyltransferase 10 (Naa10) ▶     Huiyu Xu, Yong Han, Bing Liu et al.     N-α-acetyltransferase 10 (Naa10) displays alpha (N-terminal) acetyltransferase activity. It functions as a major modulator of cell growth and differentiation. Until now, a few …             PGC-1α dictates endothelial function through regulation of eNOS expression ▶     Siobhan M. Craige, Swenja Kröller-Schön, Chunying Li et al.     Endothelial dysfunction is a characteristic of many vascular related diseases such as hypertension. Peroxisome proliferator activated receptor gamma, coactivator 1α (PGC-1α) is a …             Hydrogen sulfide (H2S) emission control by aerobic sulfate reduction in landfill ▶     Yuyang Long, Yuan Fang, Dongsheng Shen et al.     H2S emissions from landfill sites resulting from sulfate reduction has become a serious human health and ecological safety issue. This study investigated H2S emission behavior …             SAG/RBX2 E3 ligase complexes with UBCH10 and UBE2S E2s to ubiquitylate β-TrCP1 via K11-linkage for degradation ▶     Peng Kuang, Mingjia Tan, Weihua Zhou et al.     SAG/RBX2 and RBX1 are two family members of RING components of Cullin-RING ligases (CRLs), required for their enzymatic activity. Previous studies showed that SAG prefers to bind …             Biomechanical Analysis of Normal Brain Development during the First Year of Life Using Finite Strain Theory ▶     Jeong Chul Kim, Li Wang, Dinggang Shen et al.     The first year of life is the most critical time period for structural and functional development of the human brain. Combining longitudinal MR imaging and finite strain theory, …             Transmission of Multiple HIV-1 Subtype C Transmitted/founder Viruses into the Same Recipients Was not Determined by Modest Phenotypic Differences ▶     Hongshuo Song, Bhavna Hora, Elena E. Giorgi et al.     A severe bottleneck exists during HIV-1 mucosal transmission. However, viral properties that determine HIV-1 transmissibility are not fully elucidated. We identified multiple …             Prostate Cancer Patients–Negative Biopsy Controls Discrimination by Untargeted Metabolomics Analysis of Urine by LC-QTOF: Upstream Information on Other Omics ▶     M. A. Fernández-Peralbo, E. Gómez-Gómez, M. Calderón-Santiago et al.     The existing clinical biomarkers for prostate cancer (PCa) diagnosis are far from ideal (e.g., the prostate specific antigen (PSA) serum level suffers from lack of specificity, …             Relationship between nanotopographical alignment and stem cell fate with live imaging and shape analysis ▶     Peter Newman, Jorge Luis Galenano-Niño, Pamela Graney et al.     The topography of a biomaterial regulates cellular interactions and determine stem cell fate. A complete understanding of how topographical properties affect cell behavior will …             Multiparameter mechanical and morphometric screening of cells ▶     Mahdokht Masaeli, Dewal Gupta, Sean O’Byrne et al.     We introduce a label-free method to rapidly phenotype and classify cells purely based on physical properties. We extract 15 biophysical parameters from cells as they deform in a …             Protein-peptide molecular docking with large-scale conformational changes: the p53-MDM2 interaction ▶     Maciej Pawel Ciemny, Aleksander Debinski, Marta Paczkowska et al.     Protein-peptide interactions are often associated with large-scale conformational changes that are difficult to study either by classical molecular modeling or by experiment. …             Selection for predation, not female fecundity, explains sexual size dimorphism in the orchid mantises ▶     Gavin J. Svenson, Sydney K. Brannoch, Henrique M. Rodrigues et al.     Here we reconstruct the evolutionary shift towards floral simulation in orchid mantises and suggest female predatory selection as the likely driving force behind the development …             Discovery and structural characterisation of new fold type IV-transaminases exemplify the diversity of this enzyme fold ▶     Tea Pavkov-Keller, Gernot A. Strohmeier, Matthias Diepold et al.     Transaminases are useful biocatalysts for the production of amino acids and chiral amines as intermediates for a broad range of drugs and fine chemicals. Here, we describe the …             Corrigendum: MuSK Kinase Activity is Modulated By A Serine Phosphorylation Site in The Kinase Loop ▶     B. Z. Camurdanoglu, C. Hrovat, G. Dürnberger et al.                 Seagrass (Posidonia oceanica) seedlings in a high-CO2 world: from physiology to herbivory ▶     Gema Hernán, Laura Ramajo, Lorena Basso et al.     Under future increased CO2 concentrations, seagrasses are predicted to perform better as a result of increased photosynthesis, but the effects in carbon balance and growth are …             Immune-responsiveness of CD4+ T cells during Streptococcus suis serotype 2 infection ▶     Marie-Pier Lecours, Corinne Letendre, Damian Clarke et al.     The pathogenesis of Streptococcus suis infection, a major swine and human pathogen, is only partially understood and knowledge on the host adaptive immune response is critically …             Increased temperature delays the late-season phenology of multivoltine insect ▶     Adam Glazaczow, David Orwin, Michał Bogdziewicz     We analyzed the impact of increased water temperature on the late-season phenology of the mayfly (Baetis liebenauae). The River Gwda, unlike two other examined rivers (controls), …             Transcriptome analysis confers a complex disease resistance network in wild rice Oryza meyeriana against Xanthomonas oryzae pv. oryzae ▶     Xiao-Jie Cheng, Bin He, Lin Chen et al.     Rice bacterial blight (BB), caused by Xanthomonas oryzae pv. oryzae (Xoo), is one of the devastating diseases of rice. It is well established that the wild rice Oryza meyeriana …             Inter-laboratory evolution of a model organism and its epistatic effects on mutagenesis screens ▶     Michael D. Bradley, Devin Neu, Fatmagul Bahar et al.     In theory, a few naturally occurring evolutionary changes in the genome of a model organism may have little or no observable impact on its wild type phenotype, and yet still …             Whole-genome scanning for the litter size trait associated genes and SNPs under selection in dairy goat (Capra hircus) ▶     Fang-Nong Lai, Hong-Li Zhai, Ming Cheng et al.     Dairy goats are one of the most utilized domesticated animals in China. Here, we selected extreme populations based on differential fecundity in two Laoshan dairy goat …             Post-Translational Incorporation of L-Phenylalanine into the C-Terminus of α-Tubulin as a Possible Cause of Neuronal Dysfunction ▶     Yanina Ditamo, Yanela M. Dentesano, Silvia A. Purro et al.     α-Tubulin C-terminus undergoes post-translational, cyclic tyrosination/detyrosination, and L-Phenylalanine (Phe) can be incorporated in place of tyrosine. Using cultured mouse …             Association between preterm brain injury and exposure to chorioamnionitis during fetal life ▶     Devasuda Anblagan, Rozalia Pataky, Margaret J. Evans et al.     Preterm infants are susceptible to inflammation-induced white matter injury but the exposures that lead to this are uncertain. Histologic chorioamnionitis (HCA) reflects …             Advancing ovarian folliculometry with selective plane illumination microscopy ▶     Hsiao-Chun Amy Lin, Rahul Dutta, Subhamoy Mandal et al.     Determination of ovarian status and follicle monitoring are common methods of diagnosing female infertility. We evaluated the suitability of selective plane illumination …             Application of profile fitting method to neutron time-of-flight protein single crystal diffraction data collected at the iBIX ▶     Naomine Yano, Taro Yamada, Takaaki Hosoya et al.     We developed and employed a profile fitting method for the peak integration of neutron time-of-flight diffraction data collected by the IBARAKI Biological Crystal Diffractometer …             G4IPDB: A database for G-quadruplex structure forming nucleic acid interacting proteins ▶     Subodh Kumar Mishra, Arpita Tawani, Amit Mishra et al.     Nucleic acid G-quadruplex structure (G4) Interacting Proteins DataBase (G4IPDB) is an important database that contains detailed information about proteins interacting with …             Deep sequencing of transcriptome profiling of GSTM2 knock-down in swine testis cells ▶     Yuqi Lv, Yi Jin, Yongqiang Zhou et al.     