Nature Structural & Molecular Biology Contents: 2016 Volume #23 pp 1085-1168

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TABLE OF CONTENTS December 2016 Volume 23, Issue 12 Focus Editorial Perspective Reviews News and Views Obituary Articles Analysis Technical Report Subscribe   Facebook   RSS   Recommend to library   Twitter   Focus Top Focus on Cycles and Rhythms Focus issue: December 2016 Volume 23 No 12 Contents Editorial Perspectives Reviews Editorial Top Focus on Cycles and Rhythms Keeping time   p1029 doi:10.1038/nsmb.3341 Daily rhythms are a constant part of life. This special Focus issue explores the molecular mechanisms that underlie the generation of circadian dynamics. Perspective Top Focus on Cycles and Rhythms Elements of biological oscillations in time and space   pp1030 - 1034 Yangxiaolu Cao, Allison Lopatkin and Lingchong You doi:10.1038/nsmb.3320 This Perspective focuses on five distinct regulatory elements that have been recognized as being critical for generating and modulating oscillatory dynamics in time and space, in both natural and synthetic biological networks. Reviews Top Focus on Cycles and Rhythms The molecular basis of metabolic cycles and their relationship to circadian rhythms   pp1035 - 1044 Jane Mellor doi:10.1038/nsmb.3311 This review explores the molecular basis of metabolic and gene-expression oscillations in the yeast Saccharomyces cerevisiae and describes how they relate to other biological time-keeping mechanisms, such as circadian rhythms. Focus on Cycles and Rhythms Genetic and epigenomic mechanisms of mammalian circadian transcription   pp1045 - 1052 Romeo Papazyan, Yuxiang Zhang and Mitchell A Lazar doi:10.1038/nsmb.3324 In this Review, the authors consider the functions of key clock transcription factors and the epigenetic regulatory mechanisms that direct circadian gene expression in mammalian cells. Focus on Cycles and Rhythms The intricate dance of post-translational modifications in the rhythm of life   pp1053 - 1060 Arisa Hirano, Ying-Hui Fu and Louis J Ptáček doi:10.1038/nsmb.3326 Clock proteins are controlled by multiple post-translational modifications during the circadian cycle. In this Review, the authors examine how post-translational modifications influence the stability, interactions and activity of mammalian clock proteins and how they contribute to proper clock function or are altered in circadian disorders. Focus on Cycles and Rhythms Molecular mechanisms at the core of the plant circadian oscillator   pp1061 - 1069 Maria A Nohales and Steve A Kay doi:10.1038/nsmb.3327 This Review examines the molecular mechanisms underlying the plant circadian clock, highlighting the functions of transcriptional circuits and post-translational regulation in timing and describing how clock components integrate and respond to environmental signals. News and Views Top The origin of oxidized guanine resolves the puzzle of oxidation-induced telomere-length alterations   pp1070 - 1071 Jaya Sarkar and Yie Liu doi:10.1038/nsmb.3332 Although oxidative stress has long been considered to be a major factor contributing to telomere shortening, recent work has established that oxidative stress and DNA damage are linked to telomere lengthening. Now, Opresko and colleagues resolve this apparent discrepancy by showing that differential modulation of telomerase activity depends on the origin of a common oxidative guanine lesion. See also: Article by Fouquerel et al. Obituary Susan Lindquist 1949-2016   pp1072 - 1073 Richard I Morimoto doi:10.1038/nsmb.3339 Structural & Molecular Biology JOBS of the week FACULTY POSITION Physics - Atomic, Molecular and Optical physics ; NYU Shanghai NYU SHANGHAI Research Group Leader (M / F) with Focus on Molecular Biology / Gastrointestinal Oncology / Hepatology University Hospital Regensburg Tenure Track Position in Developmental Biology & Molecular Genetics University of Calgary Postdoctoral Scientist in Molecular genetics of human