Nature Reviews Molecular Cell Biology contents January 2017 Volume 18 Number 1 pp 1-67

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TABLE OF CONTENTS
January 2017 Volume 18 Number 1		Advertisement
2015 2-year Impact Factor 38.602 Journal Metrics 2-year Median 30	In this issue Research Highlights Reviews Also this month Article series: RNA processing and modifications Article series: Adult stem cells  Featured article: Reverse-topology membrane scission by the ESCRT proteins Johannes Schöneberg, Il-Hyung Lee, Janet H. Iwasa & James H. Hurley	To celebrate the continuing rise to fame of the CRISPR system, the Nature Reviews Genetics 2017 CRISPR calendar highlights the underlying biology of CRISPR, as well as its diverse range of exciting potential applications in genetic research, biotechnology and therapeutics. Download the calendar free online Produced with support from  OriGene
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RESEARCH HIGHLIGHTS Top Stem cells: HSC function determined by epigenetic memory p1 | doi:10.1038/nrm.2016.161 The functional behaviour of haematopoietic stem cells is determined in a cell-autonomous manner by clone-specific epigenetic modifications. PDF Cell migration: Let your fingers do the walking p2 | doi:10.1038/nrm.2016.160 Cadherin-based, finger-like cell-cell contacts are shown to serve as instructive structural cues that coordinate motility during collective cell migration. PDF Chromatin: The chemical brothers: nucleosomes and transcription p2 | doi:10.1038/nrm.2016.167 A chemical approach for precisely mapping nucleosomes genome-wide provides novel insights into the regulation of transcription and splicing. PDF Protein translocation: The third route to the ER p3 | doi:10.1038/nrm.2016.164 The newly identified SND pathway is an alternative route for the targeting of proteins to the endoplasmic reticulum that functions in parallel to the SRP and GET pathways. PDF Cellular senescence: Senescence and reprogramming go hand-in-hand p4 | doi:10.1038/nrm.2016.165 OSKM-mediated reprogramming to pluripotency in vivo is facilitated by cellular senescence through the secretion of key cytokines. PDF IN BRIEF Organelle dynamics: Controlling phase separation of P granules | Genome engineering: NHEJ and CRISPR-Cas9 improve gene therapy | RNA decay: NoBody binds to mRNA decapping proteins PDF Molecular Cell Biology JOBS of the week Post-doctoral Research Assistant in Cell Biology St. George's University of London Exciting PhD Positions in Molecular Medicine CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences Staff Scientist Wellcome Trust Sanger Institute Postdoctoral fellow University of Toronto Postdoctoral Research Fellow The Hospital for Sick Children More Science jobs from
REVIEWS		Top
Reverse-topology membrane scission by the ESCRT proteins Johannes Schöneberg, Il-Hyung Lee, Janet H. Iwasa & James H. Hurley p5 | doi:10.1038/nrm.2016.121 New observations of ESCRT-mediated reverse-topology membrane scission are building towards a structural and biophysical explanation of the mechanism involved. Abstract | Full Text | PDF | Supplementary information
Article series: RNA processing and modifications Alternative polyadenylation of mRNA precursors Bin Tian & James L. Manley p18 | doi:10.1038/nrm.2016.116 Alternative polyadenylation (APA) generates mRNAs with varying 3' termini. It is regulated by variation in the concentration of cleavage and polyadenylation factors and by RNA-binding proteins, as well as by splicing and transcription. APA is important for cell proliferation and differentiation owing to its roles in mRNA metabolism and protein diversification. Abstract | Full Text | PDF | Supplementary information
Article series: RNA processing and modifications Post-transcriptional gene regulation by mRNA modifications Boxuan Simen Zhao, Ian A. Roundtree & Chuan He p31 | doi:10.1038/nrm.2016.132 Reversible mRNA methylation is an emerging mode of eukaryotic post-transcriptional gene regulation. N 6-methyladenosine (m6A) affects mRNA processing, translation and decay during cell differentiation, embryonic development and stress responses. Other mRNA modifications – N 1-methyladenosine (m1A), 5-methylcytosine (m5C) and pseudouridine – together with m6A code a new layer of information that controls protein synthesis. Abstract | Full Text | PDF | Supplementary information
Mechanisms and in vivo functions of contact inhibition of locomotion Brian Stramer & Roberto Mayor p43 | doi:10.1038/nrm.2016.118 Contact inhibition of locomotion (CIL) involves collisions with other cells during cell migration that typically induce cessation of movement or a change of migratory direction. A molecular description of CIL and details of its involvement in various cellular processes are emerging, demonstrating that CIL is a highly heterogeneous response with important functions in vivo. Abstract | Full Text | PDF | Supplementary information
Article series: Adult stem cells A view of human haematopoietic development from the Petri dish Andrea Ditadi, Christopher M. Sturgeon & Gordon Keller p56 | doi:10.1038/nrm.2016.127 Human pluripotent stem cells constitute a unique system to study the earliest stages of human embryonic haematopoiesis and the origins of human blood cell diseases, and they are an invaluable tool for the generation of haematopoietic stem and progenitor cell populations for cell-based regenerative therapies. Abstract | Full Text | PDF
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*2015 Journal Citation Reports (Thomson Reuters, 2016)

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