Glutathione-S-transferases mu 2 (GSTM2), a kind of important Phase II antioxidant enzyme of eukaryotes, is degraded by nonsense mediated mRNA decay due to a C27T substitution in …             The impact of DNA damage response gene polymorphisms on therapeutic outcomes in late stage ovarian cancer ▶     F. Guffanti, R. Fruscio, E. Rulli et al.     Late stage epithelial ovarian cancer has a dismal prognosis. Identification of pharmacogenomic markers (i.e. polymorphisms) to stratify patients to optimize individual therapy is …             Inhibition of cystathionine β-synthetase suppresses sodium channel activities of dorsal root ganglion neurons of rats with lumbar disc herniation ▶     Jun Yan, Shufen Hu, Kang Zou et al.     The pathogenesis of pain in lumbar disc herniation (LDH) remains poorly understood. We have recently demonstrated that voltage-gated sodium channels (VGSCs) in dorsal root …             Pesticide toxicogenomics across scales: in vitro transcriptome predicts mechanisms and outcomes of exposure in vivo ▶     Immacolata Porreca, Fulvio D’Angelo, Lucia De Franceschi et al.     In vitro Omics analysis (i.e. transcriptome) is suggested to predict in vivo toxicity and adverse effects in humans, although the causal link between high-throughput data and …             Efficient targeted mutagenesis of rice and tobacco genomes using Cpf1 from Francisella novicida ▶     Akira Endo, Mikami Masafumi, Hidetaka Kaya et al.     CRISPR/Cas9 systems are nowadays applied extensively to effect genome editing in various organisms including plants. CRISPR from Prevotella and Francisella 1 (Cpf1) is a newly …             Discovery of piperonal-converting oxidase involved in the metabolism of a botanical aromatic aldehyde ▶     Shiori Doi, Yoshiteru Hashimoto, Chiaki Tomita et al.     Piperonal-catabolizing microorganisms were isolated from soil, the one (strain CT39-3) exhibiting the highest activity being identified as Burkholderia sp. The …             Shikonin induces mitochondria-mediated apoptosis and enhances chemotherapeutic sensitivity of gastric cancer through reactive oxygen species ▶     Wenquan Liang, Aizhen Cai, Guozhu Chen et al.     The prognosis of gastric cancer remains poor due to clinical drug resistance. Novel drugs are urgently needed. Shikonin (SHK), a natural naphthoquinone, has been reported to …             Bordetella pertussis outer membrane vesicle vaccine confers equal efficacy in mice with milder inflammatory responses compared to a whole-cell vaccine ▶     René H. M. Raeven, Jolanda Brummelman, Jeroen L. A. Pennings et al.     The demand for improved pertussis vaccines is urgent due to the resurgence of whooping cough. A deeper understanding of the mode of action of pertussis vaccines is required to …             The ER stress regulator Bip mediates cadmium-induced autophagy and neuronal senescence ▶     Tao Wang, Yan Yuan, Hui Zou et al.     Autophagy is protective in cadmium (Cd)-induced oxidative damage. Endoplasmic reticulum (ER) stress has been shown to induce autophagy in a process requiring the unfolded protein …             On the ability of molecular dynamics simulation and continuum electrostatics to treat interfacial water molecules in protein-protein complexes ▶     Guillaume Copie, Fabrizio Cleri, Ralf Blossey et al.     Interfacial waters are increasingly appreciated as playing a key role in protein-protein interactions. We report on a study of the prediction of interfacial water positions by …             MicroRNA mir-34 provides robustness to environmental stress response via the DAF-16 network in C. elegans ▶     Meltem Isik, T. Keith Blackwell, Eugene Berezikov     Diverse stresses and aging alter expression levels of microRNAs, suggesting a role for these posttranscriptional regulators of gene expression in stress modulation and longevity. …             The effects of repetitive transcranial magnetic stimulation in an animal model of tinnitus ▶     Wilhelmina H. A. M. Mulders, Vanessa Vooys, Kalina Makowiecki et al.     Tinnitus (phantom auditory perception associated with hearing loss) can seriously affect wellbeing. Its neural substrate is unknown however it has been linked with abnormal …             Neonicotinoid-induced impairment of odour coding in the honeybee ▶     Mara Andrione, Giorgio Vallortigara, Renzo Antolini et al.     Exposure to neonicotinoid pesticides is considered one of the possible causes of honeybee (Apis mellifera) population decline. At sublethal doses, these chemicals have been shown …             Defining an olfactory receptor function in airway smooth muscle cells ▶     William H. Aisenberg, Jessie Huang, Wanqu Zhu et al.     Pathways that control, or can be exploited to alter, the increase in airway smooth muscle (ASM) mass and cellular remodeling that occur in asthma are not well defined. Here we …             The mammalian LINC complex regulates genome transcriptional responses to substrate rigidity ▶     Samer G. Alam, Qiao Zhang, Nripesh Prasad et al.     Mechanical integration of the nucleus with the extracellular matrix (ECM) is established by linkage between the cytoskeleton and the nucleus. This integration is hypothesized to …             Structural basis for broad neutralization of HIV-1 through the molecular recognition of 10E8 helical epitope at the membrane interface ▶     Edurne Rujas, Jose M. M. Caaveiro, Angélica Partida-Hanon et al.     The mechanism by which the HIV-1 MPER epitope is recognized by the potent neutralizing antibody 10E8 at membrane interfaces remains poorly understood. To solve this problem, we …             Endothelin-3 stimulates cell adhesion and cooperates with β1-integrins during enteric nervous system ontogenesis ▶     Elodie Gazquez, Yuli Watanabe, Florence Broders-Bondon et al.     Endothelin-3 (EDN3) and β1-integrins are required for the colonization of the embryonic gut by enteric neural crest cells (ENCCs) to form the enteric nervous system (ENS). …             Increased plasma VEGF levels following ischemic preconditioning are associated with downregulation of miRNA-762 and miR-3072-5p ▶     Koji Ueno, Makoto Samura, Tamami Nakamura et al.     Ischemic preconditioning (IPC) has protective effects against ischemia-perfusion injury of organs. In the present study, we investigated the associated mechanisms after …             Evidence of genotypic adaptation to the exposure to volcanic risk at the dopamine receptor DRD4 locus ▶     Charlotte Faurie, Clement Mettling, Mohamed Ali Bchir et al.     Humans have colonized and adapted to extremely diverse environments, and the genetic basis of some such adaptations, for example to high altitude, is understood. In some cases, …             Erratum: Can native clonal moso bamboo encroach on adjacent natural forest without human intervention? ▶     Shangbin Bai, Yixiang Wang, Richard T. Conant et al.                 Corrigendum: EGFR tyrosine kinase inhibitors versus chemotherapy as first-line therapy for non-small cell lung cancer patients with the L858R point mutation ▶     Jianlin Xu, Haitang Yang, Bo Jin et al.                 Cellular reactions to long-term volatile organic compound (VOC) exposures ▶     Johanna M. Gostner, Johannes Zeisler, Mohammad Tauqeer Alam et al.     Investigations of cellular processes initiated by volatile organic compounds (VOCs) are limited when modelling realistic long-term exposure scenarios at low concentrations. …             Pharmacologic modulation of RORγt translates to efficacy in preclinical and translational models of psoriasis and inflammatory arthritis ▶     Xiaohua Xue, Pejman Soroosh, Aimee De Leon-Tabaldo et al.     The IL-23/IL-17 pathway is implicated in autoimmune diseases, particularly psoriasis, where biologics targeting IL-23 and IL-17 have shown significant clinical efficacy. …             Neurexin regulates nighttime sleep by modulating synaptic transmission ▶     Huawei Tong, Qian Li, Zi Chao Zhang et al.     Neurexins are cell adhesion molecules involved in synaptic formation and synaptic transmission. Mutations in neurexin genes are linked to autism spectrum disorders (ASDs), which …             Biochemical and Structural Analysis of a Novel Esterase from Caulobacter crescentus related to Penicillin-Binding Protein (PBP) ▶     Bum Han Ryu, Tri Duc Ngo, Wanki Yoo et al.     Considering that the prevalence of antibiotic-resistant pathogenic bacteria is largely increasing, a thorough understanding of penicillin-binding proteins (PBPs) is of great …             Cellular aspartyl proteases promote the unconventional secretion of biologically active HIV-1 matrix protein p17 ▶     Francesca Caccuri, Maria Luisa Iaria, Federica Campilongo et al.     