T cell development Ghent University Postdoc Positions in Cell Biology and Molecular Neuroscience Laboratory Lee Kong Chian School of Medicine, Joint medical school between, Imperial College London and Nanyang Technological University in Singapore More Science jobs from Advertisement Online-only and open access, Cell Death Discovery publishes scientifically sound research at the intersection of cell death and medicine. Increasing the reproducibility of research, the journal fosters a dynamic dialogue with a focus on cancer, neurobiology and inflammation research. Submit your manuscript >>   Articles Top Ribosome-stalk biogenesis is coupled with recruitment of nuclear-export factor to the nascent 60S subunit   pp1074 - 1082 Anshuk Sarkar, Markus Pech, Matthias Thoms, Roland Beckmann and Ed Hurt doi:10.1038/nsmb.3312 The ribosome-assembly factor Mrt4 prevents untimely recruitment of the RNA-export receptor Mex67-Mtr2 to the nascent 60S ribosomal subunit, thereby ensuring appropriately timed nuclear export. Staggered ATP binding mechanism of eukaryotic chaperonin TRiC (CCT) revealed through high-resolution cryo-EM   pp1083 - 1091 Yunxiang Zang, Mingliang Jin, Huping Wang, Zhicheng Cui, Liangliang Kong et al. doi:10.1038/nsmb.3309 Cryo-EM analyses of yeast TRiC (CCT) reveal conformational changes induced by ATP binding and a staggered mode of nucleotide binding to the different subunits. Oxidative guanine base damage regulates human telomerase activity   pp1092 - 1100 Elise Fouquerel, Justin Lormand, Arindam Bose, Hui-Ting Lee, Grace S Kim et al. doi:10.1038/nsmb.3319 Opposing effects of 8-oxodGTP on telomerase activity - promoting elongation by destabilizing G4 structures or inhibiting elongation by acting as a chain terminator - explain the differential sensitivity of cells with short telomeres to oxidative stress. See also: News and Views by Sarkar & Liu RNA-binding protein CPEB1 remodels host and viral RNA landscapes   pp1101 - 1110 Ranjan Batra, Thomas J Stark, Elizabeth Clark, Jean-Philippe Belzile, Emily C Wheeler et al. doi:10.1038/nsmb.3310 The RNA-binding protein CPEB1 drives post-transcriptional changes in the host transcriptome and poly(A)-tail lengthening of viral RNAs, processes essential for productive HCMV infection. Large-scale ATP-independent nucleosome unfolding by a histone chaperone   pp1111 - 1116 Maria E Valieva, Grigoriy A Armeev, Kseniya S Kudryashova, Nadezhda S Gerasimova, Alexey K Shaytan et al. doi:10.1038/nsmb.3321 spFRET microscopy analysis reveals how FACT reversibly uncoils DNA from nucleosomes during remodeling, thus modulating DNA accessibility in vitro and in vivo. Advertisement npj Systems Biology and Applications is a new online, open access, multi- and cross- disciplinary journal dedicated to publishing finest research on systems biology and all its approaches. Read the latest featured article: Systems biology driving drug development: From design to the clinical testing of the anti-ErbB3 antibody Seribantumab   Analysis Top The ribosome-engaged landscape of alternative splicing   pp1117 - 1123 Robert J Weatheritt, Timothy Sterne-Weiler and Benjamin J Blencowe doi:10.1038/nsmb.3317 Comparative analysis of RNA-seq and ribosome profiling data show that a major fraction of exon-skipping events in transcripts with medium-to-high abundance are engaged by ribosomes and therefore are likely to be translated. Technical Report Top Cotranscriptional folding of a riboswitch at nucleotide resolution   pp1124 - 1131 Kyle E Watters, Eric J Strobel, Angela M Yu, John T Lis and Julius B Lucks doi:10.1038/nsmb.3316 Applying SHAPE-seq to analyze cotranscriptional folding of the B. cereus crcB fluoride riboswitch at nucleotide resolution shows that the folding pathway undergoes a ligand-dependent bifurcation that influences terminator formation via coordinated structural transitions. Top Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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