The human immune deficiency virus type 1 (HIV-1) matrix protein p17 (p17), although devoid of a signal sequence, is released by infected cells and detected in blood and in …             Independent control of natural killer cell responsiveness and homeostasis at steady-state by CD11c+ dendritic cells ▶     Thuy Thanh Luu, Sridharan Ganesan, Arnika Kathleen Wagner et al.     During infection and inflammation, dendritic cells (DC) provide priming signals for natural killer (NK) cells via mechanisms distinct from their antigen processing and …             The complex nature of calcium cation interactions with phospholipid bilayers ▶     Adéla Melcrová, Sarka Pokorna, Saranya Pullanchery et al.     Understanding interactions of calcium with lipid membranes at the molecular level is of great importance in light of their involvement in calcium signaling, association of …             Early-onset epileptic encephalopathy caused by a reduced sensitivity of Kv7.2 potassium channels to phosphatidylinositol 4,5-bisphosphate ▶     Maria Virginia Soldovieri, Paolo Ambrosino, Ilaria Mosca et al.     Kv7.2 and Kv7.3 subunits underlie the M-current, a neuronal K+ current characterized by an absolute functional requirement for phosphatidylinositol 4,5-bisphosphate (PIP2). Kv7.2 …             Compound danshen dripping pills modulate the perturbed energy metabolism in a rat model of acute myocardial ischemia ▶     Jiahua Guo, Yonghong Yong, Jiye Aa et al.     The continuous administration of compound danshen dripping pills (CDDP) showed good efficacy in relieving myocardial ischemia clinically. To probe the underlying mechanism, …             Changes in urinary metabolomic profile during relapsing renal vasculitis ▶     Bahjat Al-Ani, Martin Fitzpatrick, Hamad Al-Nuaimi et al.     Current biomarkers of renal disease in systemic vasculitis lack predictive value and are insensitive to early damage. To identify novel biomarkers of renal vasculitis flare, we …             Uterine glands impact uterine receptivity, luminal fluid homeostasis and blastocyst implantation ▶     Andrew M. Kelleher, Gregory W. Burns, Susanta Behura et al.     Uterine glands are essential for pregnancy in mice and likely humans, because they secrete or transport bioactive substances that regulate uterine receptivity for blastocyst …             Unique nonstructural proteins of Pneumonia Virus of Mice (PVM) promote degradation of interferon (IFN) pathway components and IFN-stimulated gene proteins ▶     Jayeeta Dhar, Sailen Barik     Pneumonia Virus of Mice (PVM) is the only virus that shares the Pneumovirus genus of the Paramyxoviridae family with Respiratory Syncytial Virus (RSV). A deadly mouse pathogen, …             Plant phenolic volatiles inhibit quorum sensing in pectobacteria and reduce their virulence by potential binding to ExpI and ExpR proteins ▶     Janak Raj Joshi, Netaly Khazanov, Hanoch Senderowitz et al.     Quorum sensing (QS) is a population density-dependent regulatory system in bacteria that couples gene expression to cell density through accumulation of diffusible signaling …             Remarkable alterations of Nav1.6 in reactive astrogliosis during epileptogenesis ▶     Hongyan Zhu, Yuxiao Zhao, Hao Wu et al.     Voltage-gated sodium channels (VGSCs) play a vital role in controlling neuronal excitability. Nav1.6 is the most abundantly expressed VGSCs subtype in the adult central nervous …             Biomimetic Sniffing Improves the Detection Performance of a 3D Printed Nose of a Dog and a Commercial Trace Vapor Detector ▶     Matthew E. Staymates, William A. MacCrehan, Jessica L. Staymates et al.     Unlike current chemical trace detection technology, dogs actively sniff to acquire an odor sample. Flow visualization experiments with an anatomically-similar 3D printed dog’s …             Potential and optimization of two-phase anaerobic digestion of oil refinery waste activated sludge and microbial community study ▶     Qinghong Wang, Ying Liang, Peng Zhao et al.     Oil refinery waste activated sludge produced from oil wastewater biological treatment is a major industrial sludge. Two-phase anaerobic digestion of oil refinery waste activated …             B- and T-lymphocyte number and function in HIV+/HIV− lymphoma patients treated with high-dose chemotherapy and autologous bone marrow transplantation ▶     Diego Bertoli, Alessandro Re, Marco Chiarini et al.     Combination of anti-retroviral therapy, high-dose chemotherapy (HCT) and autologous stem cell transplantation (ASCT) has led to an improved survival of HIV+ non-Hodgkin lymphoma …             Limitations of MIC as sole metric of pharmacodynamic response across the range of antimicrobial susceptibilities within a single bacterial species ▶     Xuesong Wen, Ronette Gehring, Andrea Stallbaumer et al.     The minimum inhibitory concentration (MIC) of an antimicrobial drug for a bacterial pathogen is used as a measure of the bacterial susceptibility to the drug. However, …             Increased EMR2 expression on neutrophils correlates with disease severity and predicts overall mortality in cirrhotic patients ▶     Chien-Hao Huang, Wen-Juei Jeng, Yu-Pin Ho et al.     Patients with liver cirrhosis are susceptible to infections with high short-term mortalities. One CD97-related EGF-TM7 molecule, EMR2 (EGF-like molecule containing mucin-like …             Targeting intracellular p-aminobenzoic acid production potentiates the anti-tubercular action of antifolates ▶     Joshua M. Thiede, Shannon L. Kordus, Breanna J. Turman et al.     The ability to revitalize and re-purpose existing drugs offers a powerful approach for novel treatment options against Mycobacterium tuberculosis and other infectious agents. …             A previously unreported impact of a PLA2G7 gene polymorphism on the plasma levels of lipoprotein-associated phospholipase A2 activity and mass ▶     Yue Qi, Dong Zhao, Zhangrong Jia et al.     Lipoprotein-associated phospholipase A2 (Lp-PLA2) levels are associated with the development of atherosclerosis. We aimed to assess the genetic determinants of Lp-PLA2 activity …             Circulating cell-free DNA, telomere length and bilirubin in the Vienna Active Ageing Study: exploratory analysis of a randomized, controlled trial ▶     Anela Tosevska, Bernhard Franzke, Marlene Hofmann et al.     Telomere length (TL) in blood cells is widely used in human studies as a molecular marker of ageing. Circulating cell-free DNA (cfDNA) as well as unconjugated bilirubin (UCB) are …             High fidelity computational simulation of thrombus formation in Thoratec HeartMate II continuous flow ventricular assist device ▶     Wei-Tao Wu, Fang Yang, Jingchun Wu et al.     Continuous flow ventricular assist devices (cfVADs) provide a life-saving therapy for severe heart failure. However, in recent years, the incidence of device-related thrombosis …             Five key attributes can increase marine protected areas performance for small-scale fisheries management ▶     Antonio Di Franco, Pierre Thiriet, Giuseppe Di Carlo et al.     Marine protected areas (MPAs) have largely proven to be effective tools for conserving marine ecosystem, while socio-economic benefits generated by MPAs to fisheries are still …             Validation of plasma microRNAs as biomarkers for myotonic dystrophy type 1 ▶     A. Perfetti, S. Greco, R. Cardani et al.     Non-invasive and simple to measure biomarkers are still an unmet need for myotonic dystrophy type 1 (DM1). Indeed, muscle biopsies can be extremely informative, but their …             Anti-Hu antibodies activate enteric and sensory neurons ▶     Qin Li, Klaus Michel, Anita Annahazi et al.     IgG of type 1 anti-neuronal nuclear antibody (ANNA-1, anti-Hu) specificity is a serological marker of paraneoplastic neurological autoimmunity (including enteric/autonomic) …             Direct identification of antibiotic resistance genes on single plasmid molecules using CRISPR/Cas9 in combination with optical DNA mapping ▶     Vilhelm Müller, Fredrika Rajer, Karolin Frykholm et al.     Bacterial plasmids are extensively involved in the rapid global spread of antibiotic resistance. We here present an assay, based on optical DNA mapping of single plasmids in …             In silico Mapping of Protein Unfolding Mutations for Inherited Disease ▶     Caitlyn L. McCafferty, Yuri V. Sergeev     The effect of disease-causing missense mutations on protein folding is difficult to evaluate. To understand this relationship, we developed the unfolding mutation screen (UMS) …             Laser Speckle Rheology for evaluating the viscoelastic properties of hydrogel scaffolds ▶     Zeinab Hajjarian, Hadi Tavakoli Nia, Shawn Ahn et al.     Natural and synthetic hydrogel scaffolds exhibit distinct viscoelastic properties at various length scales and deformation rates. Laser Speckle Rheology (LSR) offers a novel, …             Block of nicotinic acetylcholine receptors by philanthotoxins is strongly dependent on their subunit composition ▶     Hamid S. Kachel, Rohit N. Patel, Henrik Franzyk et al.     Philanthotoxin-433 (PhTX-433) is an active component of the venom from the Egyptian digger wasp, Philanthus triangulum. PhTX-433 inhibits several excitatory ligand-gated ion …             A SILAC-Based Method for Quantitative Proteomic Analysis of Intestinal Organoids ▶     Alexis Gonneaud, Christine Jones, Naomie Turgeon et al.     Organoids have the potential to bridge 3D cell culture to tissue physiology by providing a model resembling in vivo organs. Long-term growing organoids were first isolated from …             Characterisation of functional domains in fission yeast Ams2 that are required for core histone gene transcription ▶     Yuko Takayama, Masaki Shirai, Fumie Masuda     Histone gene expression is regulated in a cell cycle-dependent manner, with a peak at S phase, which is crucial for cell division and genome integrity. However, the detailed …             A chitin deacetylase from the endophytic fungus Pestalotiopsis sp. efficiently inactivates the elicitor activity of chitin oligomers in rice cells ▶     Stefan Cord-Landwehr, Rebecca L. J. Melcher, Stephan Kolkenbrock et al.     To successfully survive in plants, endophytes need strategies to avoid being detected by the plant immune system, as the cell walls of endophytes contain easily detectible …             Fluorescence-tunable Ag-DNA biosensor with tailored cytotoxicity for live-cell applications ▶     Nelli Bossert, Donny de Bruin, Maria Götz et al.     DNA-stabilized silver clusters (Ag-DNA) show excellent promise as a multi-functional nanoagent for molecular investigations in living cells. The unique properties of these …             Depletion of tRNA-halves enables effective small RNA sequencing of low-input murine serum samples ▶     Alan Van Goethem, Nurten Yigit, Celine Everaert et al.     The ongoing ascent of sequencing technologies has enabled researchers to gain unprecedented insights into the RNA content of biological samples. MiRNAs, a class of small …             Mycobacterium avium MAV2054 protein induces macrophage apoptosis by targeting mitochondria and reduces intracellular bacterial growth ▶     Kang-In Lee, Jake Whang, Han-Gyu Choi et al.     Mycobacterium avium complex induces macrophage apoptosis. However, the M. avium components that inhibit or trigger apoptosis and their regulating mechanisms remain unclear. We …             Analysis of chikungunya virus proteins reveals that non-structural proteins nsP2 and nsP3 exhibit RNA interference (RNAi) suppressor activity ▶     Kalika Mathur, Abhishek Anand, Sunil Kumar Dubey et al.     RNAi pathway is an antiviral defence mechanism employed by insects that result in degradation of viral RNA thereby curbing infection. Several viruses including flaviviruses …             TMED3 promotes hepatocellular carcinoma progression via IL-11/STAT3 signaling ▶     Hao Zheng, Yuan Yang, Jun Han et al.     Transmembrane p24 trafficking protein 3(TMED3) is a metastatic suppressor in colon cancer, but its function in the progression of hepatocellular carcinoma (HCC) is unknown. Here, …             Development and evaluation of near-isogenic lines for brown planthopper resistance in rice cv. 9311 ▶     Cong Xiao, Jie Hu, Yi-Ting Ao et al.     Brown planthopper (BPH) is the most destructive pest of rice in Asia. To date 29 BPH resistance genes have been identified, but only a few genes are being used in breeding due to …             Wide variation in susceptibility of transmitted/founder HIV-1 subtype C Isolates to protease inhibitors and association with in vitro replication efficiency ▶     Katherine A. Sutherland, Dami A. Collier, Daniel T. Claiborne et al.     The gag gene is highly polymorphic across HIV-1 subtypes and contributes to susceptibility to protease inhibitors (PI), a critical class of antiretrovirals that will be used in …             Rab14 specifies the apical membrane through Arf6-mediated regulation of lipid domains and Cdc42 ▶     Ruifeng Lu, Jean M. Wilson     The generation of cell polarity is essential for the development of multi-cellular organisms as well as for the function of epithelial organs in the mature animal. Small GTPases …             Resveratrol serves as a protein-substrate interaction stabilizer in human SIRT1 activation ▶     Xuben Hou, David Rooklin, Hao Fang et al.     Resveratrol is a natural compound found in red wine that has been suggested to exert its potential health benefit through the activation of SIRT1, a crucial member of the …             Tumor-specific delivery of biologics by a novel T-cell line HOZOT ▶     Teppei Onishi, Hiroshi Tazawa, Yuuri Hashimoto et al.     “Cell-in-cell” denotes an invasive phenotype in which one cell actively internalizes in another. The novel human T-cell line HOZOT, established from human umbilical cord blood, …             Programmed necrosis - a new mechanism of steroidogenic luteal cell death and elimination during luteolysis in cows ▶     Takuo Hojo, Marta J. Siemieniuch, Karolina Lukasik et al.     Programmed necrosis (necroptosis) is an alternative form of programmed cell death that is regulated by receptor-interacting protein kinase (RIPK) 1 and 3-dependent, but is a …             Assessing the feasibility of fly based surveillance of wildlife infectious diseases ▶     Constanze Hoffmann, Melanie Stockhausen, Kevin Merkel et al.     Monitoring wildlife infectious agents requires acquiring samples suitable for analyses, which is often logistically demanding. A possible alternative to invasive or non-invasive …             Rice volatiles lure gravid malaria mosquitoes, Anopheles arabiensis ▶     Betelehem Wondwosen, Göran Birgersson, Emiru Seyoum et al.     Mosquito oviposition site selection is essential for vector population dynamics and malaria epidemiology. Irrigated rice cultivations provide ideal larval habitats for malaria …             Polymorphism of fibrillar structures depending on the size of assembled Aβ17-42 peptides ▶     Mookyung Cheon, Mooseok Kang, Iksoo Chang     The size of assembled Aβ17-42 peptides can determine polymorphism during oligomerization and fibrillization, but the mechanism of this effect is unknown. Starting from separate …             Low-level light treatment ameliorates immune thrombocytopenia ▶     Jingke Yang, Qi Zhang, Peiyu Li et al.     Immune thrombocytopenia (ITP) is an immune-mediated acquired bleeding disorder characterized by abnormally low platelet counts. We reported here the ability of low-level light …             Perceptual training yields rapid improvements in visually impaired youth ▶     Jeffrey B. Nyquist, Joseph S. Lappin, Ruyuan Zhang et al.     Visual function demands coordinated responses to information over a wide field of view, involving both central and peripheral vision. Visually impaired individuals often seem to …             Asian Citrus Psyllid RNAi Pathway – RNAi evidence ▶     Clauvis N. T. Taning, Eduardo C. Andrade, Wayne B. Hunter et al.     Diaphorina citri, known as the Asian citrus psyllid, is an important pest of citrus because it transmits a phloem-limited bacteria strongly implicated in huanglongbing (citrus …             Structural basis for the dissociation of α-synuclein fibrils triggered by pressure perturbation of the hydrophobic core ▶     Guilherme A. P. de Oliveira, Mayra de A. Marques, Carolina Cruzeiro-Silva et al.     Parkinson’s disease is a neurological disease in which aggregated forms of the α-synuclein (α-syn) protein are found. We used high hydrostatic pressure (HHP) coupled with NMR …             Parental and sexual conflicts over the Peg3 imprinted domain ▶     Hongzhi He, Bambarendage P. U. Perera, An Ye et al.     In the current study, the imprinting control region of the mouse Peg3 domain was deleted to test its functional impact on animal growth and survival. The paternal transmission of …             Digital gene expression profiling analysis of duodenum transcriptomes in SD rats administered ferrous sulfate or ferrous glycine chelate by gavage ▶     Zhao Zhuo, Shenglin Fang, Qiaoling Hu et al.     The absorption of different iron sources is a trending research topic. Many studies have revealed that organic iron exhibits better bioavailability than inorganic iron, but the …             Hill number as a bacterial diversity measure framework with high-throughput sequence data ▶     Sanghoon Kang, Jorge L. M. Rodrigues, Justin P. Ng et al.     Bacterial diversity is an important parameter for measuring bacterial contributions to the global ecosystem. However, even the task of describing bacterial diversity is …             Survey of the green picoalga Bathycoccus genomes in the global ocean ▶     Thomas Vannier, Jade Leconte, Yoann Seeleuthner et al.     Bathycoccus is a cosmopolitan green micro-alga belonging to the Mamiellophyceae, a class of picophytoplankton that contains important contributors to oceanic primary production. …             Pharmacological characterization of a high-affinity p-tyramine transporter in rat brain synaptosomes ▶     Mark D. Berry, Shannon Hart, Anthony R. Pryor et al.     p-Tyramine is an archetypal member of the endogenous family of monoamines known as trace amines, and is one of the endogenous agonists for trace amine-associated receptor …             Visual search performance is predicted by both prestimulus and poststimulus electrical brain activity ▶     Berry van den Berg, Lawrence G. Appelbaum, Kait Clark et al.     An individual’s performance on cognitive and perceptual tasks varies considerably across time and circumstances. We investigated neural mechanisms underlying such performance …             Complete genome sequence and transcriptomic analysis of a novel marine strain Bacillus weihaiensis reveals the mechanism of brown algae degradation ▶     Yueming Zhu, Peng Chen, Yunjuan Bao et al.     A novel marine strain representing efficient degradation ability toward brown algae was isolated, identified, and assigned to Bacillus weihaiensis Alg07. The alga-associated …             Targeted killing of myofibroblasts by biosurfactant di-rhamnolipid suggests a therapy against scar formation ▶     Chong Shen, Lifang Jiang, Huawei Shao et al.     Pathological myofibroblasts are often involved in skin scarring via generating contractile force and over-expressing collagen fibers, but no compound has been found to inhibit …             The use of the NEDD8 inhibitor MLN4924 (Pevonedistat) in a cyclotherapy approach to protect wild-type p53 cells from MLN4924 induced toxicity ▶     Lara J. Bou Malhab, Simon Descamps, Benedicte Delaval et al.     Targetting the ubiquitin pathway is an attractive strategy for cancer therapy. The inhibitor of the ubiquitin-like molecule NEDD8 pathway, MLN4924 (Pevonedistat) is in Phase II …             A-Kinase Anchoring Protein 4 (AKAP4) is an ERK1/2 substrate and a switch molecule between cAMP/PKA and PKC/ERK1/2 in human spermatozoa ▶     Liat Rahamim Ben-Navi, Tal Almog, Zhong Yao et al.     Mammalian spermatozoa undergo capacitation and acrosome reaction in order to fertilize the egg. The PKC-ERK1/2 pathway plays an important role in human spermatozoa motility, …             Staphylococcus aureus-dependent septic arthritis in murine knee joints: local immune response and beneficial effects of vaccination ▶     Alessia Corrado, Paolo Donato, Silvia Maccari et al.     Staphylococcus aureus is the major cause of human septic arthritis and osteomyelitis, which deserve special attention due to their rapid evolution and resistance to treatment. …             Rhein and rhubarb similarly protect the blood-brain barrier after experimental traumatic brain injury via gp91phox subunit of NADPH oxidase/ROS/ERK/MMP-9 signaling pathway ▶     Yang Wang, Xuegong Fan, Tao Tang et al.     Oxidative stress chiefly contributes to the disruption of the BBB following traumatic brain injury (TBI). The Chinese herbal medicine rhubarb is a promising antioxidant in …             Genome-wide Diversity and Association Mapping for Capsaicinoids and Fruit Weight in Capsicum annuum L ▶     Padma Nimmakayala, Venkata L. Abburi, Thangasamy Saminathan et al.     Accumulated capsaicinoid content and increased fruit size are traits resulting from Capsicum annuum domestication. In this study, we used a diverse collection of C. annuum to …             FSH protects mouse granulosa cells from oxidative damage by repressing mitophagy ▶     Ming Shen, Yi Jiang, Zhiqiang Guan et al.     Oxidative stress has been implicated in triggering granulosa cell (GC) death during follicular atresia. Recent studies suggested that follicle-stimulating hormone (FSH) has a …             p53 coordinates DNA repair with nucleotide synthesis by suppressing PFKFB3 expression and promoting the pentose phosphate pathway ▶     Derek A. Franklin, Yizhou He, Patrick L. Leslie et al.     Activation of p53 in response to DNA damage is essential for tumor suppression. Although previous studies have emphasized the importance of p53-dependent cell cycle arrest and …             Development of mouthparts in the cicada Meimuna mongolica (Distant): successive morphological patterning and sensilla differentiation from nymph to adult ▶     Yanan Hao, Christopher H. Dietrich, Wu Dai     Development of the mouthparts in the cicada Meimuna mongolica (Distant) is investigated here for the first time using scanning electron microscopy in order to document changes …             Glucocorticoid receptor and Histone deacetylase 6 mediate the differential effect of dexamethasone during osteogenesis of mesenchymal stromal cells (MSCs) ▶     Marilyn G. Rimando, Hao-Hsiang Wu, Yu-An Liu et al.     Lineage commitment and differentiation of mesenchymal stromal cells (MSCs) into osteoblasts in vitro is enhanced by a potent synthetic form of glucocorticoid (GC), dexamethasone …             How a life-like system emerges from a simplistic particle motion law ▶     Thomas Schmickl, Martin Stefanec, Karl Crailsheim     Self-structuring patterns can be observed all over the universe, from galaxies to molecules to living matter, yet their emergence is waiting for full understanding. We discovered …             THD-Module Extractor: An Application for CEN Module Extraction and Interesting Gene Identification for Alzheimer’s Disease ▶     Tulika Kakati, Hirak Kashyap, Dhruba K. Bhattacharyya     There exist many tools and methods for construction of co-expression network from gene expression data and for extraction of densely connected gene modules. In this paper, a …             Very rapid long-distance sea crossing by a migratory bird ▶     José A. Alves, Maria P. Dias, Verónica Méndez et al.     Landbirds undertaking within-continent migrations have the possibility to stop en route, but most long-distance migrants must also undertake large non-stop sea crossings, the …             Macrophage-dependent tumor cell transendothelial migration is mediated by Notch1/MenaINV-initiated invadopodium formation ▶     Jeanine Pignatelli, Jose Javier Bravo-Cordero, Minna Roh-Johnson et al.     The process of intravasation involving transendothelial migration is a key step in metastatic spread. How the triple cell complex composed of a macrophage, Mena over-expressing …             Obesity- and gender-dependent role of endogenous somatostatin and cortistatin in the regulation of endocrine and metabolic homeostasis in mice ▶     Raúl M. Luque, José Cordoba-Chacon, Ana I. Pozo-Salas et al.     Somatostatin (SST) and cortistatin (CORT) regulate numerous endocrine secretions and their absence [knockout (KO)-models] causes important endocrine-metabolic alterations, …             The rodent malaria liver stage survives in the rapamycin-induced autophagosome of infected Hepa1–6 cells ▶     Chenghao Zhao, Taiping Liu, Taoli Zhou et al.     It has been reported that non-selective autophagy of infected hepatocytes could facilitate the development of malaria in the liver stage, but the fate of parasites following …             Optogenetic clustering of CNK1 reveals mechanistic insights in RAF and AKT signalling controlling cell fate decisions ▶     Adrian Fischer, Bettina Warscheid, Wilfried Weber et al.     Scaffold proteins such as the multidomain protein CNK1 orchestrate the signalling network by integrating and controlling the underlying pathways. Using an optogenetic approach to …             Imaging analysis of Parkinson’s disease patients using SPECT and tractography ▶     Seong-Jin Son, Mansu Kim, Hyunjin Park     Parkinson’s disease (PD) is a degenerative disorder that affects the central nervous system. PD-related alterations in structural and functional neuroimaging have not been fully …             Inter-individual variability and modeling of electrical activity: a possible new approach to explore cardiac safety? ▶     Jean-Yves Le Guennec, Jérôme Thireau, Aude Ouillé et al.     Safety pharmacology aims to predict rare side effects of new drugs. We explored whether rare pro-arrhythmic effects could be linked to the variability of the effects of these …             Photodegradation of organic pollutants RhB dye using UV simulated sunlight on ceria based TiO2 nanomaterials for antibacterial applications ▶     Kaviyarasu Kasinathan, John Kennedy, Manikandan Elayaperumal et al.     To photo-catalytically degrade RhB dye using solar irradiation, CeO2 doped TiO2 nanocomposites were synthesized hydrothermally at 700 °C for 9 hrs. All emission spectra showed a …             Membrane Core-Specific Antimicrobial Action of Cathelicidin LL-37 Peptide Switches Between Pore and Nanofibre Formation ▶     Mahdi Shahmiri, Marta Enciso, Christopher G. Adda et al.     Membrane-disrupting antimicrobial peptides provide broad-spectrum defence against localized bacterial invasion in a range of hosts including humans. The most generally held …             Sparsity-based multi-height phase recovery in holographic microscopy ▶     Yair Rivenson, Yichen Wu, Hongda Wang et al.     High-resolution imaging of densely connected samples such as pathology slides using digital in-line holographic microscopy requires the acquisition of several holograms, e.g., at …             HUWE1 plays important role in mouse preimplantation embryo development and the dysregulation is associated with poor embryo development in humans ▶     L. J. Chen, W. M. Xu, M. Yang et al.     HUWE1 is a HECT domain containing ubiquitin ligase implicated in neurogenesis, spermatogenesis and cancer development. The purpose of the current study is to investigate the role …             Glycycoumarin inhibits hepatocyte lipoapoptosis through activation of autophagy and inhibition of ER stress/GSK-3-mediated mitochondrial pathway ▶     Enxiang Zhang, Shutao Yin, Xinhua Song et al.     Herbal medicine as an alternative approach in the treatment of disease has drawn growing attention. Identification of the active ingredient is needed for effective utilization of …             Nanomechanical properties of distinct fibrillar polymorphs of the protein α-synuclein ▶     Ali Makky, Luc Bousset, Jérôme Polesel-Maris et al.     Alpha-synuclein (α-Syn) is a small presynaptic protein of 140 amino acids. Its pathologic intracellular aggregation within the central nervous system yields protein fibrillar …             Sequencing-based breast cancer diagnostics as an alternative to routine biomarkers ▶     Mattias Rantalainen, Daniel Klevebring, Johan Lindberg et al.     Sequencing-based breast cancer diagnostics have the potential to replace routine biomarkers and provide molecular characterization that enable personalized precision medicine. …             Functional defects in CD4+ CD25high FoxP3+ regulatory cells in ankylosing spondylitis ▶     Huifang Guo, Ming Zheng, Kui Zhang et al.     Forkhead box P3 (FoxP3)-positive regulatory T cells (Tregs) play a pivotal role in the preservation of self-tolerance, and Treg dysfunction has been implicated in many autoimmune …             Regulation of α2B-Adrenergic Receptor Cell Surface Transport by GGA1 and GGA2 ▶     Maoxiang Zhang, Wei Huang, Jie Gao et al.     The molecular mechanisms that control the targeting of newly synthesized G protein-coupled receptors (GPCRs) to the functional destinations remain poorly elucidated. Here, we …             The role of PIM1/PIM2 kinases in tumors of the male reproductive system ▶     Manuel Pedro Jiménez-García, Antonio Lucena-Cacace, María José Robles-Frías et al.     The PIM family of serine/threonine kinases has three highly conserved isoforms (PIM1, PIM2 and PIM3). PIM proteins are regulated through transcription and stability by JAK/STAT …             Greater efficacy of atorvastatin versus a non-statin lipid-lowering agent against renal injury: potential role as a histone deacetylase inhibitor ▶     Ravi Shankar Singh, Dharmendra Kumar Chaudhary, Aradhana Mohan et al.     Statins, 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitors have been shown to improve diabetic nephropathy. However, whether they provide protection via Histone …             Dysbiosis by neutralizing commensal mediated inhibition of pathobionts ▶     Esteban Rodriguez Herrero, Vera Slomka, Nico Boon et al.     Dysbiosis in the periodontal microbiota is associated with the development of periodontal diseases. Little is known about the initiation of dysbiosis. It was hypothesized that …             Engineering Genetically-Encoded Mineralization and Magnetism via Directed Evolution ▶     Xueliang Liu, Paola A. Lopez, Tobias W. Giessen et al.     Genetically encoding the synthesis of functional nanomaterials such as magnetic nanoparticles enables sensitive and non-invasive biological sensing and control. Via directed …             Versatile, sensitive liquid chromatography mass spectrometry – Implementation of 10 μm OT columns suitable for small molecules, peptides and proteins ▶     T. Vehus, H. Roberg-Larsen, J. Waaler et al.     We have designed a versatile and sensitive liquid chromatographic (LC) system, featuring a monolithic trap column and a very narrow (10 μm ID) fused silica open tubular liquid …             Hyperglycaemia and Pseudomonas aeruginosa acidify cystic fibrosis airway surface liquid by elevating epithelial monocarboxylate transporter 2 dependent lactate-H+ secretion ▶     James Peter Garnett, Kameljit K. Kalsi, Mirko Sobotta et al.     The cystic fibrosis (CF) airway surface liquid (ASL) provides a nutrient rich environment for bacterial growth including elevated glucose, which together with defective bacterial …             Corrigendum: SREBP-2/PNPLA8 axis improves non-alcoholic fatty liver disease through activation of autophagy ▶     Kwang-Youn Kim, Hyun-Jun Jang, Yong Ryoul Yang et al.                 Erratum: Effects of low dose estrogen therapy on the vaginal microbiomes of women with atrophic vaginitis ▶     Jian Shen, Ning Song, Christopher J. Williams et al.                 Impact of the microbial derived short chain fatty acid propionate on host susceptibility to bacterial and fungal infections in vivo ▶     Eleonora Ciarlo, Tytti Heinonen, Jacobus Herderschee et al.     Short chain fatty acids (SCFAs) produced by intestinal microbes mediate anti-inflammatory effects, but whether they impact on antimicrobial host defenses remains largely unknown. …             CCL5/RANTES contributes to hypothalamic insulin signaling for systemic insulin responsiveness through CCR5 ▶     Szu-Yi Chou, Reni Ajoy, Chun Austin Changou et al.     Many neurodegenerative diseases are accompanied by metabolic disorders. CCL5/RANTES, and its receptor CCR5 are known to contribute to neuronal function as well as to metabolic …             The invasive stoloniferous clonal plant Alternanthera philoxeroides outperforms its co-occurring non-invasive functional counterparts in heterogeneous soil environments – invasion implications ▶     Tong Wang, Jiangtao Hu, Linlin Miao et al.     Environmental heterogeneity is considered to play a defining role in promoting invasion success, and it favours clonal plants. Although clonality has been demonstrated to be …             Body mass index and risk of non-melanoma skin cancer: cumulative evidence from prospective studies ▶     Daijun Zhou, Jun Wu, Gaoxing Luo     Prospective epidemiologic studies that investigated the association between body mass index (BMI) and non-melanoma skin cancer (NMSC) yielded inconsistent findings. A …             Structural insight for chain selection and stagger control in collagen ▶     Sergei P. Boudko, Hans Peter Bächinger     Collagen plays a fundamental role in all known metazoans. In collagens three polypeptides form a unique triple-helical structure with a one-residue stagger to fit every third …             Evaluation of association of common variants in HTR1A and HTR5A with schizophrenia and executive function ▶     Fanglin Guan, Huali Lin, Gang Chen et al.     The 5-HT1A receptor (HTR1A) and the 5-HT5A receptor (HTR5A) are key 5-HT receptors with distinct inhibitory functions. Studies have been conducted to investigate the association …             Beta 1-integrin ligation and TLR ligation enhance GM-CSF–induced ALDH1A2 expression in dendritic cells, but differentially regulate their anti-inflammatory properties ▶     Aya Yokota-Nakatsuma, Yoshiharu Ohoka, Hajime Takeuchi et al.     Retinoic acid (RA)–producing CD103+ mature dendritic cells (DCs) in mesenteric lymph nodes (MLNs) play crucial roles in gut immunity. GM-CSF and RA contribute to the expression …             Fold formation at the compartment boundary of Drosophila wing requires Yki signaling to suppress JNK dependent apoptosis ▶     Suning Liu, Jie Sun, Dan Wang et al.     Compartment boundaries prevent cell populations of different lineage from intermingling. In many cases, compartment boundaries are associated with morphological folds. However, …             Analysis of the interaction of calcitriol with the disulfide isomerase ERp57 ▶     Elisa Gaucci, Domenico Raimondo, Caterina Grillo et al.     Calcitriol, the active form of vitamin D3, can regulate the gene expression through the binding to the nuclear receptor VDR, but it can also display nongenomic actions, acting …             Soil respiration and its environmental response varies by day/night and by growing/dormant season in a subalpine forest ▶     Zongda Hu, Shirong Liu, Xingliang Liu et al.     Comparisons of soil respiration (RS) and its components of heterotrophic (RH) and rhizospheric (RR) respiration during daytime and nighttime, growing (GS) and dormant season …             A Novel Therapeutic Peptide as a Partial Agonist of RANKL in Ischemic Stroke ▶     Hitomi Kurinami, Munehisa Shimamura, Hironori Nakagami et al.     The enhanced receptor activator of nuclear factor-κB (NFκB) ligand (RANKL) and its receptor (RANK) signal have been reported to attenuate ischemic brain injury through inhibition …             Mutations in Acetylcholinesterase2 (ace2) increase the insensitivity of acetylcholinesterase to fosthiazate in the root-knot nematode Meloidogyne incognita ▶     Wen-Kun Huang, Qin-Song Wu, Huan Peng et al.     The root-knot nematode Meloidogyne incognita causes severe damage to continuously cropping vegetables. The control of this nematode relies heavily on organophosphate nematicides …             Expression level and clinical significance of HOX transcript antisense intergenic RNA in cervical cancer: a meta-analysis ▶     Shasha Liu, Min Zhang, Pengpeng Qu     The long noncoding RNA HOX transcript antisense intergenic RNA (HOTAIR) is associated with the development and progression of several types of cancer; however, its role in …             Chemical induction of hairpin RNAi molecules to silence vital genes in plant roots ▶     Siming Liu, John I. Yoder     Understanding the functions encoded by plant genes can be facilitated by reducing transcript levels by hairpin RNA (hpRNA) mediated silencing. A bottleneck to this technology …             Decision making processes based on social conventional rules in early adolescents with and without autism spectrum disorders ▶     Hidetsugu Komeda, Hidekazu Osanai, Kaichi Yanaoka et al.     Autism spectrum disorder (ASD) is characterized by problems with reciprocal social interaction, repetitive behaviours/narrow interests, and impairments in the social cognition …             NADPH oxidase gp91phox contributes to RANKL-induced osteoclast differentiation by upregulating NFATc1 ▶     In Soon Kang, Chaekyun Kim     Bone-marrow derived monocyte-macrophages (BMMs) differentiate into osteoclasts by M-CSF along subsequent RANKL stimulation possibly in collaboration with many other unknown …             A Role of the FUZZY ONIONS LIKE Gene in Regulating Cell Death and Defense in Arabidopsis ▶     Arianne Tremblay, Savanna Seabolt, Hongyun Zeng et al.     Programmed cell death (PCD) is critical for development and responses to environmental stimuli in many organisms. FUZZY ONIONS (FZO) proteins in yeast, flies, and mammals are …             Genome-wide analysis of miRNAs in the ovaries of Jining Grey and Laiwu Black goats to explore the regulation of fecundity ▶     Xiangyang Miao, Qingmiao Luo, Huijing Zhao et al.     Goat fecundity is important for agriculture and varies depending on the genetic background of the goat. Two excellent domestic breeds in China, the Jining Grey and Laiwu Black …             High-level expression of improved thermo-stable alkaline xylanase variant in Pichia Pastoris through codon optimization, multiple gene insertion and high-density fermentation ▶     Yihong Lu, Cheng Fang, Qinhong Wang et al.     In paper industry, xylanases are used to increase the pulp properties in bleaching process as its eco-friendly nature. The xylanases activity is hindered by high temperature and …             Changes in the Membrane-Associated Proteins of Exosomes Released from Human Macrophages after Mycobacterium tuberculosis Infection ▶     Gustavo Diaz, Lisa M. Wolfe, Nicole A. Kruh-Garcia et al.     Tuberculosis (TB) is the deadliest infectious disease worldwide. One obstacle hindering the elimination of TB is our lack of understanding of host-pathogen interactions. …             Characterizations of H4 avian influenza viruses isolated from ducks in live poultry markets and farm in Shanghai ▶     Ying Shi, Hongrui Cui, Junheng Wang et al.     H4 avian influenza virus is one of the most prevalent influenza virus subtypes in birds. The evolution and pathogenicity of H4 AIV in domestic birds of China remain largely …             LINC00978 predicts poor prognosis in breast cancer patients ▶     Lin-lin Deng, Ya-yun Chi, Lei Liu et al.     Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death among women worldwide. Long non-coding RNAs (lncRNAs) are a class of non-coding RNAs …             Corrigendum: Combinatorial nanocarrier based drug delivery approach for amalgamation of anti-tumor agents in breast cancer cells: an improved nanomedicine strategy ▶     Chandran Murugan, Kathirvel Rayappan, Ramar Thangam et al.                 Principal function of mineralocorticoid signaling suggested by constitutive knockout of the mineralocorticoid receptor in medaka fish ▶     Tatsuya Sakamoto, Madoka Yoshiki, Hideya Takahashi et al.     As in osmoregulation, mineralocorticoid signaling is implicated in the control of brain-behavior actions. Nevertheless, the understanding of this role is limited, partly due to …             Lipid-II Independent Antimicrobial Mechanism of Nisin Depends On Its Crowding And Degree Of Oligomerization ▶     Ashutosh Prince, Padmani Sandhu, Pankaj Kumar et al.     Nisin inhibits bacterial growth by generating pores in cell membrane and interrupting cell-wall biosynthesis through specific lipid II interaction. However, the role of the hinge …             Calmodulin interacts with Rab3D and modulates osteoclastic bone resorption ▶     Sipin Zhu, Shek Man Chim, Taksum Cheng et al.     Calmodulin is a highly versatile protein that regulates intracellular calcium homeostasis and is involved in a variety of cellular functions including cardiac excitability, …             Functional Involvement of a Mitogen Activated Protein Kinase Module, OsMKK3-OsMPK7-OsWRK30 in Mediating Resistance against Xanthomonas oryzae in Rice ▶     Siddhi Kashinath Jalmi, Alok Krishna Sinha     Mitogen-activated protein kinases (MAPKs) are highly conserved signaling modules in eukaryotes, transmitting signals from upstream receptor to downstream target by phosphorelay …             Glyoxalase 1-knockdown in human aortic endothelial cells – effect on the proteome and endothelial function estimates ▶     Bernd Stratmann, Britta Engelbrecht, Britta C. Espelage et al.     Methylglyoxal (MG), an arginine-directed glycating agent, is implicated in diabetic late complications. MG is detoxified by glyoxalase 1 (GLO1) of the cytosolic glyoxalase …             Comparative photochemistry activity and antioxidant responses in male and female Populus cathayana cuttings inoculated with arbuscular mycorrhizal fungi under salt ▶     Na Wu, Zhen Li, Fei Wu et al.     We investigated the impact of arbuscular mycorrhizal fungi (AMF) on the morphology and physiology of two genders of the typical dioecious plant Populus cathayana under salt …             Global gene regulation during activation of immunoglobulin class switching in human B cells ▶     Youming Zhang, David J. Fear, Saffron A. G. Willis-Owen et al.     Immunoglobulin class switch recombination (CSR) to IgE is a tightly regulated process central to atopic disease. To profile the B-cell transcriptional responses underlying the …             Product release is rate-limiting for catalytic processing by the Dengue virus protease ▶     A. E. Shannon, M. M. Pedroso, K. J. Chappell et al.     Dengue Virus (DENV) is the most prevalent global arbovirus, yet despite an increasing burden to health care there are currently no therapeutics available to treat infection. A …             Reducing GABAA-mediated inhibition improves forelimb motor function after focal cortical stroke in mice ▶     Claudia Alia, Cristina Spalletti, Stefano Lai et al.     A deeper understanding of post-stroke plasticity is critical to devise more effective pharmacological and rehabilitative treatments. The GABAergic system is one of the key …             Neural oscillations in the temporal pole for a temporally congruent audio-visual speech detection task ▶     Takefumi Ohki, Atsuko Gunji, Yuichi Takei et al.     Though recent studies have elucidated the earliest mechanisms of processing in multisensory integration, our understanding of how multisensory integration of more sustained and …             Cortical synaptic and dendritic spine abnormalities in a presymptomatic TDP-43 model of amyotrophic lateral sclerosis ▶     Matthew J. Fogarty, Paul M. Klenowski, John D. Lee et al.     Layer V pyramidal neurons (LVPNs) within the motor cortex integrate sensory cues and co-ordinate voluntary control of motor output. In amyotrophic lateral sclerosis (ALS) LVPNs …             Monotreme glucagon-like peptide-1 in venom and gut: one gene – two very different functions ▶     Enkhjargal Tsend-Ayush, Chuan He, Mark A. Myers et al.     The importance of Glucagon like peptide 1 (GLP-1) for metabolic control and insulin release sparked the evolution of genes mimicking GLP-1 action in venomous species (e.g. …             Functional brain mapping using specific sensory-circuit stimulation and a theoretical graph network analysis in mice with neuropathic allodynia ▶     Yuji Komaki, Keigo Hikishima, Shinsuke Shibata et al.     Allodynia, a form of neuropathic pain, is defined as pain in response to a non-nociceptive stimulus. The brain regions responsible for pain, which are not normally activated, can …             Rapid control of pandemic H1N1 influenza by targeting NKT-cells ▶     Bianca L. Artiaga, Guan Yang, Tarun E. Hutchinson et al.     Swine influenza A viruses (IAV) are a major cause of respiratory disease in pigs and humans. Currently approved anti-influenza therapies directly target the virus, but these …             Mitochondrial control through nutritionally regulated global histone H3 lysine-4 demethylation ▶     Maria Soloveychik, Mengshu Xu, Olga Zaslaver et al.     Histone demethylation by Jumonji-family proteins is coupled with the decarboxylation of α-ketoglutarate (αKG) to yield succinate, prompting hypotheses that their activities are …             ECM proteins in a microporous scaffold influence hepatocyte morphology, function, and gene expression ▶     Yan Wang, Myung Hee Kim, Hitomi Shirahama et al.     It is well known that a three-dimensional (3D) culture environment and the presence of extracellular matrix (ECM) proteins facilitate hepatocyte viability and maintenance of the …             TGF-β1 Induces Polypyrimidine Tract-Binding Protein to Alter Fibroblasts Proliferation and Fibronectin Deposition in Keloid ▶     Hu Jiao, Ping Dong, Li Yan et al.     Human dermal fibrotic disease keloid has been a clinical challenge because of its tumour-like growth and the lack of effective therapy. Dysregulated alternative splicing events …             Artemisinin analogue SM934 attenuate collagen-induced arthritis by suppressing T follicular helper cells and T helper 17 cells ▶     Ze-Min Lin, Xiao-Qian Yang, Feng-Hua Zhu et al.     SM934 is an artemisinin analogue with immunosuppressive properties and potent therapeutic activity against lupus-like diseases in autoimmune mice. In this report, the therapeutic …             Platycodin D potentiates proliferation inhibition and apoptosis induction upon AKT inhibition via feedback blockade in non-small cell lung cancer cells ▶     Ting Li, Xin Chen, Xiuping Chen et al.     AKT is the frequently overexpressed and constitutively active kinase within NSCLC cells and recognized as a promising target for NSCLC treatment. However, AKT inhibition relieves …             Quantitative Evaluation of the Mechanical Risks Caused by Focal Cartilage Defects in the Knee ▶     Mikko S. Venäläinen, Mika E. Mononen, Jari Salo et al.     Focal cartilage lesions can proceed to severe osteoarthritis or remain unaltered even for years. A method to identify high risk defects would be of utmost importance to guide …             Hydroxychavicol: A phytochemical targeting cutaneous fungal infections ▶     Intzar Ali, Naresh Kumar Satti, Prabhu Dutt et al.     The present study was designed to investigate the potency of hydroxychavicol on selected cutaneous human pathogenic fungi by the use of in vitro and in vivo assays and …             Long intergenic non-coding RNA expression signature in human breast cancer ▶     Yanfeng Zhang, Erin K. Wagner, Xingyi Guo et al.     Breast cancer is a complex disease, characterized by gene deregulation. There is less systematic investigation of the capacity of long intergenic non-coding RNAs (lincRNAs) as …             Preparation of 6/8/11-Amino/Chloro-Oxoisoaporphine and Group-10 Metal Complexes and Evaluation of Their in Vitro and in Vivo Antitumor Activity ▶     Qi-Pin Qin, Jiao-Lan Qin, Ting Meng et al.     A series of group-10 metal complexes 1–14 of oxoisoaporphine derivatives were designed and synthesized. 1–14 were more selectively cytotoxic to Hep-G2 cells comparing with normal …             Human mitochondrial transcriptional factor A breaks the mitochondria-mediated vicious cycle in Alzheimer’s disease ▶     Sugako Oka, Julio Leon, Kunihiko Sakumi et al.     In the mitochondria-mediated vicious cycle of Alzheimer’s disease (AD), intracellular amyloid β (Aβ) induces mitochondrial dysfunction and reactive oxygen species, which further …               • Careers & Jobs           naturejobs.com Science jobs of the week       Post-doctoral fellows     KU Leuven, The Laboratory for Cell Death Research & Therapy (CDRT)            Postdoctoral Fellow in Bioinformatics     Swiss Tropical Institute            Junior Group Leaders Positions     CRUK Manchester Institute             Postdoctoral Scientist     Medical Research Council            Postdoctoral Associate     University of Buffalo/Hunter James Kelly Research Institute            Principal Investigator / Senior Staff Fellow     Center for Biologics Evaluation and Research (CBER)            Postdoctoral Position in Cardiovascular Research     Oslo University Hospital            Early-Career Investigators     Solti Innovative Breast Cancer Research            Postdoctoral Research Associate / Fellow     University of Exeter            Assistant Professor     Oregon Health & Science University, Department of Physiology and Pharmacology          No matter what your career stage, student, postdoc or senior scientist, you will find articles on naturejobs.com to help guide you in your science career. Keep up-to-date with the latest sector trends, vote in our reader poll and sign-up to receive the monthly Naturejobs newsletter.           • Scientific Reports events Directory featured events           natureevents directory featured events         Genome rearrangements and mutation signatures in development and cancer     18.04.17 Boston, USA         Natureevents Directory is the premier resource for scientists looking for the latest scientific conferences, courses, meetings and symposia. Featured across Nature Publishing Group journals and centrally at natureevents.com it is an essential reference guide to scientific events worldwide.               Your email address is in the Scientific Reports: Biology mailing list. You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/nams/svc/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department For other enquiries, please contact our customer feedback department Nature Publishing Group | One New York Plaza, Suite 4500 | New York | NY 10004-1562 | USA Nature Publishing Group's offices: Principal offices: London - New York - Tokyo Worldwide offices: Basingstoke - Boston - Buenos Aires - Delhi - Hong Kong - Madrid - Melbourne - Munich - Paris - San Francisco - Seoul - Washington DC Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at The Campus, 4 Crinan Street, London, N1 9XW. © 2016 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.